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Verruca plana

MedGen UID:
547216
Concept ID:
C0276262
Acquired Abnormality
Synonyms: Flat wart; Plane wart
SNOMED CT: Verruca plana (240539000); Flat wart (240539000); Plane wart (240539000)
 
HPO: HP:0550004

Definition

Slightly raised wart 2-5 mm in diameter often associated with viral infections, commonly persistent in immunodeficient individuals. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVerruca plana

Conditions with this feature

Epidermodysplasia verruciformis, susceptibility to, 2
MedGen UID:
1648344
Concept ID:
C4722258
Finding
Epidermodysplasia verruciformis (EV) is a rare genodermatosis associated with a high risk of skin cancer. EV results from an abnormal susceptibility to specific related human papillomavirus (HPV) genotypes and to the oncogenic potential of some of them, mainly HPV5. Infection with EV-associated HPV leads to the early development of disseminated flat wart-like and pityriasis versicolor-like lesions. Patients are unable to reject their lesions, and cutaneous Bowen carcinomas in situ and invasive squamous cell carcinomas develop in about half of them, mainly on sun-exposed areas (summary by Ramoz et al., 2000). For a discussion of genetic heterogeneity of susceptibility to epidermodysplasia verruciformis, see EV1 (226400).

Professional guidelines

PubMed

Berumen-Glinz C, de la Barreda-Becerril F
JAMA Dermatol 2022 May 1;158(5):586-587. doi: 10.1001/jamadermatol.2022.0154. PMID: 35319721
Balevi A, Üstüner P, Özdemir M
J Dermatolog Treat 2017 Jun;28(4):368-371. Epub 2016 Oct 24 doi: 10.1080/09546634.2016.1244601. PMID: 27690747
Kim WJ, Lee WK, Song M, Kim HS, Ko HC, Kim BS, Kim MB
J Dermatol 2015 Apr;42(4):373-7. Epub 2015 Jan 9 doi: 10.1111/1346-8138.12760. PMID: 25571765

Recent clinical studies

Etiology

Kim HS, Myeong SY, Kang HY, Kim JC
Sci Rep 2024 Mar 4;14(1):5223. doi: 10.1038/s41598-024-55617-1. PMID: 38433172Free PMC Article
Liu Z, Ai J, Zhu Z, Huang L, Yi Z, Wu L, Xu Y, Zhu D, Li H, Yan Y, Zhang L, Zhong X, Yang B
Dermatol Ther 2022 Aug;35(8):e15594. Epub 2022 Jun 15 doi: 10.1111/dth.15594. PMID: 35617452
Choi SH, Park S, Kim DY
Am J Dermatopathol 2022 Jun 1;44(6):411-415. Epub 2022 Jan 7 doi: 10.1097/DAD.0000000000002140. PMID: 34999600
Kim WJ, Lee WK, Song M, Kim HS, Ko HC, Kim BS, Kim MB
J Dermatol 2015 Apr;42(4):373-7. Epub 2015 Jan 9 doi: 10.1111/1346-8138.12760. PMID: 25571765
Cengiz FP, Emiroglu N
Cutan Ocul Toxicol 2015;34(2):144-8. Epub 2014 Jun 18 doi: 10.3109/15569527.2014.924961. PMID: 24938453

Diagnosis

Chen L, Wang Y, Gao X, Qin B, Lian J, Ren M, Zhang W, Wei R, Li Q
Skin Res Technol 2022 Sep;28(5):703-707. Epub 2022 Jun 21 doi: 10.1111/srt.13170. PMID: 35726961Free PMC Article
Choi SH, Park S, Kim DY
Am J Dermatopathol 2022 Jun 1;44(6):411-415. Epub 2022 Jan 7 doi: 10.1097/DAD.0000000000002140. PMID: 34999600
Lu Q, Wang S, Wu T, Jiang G
J Coll Physicians Surg Pak 2021 Apr;31(4):450-454. doi: 10.29271/jcpsp.2021.04.450. PMID: 33866733
Dai H, Jiang HY, Xu AE
Skin Res Technol 2021 Mar;27(2):272-276. Epub 2020 Nov 11 doi: 10.1111/srt.12934. PMID: 33174647
Kim WJ, Lee WK, Song M, Kim HS, Ko HC, Kim BS, Kim MB
J Dermatol 2015 Apr;42(4):373-7. Epub 2015 Jan 9 doi: 10.1111/1346-8138.12760. PMID: 25571765

