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Blighted ovum

MedGen UID:
540053
•Concept ID:
C0266648
•
Pathologic Function
Synonyms: Anembryonic Pregnancy; Anembryonic pregnancy; Empty gestational sac with ongoing pregnancy; Pathologic ovum; Pre-Embryonic Loss; Resorbed fetus; Resorbed foetus
SNOMED CT: Resorbed foetus (35999006); Empty gestational sac with ongoing pregnancy (35999006); Resorbed fetus (35999006); Anembryonic pregnancy (35999006); Blighted ovum (35999006); Pathologic ovum (35999006)

Definition

Pregnancy loss with visible gestational sac or yolk sac or both but no visible embryo on ultrasonogram. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBlighted ovum

Professional guidelines

PubMed

Trends in the incidence, rate and treatment of miscarriage-nationwide register-study in Finland, 1998-2016.
Linnakaari R, Helle N, Mentula M, Bloigu A, Gissler M, Heikinheimo O, Niinimäki M
Hum Reprod 2019 Nov 1;34(11):2120-2128. doi: 10.1093/humrep/dez211. PMID: 31747000
Medical management of first trimester missed miscarriage: the efficacy and complication rate.
Serdinšek T, Reljič M, Kovač V
J Obstet Gynaecol 2019 Jul;39(5):647-651. Epub 2019 Mar 27 doi: 10.1080/01443615.2018.1535577. PMID: 30917727
Medical management of first trimester miscarriage (blighted ovum and missed abortion): is it effective?
Coughlin LB, Roberts D, Haddad NG, Long A
J Obstet Gynaecol 2004 Jan;24(1):69-71. doi: 10.1080/01443610310001620332. PMID: 14675986

Recent clinical studies

Etiology

Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial.
Gowachirapant S, Jaiswal N, Melse-Boonstra A, Galetti V, Stinca S, Mackenzie I, Thomas S, Thomas T, Winichagoon P, Srinivasan K, Zimmermann MB
Lancet Diabetes Endocrinol 2017 Nov;5(11):853-863. Epub 2017 Oct 10 doi: 10.1016/S2213-8587(17)30332-7. PMID: 29030199
The role of VEGF and its receptors in the etiology of early pregnancy loss.
Cöl-Madendag I, Madendag Y, Altinkaya SÖ, Bayramoglu H, Danisman N
Gynecol Endocrinol 2014 Feb;30(2):153-6. Epub 2013 Dec 4 doi: 10.3109/09513590.2013.864272. PMID: 24303885
Medical management of first trimester miscarriage (blighted ovum and missed abortion): is it effective?
Coughlin LB, Roberts D, Haddad NG, Long A
J Obstet Gynaecol 2004 Jan;24(1):69-71. doi: 10.1080/01443610310001620332. PMID: 14675986
Recent advances in the Doppler study of early fetomaternal circulation.
Kurjak A, Zudenigo D, Predanic M, Kupesic S
J Perinat Med 1993;21(6):419-39. doi: 10.1515/jpme.1993.21.6.419. PMID: 8006769
Hormonal considerations in early normal pregnancy and blighted ovum syndrome.
Schweditsch MO, Dubin NH, Jones GS, Wentz AC
Fertil Steril 1979 Mar;31(3):252-7. doi: 10.1016/s0015-0282(16)43870-7. PMID: 437159

Diagnosis

National register data are of value in studies on miscarriage-Validation of the healthcare register data in Finland.
Helle N, Niinimäki M, Linnakaari R, But A, Gissler M, Heikinheimo O, Mentula M
Acta Obstet Gynecol Scand 2022 Nov;101(11):1245-1252. Epub 2022 Sep 3 doi: 10.1111/aogs.14445. PMID: 36056916Free PMC Article
Blighted ovum and tubal pregnancy: a rare form of heterotopic pregnancy: case report.
Aroke D, Ngek LT, Tindong M, Fomanka E, Achu C, Tanah AA, Kadia BM
BMC Res Notes 2018 Apr 12;11(1):242. doi: 10.1186/s13104-018-3345-2. PMID: 29650046Free PMC Article
Recent advances in the Doppler study of early fetomaternal circulation.
Kurjak A, Zudenigo D, Predanic M, Kupesic S
J Perinat Med 1993;21(6):419-39. doi: 10.1515/jpme.1993.21.6.419. PMID: 8006769
Blighted ovum: ultrasonic, histopathologic and hormonal considerations.
Liapis A, Kassanos D, Hassiakos D, Vitoratos N, Kondi-Paphiti A, Zourlas PA
Clin Exp Obstet Gynecol 1992;19(3):149-55. PMID: 1280538
Ultrasonic diagnosis in obstetrics and gynecology.
Kratochwil A
Med Prog Technol 1980 Sep;7(4):157-67. PMID: 7003339

