U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lupus anticoagulant disorder

MedGen UID:
551915
Concept ID:
C0311370
Disease or Syndrome
Synonym: Lupus anticoagulant
SNOMED CT: Lupus anticoagulant (19267009); Lupus anticoagulant disorder (19267009); Lupus anticoagulant inhibitor syndrome (19267009); SLE inhibitor syndrome (19267009)

Definition

A hypercoaguable state that results from the presence of the immunoglobulin known as Lupus Anticoagulant. The antibody interacts with cell membrane phospholipids, causing increased aggregation and adhesion of platelets, which causes increased clot formation. Though the majority of patients who test positive for lupus anticoagulant do not have lupus, those individuals afflicted with lupus have a higher probability of developing the antibody. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLupus anticoagulant disorder

Professional guidelines

PubMed

Barbhaiya M, Zuily S, Naden R, Hendry A, Manneville F, Amigo MC, Amoura Z, Andrade D, Andreoli L, Artim-Esen B, Atsumi T, Avcin T, Belmont HM, Bertolaccini ML, Branch DW, Carvalheiras G, Casini A, Cervera R, Cohen H, Costedoat-Chalumeau N, Crowther M, de Jesús G, Delluc A, Desai S, Sancho M, Devreese KM, Diz-Kucukkaya R, Duarte-García A, Frances C, Garcia D, Gris JC, Jordan N, Leaf RK, Kello N, Knight JS, Laskin C, Lee AI, Legault K, Levine SR, Levy RA, Limper M, Lockshin MD, Mayer-Pickel K, Musial J, Meroni PL, Orsolini G, Ortel TL, Pengo V, Petri M, Pons-Estel G, Gomez-Puerta JA, Raimboug Q, Roubey R, Sanna G, Seshan SV, Sciascia S, Tektonidou MG, Tincani A, Wahl D, Willis R, Yelnik C, Zuily C, Guillemin F, Costenbader K, Erkan D; ACR/EULAR APS Classification Criteria Collaborators
Ann Rheum Dis 2023 Oct;82(10):1258-1270. Epub 2023 Aug 28 doi: 10.1136/ard-2023-224609. PMID: 37640450
Barbhaiya M, Zuily S, Naden R, Hendry A, Manneville F, Amigo MC, Amoura Z, Andrade D, Andreoli L, Artim-Esen B, Atsumi T, Avcin T, Belmont HM, Bertolaccini ML, Branch DW, Carvalheiras G, Casini A, Cervera R, Cohen H, Costedoat-Chalumeau N, Crowther M, de Jesus G, Delluc A, Desai S, De Sancho M, Devreese KM, Diz-Kucukkaya R, Duarte-Garcia A, Frances C, Garcia D, Gris JC, Jordan N, Leaf RK, Kello N, Knight JS, Laskin C, Lee AI, Legault K, Levine SR, Levy RA, Limper M, Lockshin MD, Mayer-Pickel K, Musial J, Meroni PL, Orsolini G, Ortel TL, Pengo V, Petri M, Pons-Estel G, Gomez-Puerta JA, Raimboug Q, Roubey R, Sanna G, Seshan SV, Sciascia S, Tektonidou MG, Tincani A, Wahl D, Willis R, Yelnik C, Zuily C, Guillemin F, Costenbader K, Erkan D; ACR/EULAR APS Classification Criteria Collaborators
Arthritis Rheumatol 2023 Oct;75(10):1687-1702. Epub 2023 Aug 28 doi: 10.1002/art.42624. PMID: 37635643
Chaturvedi S, McCrae KR
Blood Rev 2017 Nov;31(6):406-417. Epub 2017 Jul 30 doi: 10.1016/j.blre.2017.07.006. PMID: 28784423Free PMC Article

Recent clinical studies

Etiology

Sammaritano LR
Best Pract Res Clin Rheumatol 2020 Feb;34(1):101463. Epub 2019 Dec 19 doi: 10.1016/j.berh.2019.101463. PMID: 31866276
Fernandes MA, Gerardi MC, Andreoli L, Tincani A
Clin Exp Rheumatol 2020 Jan-Feb;38(1):149-156. Epub 2019 Jun 28 PMID: 31287415
Linnemann B, Hart C
Hamostaseologie 2019 Feb;39(1):49-61. Epub 2019 Jan 31 doi: 10.1055/s-0039-1677840. PMID: 30703819
Tanaseanu C, Moldoveanu E, Tanaseanu S, Popescu LM
Haematologia (Budap) 2002;31(4):287-302. doi: 10.1163/15685590160141314. PMID: 12038512
Schafer AI
Ann Intern Med 1985 Jun;102(6):814-28. doi: 10.7326/0003-4819-102-6-814. PMID: 3158262

Diagnosis

Gaspar P, Sciascia S, Tektonidou MG
Rheumatology (Oxford) 2024 Feb 6;63(SI):SI24-SI36. doi: 10.1093/rheumatology/kead571. PMID: 38320589Free PMC Article
Pignatelli P, Ettorre E, Menichelli D, Pani A, Violi F, Pastori D
Haematologica 2020 Mar;105(3):562-572. Epub 2020 Jan 30 doi: 10.3324/haematol.2019.221945. PMID: 32001534Free PMC Article
Sammaritano LR
Best Pract Res Clin Rheumatol 2020 Feb;34(1):101463. Epub 2019 Dec 19 doi: 10.1016/j.berh.2019.101463. PMID: 31866276
Favaloro EJ
Am J Hematol 2020 Jan;95(1):117-128. Epub 2019 Nov 20 doi: 10.1002/ajh.25669. PMID: 31674066
Linnemann B, Hart C
Hamostaseologie 2019 Feb;39(1):49-61. Epub 2019 Jan 31 doi: 10.1055/s-0039-1677840. PMID: 30703819

