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Guillain-Barre syndrome

MedGen UID:
5399
•Concept ID:
C0018378
•
Disease or Syndrome
Synonyms: Landry's ascending paralysis; Landry-Guillain-Barre-Strohl syndrome
SNOMED CT: Guillain Barre syndrome (40956001); Landry-Guillain-Barré syndrome (40956001); Guillain-Barré syndrome (40956001); Landry-Guillain-Barre syndrome (40956001); Guillain-Barre syndrome (40956001)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0016218
Orphanet: ORPHA2103

Definition

A clinically heterogeneous spectrum of rare post-infectious neuropathies that usually occur in otherwise healthy patients and encompasses acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN), Miller-Fisher syndrome (MFS) and some other regional variants. [from ORDO]

Professional guidelines

PubMed

Diagnosis and management of Guillain-Barré syndrome in ten steps.
Leonhard SE, Mandarakas MR, Gondim FAA, Bateman K, Ferreira MLB, Cornblath DR, van Doorn PA, Dourado ME, Hughes RAC, Islam B, Kusunoki S, Pardo CA, Reisin R, Sejvar JJ, Shahrizaila N, Soares C, Umapathi T, Wang Y, Yiu EM, Willison HJ, Jacobs BC
Nat Rev Neurol 2019 Nov;15(11):671-683. Epub 2019 Sep 20 doi: 10.1038/s41582-019-0250-9. PMID: 31541214Free PMC Article
Guillain-Barré syndrome: causes, immunopathogenic mechanisms and treatment.
Jasti AK, Selmi C, Sarmiento-Monroy JC, Vega DA, Anaya JM, Gershwin ME
Expert Rev Clin Immunol 2016 Nov;12(11):1175-1189. Epub 2016 Jun 21 doi: 10.1080/1744666X.2016.1193006. PMID: 27292311
Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis.
van den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA
Nat Rev Neurol 2014 Aug;10(8):469-82. Epub 2014 Jul 15 doi: 10.1038/nrneurol.2014.121. PMID: 25023340

Recent clinical studies

Etiology

Diagnosis and treatment of Guillain-Barré Syndrome in childhood and adolescence: An evidence- and consensus-based guideline.
Korinthenberg R, Trollmann R, Felderhoff-Müser U, Bernert G, Hackenberg A, Hufnagel M, Pohl M, Hahn G, Mentzel HJ, Sommer C, Lambeck J, Mecher F, Hessenauer M, Winterholler C, Kempf U, Jacobs BC, Rostasy K, Müller-Felber W
Eur J Paediatr Neurol 2020 Mar;25:5-16. Epub 2020 Jan 7 doi: 10.1016/j.ejpn.2020.01.003. PMID: 31941581
Immunotherapy of Guillain-Barré syndrome.
Liu S, Dong C, Ubogu EE
Hum Vaccin Immunother 2018;14(11):2568-2579. Epub 2018 Jul 12 doi: 10.1080/21645515.2018.1493415. PMID: 29953326Free PMC Article
Guillain-Barré syndrome mimics.
Tham SL, Prasad K, Umapathi T
Brain Behav 2018 May;8(5):e00960. Epub 2018 Apr 10 doi: 10.1002/brb3.960. PMID: 29761013Free PMC Article
Guillain-Barré and Miller Fisher syndromes--new diagnostic classification.
Wakerley BR, Uncini A, Yuki N; GBS Classification Group; GBS Classification Group
Nat Rev Neurol 2014 Sep;10(9):537-44. Epub 2014 Jul 29 doi: 10.1038/nrneurol.2014.138. PMID: 25072194
Guillain-Barré syndrome.
Walling AD, Dickson G
Am Fam Physician 2013 Feb 1;87(3):191-7. PMID: 23418763

Diagnosis

Guillain-Barré syndrome.
Shahrizaila N, Lehmann HC, Kuwabara S
Lancet 2021 Mar 27;397(10280):1214-1228. Epub 2021 Feb 26 doi: 10.1016/S0140-6736(21)00517-1. PMID: 33647239
Guillain-Barré Syndrome.
Sheikh KA
Continuum (Minneap Minn) 2020 Oct;26(5):1184-1204. doi: 10.1212/CON.0000000000000929. PMID: 33002998
Guillain-Barre Syndrome.
Malek E, Salameh J
Semin Neurol 2019 Oct;39(5):589-595. Epub 2019 Oct 22 doi: 10.1055/s-0039-1693005. PMID: 31639842
Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis.
van den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA
Nat Rev Neurol 2014 Aug;10(8):469-82. Epub 2014 Jul 15 doi: 10.1038/nrneurol.2014.121. PMID: 25023340
Guillain-Barré syndrome and variants.
Dimachkie MM, Barohn RJ
Neurol Clin 2013 May;31(2):491-510. Epub 2013 Feb 19 doi: 10.1016/j.ncl.2013.01.005. PMID: 23642721Free PMC Article

