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Humoral hypercalcemia of malignancy

MedGen UID:
56210
Concept ID:
C0149911
Disease or Syndrome
Synonym: Humoral Hypercalcemia Of Malignancy
SNOMED CT: Hypercalcemia of malignancy (47709007); Malignant hypercalcemia (47709007); HHM - humoral hypercalcemia of malignancy (47709007); MAHC - malignancy associated hypercalcemia (47709007); Humoral hypercalcemia of malignancy (47709007); Malignancy associated hypercalcemia (47709007)
 
Monarch Initiative: MONDO:0043455

Definition

Hypercalcemia generally develops as a late complication of malignancy; its appearance has grave prognostic significance. It remains unclear, however, whether death is associated with hypercalcemic crisis (uncontrolled or recurrent progressive hypercalcemia) or with advanced disease. Symptoms include central nervous system impairment such as delirium with prominent symptoms of personality change, cognitive dysfunction, disorientation, incoherent speech, and psychotic symptoms such as hallucinations and delusions, smooth muscle hypotonicity, and altered cardiovascular function. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHumoral hypercalcemia of malignancy

Professional guidelines

PubMed

Clines GA
Curr Opin Endocrinol Diabetes Obes 2011 Dec;18(6):339-46. doi: 10.1097/MED.0b013e32834b4401. PMID: 21897221
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Recent clinical studies

Etiology

Mc Donald D, Drake MT, Crowley RK
Clin Med (Lond) 2023 Sep;23(5):503-507. Epub 2023 Sep 29 doi: 10.7861/clinmed.2023-0227. PMID: 37775175Free PMC Article
Dellay B, Groth M
Adv Emerg Nurs J 2016 Jan-Mar;38(1):15-25; quiz E1. doi: 10.1097/TME.0000000000000093. PMID: 26817427
Rosner MH, Dalkin AC
Clin J Am Soc Nephrol 2012 Oct;7(10):1722-9. Epub 2012 Aug 9 doi: 10.2215/CJN.02470312. PMID: 22879438
Savvari P, Peitsidis P, Alevizaki M, Dimopoulos MA, Antsaklis A, Papadimitriou CA
Onkologie 2009 Sep;32(8-9):517-23. Epub 2009 Aug 12 doi: 10.1159/000226209. PMID: 19745599
Kaplan M
Oncol Nurs Forum 1994 Jul;21(6):1039-46; quiz 1047-8. PMID: 7971410

Diagnosis

Goldner W
J Oncol Pract 2016 May;12(5):426-32. doi: 10.1200/JOP.2016.011155. PMID: 27170690
Dellay B, Groth M
Adv Emerg Nurs J 2016 Jan-Mar;38(1):15-25; quiz E1. doi: 10.1097/TME.0000000000000093. PMID: 26817427
Meng QH, Wagar EA
Crit Rev Clin Lab Sci 2015;52(3):107-19. Epub 2014 Oct 20 doi: 10.3109/10408363.2014.970266. PMID: 25327435
Rosner MH, Dalkin AC
Clin J Am Soc Nephrol 2012 Oct;7(10):1722-9. Epub 2012 Aug 9 doi: 10.2215/CJN.02470312. PMID: 22879438
Ziegler R
J Am Soc Nephrol 2001 Feb;12 Suppl 17:S3-9. PMID: 11251025

Therapy

Mc Donald D, Drake MT, Crowley RK
Clin Med (Lond) 2023 Sep;23(5):503-507. Epub 2023 Sep 29 doi: 10.7861/clinmed.2023-0227. PMID: 37775175Free PMC Article
El-Hajj Fuleihan G, Clines GA, Hu MI, Marcocci C, Murad MH, Piggott T, Van Poznak C, Wu JY, Drake MT
J Clin Endocrinol Metab 2023 Feb 15;108(3):507-528. doi: 10.1210/clinem/dgac621. PMID: 36545746
Clines GA
Curr Opin Endocrinol Diabetes Obes 2011 Dec;18(6):339-46. doi: 10.1097/MED.0b013e32834b4401. PMID: 21897221
Sato K, Onuma E, Yocum RC, Ogata E
Semin Oncol 2003 Oct;30(5 Suppl 16):167-73. doi: 10.1053/j.seminoncol.2003.08.019. PMID: 14613038
Hall TG, Schaiff RA
Clin Pharm 1993 Feb;12(2):117-25. PMID: 8453860

