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Catarrhal Fever, Malignant

MedGen UID:
547200
•Concept ID:
C0276241
•
Disease or Syndrome
Synonyms: Catarrh, Malignant; Catarrhal Fevers, Malignant; Catarrhs, Malignant; Fever, Malignant Catarrhal; Fevers, Malignant Catarrhal; Malignant Catarrh; Malignant Catarrhal Fever; Malignant Catarrhal Fevers; Malignant Catarrhs

Definition

A herpesvirus infection of cattle characterized by catarrhal inflammation of the upper respiratory and alimentary epithelia, keratoconjunctivitis, encephalitis and lymph node enlargement. Syn: bovine epitheliosis, snotsiekte. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCatarrhal Fever, Malignant

Recent clinical studies

Etiology

Prioritization of livestock diseases by pastoralists in Oloitoktok Sub County, Kajiado County, Kenya.
Mburu CM, Bukachi S, Majiwa H, Ongore D, Baylis M, Mochabo K, Fevre E, Howland O
PLoS One 2023;18(7):e0287456. Epub 2023 Jul 12 doi: 10.1371/journal.pone.0287456. PMID: 37436965Free PMC Article
Detection of bovine gammaherpesvirus 6 in tissues of aborted fetuses from dairy cows concomitantly infected by Histophilus somni.
Headley SA, Fritzen JTT, Bon VR, Xavier AAC, Dall Agnol AM, Zucoloto NZ, Silva FHP, Figueiredo JRX, Alfieri AF, Okano W, Alfieri AA
Microb Pathog 2022 Aug;169:105621. Epub 2022 Jun 7 doi: 10.1016/j.micpath.2022.105621. PMID: 35688413
The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants Emulsigen(®) and the monomeric TLR5 ligand FliC in zebu cattle against AlHV-1 malignant catarrhal fever induced by experimental virus challenge.
Lankester F, Lugelo A, Werling D, Mnyambwa N, Keyyu J, Kazwala R, Grant D, Smith S, Parameswaran N, Cleaveland S, Russell G, Haig D
Vet Microbiol 2016 Nov 15;195:144-153. Epub 2016 Sep 23 doi: 10.1016/j.vetmic.2016.09.019. PMID: 27771060Free PMC Article

Diagnosis

Ovine gammaherpesvirus-2 infection associated with chronic interstitial pneumonia in a sheep.
Headley SA, Agnol AMD, Navolar FMN, Frucchi APS, de Matos AMRN, Pereira PFV, Xavier AAC, Dos Santos VH, Silva LE, Depes VCA, Alfieri AF, Cunha CW, Alfieri AA
Microb Pathog 2021 Dec;161(Pt A):105220. Epub 2021 Oct 1 doi: 10.1016/j.micpath.2021.105220. PMID: 34606919
Evaluation of glycoprotein Ov8 as a potential antigen for an OvHV-2-specific diagnostic assay.
Alhajri SM, Cunha CW, Knowles DP, Li H, Taus NS
PLoS One 2018;13(7):e0200130. Epub 2018 Jul 2 doi: 10.1371/journal.pone.0200130. PMID: 29966004Free PMC Article
Development of a multiplex real-time PCR for detection and differentiation of malignant catarrhal fever viruses in clinical samples.
Cunha CW, Otto L, Taus NS, Knowles DP, Li H
J Clin Microbiol 2009 Aug;47(8):2586-9. Epub 2009 Jun 3 doi: 10.1128/JCM.00997-09. PMID: 19494077Free PMC Article
Effect of interferons on the replication of alcelaphine herpesvirus-1 of malignant catarrhal fever.
Wan SK, Castro AE, Fulton RW
J Wildl Dis 1988 Jul;24(3):484-90. doi: 10.7589/0090-3558-24.3.484. PMID: 2457716
Infectious skin diseases of cattle.
Hunt E
Vet Clin North Am Large Anim Pract 1984 Mar;6(1):155-74. doi: 10.1016/s0196-9846(17)30045-9. PMID: 6330955

Prognosis

Ovine gammaherpesvirus-2 infection associated with chronic interstitial pneumonia in a sheep.
Headley SA, Agnol AMD, Navolar FMN, Frucchi APS, de Matos AMRN, Pereira PFV, Xavier AAC, Dos Santos VH, Silva LE, Depes VCA, Alfieri AF, Cunha CW, Alfieri AA
Microb Pathog 2021 Dec;161(Pt A):105220. Epub 2021 Oct 1 doi: 10.1016/j.micpath.2021.105220. PMID: 34606919
Evaluation of glycoprotein Ov8 as a potential antigen for an OvHV-2-specific diagnostic assay.
Alhajri SM, Cunha CW, Knowles DP, Li H, Taus NS
PLoS One 2018;13(7):e0200130. Epub 2018 Jul 2 doi: 10.1371/journal.pone.0200130. PMID: 29966004Free PMC Article
Viral semaphorin inhibits dendritic cell phagocytosis and migration but is not essential for gammaherpesvirus-induced lymphoproliferation in malignant catarrhal fever.
Myster F, Palmeira L, Sorel O, Bouillenne F, DePauw E, Schwartz-Cornil I, Vanderplasschen A, Dewals BG
J Virol 2015 Apr;89(7):3630-47. Epub 2015 Jan 14 doi: 10.1128/JVI.03634-14. PMID: 25589653Free PMC Article

Clinical prediction guides

Detection of bovine gammaherpesvirus 6 in tissues of aborted fetuses from dairy cows concomitantly infected by Histophilus somni.
Headley SA, Fritzen JTT, Bon VR, Xavier AAC, Dall Agnol AM, Zucoloto NZ, Silva FHP, Figueiredo JRX, Alfieri AF, Okano W, Alfieri AA
Microb Pathog 2022 Aug;169:105621. Epub 2022 Jun 7 doi: 10.1016/j.micpath.2022.105621. PMID: 35688413
Evaluation of glycoprotein Ov8 as a potential antigen for an OvHV-2-specific diagnostic assay.
Alhajri SM, Cunha CW, Knowles DP, Li H, Taus NS
PLoS One 2018;13(7):e0200130. Epub 2018 Jul 2 doi: 10.1371/journal.pone.0200130. PMID: 29966004Free PMC Article
Viral semaphorin inhibits dendritic cell phagocytosis and migration but is not essential for gammaherpesvirus-induced lymphoproliferation in malignant catarrhal fever.
Myster F, Palmeira L, Sorel O, Bouillenne F, DePauw E, Schwartz-Cornil I, Vanderplasschen A, Dewals BG
J Virol 2015 Apr;89(7):3630-47. Epub 2015 Jan 14 doi: 10.1128/JVI.03634-14. PMID: 25589653Free PMC Article

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