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Malignant histiocytosis

MedGen UID:
5569
•Concept ID:
C0019623
•
Neoplastic Process
Synonyms: Histiocytoses, Malignant; Histiocytosis, Malignant; Malignant Histiocytoses; Malignant Histiocytosis
SNOMED CT: Malignant histiocytosis (clinical) (118612006); Malignant histiocytosis (128920006); Malignant histiocytosis (118612006); Malignant reticulosis (118612006)
 
Monarch Initiative: MONDO:0004612

Definition

An antiquated term referring to cases of systemic non-Hodgkin lymphomas which are composed of large, atypical neoplastic lymphoid cells and cases of hemophagocytic syndromes. In the past, cases of anaplastic large cells lymphoma were called malignant histiocytosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant histiocytosis

Professional guidelines

PubMed

The histiocytoses: clinical presentation and differential diagnosis.
Gonzalez CL, Jaffe ES
Oncology (Williston Park) 1990 Nov;4(11):47-60; discussion 60, 62. PMID: 2150325
Histiocytoses of lymph nodes: biology and differential diagnosis.
Jaffe ES
Semin Diagn Pathol 1988 Nov;5(4):376-90. PMID: 3064218
The treatment of malignant histiocytosis.
Tseng A Jr, Coleman CN, Cox RS, Colby TV, Turner RR, Horning SJ, Rosenberg SA
Blood 1984 Jul;64(1):48-53. PMID: 6610448

Recent clinical studies

Etiology

Clinical characteristics, molecular aberrations, treatments, and outcomes of malignant histiocytosis.
Ruan GJ, Zanwar S, Ravindran A, Schram S, Abeykoon JP, Hazim A, Young JR, Shah MV, Bennani NN, Jiang L, Morlote D, Rech KL, Goyal G, Go RS; Mayo Clinic‐University of Alabama at Birmingham Histiocytosis Working Group
Am J Hematol 2024 May;99(5):871-879. Epub 2024 Feb 26 doi: 10.1002/ajh.27263. PMID: 38409747Free PMC Article
Molecular and clinicopathologic characterization of pediatric histiocytoses.
Hélias-Rodzewicz Z, Donadieu J, Terrones N, Barkaoui MA, Lambilliotte A, Moshous D, Thomas C, Azarnoush S, Pasquet M, Mansuy L, Aladjidi N, Jeziorski E, Marec-Berard P, Gilibert-Yvert M, Spiegel A, Saultier P, Pellier I, Pagnier A, Pertuisel S, Poiree M, Bodet D, Millot F, Isfan F, Stephan JL, Leruste A, Rigaud C, Filhon B, Carausu L, Reguerre Y, Kieffer I, Brichard B, Ben Jannet R, Bakari M, Idbaih A, Bodemer C, Cohen-Aubart F, Haroche J, Tazi A, Boudjemaa S, Fraitag S, Emile JF, Heritier S; French Histiocytosis Study Group
Am J Hematol 2023 Jul;98(7):1058-1069. Epub 2023 Apr 28 doi: 10.1002/ajh.26938. PMID: 37115038
Histiocytosis and Neoplasms of Macrophage-Dendritic Cell Lineages: Multimodality Imaging with Emphasis on PET/CT.
Huynh KN, Nguyen BD
Radiographics 2021 Mar-Apr;41(2):576-594. Epub 2021 Feb 19 doi: 10.1148/rg.2021200096. PMID: 33606566
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286
Familial hemophagocytic lymphohistiocytosis.
Janka GE
Eur J Pediatr 1983 Jun-Jul;140(3):221-30. doi: 10.1007/BF00443367. PMID: 6354720

Diagnosis

Clinical characteristics, molecular aberrations, treatments, and outcomes of malignant histiocytosis.
Ruan GJ, Zanwar S, Ravindran A, Schram S, Abeykoon JP, Hazim A, Young JR, Shah MV, Bennani NN, Jiang L, Morlote D, Rech KL, Goyal G, Go RS; Mayo Clinic‐University of Alabama at Birmingham Histiocytosis Working Group
Am J Hematol 2024 May;99(5):871-879. Epub 2024 Feb 26 doi: 10.1002/ajh.27263. PMID: 38409747Free PMC Article
Histiocytic disorders.
McClain KL, Bigenwald C, Collin M, Haroche J, Marsh RA, Merad M, Picarsic J, Ribeiro KB, Allen CE
Nat Rev Dis Primers 2021 Oct 7;7(1):73. doi: 10.1038/s41572-021-00307-9. PMID: 34620874Free PMC Article
Histiocytosis and Neoplasms of Macrophage-Dendritic Cell Lineages: Multimodality Imaging with Emphasis on PET/CT.
Huynh KN, Nguyen BD
Radiographics 2021 Mar-Apr;41(2):576-594. Epub 2021 Feb 19 doi: 10.1148/rg.2021200096. PMID: 33606566
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286
Familial hemophagocytic lymphohistiocytosis.
Janka GE
Eur J Pediatr 1983 Jun-Jul;140(3):221-30. doi: 10.1007/BF00443367. PMID: 6354720

