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Herpes labialis

MedGen UID:
5533
•Concept ID:
C0019345
•
Disease or Syndrome
Synonyms: Blister, Fever; Blisters, Fever; Cold Sore; Cold Sores; Fever Blister; Fever Blisters; Herpes Labialis; Herpes Simplex, Labial; Labial Herpes Simplex; Sore, Cold; Sores, Cold
SNOMED CT: Herpes labialis (1475003); Cold sores (1475003); Fever blister (1475003); Herpes simplex labialis (1475003); Cold sore (1475003)
 
Monarch Initiative: MONDO:0043653

Definition

A lesion caused by type 1 or type 2 herpes simplex virus, involving the oralfacial region. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHerpes labialis

Professional guidelines

PubMed

Clinical guidelines for herpes labialis: recommendations and quality evaluation according to AGREE II.
Ocampo JV, França FA, Santana RS, Lia ÉN, Reis TMD, Lima RF
Acta Odontol Latinoam 2024 Apr;37(1):13-24. doi: 10.54589/aol.37/1/13. PMID: 38920122Free PMC Article
A Comprehensive Overview of Epidemiology, Pathogenesis and the Management of Herpes Labialis.
Gopinath D, Koe KH, Maharajan MK, Panda S
Viruses 2023 Jan 13;15(1) doi: 10.3390/v15010225. PMID: 36680265Free PMC Article
Prevention and treatment of neonatal herpes simplex virus infection.
Samies NL, James SH
Antiviral Res 2020 Apr;176:104721. Epub 2020 Feb 7 doi: 10.1016/j.antiviral.2020.104721. PMID: 32044154Free PMC Article

Recent clinical studies

Etiology

Herpes Labialis: An Update.
Leung AKC, Barankin B
Recent Pat Inflamm Allergy Drug Discov 2017;11(2):107-113. doi: 10.2174/1872213X11666171003151717. PMID: 28971780
Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections.
Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY, Hinds DA
Nat Commun 2017 Sep 19;8(1):599. doi: 10.1038/s41467-017-00257-5. PMID: 28928442Free PMC Article
Efficacy of Topical 5% Acyclovir-1% Hydrocortisone Cream (ME-609) for Treatment of Herpes Labialis: a systematic review.
Rosa MI, Souza SL, Farias BF, Pires PD, Dondossola ER, dos Reis ME
An Acad Bras Cienc 2015 Aug;87(2 Suppl):1415-20. Epub 2015 Aug 4 doi: 10.1590/0001-3765201520140701. PMID: 26247156
Oral mucosal diseases: evaluation and management.
Stoopler ET, Sollecito TP
Med Clin North Am 2014 Nov;98(6):1323-52. Epub 2014 Sep 22 doi: 10.1016/j.mcna.2014.08.006. PMID: 25443679
Herpes simplex virus.
Riley LE
Semin Perinatol 1998 Aug;22(4):284-92. doi: 10.1016/s0146-0005(98)80017-7. PMID: 9738993

Diagnosis

A Comprehensive Overview of Epidemiology, Pathogenesis and the Management of Herpes Labialis.
Gopinath D, Koe KH, Maharajan MK, Panda S
Viruses 2023 Jan 13;15(1) doi: 10.3390/v15010225. PMID: 36680265Free PMC Article
Soft Tissue Disorders of the Mouth.
Diebold S, Overbeck M
Emerg Med Clin North Am 2019 Feb;37(1):55-68. doi: 10.1016/j.emc.2018.09.006. PMID: 30454780
Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections.
Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY, Hinds DA
Nat Commun 2017 Sep 19;8(1):599. doi: 10.1038/s41467-017-00257-5. PMID: 28928442Free PMC Article
Treatment of recurrent herpes labialis.
Sarnoff DS
J Drugs Dermatol 2014 Sep;13(9):1016-8. PMID: 25226000
Herpetic whitlow.
Wu IB, Schwartz RA
Cutis 2007 Mar;79(3):193-6. PMID: 17674583

Therapy

Herpes Labialis: An Update.
Leung AKC, Barankin B
Recent Pat Inflamm Allergy Drug Discov 2017;11(2):107-113. doi: 10.2174/1872213X11666171003151717. PMID: 28971780
Treatment of recurrent herpes labialis.
Sarnoff DS
J Drugs Dermatol 2014 Sep;13(9):1016-8. PMID: 25226000
Herpes Simplex Virus Type 1 infection: overview on relevant clinico-pathological features.
Arduino PG, Porter SR
J Oral Pathol Med 2008 Feb;37(2):107-21. doi: 10.1111/j.1600-0714.2007.00586.x. PMID: 18197856
Tailoring herpes labialis treatments.
Volpi A, Stanberry L
Herpes 2007 Dec;14(3):55. PMID: 18371286
Herpes labialis.
Worrall G
Clin Evid 2005 Dec;(14):2050-7. PMID: 16620481