Therapy

Therapeutic issues in Guillain-Barré syndrome.
Magy L, Frachet S
Expert Rev Neurother 2023 Jun;23(6):549-557. Epub 2023 May 9 doi: 10.1080/14737175.2023.2212163. PMID: 37151048
Immunoglobulin and Monoclonal Antibody Therapies in Guillain-Barré Syndrome.
Rajabally YA
Neurotherapeutics 2022 Apr;19(3):885-896. Epub 2022 Jun 1 doi: 10.1007/s13311-022-01253-4. PMID: 35648286Free PMC Article
Guillain-Barré syndrome.
Willison HJ, Jacobs BC, van Doorn PA
Lancet 2016 Aug 13;388(10045):717-27. Epub 2016 Mar 2 doi: 10.1016/S0140-6736(16)00339-1. PMID: 26948435
Guillain-Barré syndrome and variants.
Dimachkie MM, Barohn RJ
Neurol Clin 2013 May;31(2):491-510. Epub 2013 Feb 19 doi: 10.1016/j.ncl.2013.01.005. PMID: 23642721Free PMC Article
Guillain-Barré syndrome.
Hughes RA, Cornblath DR
Lancet 2005 Nov 5;366(9497):1653-66. doi: 10.1016/S0140-6736(05)67665-9. PMID: 16271648

Prognosis

Guillain-Barré syndrome mimics.
Tham SL, Prasad K, Umapathi T
Brain Behav 2018 May;8(5):e00960. Epub 2018 Apr 10 doi: 10.1002/brb3.960. PMID: 29761013Free PMC Article
Peripheral neuropathies.
Hanewinckel R, Ikram MA, Van Doorn PA
Handb Clin Neurol 2016;138:263-82. doi: 10.1016/B978-0-12-802973-2.00015-X. PMID: 27637963
Guillain-Barré syndrome.
Walling AD, Dickson G
Am Fam Physician 2013 Feb 1;87(3):191-7. PMID: 23418763
Guillain-Barré syndrome.
Yuki N, Hartung HP
N Engl J Med 2012 Jun 14;366(24):2294-304. doi: 10.1056/NEJMra1114525. PMID: 22694000
Guillain-Barré syndrome.
Hughes RA, Cornblath DR
Lancet 2005 Nov 5;366(9497):1653-66. doi: 10.1016/S0140-6736(05)67665-9. PMID: 16271648

Clinical prediction guides

Guillain-Barre Syndrome in Children and Adolescents.
Langille MM
Adv Pediatr 2023 Aug;70(1):91-103. Epub 2023 May 12 doi: 10.1016/j.yapd.2023.04.001. PMID: 37422300
Guillain-Barré Syndrome.
Sheikh KA
Continuum (Minneap Minn) 2020 Oct;26(5):1184-1204. doi: 10.1212/CON.0000000000000929. PMID: 33002998
Guillain-Barré syndrome: causes, immunopathogenic mechanisms and treatment.
Jasti AK, Selmi C, Sarmiento-Monroy JC, Vega DA, Anaya JM, Gershwin ME
Expert Rev Clin Immunol 2016 Nov;12(11):1175-1189. Epub 2016 Jun 21 doi: 10.1080/1744666X.2016.1193006. PMID: 27292311
Guillain-Barré syndrome.
Willison HJ, Jacobs BC, van Doorn PA
Lancet 2016 Aug 13;388(10045):717-27. Epub 2016 Mar 2 doi: 10.1016/S0140-6736(16)00339-1. PMID: 26948435
Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis.
van den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA
Nat Rev Neurol 2014 Aug;10(8):469-82. Epub 2014 Jul 15 doi: 10.1038/nrneurol.2014.121. PMID: 25023340

Recent systematic reviews

Triggers of Guillain-Barré Syndrome: Campylobacter jejuni Predominates.
Finsterer J
Int J Mol Sci 2022 Nov 17;23(22) doi: 10.3390/ijms232214222. PMID: 36430700Free PMC Article
Guillain-​Barré Syndrome Associated with COVID-19 Vaccination.
Shao SC, Wang CH, Chang KC, Hung MJ, Chen HY, Liao SC
Emerg Infect Dis 2021 Dec;27(12):3175-3178. Epub 2021 Oct 14 doi: 10.3201/eid2712.211634. PMID: 34648420Free PMC Article
Plasma exchange for Guillain-Barré syndrome.
Chevret S, Hughes RA, Annane D
Cochrane Database Syst Rev 2017 Feb 27;2(2):CD001798. doi: 10.1002/14651858.CD001798.pub3. PMID: 28241090Free PMC Article
Intravenous immunoglobulin for Guillain-Barré syndrome.
Hughes RA, Swan AV, van Doorn PA
Cochrane Database Syst Rev 2014 Sep 19;2014(9):CD002063. doi: 10.1002/14651858.CD002063.pub6. PMID: 25238327Free PMC Article
Multidisciplinary care for Guillain-Barré syndrome.
Khan F, Ng L, Amatya B, Brand C, Turner-Stokes L
Eur J Phys Rehabil Med 2011 Dec;47(4):607-12. Epub 2011 Sep 13 PMID: 21912364

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