Therapy

National register data are of value in studies on miscarriage-Validation of the healthcare register data in Finland.
Helle N, Niinimäki M, Linnakaari R, But A, Gissler M, Heikinheimo O, Mentula M
Acta Obstet Gynecol Scand 2022 Nov;101(11):1245-1252. Epub 2022 Sep 3 doi: 10.1111/aogs.14445. PMID: 36056916Free PMC Article
Cesarean Scar Pregnancy Complicated with Placenta Percreta.
Fatusic J, Hudic I, Zildzic-Moralic A, Hadziefendic B
Med Arch 2019 Feb;73(1):58-60. doi: 10.5455/medarh.2019.73.58-60. PMID: 31097863Free PMC Article
Medical management of first trimester missed miscarriage: the efficacy and complication rate.
Serdinšek T, Reljič M, Kovač V
J Obstet Gynaecol 2019 Jul;39(5):647-651. Epub 2019 Mar 27 doi: 10.1080/01443615.2018.1535577. PMID: 30917727
Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial.
Gowachirapant S, Jaiswal N, Melse-Boonstra A, Galetti V, Stinca S, Mackenzie I, Thomas S, Thomas T, Winichagoon P, Srinivasan K, Zimmermann MB
Lancet Diabetes Endocrinol 2017 Nov;5(11):853-863. Epub 2017 Oct 10 doi: 10.1016/S2213-8587(17)30332-7. PMID: 29030199
Medical management of first trimester miscarriage (blighted ovum and missed abortion): is it effective?
Coughlin LB, Roberts D, Haddad NG, Long A
J Obstet Gynaecol 2004 Jan;24(1):69-71. doi: 10.1080/01443610310001620332. PMID: 14675986

Prognosis

Blighted ovum and tubal pregnancy: a rare form of heterotopic pregnancy: case report.
Aroke D, Ngek LT, Tindong M, Fomanka E, Achu C, Tanah AA, Kadia BM
BMC Res Notes 2018 Apr 12;11(1):242. doi: 10.1186/s13104-018-3345-2. PMID: 29650046Free PMC Article
Medical management of first trimester miscarriage (blighted ovum and missed abortion): is it effective?
Coughlin LB, Roberts D, Haddad NG, Long A
J Obstet Gynaecol 2004 Jan;24(1):69-71. doi: 10.1080/01443610310001620332. PMID: 14675986
Recent advances in the Doppler study of early fetomaternal circulation.
Kurjak A, Zudenigo D, Predanic M, Kupesic S
J Perinat Med 1993;21(6):419-39. doi: 10.1515/jpme.1993.21.6.419. PMID: 8006769
Hormonal considerations in early normal pregnancy and blighted ovum syndrome.
Schweditsch MO, Dubin NH, Jones GS, Wentz AC
Fertil Steril 1979 Mar;31(3):252-7. doi: 10.1016/s0015-0282(16)43870-7. PMID: 437159
Alpha-fetoprotein in abortion.
Seppälä M, Ruoslahti E
Br Med J 1972 Dec 30;4(5843):769-71. doi: 10.1136/bmj.4.5843.769. PMID: 4646508Free PMC Article

Clinical prediction guides

Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion.
Gulic T, Laskarin G, Dominovic M, Glavan Gacanin L, Babarović E, Rubesa Z, Haller H, Rukavina D
Am J Reprod Immunol 2018 Sep;80(3):e12978. Epub 2018 May 18 doi: 10.1111/aji.12978. PMID: 29774968
Medical management of first trimester miscarriage (blighted ovum and missed abortion): is it effective?
Coughlin LB, Roberts D, Haddad NG, Long A
J Obstet Gynaecol 2004 Jan;24(1):69-71. doi: 10.1080/01443610310001620332. PMID: 14675986
Recent advances in the Doppler study of early fetomaternal circulation.
Kurjak A, Zudenigo D, Predanic M, Kupesic S
J Perinat Med 1993;21(6):419-39. doi: 10.1515/jpme.1993.21.6.419. PMID: 8006769
The vanishing twin.
Landy HJ, Keith L, Keith D
Acta Genet Med Gemellol (Roma) 1982;31(3-4):179-94. doi: 10.1017/s0001566000008278. PMID: 7170918
Alpha-fetoprotein in abortion.
Seppälä M, Ruoslahti E
Br Med J 1972 Dec 30;4(5843):769-71. doi: 10.1136/bmj.4.5843.769. PMID: 4646508Free PMC Article

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