Prognosis

Common Cutaneous Infections: Patient Presentation, Clinical Course, and Treatment Options.
Preda-Naumescu A, Elewski B, Mayo TT
Med Clin North Am 2021 Jul;105(4):783-797. doi: 10.1016/j.mcna.2021.04.012. PMID: 34059250
Biopsy techniques and diagnoses & treatment of mucocutaneous lesions.
Chan MH, Wolf JC
Dent Clin North Am 2012 Jan;56(1):43-73, vii-viii. doi: 10.1016/j.cden.2011.09.004. PMID: 22117942
Herpes simplex virus.
Waggoner-Fountain LA, Grossman LB
Pediatr Rev 2004 Mar;25(3):86-93. doi: 10.1542/pir.25-3-86. PMID: 14993516
Treatment of herpes simplex labialis.
Spruance SL, Kriesel JD
Herpes 2002 Dec;9(3):64-9. PMID: 12470603
Herpes simplex viruses 1 and 2.
Yeung-Yue KA, Brentjens MH, Lee PC, Tyring SK
Dermatol Clin 2002 Apr;20(2):249-66. doi: 10.1016/s0733-8635(01)00003-1. PMID: 12120439

Clinical prediction guides

Skin changes during pregnancy. Is that an important issue for pregnant women?
Ciechanowicz P, Sikora M, Taradaj K, Ruta A, Rakowska A, Kociszewska-Najman B, Wielgoś M, Rudnicka L
Ginekol Pol 2018;89(8):449-52. doi: 10.5603/GP.a2018.0077. PMID: 30215465
Herpes labialis.
Worrall G
BMJ Clin Evid 2009 Sep 23;2009 PMID: 21726482Free PMC Article
Punch grafting for lip leucoderma.
Malakar S, Lahiri K
Dermatology 2004;208(2):125-8. doi: 10.1159/000076485. PMID: 15057001
Drug therapy. Treatment of herpesvirus infections.
Hirsch MS, Schooley RT
N Engl J Med 1983 Oct 27;309(17):1034-9. doi: 10.1056/NEJM198310273091706. PMID: 6312313
Topical treatment of herpes labialis with chloroform.
Taylor CA, Hendley JO, Greer KE, Gwaltney JM Jr
Arch Dermatol 1977 Nov;113(11):1550-2. PMID: 931393

Recent systematic reviews

COMPARATIVE EFFICACY OF ANTIVIRAL AGENTS FOR PREVENTION AND MANAGEMENT OF HERPES LABIALIS: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS.
Koe KH, Veettil SK, Maharajan MK, Syeed MS, Nair AB, Gopinath D
J Evid Based Dent Pract 2023 Mar;23(1):101778. Epub 2022 Sep 14 doi: 10.1016/j.jebdp.2022.101778. PMID: 36914303
Is low-level laser therapy effective in the treatment of herpes labialis? Systematic review and meta-analysis.
Barros AWP, Sales PHDH, Silva PGB, Gomes ACA, Carvalho AAT, Leão JC
Lasers Med Sci 2022 Dec;37(9):3393-3402. Epub 2022 Oct 10 doi: 10.1007/s10103-022-03653-6. PMID: 36214942
Herpes Virus, Oral Clinical Signs and QoL: Systematic Review of Recent Data.
Crimi S, Fiorillo L, Bianchi A, D'Amico C, Amoroso G, Gorassini F, Mastroieni R, Marino S, Scoglio C, Catalano F, Campagna P, Bocchieri S, De Stefano R, Fiorillo MT, Cicciù M
Viruses 2019 May 21;11(5) doi: 10.3390/v11050463. PMID: 31117264Free PMC Article
Interventions for prevention of herpes simplex labialis (cold sores on the lips).
Chi CC, Wang SH, Delamere FM, Wojnarowska F, Peters MC, Kanjirath PP
Cochrane Database Syst Rev 2015 Aug 7;2015(8):CD010095. doi: 10.1002/14651858.CD010095.pub2. PMID: 26252373Free PMC Article
Herpes labialis.
Worrall G
BMJ Clin Evid 2009 Sep 23;2009 PMID: 21726482Free PMC Article

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