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Dengue hemorrhagic fever

MedGen UID:
5506
•Concept ID:
C0019100
•
Disease or Syndrome
Synonyms: Hemorrhagic dengue; Philippine hemorrhagic fever; Singapore hemorrhagic fever; Thai hemorrhagic fever
SNOMED CT: DHF - Dengue hemorrhagic fever (20927009); Severe dengue (20927009); Dengue hemorrhagic fever (20927009)
 
Monarch Initiative: MONDO:0005358

Definition

A serious condition caused by Dengue virus infection. Patients present with an acute febrile illness followed by restlessness, irritability, and bleeding. It may lead to hemorrhagic shock and death. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDengue hemorrhagic fever

Professional guidelines

PubMed

Papaya Leaf Extracts as Potential Dengue Treatment: An In-Silico Study.
Madushanka A, Verma N, Freindorf M, Kraka E
Int J Mol Sci 2022 Oct 14;23(20) doi: 10.3390/ijms232012310. PMID: 36293162Free PMC Article
Symptomatic treatment of dengue: should the NSAID contraindication be reconsidered?
Kellstein D, Fernandes L
Postgrad Med 2019 Mar;131(2):109-116. Epub 2019 Jan 16 doi: 10.1080/00325481.2019.1561916. PMID: 30575425
Dengue Hemorrhagic Fever at 60 Years: Early Evolution of Concepts of Causation and Treatment.
Halstead SB, Cohen SN
Microbiol Mol Biol Rev 2015 Sep;79(3):281-91. doi: 10.1128/MMBR.00009-15. PMID: 26085471Free PMC Article

Recent clinical studies

Etiology

Dengue overview: An updated systemic review.
Khan MB, Yang ZS, Lin CY, Hsu MC, Urbina AN, Assavalapsakul W, Wang WH, Chen YH, Wang SF
J Infect Public Health 2023 Oct;16(10):1625-1642. Epub 2023 Aug 3 doi: 10.1016/j.jiph.2023.08.001. PMID: 37595484
Immune-Mediated Pathogenesis in Dengue Virus Infection.
Khanam A, Gutiérrez-Barbosa H, Lyke KE, Chua JV
Viruses 2022 Nov 21;14(11) doi: 10.3390/v14112575. PMID: 36423184Free PMC Article
Dengue hemorrhagic fever - A systemic literature review of current perspectives on pathogenesis, prevention and control.
Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, Wang SF
J Microbiol Immunol Infect 2020 Dec;53(6):963-978. Epub 2020 Mar 26 doi: 10.1016/j.jmii.2020.03.007. PMID: 32265181
Symptomatic treatment of dengue: should the NSAID contraindication be reconsidered?
Kellstein D, Fernandes L
Postgrad Med 2019 Mar;131(2):109-116. Epub 2019 Jan 16 doi: 10.1080/00325481.2019.1561916. PMID: 30575425
Dengue virus pathogenesis: an integrated view.
Martina BE, Koraka P, Osterhaus AD
Clin Microbiol Rev 2009 Oct;22(4):564-81. doi: 10.1128/CMR.00035-09. PMID: 19822889Free PMC Article

Diagnosis

Dengue hemorrhagic fever: a growing global menace.
Parveen S, Riaz Z, Saeed S, Ishaque U, Sultana M, Faiz Z, Shafqat Z, Shabbir S, Ashraf S, Marium A
J Water Health 2023 Nov;21(11):1632-1650. doi: 10.2166/wh.2023.114. PMID: 38017595
Neurological Complications of Dengue Fever.
Trivedi S, Chakravarty A
Curr Neurol Neurosci Rep 2022 Aug;22(8):515-529. Epub 2022 Jun 21 doi: 10.1007/s11910-022-01213-7. PMID: 35727463Free PMC Article
Dengue hemorrhagic fever - A systemic literature review of current perspectives on pathogenesis, prevention and control.
Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, Wang SF
J Microbiol Immunol Infect 2020 Dec;53(6):963-978. Epub 2020 Mar 26 doi: 10.1016/j.jmii.2020.03.007. PMID: 32265181
Dengue Fever: Causes, Complications, and Vaccine Strategies.
Khetarpal N, Khanna I
J Immunol Res 2016;2016:6803098. Epub 2016 Jul 20 doi: 10.1155/2016/6803098. PMID: 27525287Free PMC Article
Dengue and dengue hemorrhagic fever.
Gubler DJ
Clin Microbiol Rev 1998 Jul;11(3):480-96. doi: 10.1128/CMR.11.3.480. PMID: 9665979Free PMC Article

Therapy

Dengue overview: An updated systemic review.
Khan MB, Yang ZS, Lin CY, Hsu MC, Urbina AN, Assavalapsakul W, Wang WH, Chen YH, Wang SF
J Infect Public Health 2023 Oct;16(10):1625-1642. Epub 2023 Aug 3 doi: 10.1016/j.jiph.2023.08.001. PMID: 37595484
Clinical Safety Experience of TAK-003 for Dengue Fever: A New Tetravalent Live Attenuated Vaccine Candidate.
Patel SS, Rauscher M, Kudela M, Pang H
Clin Infect Dis 2023 Feb 8;76(3):e1350-e1359. doi: 10.1093/cid/ciac418. PMID: 35639602Free PMC Article
Symptomatic treatment of dengue: should the NSAID contraindication be reconsidered?
Kellstein D, Fernandes L
Postgrad Med 2019 Mar;131(2):109-116. Epub 2019 Jan 16 doi: 10.1080/00325481.2019.1561916. PMID: 30575425
Dengue Fever: Causes, Complications, and Vaccine Strategies.
Khetarpal N, Khanna I
J Immunol Res 2016;2016:6803098. Epub 2016 Jul 20 doi: 10.1155/2016/6803098. PMID: 27525287Free PMC Article
Dengue and dengue hemorrhagic fever.
Gubler DJ
Clin Microbiol Rev 1998 Jul;11(3):480-96. doi: 10.1128/CMR.11.3.480. PMID: 9665979Free PMC Article