Prognosis

Efthymiou C, Spyratos D, Kontakiotis T
Hormones (Athens) 2018 Sep;17(3):351-358. Epub 2018 Jul 2 doi: 10.1007/s42000-018-0046-0. PMID: 29968234
Goldner W
J Oncol Pract 2016 May;12(5):426-32. doi: 10.1200/JOP.2016.011155. PMID: 27170690
Dellay B, Groth M
Adv Emerg Nurs J 2016 Jan-Mar;38(1):15-25; quiz E1. doi: 10.1097/TME.0000000000000093. PMID: 26817427
Rosner MH, Dalkin AC
Clin J Am Soc Nephrol 2012 Oct;7(10):1722-9. Epub 2012 Aug 9 doi: 10.2215/CJN.02470312. PMID: 22879438
Clines GA
Curr Opin Endocrinol Diabetes Obes 2011 Dec;18(6):339-46. doi: 10.1097/MED.0b013e32834b4401. PMID: 21897221

Clinical prediction guides

Copur MS, Vargas L, Wedel W, Merani S, Cushman-Vokoun A, Drincic A
Oncology (Williston Park) 2020 Dec 7;34(12):548-552. doi: 10.46883/ONC.2020.3412.0548. PMID: 33395496
Goldner W
J Oncol Pract 2016 May;12(5):426-32. doi: 10.1200/JOP.2016.011155. PMID: 27170690
Szymanski JJ, Otrock ZK, Patel KK, Scott MG
Clin Chim Acta 2016 Jan 30;453:190-3. Epub 2015 Dec 17 doi: 10.1016/j.cca.2015.12.017. PMID: 26706788
Kobayashi N, Higurashi T, Iida H, Mawatari H, Endo H, Nozaki Y, Tomimoto A, Yoneda K, Akiyama T, Fujita K, Takahashi H, Yoneda M, Inamori M, Abe Y, Kirikoshi H, Kubota K, Saito S, Ueno N, Nakajima A, Yamanaka S, Inayama Y
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Jüppner H
Pediatr Nephrol 2000 Jul;14(7):606-11. doi: 10.1007/s004670000343. PMID: 10912527

Recent systematic reviews

Mc Donald D, Drake MT, Crowley RK
Clin Med (Lond) 2023 Sep;23(5):503-507. Epub 2023 Sep 29 doi: 10.7861/clinmed.2023-0227. PMID: 37775175Free PMC Article
El-Hajj Fuleihan G, Clines GA, Hu MI, Marcocci C, Murad MH, Piggott T, Van Poznak C, Wu JY, Drake MT
J Clin Endocrinol Metab 2023 Feb 15;108(3):507-528. doi: 10.1210/clinem/dgac621. PMID: 36545746
Bassatne A, Murad MH, Piggott T, Drake MT, Rahme M, El-Hajj Fuleihan G
J Clin Endocrinol Metab 2023 Feb 15;108(3):563-584. doi: 10.1210/clinem/dgac630. PMID: 36545699
Testini M, Gurrado A, Lissidini G, Piccinni G, Greco L, Basile F, Biondi A
Front Biosci (Schol Ed) 2010 Jan 1;2(1):299-312. doi: 10.2741/s65. PMID: 20036948
Savvari P, Peitsidis P, Alevizaki M, Dimopoulos MA, Antsaklis A, Papadimitriou CA
Onkologie 2009 Sep;32(8-9):517-23. Epub 2009 Aug 12 doi: 10.1159/000226209. PMID: 19745599

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