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Labial adhesion

MedGen UID:: 539906
•Concept ID:: C0266419
•: Congenital Abnormality

Synonym:	labial adhesions
SNOMED CT:	Synechia vulvae (13262009)

HPO:	HP:0033588

Definition

Synechia vulvae (adhesions of the labia minora) are characterized by a complete or partial fusion of the labia minora in the midline. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLabial adhesion

Abnormality of the genital system
- Abnormal reproductive system morphology
  - Abnormality of the female genitalia
    - Abnormal female external genitalia morphology
      - Abnormal labia morphology
        Abnormal labia majora morphology
        Labial adhesion

Professional guidelines

PubMed

Labial Adhesion: New Classification and Treatment Protocol.

Huseynov M, Hakalmaz AE
J Pediatr Adolesc Gynecol 2020 Aug;33(4):343-348. Epub 2020 Mar 26 doi: 10.1016/j.jpag.2020.03.005. PMID: 32224247

Labial adhesion - diagnostics and treatment.

Knudtzon S, Haugen SE, Myhre AK
Tidsskr Nor Laegeforen 2017 Jan;137(1):31-35. Epub 2017 Jan 10 doi: 10.4045/tidsskr.16.0101. PMID: 28073227

Comparison of estrogen and betamethasone in the topical treatment of labial adhesions in prepubertal girls.

Ertürk N
Turk J Med Sci 2014;44(6):1103-7. doi: 10.3906/sag-1312-3. PMID: 25552168

See all (6)

Recent clinical studies

Etiology

Labial Adhesion: New Classification and Treatment Protocol.

Huseynov M, Hakalmaz AE
J Pediatr Adolesc Gynecol 2020 Aug;33(4):343-348. Epub 2020 Mar 26 doi: 10.1016/j.jpag.2020.03.005. PMID: 32224247

Treatment of Prepubertal Labial Adhesions: A Randomized Controlled Trial.

Dowlut-McElroy T, Higgins J, Williams KB, Strickland JL
J Pediatr Adolesc Gynecol 2019 Jun;32(3):259-263. Epub 2018 Oct 29 doi: 10.1016/j.jpag.2018.10.006. PMID: 30385397

Labial adhesion - diagnostics and treatment.

Knudtzon S, Haugen SE, Myhre AK
Tidsskr Nor Laegeforen 2017 Jan;137(1):31-35. Epub 2017 Jan 10 doi: 10.4045/tidsskr.16.0101. PMID: 28073227

Labial adhesion in children at the Jos University Teaching Hospital.

Samuels E, Ocheke AN, Samuels NE
Afr J Paediatr Surg 2016 Jan-Mar;13(1):6-8. doi: 10.4103/0189-6725.181622. PMID: 27251516 Free PMC Article

Labial adhesion and urinary tract problems: The importance of genital examination.

Melek E, Kılıçbay F, Sarıkaş NG, Bayazıt AK
J Pediatr Urol 2016 Apr;12(2):111.e1-5. Epub 2015 Oct 23 doi: 10.1016/j.jpurol.2015.10.002. PMID: 26590736

See all (18)

Diagnosis

Vulvovaginitis- presentation of more common problems in pediatric and adolescent gynecology.

Loveless M, Myint O
Best Pract Res Clin Obstet Gynaecol 2018 Apr;48:14-27. Epub 2017 Sep 5 doi: 10.1016/j.bpobgyn.2017.08.014. PMID: 28927766

Labial adhesion - diagnostics and treatment.

Knudtzon S, Haugen SE, Myhre AK
Tidsskr Nor Laegeforen 2017 Jan;137(1):31-35. Epub 2017 Jan 10 doi: 10.4045/tidsskr.16.0101. PMID: 28073227

Labial adhesion in children at the Jos University Teaching Hospital.

Samuels E, Ocheke AN, Samuels NE
Afr J Paediatr Surg 2016 Jan-Mar;13(1):6-8. doi: 10.4103/0189-6725.181622. PMID: 27251516 Free PMC Article

Labial adhesion and urinary tract problems: The importance of genital examination.

Melek E, Kılıçbay F, Sarıkaş NG, Bayazıt AK
J Pediatr Urol 2016 Apr;12(2):111.e1-5. Epub 2015 Oct 23 doi: 10.1016/j.jpurol.2015.10.002. PMID: 26590736

Postpartum labial adhesions.

Seehusen DA, Earwood JS
J Am Board Fam Med 2007 Jul-Aug;20(4):408-10. doi: 10.3122/jabfm.2007.04.060214. PMID: 17615422

See all (17)

Therapy

Surgical management of female genital mutilation-related morbidity: A scoping review.

Chappell AG, Sood R, Hu A, Folsom SM, Wafford QE, Bowen DK, Post LA, Jordan SW
J Plast Reconstr Aesthet Surg 2021 Oct;74(10):2467-2478. Epub 2021 Jun 6 doi: 10.1016/j.bjps.2021.05.022. PMID: 34219039

Labial adhesion in a postmenopausal female: A case report.

