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Kernicterus due to isoimmunization

MedGen UID:
542597
•Concept ID:
C0270204
•
Disease or Syndrome
Synonyms: kernicterus - due to isoimm.; Kernicterus due to Isoimmunization; kernicterus due to isoimmunization; kernicterus due to isoimmunization of fetus or newborn; Kernicterus Related to Isoimmunization; kernicterus related to isoimmunization
SNOMED CT: Kernicterus due to isoimmunization (359007)
 
Monarch Initiative: MONDO:0006567

Definition

Encephalopathy in infants due to high levels of unconjugated bilirubin that are a result of Rh incompatibility between the mother and the fetus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKernicterus due to isoimmunization

Professional guidelines

PubMed

Technical Report: Diagnosis and Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation.
Slaughter JL, Kemper AR, Newman TB
Pediatrics 2022 Sep 1;150(3) doi: 10.1542/peds.2022-058865. PMID: 35927519
Diagnostic laboratory technologies for the fetus and neonate with isoimmunization.
Geaghan SM
Semin Perinatol 2011 Jun;35(3):148-54. doi: 10.1053/j.semperi.2011.02.009. PMID: 21641488
The management of hemolytic disease in the fetus and newborn.
Bowman J
Semin Perinatol 1997 Feb;21(1):39-44. doi: 10.1016/s0146-0005(97)80018-3. PMID: 9190032

Recent clinical studies

Etiology

Technical Report: Diagnosis and Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation.
Slaughter JL, Kemper AR, Newman TB
Pediatrics 2022 Sep 1;150(3) doi: 10.1542/peds.2022-058865. PMID: 35927519
Neonatal hyperbilirubinemia and bilirubin neurotoxicity in hospitalized neonates: analysis of the US Database.
Qattea I, Farghaly MAA, Elgendy M, Mohamed MA, Aly H
Pediatr Res 2022 Jun;91(7):1662-1668. Epub 2021 Aug 24 doi: 10.1038/s41390-021-01692-3. PMID: 34429513
Diagnostic laboratory technologies for the fetus and neonate with isoimmunization.
Geaghan SM
Semin Perinatol 2011 Jun;35(3):148-54. doi: 10.1053/j.semperi.2011.02.009. PMID: 21641488
Component therapy.
Radhakrishnan KM, Chakravarthi S, Pushkala S, Jayaraju J
Indian J Pediatr 2003 Aug;70(8):661-6. doi: 10.1007/BF02724257. PMID: 14510088
Maternal CW alloimmunization.
Bowman JM, Pollock J
Vox Sang 1993;64(4):226-30. PMID: 8517051

Diagnosis

Technical Report: Diagnosis and Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation.
Slaughter JL, Kemper AR, Newman TB
Pediatrics 2022 Sep 1;150(3) doi: 10.1542/peds.2022-058865. PMID: 35927519
Neonatal hyperbilirubinemia and bilirubin neurotoxicity in hospitalized neonates: analysis of the US Database.
Qattea I, Farghaly MAA, Elgendy M, Mohamed MA, Aly H
Pediatr Res 2022 Jun;91(7):1662-1668. Epub 2021 Aug 24 doi: 10.1038/s41390-021-01692-3. PMID: 34429513
Rh Alloimmunisation: Current Updates in Antenatal and Postnatal Management.
Sahoo T, Sahoo M, Gulla KM, Gupta M
Indian J Pediatr 2020 Dec;87(12):1018-1028. Epub 2020 Jul 1 doi: 10.1007/s12098-020-03366-0. PMID: 32607667
Diagnostic laboratory technologies for the fetus and neonate with isoimmunization.
Geaghan SM
Semin Perinatol 2011 Jun;35(3):148-54. doi: 10.1053/j.semperi.2011.02.009. PMID: 21641488
Vigintiphobia revisited.
Watchko JF
Pediatrics 2005 Jun;115(6):1747-53. doi: 10.1542/peds.2004-1748. PMID: 15930239