Therapy

Linnemann B, Hart C
Hamostaseologie 2019 Feb;39(1):49-61. Epub 2019 Jan 31 doi: 10.1055/s-0039-1677840. PMID: 30703819
Uthman I, Noureldine MHA, Ruiz-Irastorza G, Khamashta M
Ann Rheum Dis 2019 Feb;78(2):155-161. Epub 2018 Oct 3 doi: 10.1136/annrheumdis-2018-213846. PMID: 30282668
Schreiber K, Sciascia S, de Groot PG, Devreese K, Jacobsen S, Ruiz-Irastorza G, Salmon JE, Shoenfeld Y, Shovman O, Hunt BJ
Nat Rev Dis Primers 2018 Jan 11;4:17103. doi: 10.1038/nrdp.2017.103. PMID: 29321641
Chaturvedi S, McCrae KR
Blood Rev 2017 Nov;31(6):406-417. Epub 2017 Jul 30 doi: 10.1016/j.blre.2017.07.006. PMID: 28784423Free PMC Article
George D, Erkan D
Prog Cardiovasc Dis 2009 Sep-Oct;52(2):115-25. doi: 10.1016/j.pcad.2009.06.005. PMID: 19732604

Prognosis

Chaturvedi S, McCrae KR
Blood Rev 2017 Nov;31(6):406-417. Epub 2017 Jul 30 doi: 10.1016/j.blre.2017.07.006. PMID: 28784423Free PMC Article
Lightstone L, Hladunewich MA
Semin Nephrol 2017 Jul;37(4):347-353. doi: 10.1016/j.semnephrol.2017.05.006. PMID: 28711073
Carmi O, Berla M, Shoenfeld Y, Levy Y
Expert Rev Hematol 2017 Apr;10(4):365-374. Epub 2017 Mar 13 doi: 10.1080/17474086.2017.1300522. PMID: 28277850
Buyon JP, Kim MY, Guerra MM, Laskin CA, Petri M, Lockshin MD, Sammaritano L, Branch DW, Porter TF, Sawitzke A, Merrill JT, Stephenson MD, Cohn E, Garabet L, Salmon JE
Ann Intern Med 2015 Aug 4;163(3):153-63. doi: 10.7326/M14-2235. PMID: 26098843Free PMC Article
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807

Clinical prediction guides

Barbhaiya M, Zuily S, Naden R, Hendry A, Manneville F, Amigo MC, Amoura Z, Andrade D, Andreoli L, Artim-Esen B, Atsumi T, Avcin T, Belmont HM, Bertolaccini ML, Branch DW, Carvalheiras G, Casini A, Cervera R, Cohen H, Costedoat-Chalumeau N, Crowther M, de Jesus G, Delluc A, Desai S, De Sancho M, Devreese KM, Diz-Kucukkaya R, Duarte-Garcia A, Frances C, Garcia D, Gris JC, Jordan N, Leaf RK, Kello N, Knight JS, Laskin C, Lee AI, Legault K, Levine SR, Levy RA, Limper M, Lockshin MD, Mayer-Pickel K, Musial J, Meroni PL, Orsolini G, Ortel TL, Pengo V, Petri M, Pons-Estel G, Gomez-Puerta JA, Raimboug Q, Roubey R, Sanna G, Seshan SV, Sciascia S, Tektonidou MG, Tincani A, Wahl D, Willis R, Yelnik C, Zuily C, Guillemin F, Costenbader K, Erkan D; ACR/EULAR APS Classification Criteria Collaborators
Arthritis Rheumatol 2023 Oct;75(10):1687-1702. Epub 2023 Aug 28 doi: 10.1002/art.42624. PMID: 37635643
Grygiel-Górniak B, Mazurkiewicz Ł
J Thromb Thrombolysis 2023 Aug;56(2):301-314. Epub 2023 Jun 1 doi: 10.1007/s11239-023-02834-6. PMID: 37264223Free PMC Article
Chaturvedi S, McCrae KR
Blood Rev 2017 Nov;31(6):406-417. Epub 2017 Jul 30 doi: 10.1016/j.blre.2017.07.006. PMID: 28784423Free PMC Article
Lightstone L, Hladunewich MA
Semin Nephrol 2017 Jul;37(4):347-353. doi: 10.1016/j.semnephrol.2017.05.006. PMID: 28711073
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807

Recent systematic reviews

Merashli M, Bucci T, Pastori D, Pignatelli P, Marottoli V, Arcaro A, Gentile F, Ames PR
Semin Arthritis Rheum 2020 Dec;50(6):1291-1298. Epub 2020 Aug 30 doi: 10.1016/j.semarthrit.2020.08.012. PMID: 33065424
Ames PRJ, Merashli M, Bucci T, Pastori D, Pignatelli P, Arcaro A, Gentile F
Int J Mol Sci 2020 Jun 9;21(11) doi: 10.3390/ijms21114120. PMID: 32527000Free PMC Article
Islam MA, Alam F, Wong KK
Autoimmun Rev 2017 May;16(5):512-522. Epub 2017 Mar 7 doi: 10.1016/j.autrev.2017.03.005. PMID: 28279839
Zhu W, Wu Y, Xu M, Wang JY, Meng YF, Gu Z, Lu J
PLoS One 2014;10(4):e0122814. Epub 2015 Apr 28 doi: 10.1371/journal.pone.0122814. PMID: 25918850Free PMC Article
Appenzeller S, Souza FH, Wagner Silva de Souza A, Shoenfeld Y, de Carvalho JF
Semin Arthritis Rheum 2011 Dec;41(3):517-23. Epub 2011 Aug 24 doi: 10.1016/j.semarthrit.2011.05.007. PMID: 21868064

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...