U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Guillain-Barre syndrome

MedGen UID:
5399
•Concept ID:
C0018378
•
Disease or Syndrome
Synonyms: Landry's ascending paralysis; Landry-Guillain-Barre-Strohl syndrome
SNOMED CT: Guillain Barre syndrome (40956001); Landry-Guillain-Barré syndrome (40956001); Guillain-Barré syndrome (40956001); Landry-Guillain-Barre syndrome (40956001); Guillain-Barre syndrome (40956001)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on a mixture of major and minor genetic determinants possibly together with environmental factors. Diseases inherited in this manner are termed complex diseases.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0016218
Orphanet: ORPHA2103

Definition

A clinically heterogeneous spectrum of rare post-infectious neuropathies that usually occur in otherwise healthy patients and encompasses acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN), Miller-Fisher syndrome (MFS) and some other regional variants. [from ORDO]

Professional guidelines

PubMed

Diagnosis and management of Guillain-Barré syndrome in ten steps.
Leonhard SE, Mandarakas MR, Gondim FAA, Bateman K, Ferreira MLB, Cornblath DR, van Doorn PA, Dourado ME, Hughes RAC, Islam B, Kusunoki S, Pardo CA, Reisin R, Sejvar JJ, Shahrizaila N, Soares C, Umapathi T, Wang Y, Yiu EM, Willison HJ, Jacobs BC
Nat Rev Neurol 2019 Nov;15(11):671-683. Epub 2019 Sep 20 doi: 10.1038/s41582-019-0250-9. PMID: 31541214Free PMC Article
Guillain-Barré syndrome: causes, immunopathogenic mechanisms and treatment.
Jasti AK, Selmi C, Sarmiento-Monroy JC, Vega DA, Anaya JM, Gershwin ME
Expert Rev Clin Immunol 2016 Nov;12(11):1175-1189. Epub 2016 Jun 21 doi: 10.1080/1744666X.2016.1193006. PMID: 27292311
Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis.
van den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA
Nat Rev Neurol 2014 Aug;10(8):469-82. Epub 2014 Jul 15 doi: 10.1038/nrneurol.2014.121. PMID: 25023340

Recent clinical studies

Etiology

Supervised, individualised exercise reduces fatigue and improves strength and quality of life more than unsupervised home exercise in people with chronic Guillain-Barré syndrome: a randomised trial.
Shah N, Shrivastava M, Kumar S, Nagi RS
J Physiother 2022 Apr;68(2):123-129. Epub 2022 Apr 5 doi: 10.1016/j.jphys.2022.03.007. PMID: 35396175
Novel Immunological and Therapeutic Insights in Guillain-Barré Syndrome and CIDP.
Querol L, Lleixà C
Neurotherapeutics 2021 Oct;18(4):2222-2235. Epub 2021 Sep 21 doi: 10.1007/s13311-021-01117-3. PMID: 34549385Free PMC Article
Immunotherapy of Guillain-Barré syndrome.
Liu S, Dong C, Ubogu EE
Hum Vaccin Immunother 2018;14(11):2568-2579. Epub 2018 Jul 12 doi: 10.1080/21645515.2018.1493415. PMID: 29953326Free PMC Article
Guillain-Barré syndrome mimics.
Tham SL, Prasad K, Umapathi T
Brain Behav 2018 May;8(5):e00960. Epub 2018 Apr 10 doi: 10.1002/brb3.960. PMID: 29761013Free PMC Article
Guillain-Barré syndrome.
Walling AD, Dickson G
Am Fam Physician 2013 Feb 1;87(3):191-7. PMID: 23418763

Diagnosis

Guillain-Barré syndrome.
Shahrizaila N, Lehmann HC, Kuwabara S
Lancet 2021 Mar 27;397(10280):1214-1228. Epub 2021 Feb 26 doi: 10.1016/S0140-6736(21)00517-1. PMID: 33647239
Guillain-Barre Syndrome.
Malek E, Salameh J
Semin Neurol 2019 Oct;39(5):589-595. Epub 2019 Oct 22 doi: 10.1055/s-0039-1693005. PMID: 31639842
Guillain-Barré syndrome.
Willison HJ, Jacobs BC, van Doorn PA
Lancet 2016 Aug 13;388(10045):717-27. Epub 2016 Mar 2 doi: 10.1016/S0140-6736(16)00339-1. PMID: 26948435
Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis.
van den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA
Nat Rev Neurol 2014 Aug;10(8):469-82. Epub 2014 Jul 15 doi: 10.1038/nrneurol.2014.121. PMID: 25023340
Guillain-Barré syndrome and variants.
Dimachkie MM, Barohn RJ
Neurol Clin 2013 May;31(2):491-510. Epub 2013 Feb 19 doi: 10.1016/j.ncl.2013.01.005. PMID: 23642721Free PMC Article

