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Occult blood detected in feces

MedGen UID:
540186
•Concept ID:
C0266813
•
Finding
Synonyms: Fecal Occult Blood; Fecal occult blood positive; Occult blood in stool
SNOMED CT: Occult blood in stool (59614000); Fecal occult blood positive (59614000); Occult blood detected in feces (59614000)

Definition

Blood in the feces that is not visibly apparent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOccult blood detected in feces

Professional guidelines

PubMed

Faecal immunochemical test: challenges and opportunities for cancer diagnosis in primary care.
Craig M, Turner J, Torkington J, Crosby T
Br J Gen Pract 2022 Aug;72(721):366-367. Epub 2022 Jul 28 doi: 10.3399/bjgp22X720209. PMID: 35902254Free PMC Article
Hot Topics in Primary Care: Colorectal Cancer Screening.
Elfant AB
J Fam Pract 2015 Dec;64(12 Suppl):S10-5. PMID: 26845007
Screening for colorectal cancer: possible improvements by risk assessment evaluation?
Nielsen HJ, Jakobsen KV, Christensen IJ, Brünner N; Danish Study Group on Early Detection of Colorectal Cancer
Scand J Gastroenterol 2011 Nov;46(11):1283-94. Epub 2011 Aug 19 doi: 10.3109/00365521.2011.610002. PMID: 21854094Free PMC Article

Recent clinical studies

Etiology

Multitarget Stool RNA Test for Colorectal Cancer Screening.
Barnell EK, Wurtzler EM, La Rocca J, Fitzgerald T, Petrone J, Hao Y, Kang Y, Holmes FL, Lieberman DA
JAMA 2023 Nov 14;330(18):1760-1768. doi: 10.1001/jama.2023.22231. PMID: 37870871Free PMC Article
Colorectal Cancer Screening With Repeated Fecal Immunochemical Test Versus Sigmoidoscopy: Baseline Results From a Randomized Trial.
Randel KR, Schult AL, Botteri E, Hoff G, Bretthauer M, Ursin G, Natvig E, Berstad P, Jørgensen A, Sandvei PK, Olsen ME, Frigstad SO, Darre-Næss O, Norvard ER, Bolstad N, Kørner H, Wibe A, Wensaas KA, de Lange T, Holme Ø
Gastroenterology 2021 Mar;160(4):1085-1096.e5. Epub 2020 Nov 21 doi: 10.1053/j.gastro.2020.11.037. PMID: 33227280
Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis.
Lee MW, Pourmorady JS, Laine L
Am J Gastroenterol 2020 May;115(5):662-670. doi: 10.14309/ajg.0000000000000495. PMID: 31972617
Accuracy of fecal immunochemical tests for colorectal cancer: systematic review and meta-analysis.
Lee JK, Liles EG, Bent S, Levin TR, Corley DA
Ann Intern Med 2014 Feb 4;160(3):171. doi: 10.7326/M13-1484. PMID: 24658694Free PMC Article
Multitarget stool DNA testing for colorectal-cancer screening.
Imperiale TF, Ransohoff DF, Itzkowitz SH, Levin TR, Lavin P, Lidgard GP, Ahlquist DA, Berger BM
N Engl J Med 2014 Apr 3;370(14):1287-97. Epub 2014 Mar 19 doi: 10.1056/NEJMoa1311194. PMID: 24645800

Diagnosis

Multitarget Stool RNA Test for Colorectal Cancer Screening.
Barnell EK, Wurtzler EM, La Rocca J, Fitzgerald T, Petrone J, Hao Y, Kang Y, Holmes FL, Lieberman DA
JAMA 2023 Nov 14;330(18):1760-1768. doi: 10.1001/jama.2023.22231. PMID: 37870871Free PMC Article
Comparing the Cost-Effectiveness of Innovative Colorectal Cancer Screening Tests.
Peterse EFP, Meester RGS, de Jonge L, Omidvari AH, Alarid-Escudero F, Knudsen AB, Zauber AG, Lansdorp-Vogelaar I
J Natl Cancer Inst 2021 Feb 1;113(2):154-161. doi: 10.1093/jnci/djaa103. PMID: 32761199Free PMC Article
Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis.
Lee MW, Pourmorady JS, Laine L
Am J Gastroenterol 2020 May;115(5):662-670. doi: 10.14309/ajg.0000000000000495. PMID: 31972617
Accuracy of fecal immunochemical tests for colorectal cancer: systematic review and meta-analysis.
Lee JK, Liles EG, Bent S, Levin TR, Corley DA
Ann Intern Med 2014 Feb 4;160(3):171. doi: 10.7326/M13-1484. PMID: 24658694Free PMC Article
Multitarget stool DNA testing for colorectal-cancer screening.
Imperiale TF, Ransohoff DF, Itzkowitz SH, Levin TR, Lavin P, Lidgard GP, Ahlquist DA, Berger BM
N Engl J Med 2014 Apr 3;370(14):1287-97. Epub 2014 Mar 19 doi: 10.1056/NEJMoa1311194. PMID: 24645800

