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Gonadotropin independent precocious puberty

MedGen UID:
548647
•Concept ID:
C0278090
•
Disease or Syndrome
Synonym: Precocious puberty, gonadotropin-independent
SNOMED CT: Peripheral precocious puberty (736606009); Gonadotropin independent precocious puberty (736606009); Precocious pseudopuberty (736606009)

Definition

Premature development of secondary sexual characteristics due to the presence of sex steroids independent of pituitary gonadotropin release. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGonadotropin independent precocious puberty

Professional guidelines

PubMed

Update on the etiology, diagnosis and therapeutic management of sexual precocity.
Brito VN, Latronico AC, Arnhold IJ, Mendonça BB
Arq Bras Endocrinol Metabol 2008 Feb;52(1):18-31. doi: 10.1590/s0004-27302008000100005. PMID: 18345393
Long-acting gonadotropin-releasing hormone agonists in the differential diagnosis of male precocious puberty.
Albano MC, Latronico AC, Arnhold IJ, Domenice S, Bloise W, Mendonca BB
J Pediatr Endocrinol Metab 1997 Sep-Oct;10(5):499-503. doi: 10.1515/jpem.1997.10.5.499. PMID: 9401906

Recent clinical studies

Etiology

Effect of Antiandrogen, Aromatase Inhibitor, and Gonadotropin-releasing Hormone Analog on Adult Height in Familial Male Precocious Puberty.
Leschek EW, Flor AC, Bryant JC, Jones JV, Barnes KM, Cutler GB Jr
J Pediatr 2017 Nov;190:229-235. doi: 10.1016/j.jpeds.2017.07.047. PMID: 29144249Free PMC Article
McCune-Albright syndrome and the extraskeletal manifestations of fibrous dysplasia.
Collins MT, Singer FR, Eugster E
Orphanet J Rare Dis 2012 May 24;7 Suppl 1(Suppl 1):S4. doi: 10.1186/1750-1172-7-S1-S4. PMID: 22640971Free PMC Article
Use of aromatase inhibitors in children and adolescents: what's new?
Diaz-Thomas A, Shulman D
Curr Opin Pediatr 2010 Aug;22(4):501-7. doi: 10.1097/MOP.0b013e32833ab888. PMID: 20489637
Lack of efficacy of fadrozole in treating precocious puberty in girls with the McCune-Albright syndrome.
Nunez SB, Calis K, Cutler GB Jr, Jones J, Feuillan PP
J Clin Endocrinol Metab 2003 Dec;88(12):5730-3. doi: 10.1210/jc.2003-030864. PMID: 14671160
Gonadotropin-independent precocious puberty.
Holland FJ
Endocrinol Metab Clin North Am 1991 Mar;20(1):191-210. PMID: 1903104

Diagnosis

McCune-Albright Syndrome: A Case Report and Review of Literature.
Nicolaides NC, Kontou M, Vasilakis IA, Binou M, Lykopoulou E, Kanaka-Gantenbein C
Int J Mol Sci 2023 May 9;24(10) doi: 10.3390/ijms24108464. PMID: 37239810Free PMC Article
Precocious puberty.
Gangat M, Radovick S
Minerva Pediatr 2020 Dec;72(6):491-500. Epub 2020 Aug 4 doi: 10.23736/S0026-4946.20.05970-8. PMID: 32748611
Precocious puberty and statural growth.
Carel JC, Lahlou N, Roger M, Chaussain JL
Hum Reprod Update 2004 Mar-Apr;10(2):135-47. doi: 10.1093/humupd/dmh012. PMID: 15073143
Gonadotropin independent precocious puberty.
Low LC, Wang Q
J Pediatr Endocrinol Metab 1998 Jul-Aug;11(4):497-507. doi: 10.1515/jpem.1998.11.4.497. PMID: 9777570
Gonadotropin-independent precocious puberty.
Holland FJ
Endocrinol Metab Clin North Am 1991 Mar;20(1):191-210. PMID: 1903104

