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Hepatic veno-occlusive disease

MedGen UID:
5514
Concept ID:
C0019156
Disease or Syndrome
Synonyms: Disease, Hepatic Veno-Occlusive; Hepatic Veno Occlusive Disease; Hepatic Veno-Occlusive Disease; Hepatic Veno-Occlusive Diseases; Sinusoidal Obstruction Syndrome; Syndrome, Sinusoidal Obstruction; Veno Occlusive Disease, Hepatic; Veno-Occlusive Disease, Hepatic
SNOMED CT: Veno-occlusive disease of the liver (65617004); Hepatic veno-occlusive disease (65617004); Hepatic sinusoidal obstruction syndrome (65617004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019514
Orphanet: ORPHA890

Definition

A rare vascular liver disease characterized by toxic injury to the hepatic sinusoidal capillaries that leads to obstruction of the small hepatic veins and sinusoids. Clinical manifestations include painful hepatomegaly, jaundice, and fluid retention that manifests by weight gain, edemas, and ascites. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatic veno-occlusive disease
Follow this link to review classifications for Hepatic veno-occlusive disease in Orphanet.

Professional guidelines

PubMed

Bonifazi F, Barbato F, Ravaioli F, Sessa M, Defrancesco I, Arpinati M, Cavo M, Colecchia A
Front Immunol 2020;11:489. Epub 2020 Apr 3 doi: 10.3389/fimmu.2020.00489. PMID: 32318059Free PMC Article
Cairo MS, Cooke KR, Lazarus HM, Chao N
Br J Haematol 2020 Sep;190(6):822-836. Epub 2020 Mar 4 doi: 10.1111/bjh.16557. PMID: 32133623Free PMC Article
Richardson PG, Triplett BM, Ho VT, Chao N, Dignan FL, Maglio M, Mohty M
Expert Rev Clin Pharmacol 2018 Feb;11(2):113-124. Epub 2018 Jan 5 doi: 10.1080/17512433.2018.1421943. PMID: 29301447

Recent clinical studies

Etiology

Bonifazi F, Barbato F, Ravaioli F, Sessa M, Defrancesco I, Arpinati M, Cavo M, Colecchia A
Front Immunol 2020;11:489. Epub 2020 Apr 3 doi: 10.3389/fimmu.2020.00489. PMID: 32318059Free PMC Article
Cairo MS, Cooke KR, Lazarus HM, Chao N
Br J Haematol 2020 Sep;190(6):822-836. Epub 2020 Mar 4 doi: 10.1111/bjh.16557. PMID: 32133623Free PMC Article
Corbacioglu S, Jabbour EJ, Mohty M
Biol Blood Marrow Transplant 2019 Jul;25(7):1271-1280. Epub 2019 Feb 22 doi: 10.1016/j.bbmt.2019.02.018. PMID: 30797942
Richardson PG, Riches ML, Kernan NA, Brochstein JA, Mineishi S, Termuhlen AM, Arai S, Grupp SA, Guinan EC, Martin PL, Steinbach G, Krishnan A, Nemecek ER, Giralt S, Rodriguez T, Duerst R, Doyle J, Antin JH, Smith A, Lehmann L, Champlin R, Gillio A, Bajwa R, D'Agostino RB Sr, Massaro J, Warren D, Miloslavsky M, Hume RL, Iacobelli M, Nejadnik B, Hannah AL, Soiffer RJ
Blood 2016 Mar 31;127(13):1656-65. Epub 2016 Jan 29 doi: 10.1182/blood-2015-10-676924. PMID: 26825712Free PMC Article
Dignan FL, Wynn RF, Hadzic N, Karani J, Quaglia A, Pagliuca A, Veys P, Potter MN; Haemato-oncology Task Force of British Committee for Standards in Haematology; British Society for Blood and Marrow Transplantation
Br J Haematol 2013 Nov;163(4):444-57. Epub 2013 Sep 17 doi: 10.1111/bjh.12558. PMID: 24102514