Therapy

Technical Report: Diagnosis and Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation.
Slaughter JL, Kemper AR, Newman TB
Pediatrics 2022 Sep 1;150(3) doi: 10.1542/peds.2022-058865. PMID: 35927519
Hyperbilirubinemia: current guidelines and emerging therapies.
Schwartz HP, Haberman BE, Ruddy RM
Pediatr Emerg Care 2011 Sep;27(9):884-9. doi: 10.1097/PEC.0b013e31822c9b4c. PMID: 21926893
Rhesus haemolytic disease of the newborn: Postnatal management, associated morbidity and long-term outcome.
Smits-Wintjens VE, Walther FJ, Lopriore E
Semin Fetal Neonatal Med 2008 Aug;13(4):265-71. Epub 2008 Apr 2 doi: 10.1016/j.siny.2008.02.005. PMID: 18387863
Vigintiphobia revisited.
Watchko JF
Pediatrics 2005 Jun;115(6):1747-53. doi: 10.1542/peds.2004-1748. PMID: 15930239
Rh erythroblastosis fetalis 1975.
Bowman JM
Semin Hematol 1975 Apr;12(2):189-207. PMID: 47184

Prognosis

Rh Alloimmunisation: Current Updates in Antenatal and Postnatal Management.
Sahoo T, Sahoo M, Gulla KM, Gupta M
Indian J Pediatr 2020 Dec;87(12):1018-1028. Epub 2020 Jul 1 doi: 10.1007/s12098-020-03366-0. PMID: 32607667
Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at regional and global levels.
Bhutani VK, Zipursky A, Blencowe H, Khanna R, Sgro M, Ebbesen F, Bell J, Mori R, Slusher TM, Fahmy N, Paul VK, Du L, Okolo AA, de Almeida MF, Olusanya BO, Kumar P, Cousens S, Lawn JE
Pediatr Res 2013 Dec;74 Suppl 1(Suppl 1):86-100. doi: 10.1038/pr.2013.208. PMID: 24366465Free PMC Article
Vigintiphobia revisited.
Watchko JF
Pediatrics 2005 Jun;115(6):1747-53. doi: 10.1542/peds.2004-1748. PMID: 15930239
The management of hemolytic disease in the fetus and newborn.
Bowman J
Semin Perinatol 1997 Feb;21(1):39-44. doi: 10.1016/s0146-0005(97)80018-3. PMID: 9190032
Maternal CW alloimmunization.
Bowman JM, Pollock J
Vox Sang 1993;64(4):226-30. PMID: 8517051

Clinical prediction guides

Technical Report: Diagnosis and Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation.
Slaughter JL, Kemper AR, Newman TB
Pediatrics 2022 Sep 1;150(3) doi: 10.1542/peds.2022-058865. PMID: 35927519
Severe neonatal hyperbilirubinemia in the southeast region of Turkey.
Bozkurt Ö, Yücesoy E, Oğuz B, Akinel Ö, Palali MF, Ataş N
Turk J Med Sci 2020 Feb 13;50(1):103-109. doi: 10.3906/sag-1906-22. PMID: 31731336
Intervention guidelines for neonatal hyperbilirubinemia: an evidence based quagmire.
Wennberg RP, Ahlfors CE, Aravkin AY
Curr Pharm Des 2009;15(25):2939-45. doi: 10.2174/138161209789058228. PMID: 19754370
Component therapy.
Radhakrishnan KM, Chakravarthi S, Pushkala S, Jayaraju J
Indian J Pediatr 2003 Aug;70(8):661-6. doi: 10.1007/BF02724257. PMID: 14510088
The management of hemolytic disease in the fetus and newborn.
Bowman J
Semin Perinatol 1997 Feb;21(1):39-44. doi: 10.1016/s0146-0005(97)80018-3. PMID: 9190032

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