Therapy

Idiopathic gonadotropin-independent precocious puberty - is regular surveillance required?
Arya VB, Davies JH
J Pediatr Endocrinol Metab 2019 Apr 24;32(4):403-407. doi: 10.1515/jpem-2018-0419. PMID: 30849047
Testosterone exposure in childhood: discerning pathology from physiology.
Cabrera SM, Rogol AD
Expert Opin Drug Saf 2013 May;12(3):375-88. Epub 2013 Mar 21 doi: 10.1517/14740338.2013.782000. PMID: 23517636
Aromatase inhibitors in men: effects and therapeutic options.
de Ronde W, de Jong FH
Reprod Biol Endocrinol 2011 Jun 21;9:93. doi: 10.1186/1477-7827-9-93. PMID: 21693046Free PMC Article
Use of aromatase inhibitors in children and adolescents: what's new?
Diaz-Thomas A, Shulman D
Curr Opin Pediatr 2010 Aug;22(4):501-7. doi: 10.1097/MOP.0b013e32833ab888. PMID: 20489637
Aromatase inhibitors in precocious puberty: rationale and experience to date.
Eugster EA
Treat Endocrinol 2004;3(3):141-51. doi: 10.2165/00024677-200403030-00002. PMID: 16026110

Prognosis

Idiopathic gonadotropin-independent precocious puberty - is regular surveillance required?
Arya VB, Davies JH
J Pediatr Endocrinol Metab 2019 Apr 24;32(4):403-407. doi: 10.1515/jpem-2018-0419. PMID: 30849047
Effect of Antiandrogen, Aromatase Inhibitor, and Gonadotropin-releasing Hormone Analog on Adult Height in Familial Male Precocious Puberty.
Leschek EW, Flor AC, Bryant JC, Jones JV, Barnes KM, Cutler GB Jr
J Pediatr 2017 Nov;190:229-235. doi: 10.1016/j.jpeds.2017.07.047. PMID: 29144249Free PMC Article
McCune-Albright syndrome and the extraskeletal manifestations of fibrous dysplasia.
Collins MT, Singer FR, Eugster E
Orphanet J Rare Dis 2012 May 24;7 Suppl 1(Suppl 1):S4. doi: 10.1186/1750-1172-7-S1-S4. PMID: 22640971Free PMC Article
Use of aromatase inhibitors in children and adolescents: what's new?
Diaz-Thomas A, Shulman D
Curr Opin Pediatr 2010 Aug;22(4):501-7. doi: 10.1097/MOP.0b013e32833ab888. PMID: 20489637
Precocious puberty and statural growth.
Carel JC, Lahlou N, Roger M, Chaussain JL
Hum Reprod Update 2004 Mar-Apr;10(2):135-47. doi: 10.1093/humupd/dmh012. PMID: 15073143

Clinical prediction guides

Idiopathic gonadotropin-independent precocious puberty - is regular surveillance required?
Arya VB, Davies JH
J Pediatr Endocrinol Metab 2019 Apr 24;32(4):403-407. doi: 10.1515/jpem-2018-0419. PMID: 30849047
Use of aromatase inhibitors in children and adolescents: what's new?
Diaz-Thomas A, Shulman D
Curr Opin Pediatr 2010 Aug;22(4):501-7. doi: 10.1097/MOP.0b013e32833ab888. PMID: 20489637
Precocious puberty and statural growth.
Carel JC, Lahlou N, Roger M, Chaussain JL
Hum Reprod Update 2004 Mar-Apr;10(2):135-47. doi: 10.1093/humupd/dmh012. PMID: 15073143
Etiology and age incidence of precocious puberty in girls: a multicentric study.
Cisternino M, Arrigo T, Pasquino AM, Tinelli C, Antoniazzi F, Beduschi L, Bindi G, Borrelli P, De Sanctis V, Farello G, Galluzzi F, Gargantini L, Lo Presti D, Sposito M, Tatò L
J Pediatr Endocrinol Metab 2000 Jul;13 Suppl 1:695-701. doi: 10.1515/jpem.2000.13.s1.695. PMID: 10969911
Regulation of testicular anti-M ullerian hormone secretion.
Rey R, Josso N
Eur J Endocrinol 1996 Aug;135(2):144-52. doi: 10.1530/eje.0.1350144. PMID: 8810722

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