Therapy

Multitarget Stool RNA Test for Colorectal Cancer Screening.
Barnell EK, Wurtzler EM, La Rocca J, Fitzgerald T, Petrone J, Hao Y, Kang Y, Holmes FL, Lieberman DA
JAMA 2023 Nov 14;330(18):1760-1768. doi: 10.1001/jama.2023.22231. PMID: 37870871Free PMC Article
Comparison of Colonoscopy, Fecal Immunochemical Test, and Risk-Adapted Approach in a Colorectal Cancer Screening Trial (TARGET-C).
Chen H, Shi J, Lu M, Li Y, Du L, Liao X, Wei D, Dong D, Gao Y, Zhu C, Ying R, Zheng W, Yan S, Xiao H, Zhang J, Kong Y, Li F, Zou S, Liu C, Wang H, Zhang Y, Lu B, Luo C, Cai J, Tian J, Miao X, Ding K, Brenner H, Dai M
Clin Gastroenterol Hepatol 2023 Mar;21(3):808-818. Epub 2022 Aug 11 doi: 10.1016/j.cgh.2022.08.003. PMID: 35964896
Colorectal Cancer Screening With Repeated Fecal Immunochemical Test Versus Sigmoidoscopy: Baseline Results From a Randomized Trial.
Randel KR, Schult AL, Botteri E, Hoff G, Bretthauer M, Ursin G, Natvig E, Berstad P, Jørgensen A, Sandvei PK, Olsen ME, Frigstad SO, Darre-Næss O, Norvard ER, Bolstad N, Kørner H, Wibe A, Wensaas KA, de Lange T, Holme Ø
Gastroenterology 2021 Mar;160(4):1085-1096.e5. Epub 2020 Nov 21 doi: 10.1053/j.gastro.2020.11.037. PMID: 33227280
Controversies in colorectal cancer screening.
Pox CP
Digestion 2014;89(4):274-81. Epub 2014 Jul 11 doi: 10.1159/000363287. PMID: 25034478
Multitarget stool DNA testing for colorectal-cancer screening.
Imperiale TF, Ransohoff DF, Itzkowitz SH, Levin TR, Lavin P, Lidgard GP, Ahlquist DA, Berger BM
N Engl J Med 2014 Apr 3;370(14):1287-97. Epub 2014 Mar 19 doi: 10.1056/NEJMoa1311194. PMID: 24645800

Prognosis

Multitarget Stool RNA Test for Colorectal Cancer Screening.
Barnell EK, Wurtzler EM, La Rocca J, Fitzgerald T, Petrone J, Hao Y, Kang Y, Holmes FL, Lieberman DA
JAMA 2023 Nov 14;330(18):1760-1768. doi: 10.1001/jama.2023.22231. PMID: 37870871Free PMC Article
Faecal immunochemical test outside colorectal cancer screening?
Pin-Vieito N, Puga M, Fernández-de-Castro D, Cubiella J
World J Gastroenterol 2021 Oct 14;27(38):6415-6429. doi: 10.3748/wjg.v27.i38.6415. PMID: 34720531Free PMC Article
Metabolomics profile in gastrointestinal cancers: Update and future perspectives.
Nannini G, Meoni G, Amedei A, Tenori L
World J Gastroenterol 2020 May 28;26(20):2514-2532. doi: 10.3748/wjg.v26.i20.2514. PMID: 32523308Free PMC Article
Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis.
Lee MW, Pourmorady JS, Laine L
Am J Gastroenterol 2020 May;115(5):662-670. doi: 10.14309/ajg.0000000000000495. PMID: 31972617
Is Colorectal Cancer Screening Appropriate in Nigeria?
Knapp GC, Alatise OI, Olasehinde OO, Adeyeye A, Ayandipo OO, Weiser MR, Kingham TP
J Glob Oncol 2019 Jun;5:1-10. doi: 10.1200/JGO.19.00035. PMID: 31170018Free PMC Article