Laih CY, Huang CP, Chou EC
Medicine (Baltimore) 2020 Jun 26;99(26):e20803. doi: 10.1097/MD.0000000000020803. PMID: 32590764 Free PMC Article

Labial Adhesion: New Classification and Treatment Protocol.

Huseynov M, Hakalmaz AE
J Pediatr Adolesc Gynecol 2020 Aug;33(4):343-348. Epub 2020 Mar 26 doi: 10.1016/j.jpag.2020.03.005. PMID: 32224247

Treatment of Prepubertal Labial Adhesions: A Randomized Controlled Trial.

Dowlut-McElroy T, Higgins J, Williams KB, Strickland JL
J Pediatr Adolesc Gynecol 2019 Jun;32(3):259-263. Epub 2018 Oct 29 doi: 10.1016/j.jpag.2018.10.006. PMID: 30385397

Labial adhesion - diagnostics and treatment.

Knudtzon S, Haugen SE, Myhre AK
Tidsskr Nor Laegeforen 2017 Jan;137(1):31-35. Epub 2017 Jan 10 doi: 10.4045/tidsskr.16.0101. PMID: 28073227

See all (18)

Prognosis

Characterization of enamel developmental defects in patients with orofacial clefts and their relationship to surgical procedures.

Farias A, Rojas-Gualdrón DF, Restrepo M, Zecchin KG, Bussaneli DG, Yupanqui K, Raposo-Amaral CE, Dos Santos-Pinto L
Clin Oral Investig 2023 Dec;27(12):7809-7820. Epub 2023 Nov 13 doi: 10.1007/s00784-023-05370-y. PMID: 37955725

Genital lichen sclerosus in childhood and adolescence-a retrospective case series of 15 patients: early diagnosis is crucial to avoid long-term sequelae.

Nerantzoulis I, Grigoriadis T, Michala L
Eur J Pediatr 2017 Oct;176(10):1429-1432. Epub 2017 Aug 30 doi: 10.1007/s00431-017-3004-y. PMID: 28856426

Labial adhesion - diagnostics and treatment.

Knudtzon S, Haugen SE, Myhre AK
Tidsskr Nor Laegeforen 2017 Jan;137(1):31-35. Epub 2017 Jan 10 doi: 10.4045/tidsskr.16.0101. PMID: 28073227

Labial adhesion and urinary tract problems: The importance of genital examination.

Melek E, Kılıçbay F, Sarıkaş NG, Bayazıt AK
J Pediatr Urol 2016 Apr;12(2):111.e1-5. Epub 2015 Oct 23 doi: 10.1016/j.jpurol.2015.10.002. PMID: 26590736

See all (4)

Clinical prediction guides

Patterns of pediatric and adolescent female genital inflammation in China: an eight-year retrospective study of 49,175 patients in China.

Gao H, Zhang Y, Pan Y, Zhao M, Qi Y, Zhou M, Chan SSC, Huang S, Song P, Tang K, Sun L, Yuan C
Front Public Health 2023;11:1073886. Epub 2023 Sep 4 doi: 10.3389/fpubh.2023.1073886. PMID: 37727603 Free PMC Article

Effect of topical estrogen cream compared with observation in prepubertal girls with labial adhesions.

Kim SW, Han JY, Han SJ, Kim H, Ku SY
J Pediatr Urol 2023 Aug;19(4):403.e1-403.e6. Epub 2023 Jan 13 doi: 10.1016/j.jpurol.2023.01.006. PMID: 37179197

Persistent Labial Minora Fusion in Reproductive Age Women: A Retrospective Case Series of Nine Patients and Review of Literature.

Liang Z, Chen J, Yu X, Zhu L
Organogenesis 2021 Apr 3;17(1-2):20-25. Epub 2021 May 20 doi: 10.1080/15476278.2021.1905477. PMID: 34014808 Free PMC Article

Thickness of orbicularis oris muscle in unilateral cleft lip: before and after labial adhesion.

Ridgway EB, Estroff JA, Mulliken JB
J Craniofac Surg 2011 Sep;22(5):1822-6. doi: 10.1097/SCS.0b013e31822e824f. PMID: 21959443

Office pediatric urologic procedures from a parental perspective.

Smith C, Smith DP
Urology 2000 Feb;55(2):272-6. doi: 10.1016/s0090-4295(99)00571-3. PMID: 10688093

See all (8)

Recent systematic reviews

Surgical management of female genital mutilation-related morbidity: A scoping review.

Chappell AG, Sood R, Hu A, Folsom SM, Wafford QE, Bowen DK, Post LA, Jordan SW
J Plast Reconstr Aesthet Surg 2021 Oct;74(10):2467-2478. Epub 2021 Jun 6 doi: 10.1016/j.bjps.2021.05.022. PMID: 34219039

Effects of labial adhesion on maxillary arch dimensions and nasolabial esthetics in cleft lip and palate: a systematic review.

Thierens L, Brusselaers N, De Roo N, De Pauw G
Oral Dis 2017 Oct;23(7):889-896. Epub 2017 Jan 24 doi: 10.1111/odi.12613. PMID: 27878905

See all (2)

MedGen

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Labial adhesion

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Recent activity