Diagnosis

Mohty M, Malard F, Alaskar AS, Aljurf M, Arat M, Bader P, Baron F, Bazarbachi A, Blaise D, Brissot E, Ciceri F, Corbacioglu S, Dalle JH, Dignan F, Huynh A, Kenyon M, Nagler A, Pagliuca A, Perić Z, Richardson PG, Ruggeri A, Ruutu T, Yakoub-Agha I, Duarte RF, Carreras E
Bone Marrow Transplant 2023 Jul;58(7):749-754. Epub 2023 Apr 24 doi: 10.1038/s41409-023-01992-8. PMID: 37095231
Bonifazi F, Barbato F, Ravaioli F, Sessa M, Defrancesco I, Arpinati M, Cavo M, Colecchia A
Front Immunol 2020;11:489. Epub 2020 Apr 3 doi: 10.3389/fimmu.2020.00489. PMID: 32318059Free PMC Article
Cairo MS, Cooke KR, Lazarus HM, Chao N
Br J Haematol 2020 Sep;190(6):822-836. Epub 2020 Mar 4 doi: 10.1111/bjh.16557. PMID: 32133623Free PMC Article
Corbacioglu S, Jabbour EJ, Mohty M
Biol Blood Marrow Transplant 2019 Jul;25(7):1271-1280. Epub 2019 Feb 22 doi: 10.1016/j.bbmt.2019.02.018. PMID: 30797942
Dignan FL, Wynn RF, Hadzic N, Karani J, Quaglia A, Pagliuca A, Veys P, Potter MN; Haemato-oncology Task Force of British Committee for Standards in Haematology; British Society for Blood and Marrow Transplantation
Br J Haematol 2013 Nov;163(4):444-57. Epub 2013 Sep 17 doi: 10.1111/bjh.12558. PMID: 24102514

Therapy

Bonifazi F, Barbato F, Ravaioli F, Sessa M, Defrancesco I, Arpinati M, Cavo M, Colecchia A
Front Immunol 2020;11:489. Epub 2020 Apr 3 doi: 10.3389/fimmu.2020.00489. PMID: 32318059Free PMC Article
Kantarjian HM, DeAngelo DJ, Stelljes M, Liedtke M, Stock W, Gökbuget N, O'Brien SM, Jabbour E, Wang T, Liang White J, Sleight B, Vandendries E, Advani AS
Cancer 2019 Jul 15;125(14):2474-2487. Epub 2019 Mar 28 doi: 10.1002/cncr.32116. PMID: 30920645Free PMC Article
Corbacioglu S, Jabbour EJ, Mohty M
Biol Blood Marrow Transplant 2019 Jul;25(7):1271-1280. Epub 2019 Feb 22 doi: 10.1016/j.bbmt.2019.02.018. PMID: 30797942
Aguilar-Guisado M, Espigado I, Martín-Peña A, Gudiol C, Royo-Cebrecos C, Falantes J, Vázquez-López L, Montero MI, Rosso-Fernández C, de la Luz Martino M, Parody R, González-Campos J, Garzón-López S, Calderón-Cabrera C, Barba P, Rodríguez N, Rovira M, Montero-Mateos E, Carratalá J, Pérez-Simón JA, Cisneros JM
Lancet Haematol 2017 Dec;4(12):e573-e583. Epub 2017 Nov 15 doi: 10.1016/S2352-3026(17)30211-9. PMID: 29153975
Richardson PG, Riches ML, Kernan NA, Brochstein JA, Mineishi S, Termuhlen AM, Arai S, Grupp SA, Guinan EC, Martin PL, Steinbach G, Krishnan A, Nemecek ER, Giralt S, Rodriguez T, Duerst R, Doyle J, Antin JH, Smith A, Lehmann L, Champlin R, Gillio A, Bajwa R, D'Agostino RB Sr, Massaro J, Warren D, Miloslavsky M, Hume RL, Iacobelli M, Nejadnik B, Hannah AL, Soiffer RJ
Blood 2016 Mar 31;127(13):1656-65. Epub 2016 Jan 29 doi: 10.1182/blood-2015-10-676924. PMID: 26825712Free PMC Article

Prognosis

Renaghan AD, Jaimes EA, Malyszko J, Perazella MA, Sprangers B, Rosner MH
Clin J Am Soc Nephrol 2020 Feb 7;15(2):289-297. Epub 2019 Dec 13 doi: 10.2215/CJN.08580719. PMID: 31836598Free PMC Article
Günther S, Perros F, Rautou PE, Girerd B, Ghigna MR, Cazals-Hatem D, Lau EM, Dorfmüller P, Sitbon O, Valla DC, Humbert M, Montani D
Am J Pathol 2019 Jun;189(6):1159-1175. Epub 2019 Mar 26 doi: 10.1016/j.ajpath.2019.02.007. PMID: 30926335
Kantarjian HM, DeAngelo DJ, Stelljes M, Liedtke M, Stock W, Gökbuget N, O'Brien SM, Jabbour E, Wang T, Liang White J, Sleight B, Vandendries E, Advani AS
Cancer 2019 Jul 15;125(14):2474-2487. Epub 2019 Mar 28 doi: 10.1002/cncr.32116. PMID: 30920645Free PMC Article
Corbacioglu S, Carreras E, Ansari M, Balduzzi A, Cesaro S, Dalle JH, Dignan F, Gibson B, Guengoer T, Gruhn B, Lankester A, Locatelli F, Pagliuca A, Peters C, Richardson PG, Schulz AS, Sedlacek P, Stein J, Sykora KW, Toporski J, Trigoso E, Vetteranta K, Wachowiak J, Wallhult E, Wynn R, Yaniv I, Yesilipek A, Mohty M, Bader P
Bone Marrow Transplant 2018 Feb;53(2):138-145. Epub 2017 Jul 31 doi: 10.1038/bmt.2017.161. PMID: 28759025Free PMC Article
Ribaud P, Gluckman E
Pediatr Transplant 1999;3 Suppl 1:41-4. doi: 10.1034/j.1399-3046.1999.00077.x. PMID: 10587970

