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Subretinal hemorrhage

MedGen UID:
543137
•Concept ID:
C0271049
•
Pathologic Function
Synonyms: Subretinal haemorrhage; Subretinal heme
SNOMED CT: Subretinal hemorrhage (13937002)
 
HPO: HP:0025243

Definition

Accumulation of blood located beneath the neurosensory retina in the space between the neurosensory retina and the retinal pigment epithelium. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubretinal hemorrhage

Professional guidelines

PubMed

Development of subretinal hemorrhage after treatment discontinuation for neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.
Kim JH, Kim JW, Kim CG
Graefes Arch Clin Exp Ophthalmol 2022 Oct;260(10):3231-3239. Epub 2022 May 25 doi: 10.1007/s00417-022-05702-w. PMID: 35612614
Current management strategy of polypoidal choroidal vasculopathy.
Ho CPS, Lai TYY
Indian J Ophthalmol 2018 Dec;66(12):1727-1735. doi: 10.4103/ijo.IJO_975_18. PMID: 30451173Free PMC Article
Pathophysiology and management of subretinal hemorrhage.
Hochman MA, Seery CM, Zarbin MA
Surv Ophthalmol 1997 Nov-Dec;42(3):195-213. doi: 10.1016/s0039-6257(97)00089-1. PMID: 9406367

Recent clinical studies

Etiology

Pars plana vitrectomy versus scleral buckle: A comprehensive meta-analysis of 15,947 eyes.
Dhoot AS, Popovic MM, Nichani PAH, Eshtiaghi A, Mihalache A, Sayal AP, Yu H, Wykoff CC, Kertes PJ, Muni RH
Surv Ophthalmol 2022 Jul-Aug;67(4):932-949. Epub 2021 Dec 9 doi: 10.1016/j.survophthal.2021.12.005. PMID: 34896191
Bacillary layer detachment in acute nonpenetrating ocular trauma.
Venkatesh R, Agrawal S, Reddy NG, Pereira A, Yadav NK, Chhablani J
Can J Ophthalmol 2022 Oct;57(5):328-336. Epub 2021 Jun 27 doi: 10.1016/j.jcjo.2021.05.017. PMID: 34192520
Surgical Technique, Indications, and Outcomes of BIOM-Assisted Transvitreal Biopsy for Uveal Melanoma.
Snyder LL, Daniels AB
Retina 2022 Nov 1;42(11):2229-2235. Epub 2019 Dec 5 doi: 10.1097/IAE.0000000000002677. PMID: 31815876Free PMC Article
Characteristics of pachychoroid neovasculopathy.
Tagawa M, Ooto S, Yamashiro K, Tamura H, Oishi A, Miyata M, Hata M, Yoshikawa M, Yoshimura N, Tsujikawa A
Sci Rep 2020 Oct 1;10(1):16248. doi: 10.1038/s41598-020-73303-w. PMID: 33004959Free PMC Article
Demographic profile, clinical features, and outcome of peripapillary subretinal hemorrhage: an observational study.
Zou M, Zhang Y, Huang X, Gao S, Zhang J
BMC Ophthalmol 2020 Apr 19;20(1):156. doi: 10.1186/s12886-020-01426-9. PMID: 32306917Free PMC Article

Diagnosis

Characteristics of pachychoroid neovasculopathy.
Tagawa M, Ooto S, Yamashiro K, Tamura H, Oishi A, Miyata M, Hata M, Yoshikawa M, Yoshimura N, Tsujikawa A
Sci Rep 2020 Oct 1;10(1):16248. doi: 10.1038/s41598-020-73303-w. PMID: 33004959Free PMC Article
Current management strategy of polypoidal choroidal vasculopathy.
Ho CPS, Lai TYY
Indian J Ophthalmol 2018 Dec;66(12):1727-1735. doi: 10.4103/ijo.IJO_975_18. PMID: 30451173Free PMC Article
Subretinal hemorrhage.
Yiu G, Mahmoud TH
Dev Ophthalmol 2014;54:213-22. Epub 2014 Aug 26 doi: 10.1159/000360469. PMID: 25196772
Pathophysiology and management of subretinal hemorrhage.
Hochman MA, Seery CM, Zarbin MA
Surv Ophthalmol 1997 Nov-Dec;42(3):195-213. doi: 10.1016/s0039-6257(97)00089-1. PMID: 9406367
Retinal arterial macroaneurysms.
Rabb MF, Gagliano DA, Teske MP
Surv Ophthalmol 1988 Sep-Oct;33(2):73-96. doi: 10.1016/0039-6257(88)90160-9. PMID: 3055391