Therapy

Immunoglobulin and Monoclonal Antibody Therapies in Guillain-Barré Syndrome.
Rajabally YA
Neurotherapeutics 2022 Apr;19(3):885-896. Epub 2022 Jun 1 doi: 10.1007/s13311-022-01253-4. PMID: 35648286Free PMC Article
Supervised, individualised exercise reduces fatigue and improves strength and quality of life more than unsupervised home exercise in people with chronic Guillain-Barré syndrome: a randomised trial.
Shah N, Shrivastava M, Kumar S, Nagi RS
J Physiother 2022 Apr;68(2):123-129. Epub 2022 Apr 5 doi: 10.1016/j.jphys.2022.03.007. PMID: 35396175
Novel Immunological and Therapeutic Insights in Guillain-Barré Syndrome and CIDP.
Querol L, Lleixà C
Neurotherapeutics 2021 Oct;18(4):2222-2235. Epub 2021 Sep 21 doi: 10.1007/s13311-021-01117-3. PMID: 34549385Free PMC Article
Guillain-Barré syndrome.
Willison HJ, Jacobs BC, van Doorn PA
Lancet 2016 Aug 13;388(10045):717-27. Epub 2016 Mar 2 doi: 10.1016/S0140-6736(16)00339-1. PMID: 26948435
Guillain-Barré syndrome and variants.
Dimachkie MM, Barohn RJ
Neurol Clin 2013 May;31(2):491-510. Epub 2013 Feb 19 doi: 10.1016/j.ncl.2013.01.005. PMID: 23642721Free PMC Article

Prognosis

Guillain-Barré syndrome mimics.
Tham SL, Prasad K, Umapathi T
Brain Behav 2018 May;8(5):e00960. Epub 2018 Apr 10 doi: 10.1002/brb3.960. PMID: 29761013Free PMC Article
Peripheral neuropathies.
Hanewinckel R, Ikram MA, Van Doorn PA
Handb Clin Neurol 2016;138:263-82. doi: 10.1016/B978-0-12-802973-2.00015-X. PMID: 27637963
Guillain-Barré syndrome.
Walling AD, Dickson G
Am Fam Physician 2013 Feb 1;87(3):191-7. PMID: 23418763
Multidisciplinary care for Guillain-Barré syndrome.
Khan F, Ng L, Amatya B, Brand C, Turner-Stokes L
Eur J Phys Rehabil Med 2011 Dec;47(4):607-12. Epub 2011 Sep 13 PMID: 21912364
Guillain-Barré syndrome.
Hughes RA, Cornblath DR
Lancet 2005 Nov 5;366(9497):1653-66. doi: 10.1016/S0140-6736(05)67665-9. PMID: 16271648

Clinical prediction guides

Mechanical ventilation in Guillain-Barré syndrome.
Shang P, Zhu M, Baker M, Feng J, Zhou C, Zhang HL
Expert Rev Clin Immunol 2020 Nov;16(11):1053-1064. Epub 2020 Nov 25 doi: 10.1080/1744666X.2021.1840355. PMID: 33112177
Guillain-Barré Syndrome.
Sheikh KA
Continuum (Minneap Minn) 2020 Oct;26(5):1184-1204. doi: 10.1212/CON.0000000000000929. PMID: 33002998
Guillain-Barré syndrome: causes, immunopathogenic mechanisms and treatment.
Jasti AK, Selmi C, Sarmiento-Monroy JC, Vega DA, Anaya JM, Gershwin ME
Expert Rev Clin Immunol 2016 Nov;12(11):1175-1189. Epub 2016 Jun 21 doi: 10.1080/1744666X.2016.1193006. PMID: 27292311
Guillain-Barré syndrome.
Willison HJ, Jacobs BC, van Doorn PA
Lancet 2016 Aug 13;388(10045):717-27. Epub 2016 Mar 2 doi: 10.1016/S0140-6736(16)00339-1. PMID: 26948435
Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis.
van den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA
Nat Rev Neurol 2014 Aug;10(8):469-82. Epub 2014 Jul 15 doi: 10.1038/nrneurol.2014.121. PMID: 25023340

Recent systematic reviews

Triggers of Guillain-Barré Syndrome: Campylobacter jejuni Predominates.
Finsterer J
Int J Mol Sci 2022 Nov 17;23(22) doi: 10.3390/ijms232214222. PMID: 36430700Free PMC Article
Guillain-​Barré Syndrome Associated with COVID-19 Vaccination.
Shao SC, Wang CH, Chang KC, Hung MJ, Chen HY, Liao SC
Emerg Infect Dis 2021 Dec;27(12):3175-3178. Epub 2021 Oct 14 doi: 10.3201/eid2712.211634. PMID: 34648420Free PMC Article
Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases.
Abu-Rumeileh S, Abdelhak A, Foschi M, Tumani H, Otto M
J Neurol 2021 Apr;268(4):1133-1170. Epub 2020 Aug 25 doi: 10.1007/s00415-020-10124-x. PMID: 32840686Free PMC Article
Relation between COVID-19 and Guillain-Barré syndrome in adults. Systematic review.
Trujillo Gittermann LM, Valenzuela Feris SN, von Oetinger Giacoman A
Neurologia (Engl Ed) 2020 Nov-Dec;35(9):646-654. Epub 2020 Jul 24 doi: 10.1016/j.nrl.2020.07.004. PMID: 32896460Free PMC Article
Multidisciplinary care for Guillain-Barré syndrome.
Khan F, Ng L, Amatya B, Brand C, Turner-Stokes L
Eur J Phys Rehabil Med 2011 Dec;47(4):607-12. Epub 2011 Sep 13 PMID: 21912364

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...