Clinical prediction guides

Jabbour E, Haddad FG, Short NJ, Senapati J, Jain N, Sasaki K, Jorgensen J, Wang SA, Alvarado Y, Wang X, DiNardo C, Masarova L, Kadia T, Garris RS, Ravandi F, Kantarjian H
Blood 2024 Feb 1;143(5):417-421. doi: 10.1182/blood.2023022330. PMID: 37879077
Mohty M, Malard F, Alaskar AS, Aljurf M, Arat M, Bader P, Baron F, Bazarbachi A, Blaise D, Brissot E, Ciceri F, Corbacioglu S, Dalle JH, Dignan F, Huynh A, Kenyon M, Nagler A, Pagliuca A, Perić Z, Richardson PG, Ruggeri A, Ruutu T, Yakoub-Agha I, Duarte RF, Carreras E
Bone Marrow Transplant 2023 Jul;58(7):749-754. Epub 2023 Apr 24 doi: 10.1038/s41409-023-01992-8. PMID: 37095231
Zhu C, Ren X, Liu D, Zhang C
Toxicology 2021 Aug;460:152882. Epub 2021 Aug 2 doi: 10.1016/j.tox.2021.152882. PMID: 34352347
Kantarjian HM, DeAngelo DJ, Stelljes M, Liedtke M, Stock W, Gökbuget N, O'Brien SM, Jabbour E, Wang T, Liang White J, Sleight B, Vandendries E, Advani AS
Cancer 2019 Jul 15;125(14):2474-2487. Epub 2019 Mar 28 doi: 10.1002/cncr.32116. PMID: 30920645Free PMC Article
Richardson PG, Riches ML, Kernan NA, Brochstein JA, Mineishi S, Termuhlen AM, Arai S, Grupp SA, Guinan EC, Martin PL, Steinbach G, Krishnan A, Nemecek ER, Giralt S, Rodriguez T, Duerst R, Doyle J, Antin JH, Smith A, Lehmann L, Champlin R, Gillio A, Bajwa R, D'Agostino RB Sr, Massaro J, Warren D, Miloslavsky M, Hume RL, Iacobelli M, Nejadnik B, Hannah AL, Soiffer RJ
Blood 2016 Mar 31;127(13):1656-65. Epub 2016 Jan 29 doi: 10.1182/blood-2015-10-676924. PMID: 26825712Free PMC Article

Recent systematic reviews

Kashyap R, Anwer F, Iqbal MA, Khalid F, Khan A, Ali MA, Anwar MY, Chaudhary A, Jaan A
Hematol Oncol Stem Cell Ther 2023 Jan 17;16(2):93-101. doi: 10.1016/j.hemonc.2021.09.002. PMID: 34655527
Bonifazi F, Sica S, Angeletti A, Marktel S, Prete A, Iori AP, Olivari D, Rossetti G, Bertaina A, Botti S, Busca A, Carella AM, Cerretti R, Gargiulo G, Grassi A, Gualandi F, Irrera G, Milone G, Risitano AM, Santarone S, Vassallo E, Zecca M, Ciceri F, Pomponio G
Transplantation 2021 Apr 1;105(4):686-694. doi: 10.1097/TP.0000000000003569. PMID: 33273315
Cheuk DK, Chiang AK, Ha SY, Chan GC
Cochrane Database Syst Rev 2015 May 27;2015(5):CD009311. doi: 10.1002/14651858.CD009311.pub2. PMID: 26017019Free PMC Article
Abdualmjid RJ, Sergi C
J Pharm Pharm Sci 2013;16(3):376-404. doi: 10.18433/j36g6x. PMID: 24021288
Imran H, Tleyjeh IM, Zirakzadeh A, Rodriguez V, Khan SP
Bone Marrow Transplant 2006 Apr;37(7):677-86. doi: 10.1038/sj.bmt.1705297. PMID: 16489362

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