Therapy

Langerhans cell sarcoma: a systematic review.
Howard JE, Dwivedi RC, Masterson L, Jani P
Cancer Treat Rev 2015 Apr;41(4):320-31. Epub 2015 Mar 9 doi: 10.1016/j.ctrv.2015.02.011. PMID: 25805533
Leukemia and other malignancies among GH users.
Watanabe S, Mizuno S, Oshima LH, Tsunematsu Y, Fujimoto J, Komiyama A
J Pediatr Endocrinol 1993 Jan-Mar;6(1):99-108. doi: 10.1515/jpem.1993.6.1.99. PMID: 8374697
Familial hemophagocytic lymphohistiocytosis.
Janka GE
Eur J Pediatr 1983 Jun-Jul;140(3):221-30. doi: 10.1007/BF00443367. PMID: 6354720
Malignant histiocytosis.
Esseltine DW, De Leeuw NK, Berry GR
Cancer 1983 Nov 15;52(10):1904-10. doi: 10.1002/1097-0142(19831115)52:10<1904::aid-cncr2820521022>3.0.co;2-k. PMID: 6354417
Malignant histiocytosis in childhood: clinical study and therapeutic results in 22 cases.
Zucker JM, Caillaux JM, Vanel D, Gerard-Marchant R
Cancer 1980 Jun 1;45(11):2821-9. doi: 10.1002/1097-0142(19800601)45:11<2821::aid-cncr2820451118>3.0.co;2-0. PMID: 7379013

Prognosis

Clinical characteristics, molecular aberrations, treatments, and outcomes of malignant histiocytosis.
Ruan GJ, Zanwar S, Ravindran A, Schram S, Abeykoon JP, Hazim A, Young JR, Shah MV, Bennani NN, Jiang L, Morlote D, Rech KL, Goyal G, Go RS; Mayo Clinic‐University of Alabama at Birmingham Histiocytosis Working Group
Am J Hematol 2024 May;99(5):871-879. Epub 2024 Feb 26 doi: 10.1002/ajh.27263. PMID: 38409747Free PMC Article
Histiocytic proliferations.
Ranganathan S
Semin Diagn Pathol 2016 Nov;33(6):396-409. Epub 2016 Sep 1 doi: 10.1053/j.semdp.2016.08.009. PMID: 27720561
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286
Familial hemophagocytic lymphohistiocytosis.
Janka GE
Eur J Pediatr 1983 Jun-Jul;140(3):221-30. doi: 10.1007/BF00443367. PMID: 6354720
Idiopathic differentiated histiocytosis.
Daneshbod K, Kissane JM
Am J Clin Pathol 1978 Sep;70(3):381-9. doi: 10.1093/ajcp/70.3.381. PMID: 309279

Clinical prediction guides

Bone marrow findings in malignant histiocytosis and/or malignant lymphoma with concurrent hemophagocytic syndrome.
Takeshita M, Kikuchi M, Ohshima K, Nibu K, Suzumiya J, Hisano S, Miyamoto Y, Okamura T
Leuk Lymphoma 1993 Dec;12(1-2):79-89. doi: 10.3109/10428199309059574. PMID: 8161938
Hematologic neoplasia associated with primary mediastinal germ-cell tumors.
Nichols CR, Roth BJ, Heerema N, Griep J, Tricot G
N Engl J Med 1990 May 17;322(20):1425-9. doi: 10.1056/NEJM199005173222004. PMID: 2158625
Malignant histiocytosis: a clinical, histologic, and immunohistochemical study of 20 cases.
Ducatman BS, Wick MR, Morgan TW, Banks PM, Pierre RV
Hum Pathol 1984 Apr;15(4):368-77. doi: 10.1016/s0046-8177(84)80036-2. PMID: 6370827
Malignant histiocytosis.
Esseltine DW, De Leeuw NK, Berry GR
Cancer 1983 Nov 15;52(10):1904-10. doi: 10.1002/1097-0142(19831115)52:10<1904::aid-cncr2820521022>3.0.co;2-k. PMID: 6354417
Malignant histiocytosis: a histological and ultrastructural study of lymph nodes in six cases.
Lombardi L, Carbone A, Pilotti S, Rilke F
Histopathology 1978 Sep;2(5):315-28. doi: 10.1111/j.1365-2559.1978.tb01724.x. PMID: 721076

Recent systematic reviews

Langerhans cell sarcoma: a systematic review.
Howard JE, Dwivedi RC, Masterson L, Jani P
Cancer Treat Rev 2015 Apr;41(4):320-31. Epub 2015 Mar 9 doi: 10.1016/j.ctrv.2015.02.011. PMID: 25805533

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