Prognosis

Neurological Complications of Dengue Fever.
Trivedi S, Chakravarty A
Curr Neurol Neurosci Rep 2022 Aug;22(8):515-529. Epub 2022 Jun 21 doi: 10.1007/s11910-022-01213-7. PMID: 35727463Free PMC Article
Dengue Hemorrhagic Fever Virus in Saudi Arabia: A Review.
Al-Tawfiq JA, Memish ZA
Vector Borne Zoonotic Dis 2018 Feb;18(2):75-81. Epub 2018 Jan 10 doi: 10.1089/vbz.2017.2209. PMID: 29319426
Meta-Analysis of Dengue Severity during Infection by Different Dengue Virus Serotypes in Primary and Secondary Infections.
Soo KM, Khalid B, Ching SM, Chee HY
PLoS One 2016;11(5):e0154760. Epub 2016 May 23 doi: 10.1371/journal.pone.0154760. PMID: 27213782Free PMC Article
Dengue.
Halstead SB
Curr Opin Infect Dis 2002 Oct;15(5):471-6. doi: 10.1097/00001432-200210000-00003. PMID: 12686878
Dengue and dengue hemorrhagic fever.
Gubler DJ
Clin Microbiol Rev 1998 Jul;11(3):480-96. doi: 10.1128/CMR.11.3.480. PMID: 9665979Free PMC Article

Clinical prediction guides

Spatial model of Dengue Hemorrhagic Fever (DHF) risk: scoping review.
Pakaya R, Daniel D, Widayani P, Utarini A
BMC Public Health 2023 Dec 7;23(1):2448. doi: 10.1186/s12889-023-17185-3. PMID: 38062404Free PMC Article
Flavivirus proteases: The viral Achilles heel to prevent future pandemics.
Teramoto T, Choi KH, Padmanabhan R
Antiviral Res 2023 Feb;210:105516. Epub 2022 Dec 29 doi: 10.1016/j.antiviral.2022.105516. PMID: 36586467Free PMC Article
Neurological Complications of Dengue Fever.
Trivedi S, Chakravarty A
Curr Neurol Neurosci Rep 2022 Aug;22(8):515-529. Epub 2022 Jun 21 doi: 10.1007/s11910-022-01213-7. PMID: 35727463Free PMC Article
Meta-Analysis of Dengue Severity during Infection by Different Dengue Virus Serotypes in Primary and Secondary Infections.
Soo KM, Khalid B, Ching SM, Chee HY
PLoS One 2016;11(5):e0154760. Epub 2016 May 23 doi: 10.1371/journal.pone.0154760. PMID: 27213782Free PMC Article
Dengue.
Halstead SB
Curr Opin Infect Dis 2002 Oct;15(5):471-6. doi: 10.1097/00001432-200210000-00003. PMID: 12686878

Recent systematic reviews

Dengue overview: An updated systemic review.
Khan MB, Yang ZS, Lin CY, Hsu MC, Urbina AN, Assavalapsakul W, Wang WH, Chen YH, Wang SF
J Infect Public Health 2023 Oct;16(10):1625-1642. Epub 2023 Aug 3 doi: 10.1016/j.jiph.2023.08.001. PMID: 37595484
Epidemiology of dengue in SAARC territory: a systematic review and meta-analysis.
Shrestha DB, Budhathoki P, Gurung B, Subedi S, Aryal S, Basukala A, Aryal B, Adhikari A, Poudel A, Yadav GK, Khoury M, Rayamajhee B, Shrestha LB
Parasit Vectors 2022 Oct 24;15(1):389. doi: 10.1186/s13071-022-05409-1. PMID: 36280877Free PMC Article
Cardiovascular sequelae of dengue fever: a systematic review.
Rahim A, Hameed A, Ishaq U, Malik J, Zaidi SMJ, Khurshid H, Malik A, Satti DI, Naz H
Expert Rev Cardiovasc Ther 2022 Jun;20(6):465-479. Epub 2022 Jun 2 doi: 10.1080/14779072.2022.2082945. PMID: 35612830
Dengue hemorrhagic fever - A systemic literature review of current perspectives on pathogenesis, prevention and control.
Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, Wang SF
J Microbiol Immunol Infect 2020 Dec;53(6):963-978. Epub 2020 Mar 26 doi: 10.1016/j.jmii.2020.03.007. PMID: 32265181
Meta-Analysis of Dengue Severity during Infection by Different Dengue Virus Serotypes in Primary and Secondary Infections.
Soo KM, Khalid B, Ching SM, Chee HY
PLoS One 2016;11(5):e0154760. Epub 2016 May 23 doi: 10.1371/journal.pone.0154760. PMID: 27213782Free PMC Article

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