Therapy

Pars plana vitrectomy versus scleral buckle: A comprehensive meta-analysis of 15,947 eyes.
Dhoot AS, Popovic MM, Nichani PAH, Eshtiaghi A, Mihalache A, Sayal AP, Yu H, Wykoff CC, Kertes PJ, Muni RH
Surv Ophthalmol 2022 Jul-Aug;67(4):932-949. Epub 2021 Dec 9 doi: 10.1016/j.survophthal.2021.12.005. PMID: 34896191
Current management strategy of polypoidal choroidal vasculopathy.
Ho CPS, Lai TYY
Indian J Ophthalmol 2018 Dec;66(12):1727-1735. doi: 10.4103/ijo.IJO_975_18. PMID: 30451173Free PMC Article
Management of submacular hemorrhage.
Tennant MT, Borrillo JL, Regillo CD
Ophthalmol Clin North Am 2002 Dec;15(4):445-52, vi. doi: 10.1016/s0896-1549(02)00049-4. PMID: 12515076
Pathophysiology and management of subretinal hemorrhage.
Hochman MA, Seery CM, Zarbin MA
Surv Ophthalmol 1997 Nov-Dec;42(3):195-213. doi: 10.1016/s0039-6257(97)00089-1. PMID: 9406367
Retinal arterial macroaneurysms.
Rabb MF, Gagliano DA, Teske MP
Surv Ophthalmol 1988 Sep-Oct;33(2):73-96. doi: 10.1016/0039-6257(88)90160-9. PMID: 3055391

Prognosis

Surgical Technique, Indications, and Outcomes of BIOM-Assisted Transvitreal Biopsy for Uveal Melanoma.
Snyder LL, Daniels AB
Retina 2022 Nov 1;42(11):2229-2235. Epub 2019 Dec 5 doi: 10.1097/IAE.0000000000002677. PMID: 31815876Free PMC Article
Characteristics of pachychoroid neovasculopathy.
Tagawa M, Ooto S, Yamashiro K, Tamura H, Oishi A, Miyata M, Hata M, Yoshikawa M, Yoshimura N, Tsujikawa A
Sci Rep 2020 Oct 1;10(1):16248. doi: 10.1038/s41598-020-73303-w. PMID: 33004959Free PMC Article
Demographic profile, clinical features, and outcome of peripapillary subretinal hemorrhage: an observational study.
Zou M, Zhang Y, Huang X, Gao S, Zhang J
BMC Ophthalmol 2020 Apr 19;20(1):156. doi: 10.1186/s12886-020-01426-9. PMID: 32306917Free PMC Article
Pathophysiology and management of subretinal hemorrhage.
Hochman MA, Seery CM, Zarbin MA
Surv Ophthalmol 1997 Nov-Dec;42(3):195-213. doi: 10.1016/s0039-6257(97)00089-1. PMID: 9406367
Subretinal hemorrhage removal.
Claes C, Zivojnovic R
Bull Soc Belge Ophtalmol 1993;250:85-8. PMID: 7952366

Clinical prediction guides

Pars plana vitrectomy versus scleral buckle: A comprehensive meta-analysis of 15,947 eyes.
Dhoot AS, Popovic MM, Nichani PAH, Eshtiaghi A, Mihalache A, Sayal AP, Yu H, Wykoff CC, Kertes PJ, Muni RH
Surv Ophthalmol 2022 Jul-Aug;67(4):932-949. Epub 2021 Dec 9 doi: 10.1016/j.survophthal.2021.12.005. PMID: 34896191
Bacillary layer detachment in acute nonpenetrating ocular trauma.
Venkatesh R, Agrawal S, Reddy NG, Pereira A, Yadav NK, Chhablani J
Can J Ophthalmol 2022 Oct;57(5):328-336. Epub 2021 Jun 27 doi: 10.1016/j.jcjo.2021.05.017. PMID: 34192520
Characteristics of pachychoroid neovasculopathy.
Tagawa M, Ooto S, Yamashiro K, Tamura H, Oishi A, Miyata M, Hata M, Yoshikawa M, Yoshimura N, Tsujikawa A
Sci Rep 2020 Oct 1;10(1):16248. doi: 10.1038/s41598-020-73303-w. PMID: 33004959Free PMC Article
Demographic profile, clinical features, and outcome of peripapillary subretinal hemorrhage: an observational study.
Zou M, Zhang Y, Huang X, Gao S, Zhang J
BMC Ophthalmol 2020 Apr 19;20(1):156. doi: 10.1186/s12886-020-01426-9. PMID: 32306917Free PMC Article
Management of submacular hemorrhage.
Tennant MT, Borrillo JL, Regillo CD
Ophthalmol Clin North Am 2002 Dec;15(4):445-52, vi. doi: 10.1016/s0896-1549(02)00049-4. PMID: 12515076

Recent systematic reviews

A systematic review of the cell death mechanisms in retinal pigment epithelium cells and photoreceptors after subretinal hemorrhage - Implications for treatment options.
Chhatwal S, Antony H, Lamei S, Kovács-Öller T, Klettner AK, Zille M
Biomed Pharmacother 2023 Nov;167:115572. Epub 2023 Sep 22 doi: 10.1016/j.biopha.2023.115572. PMID: 37742603
Pars plana vitrectomy versus scleral buckle: A comprehensive meta-analysis of 15,947 eyes.
Dhoot AS, Popovic MM, Nichani PAH, Eshtiaghi A, Mihalache A, Sayal AP, Yu H, Wykoff CC, Kertes PJ, Muni RH
Surv Ophthalmol 2022 Jul-Aug;67(4):932-949. Epub 2021 Dec 9 doi: 10.1016/j.survophthal.2021.12.005. PMID: 34896191
Summary of prognostic factors for choroidal neovascularization due to pathological myopia treated by intravitreal bevacizumab injection.
Wang J, Kang Z
Graefes Arch Clin Exp Ophthalmol 2012 Dec;250(12):1717-23. Epub 2012 Sep 25 doi: 10.1007/s00417-012-2159-5. PMID: 23007232

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