Clinical prediction guides

Multitarget Stool RNA Test for Colorectal Cancer Screening.
Barnell EK, Wurtzler EM, La Rocca J, Fitzgerald T, Petrone J, Hao Y, Kang Y, Holmes FL, Lieberman DA
JAMA 2023 Nov 14;330(18):1760-1768. doi: 10.1001/jama.2023.22231. PMID: 37870871Free PMC Article
Comparison of Colonoscopy, Fecal Immunochemical Test, and Risk-Adapted Approach in a Colorectal Cancer Screening Trial (TARGET-C).
Chen H, Shi J, Lu M, Li Y, Du L, Liao X, Wei D, Dong D, Gao Y, Zhu C, Ying R, Zheng W, Yan S, Xiao H, Zhang J, Kong Y, Li F, Zou S, Liu C, Wang H, Zhang Y, Lu B, Luo C, Cai J, Tian J, Miao X, Ding K, Brenner H, Dai M
Clin Gastroenterol Hepatol 2023 Mar;21(3):808-818. Epub 2022 Aug 11 doi: 10.1016/j.cgh.2022.08.003. PMID: 35964896
Faecal immunochemical test outside colorectal cancer screening?
Pin-Vieito N, Puga M, Fernández-de-Castro D, Cubiella J
World J Gastroenterol 2021 Oct 14;27(38):6415-6429. doi: 10.3748/wjg.v27.i38.6415. PMID: 34720531Free PMC Article
Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis.
Lee MW, Pourmorady JS, Laine L
Am J Gastroenterol 2020 May;115(5):662-670. doi: 10.14309/ajg.0000000000000495. PMID: 31972617
Potential of fecal microbiota for early-stage detection of colorectal cancer.
Zeller G, Tap J, Voigt AY, Sunagawa S, Kultima JR, Costea PI, Amiot A, Böhm J, Brunetti F, Habermann N, Hercog R, Koch M, Luciani A, Mende DR, Schneider MA, Schrotz-King P, Tournigand C, Tran Van Nhieu J, Yamada T, Zimmermann J, Benes V, Kloor M, Ulrich CM, von Knebel Doeberitz M, Sobhani I, Bork P
Mol Syst Biol 2014 Nov 28;10(11):766. doi: 10.15252/msb.20145645. PMID: 25432777Free PMC Article

Recent systematic reviews

Replicate and repeat faecal immunochemical tests in symptomatic patients: A systematic review.
Farkas NG, Fraser CG, Maclean W, Jourdan I, Rockall T, Benton SC
Ann Clin Biochem 2023 Jan;60(1):27-36. Epub 2022 May 5 doi: 10.1177/00045632221096036. PMID: 35394384
Guaiac-based faecal occult blood tests versus faecal immunochemical tests for colorectal cancer screening in average-risk individuals.
Grobbee EJ, Wisse PHA, Schreuders EH, van Roon A, van Dam L, Zauber AG, Lansdorp-Vogelaar I, Bramer W, Berhane S, Deeks JJ, Steyerberg EW, van Leerdam ME, Spaander MC, Kuipers EJ
Cochrane Database Syst Rev 2022 Jun 6;6(6):CD009276. doi: 10.1002/14651858.CD009276.pub2. PMID: 35665911Free PMC Article
Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis.
Lee MW, Pourmorady JS, Laine L
Am J Gastroenterol 2020 May;115(5):662-670. doi: 10.14309/ajg.0000000000000495. PMID: 31972617
Noninvasive DNA methylation biomarkers in colorectal cancer: A systematic review.
Xue M, Lai SC, Xu ZP, Wang LJ
J Dig Dis 2015 Dec;16(12):699-712. doi: 10.1111/1751-2980.12299. PMID: 26565661
Accuracy of fecal immunochemical tests for colorectal cancer: systematic review and meta-analysis.
Lee JK, Liles EG, Bent S, Levin TR, Corley DA
Ann Intern Med 2014 Feb 4;160(3):171. doi: 10.7326/M13-1484. PMID: 24658694Free PMC Article

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