Therapy

Liu Z, Ai J, Zhu Z, Huang L, Yi Z, Wu L, Xu Y, Zhu D, Li H, Yan Y, Zhang L, Zhong X, Yang B
Dermatol Ther 2022 Aug;35(8):e15594. Epub 2022 Jun 15 doi: 10.1111/dth.15594. PMID: 35617452
Berumen-Glinz C, de la Barreda-Becerril F
JAMA Dermatol 2022 May 1;158(5):586-587. doi: 10.1001/jamadermatol.2022.0154. PMID: 35319721
Zhang F, Shi L, Liu P, Zhang L, Wu Q, Wang B, Zhang G, Wang P, Zhou F, Chen WR, Wang X
Photodiagnosis Photodyn Ther 2018 Jun;22:86-90. Epub 2018 Feb 4 doi: 10.1016/j.pdpdt.2018.02.003. PMID: 29414736
Li Q, Jiao B, Zhou F, Tan Q, Ma Y, Luo L, Zhai J, Luan Q, Li C, Wang G, Gao T
J Eur Acad Dermatol Venereol 2014 Dec;28(12):1821-6. Epub 2013 Nov 25 doi: 10.1111/jdv.12319. PMID: 24267796
King B, Knopp E, Galan A, Nuovo G, Tigelaar R, McNiff J
Arch Dermatol 2009 Feb;145(2):179-82. doi: 10.1001/archdermatol.2008.548. PMID: 19221263Free PMC Article

Prognosis

Kim HS, Myeong SY, Kang HY, Kim JC
Sci Rep 2024 Mar 4;14(1):5223. doi: 10.1038/s41598-024-55617-1. PMID: 38433172Free PMC Article
Matsumoto A, Gregory N, Rady PL, Tyring SK, Carlson JA
Am J Dermatopathol 2017 May;39(5):370-373. doi: 10.1097/DAD.0000000000000693. PMID: 28426487
Saoji V, Lade NR, Gadegone R, Bhat A
Indian J Dermatol Venereol Leprol 2016 Jan-Feb;82(1):42-6. doi: 10.4103/0378-6323.171650. PMID: 26728809
Carlson JA, Rohwedder A, Daulat S, Schwartz J, Schaller J
J Am Acad Dermatol 1999 Feb;40(2 Pt 1):259-62. doi: 10.1016/s0190-9622(99)70201-x. PMID: 10025758
Wikström A, Hedblad MA, Johansson B, Kalantari M, Syrjänen S, Lindberg M, von Krogh G
Genitourin Med 1992 Apr;68(2):90-9. doi: 10.1136/sti.68.2.90. PMID: 1316310Free PMC Article

Clinical prediction guides

Choi SH, Park S, Kim DY
Am J Dermatopathol 2022 Jun 1;44(6):411-415. Epub 2022 Jan 7 doi: 10.1097/DAD.0000000000002140. PMID: 34999600
Lu Q, Wang S, Wu T, Jiang G
J Coll Physicians Surg Pak 2021 Apr;31(4):450-454. doi: 10.29271/jcpsp.2021.04.450. PMID: 33866733
Dai H, Jiang HY, Xu AE
Skin Res Technol 2021 Mar;27(2):272-276. Epub 2020 Nov 11 doi: 10.1111/srt.12934. PMID: 33174647
Kim WJ, Lee WK, Song M, Kim HS, Ko HC, Kim BS, Kim MB
J Dermatol 2015 Apr;42(4):373-7. Epub 2015 Jan 9 doi: 10.1111/1346-8138.12760. PMID: 25571765
King B, Knopp E, Galan A, Nuovo G, Tigelaar R, McNiff J
Arch Dermatol 2009 Feb;145(2):179-82. doi: 10.1001/archdermatol.2008.548. PMID: 19221263Free PMC Article

Recent systematic reviews

Maranda EL, Lim VM, Nguyen AH, Nouri K
J Eur Acad Dermatol Venereol 2016 Oct;30(10):1700-1707. Epub 2016 Jun 29 doi: 10.1111/jdv.13789. PMID: 27356496

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