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Lupus anticoagulant disorder

MedGen UID:
551915
•Concept ID:
C0311370
•
Disease or Syndrome
Synonym: Lupus anticoagulant
SNOMED CT: Lupus anticoagulant (19267009); Lupus anticoagulant disorder (19267009); Lupus anticoagulant inhibitor syndrome (19267009); SLE inhibitor syndrome (19267009)

Definition

A hypercoaguable state that results from the presence of the immunoglobulin known as Lupus Anticoagulant. The antibody interacts with cell membrane phospholipids, causing increased aggregation and adhesion of platelets, which causes increased clot formation. Though the majority of patients who test positive for lupus anticoagulant do not have lupus, those individuals afflicted with lupus have a higher probability of developing the antibody. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLupus anticoagulant disorder

Professional guidelines

PubMed

Diagnosis and management of the antiphospholipid syndrome.
Chaturvedi S, McCrae KR
Blood Rev 2017 Nov;31(6):406-417. Epub 2017 Jul 30 doi: 10.1016/j.blre.2017.07.006. PMID: 28784423Free PMC Article
Diagnosing antiphospholipid syndrome: 'extra-criteria' manifestations and technical advances.
Sciascia S, Amigo MC, Roccatello D, Khamashta M
Nat Rev Rheumatol 2017 Sep;13(9):548-560. Epub 2017 Aug 3 doi: 10.1038/nrrheum.2017.124. PMID: 28769114
Diagnosis and management of catastrophic antiphospholipid syndrome.
Carmi O, Berla M, Shoenfeld Y, Levy Y
Expert Rev Hematol 2017 Apr;10(4):365-374. Epub 2017 Mar 13 doi: 10.1080/17474086.2017.1300522. PMID: 28277850

Recent clinical studies

Etiology

Cardiovascular disease risk in antiphospholipid syndrome: Thrombo-inflammation and atherothrombosis.
Tektonidou MG
J Autoimmun 2022 Apr;128:102813. Epub 2022 Mar 2 doi: 10.1016/j.jaut.2022.102813. PMID: 35247655
Antiphospholipid antibodies and the risk of autoimmune hemolytic anemia in patients with systemic lupus erythematosus: A systematic review and meta-analysis.
Bernardoff I, Picq A, Loiseau P, Foret T, Dufrost V, Moulinet T, Unlu O, Erkan D, Wahl D, Zuily S
Autoimmun Rev 2022 Jan;21(1):102913. Epub 2021 Aug 8 doi: 10.1016/j.autrev.2021.102913. PMID: 34371159
Antiphospholipid syndrome.
Sammaritano LR
Best Pract Res Clin Rheumatol 2020 Feb;34(1):101463. Epub 2019 Dec 19 doi: 10.1016/j.berh.2019.101463. PMID: 31866276
Laboratory Diagnostics in Thrombophilia.
Linnemann B, Hart C
Hamostaseologie 2019 Feb;39(1):49-61. Epub 2019 Jan 31 doi: 10.1055/s-0039-1677840. PMID: 30703819
Lupus anticoagulant.
Creagh MD, Greaves M
Blood Rev 1991 Sep;5(3):162-7. doi: 10.1016/0268-960x(91)90033-9. PMID: 1777749

Diagnosis

Seronegative antiphospholipid syndrome: refining the value of "non-criteria" antibodies for diagnosis and clinical management.
Pignatelli P, Ettorre E, Menichelli D, Pani A, Violi F, Pastori D
Haematologica 2020 Mar;105(3):562-572. Epub 2020 Jan 30 doi: 10.3324/haematol.2019.221945. PMID: 32001534Free PMC Article
Antiphospholipid syndrome.
Sammaritano LR
Best Pract Res Clin Rheumatol 2020 Feb;34(1):101463. Epub 2019 Dec 19 doi: 10.1016/j.berh.2019.101463. PMID: 31866276
Laboratory Diagnostics in Thrombophilia.
Linnemann B, Hart C
Hamostaseologie 2019 Feb;39(1):49-61. Epub 2019 Jan 31 doi: 10.1055/s-0039-1677840. PMID: 30703819
Antiphospholipid syndrome.
George D, Erkan D
Prog Cardiovasc Dis 2009 Sep-Oct;52(2):115-25. doi: 10.1016/j.pcad.2009.06.005. PMID: 19732604
Antiphospholipid syndrome review.
Eby C
Clin Lab Med 2009 Jun;29(2):305-19. doi: 10.1016/j.cll.2009.06.001. PMID: 19665680

Therapy

Laboratory Diagnostics in Thrombophilia.
Linnemann B, Hart C
Hamostaseologie 2019 Feb;39(1):49-61. Epub 2019 Jan 31 doi: 10.1055/s-0039-1677840. PMID: 30703819
Management of antiphospholipid syndrome.
Uthman I, Noureldine MHA, Ruiz-Irastorza G, Khamashta M
Ann Rheum Dis 2019 Feb;78(2):155-161. Epub 2018 Oct 3 doi: 10.1136/annrheumdis-2018-213846. PMID: 30282668
Antiphospholipid syndrome.
Schreiber K, Sciascia S, de Groot PG, Devreese K, Jacobsen S, Ruiz-Irastorza G, Salmon JE, Shoenfeld Y, Shovman O, Hunt BJ
Nat Rev Dis Primers 2018 Jan 11;4:17103. doi: 10.1038/nrdp.2017.103. PMID: 29321641
Diagnosis and management of the antiphospholipid syndrome.
Chaturvedi S, McCrae KR
Blood Rev 2017 Nov;31(6):406-417. Epub 2017 Jul 30 doi: 10.1016/j.blre.2017.07.006. PMID: 28784423Free PMC Article
The antiphospholipid syndrome: from pathophysiology to treatment.
Negrini S, Pappalardo F, Murdaca G, Indiveri F, Puppo F
Clin Exp Med 2017 Aug;17(3):257-267. Epub 2016 Jun 22 doi: 10.1007/s10238-016-0430-5. PMID: 27334977

Prognosis

Diagnosis and management of the antiphospholipid syndrome.
Chaturvedi S, McCrae KR
Blood Rev 2017 Nov;31(6):406-417. Epub 2017 Jul 30 doi: 10.1016/j.blre.2017.07.006. PMID: 28784423Free PMC Article
Lupus Nephritis and Pregnancy: Concerns and Management.
Lightstone L, Hladunewich MA
Semin Nephrol 2017 Jul;37(4):347-353. doi: 10.1016/j.semnephrol.2017.05.006. PMID: 28711073
Diagnosis and management of catastrophic antiphospholipid syndrome.
Carmi O, Berla M, Shoenfeld Y, Levy Y
Expert Rev Hematol 2017 Apr;10(4):365-374. Epub 2017 Mar 13 doi: 10.1080/17474086.2017.1300522. PMID: 28277850
Predictors of Pregnancy Outcomes in Patients With Lupus: A Cohort Study.
Buyon JP, Kim MY, Guerra MM, Laskin CA, Petri M, Lockshin MD, Sammaritano L, Branch DW, Porter TF, Sawitzke A, Merrill JT, Stephenson MD, Cohn E, Garabet L, Salmon JE
Ann Intern Med 2015 Aug 4;163(3):153-63. doi: 10.7326/M14-2235. PMID: 26098843Free PMC Article
Antiphospholipid syndrome.
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807

Clinical prediction guides

Systemic lupus erythematosus and pregnancy: A retrospective single-center study of 215 pregnancies from Portugal.
Braga A, Barros T, Faria R, Marinho A, Carvalheira G, Rocha G, Farinha F, Neves E, Vasconcelos C, Braga J
Lupus 2021 Nov;30(13):2165-2175. Epub 2021 Oct 24 doi: 10.1177/09612033211050340. PMID: 34693803
Diagnosis and management of the antiphospholipid syndrome.
Chaturvedi S, McCrae KR
Blood Rev 2017 Nov;31(6):406-417. Epub 2017 Jul 30 doi: 10.1016/j.blre.2017.07.006. PMID: 28784423Free PMC Article
Lupus Nephritis and Pregnancy: Concerns and Management.
Lightstone L, Hladunewich MA
Semin Nephrol 2017 Jul;37(4):347-353. doi: 10.1016/j.semnephrol.2017.05.006. PMID: 28711073
Predictors of Pregnancy Outcomes in Patients With Lupus: A Cohort Study.
Buyon JP, Kim MY, Guerra MM, Laskin CA, Petri M, Lockshin MD, Sammaritano L, Branch DW, Porter TF, Sawitzke A, Merrill JT, Stephenson MD, Cohn E, Garabet L, Salmon JE
Ann Intern Med 2015 Aug 4;163(3):153-63. doi: 10.7326/M14-2235. PMID: 26098843Free PMC Article
Antiphospholipid syndrome.
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807

Recent systematic reviews

Relapse rates and risk factors for unfavorable neurological prognosis of transverse myelitis in systemic lupus erythematosus: A systematic review and meta-analysis.
Wang M, Wang Z, Zhang S, Zhang L, Zhao J, Wang Q, Tian X, Li M, Chiganer EH, Zeng X
Autoimmun Rev 2022 Feb;21(2):102996. Epub 2021 Nov 16 doi: 10.1016/j.autrev.2021.102996. PMID: 34798313
Antiphospholipid antibodies and the risk of autoimmune hemolytic anemia in patients with systemic lupus erythematosus: A systematic review and meta-analysis.
Bernardoff I, Picq A, Loiseau P, Foret T, Dufrost V, Moulinet T, Unlu O, Erkan D, Wahl D, Zuily S
Autoimmun Rev 2022 Jan;21(1):102913. Epub 2021 Aug 8 doi: 10.1016/j.autrev.2021.102913. PMID: 34371159
Antiphospholipid antibodies and lower extremity peripheral artery disease: A systematic review and meta-analysis.
Merashli M, Bucci T, Pastori D, Pignatelli P, Marottoli V, Arcaro A, Gentile F, Ames PR
Semin Arthritis Rheum 2020 Dec;50(6):1291-1298. Epub 2020 Aug 30 doi: 10.1016/j.semarthrit.2020.08.012. PMID: 33065424
Antiphospholipid Antibodies and Autoimmune Haemolytic Anaemia: A Systematic Review and Meta-Analysis.
Ames PRJ, Merashli M, Bucci T, Pastori D, Pignatelli P, Arcaro A, Gentile F
Int J Mol Sci 2020 Jun 9;21(11) doi: 10.3390/ijms21114120. PMID: 32527000Free PMC Article
Comorbid association of antiphospholipid antibodies and migraine: A systematic review and meta-analysis.
Islam MA, Alam F, Wong KK
Autoimmun Rev 2017 May;16(5):512-522. Epub 2017 Mar 7 doi: 10.1016/j.autrev.2017.03.005. PMID: 28279839

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