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Skin irritation

MedGen UID:
56257
Concept ID:
C0152030
Finding
Synonym: Skin Irritation
SNOMED CT: Skin irritation (367466007)

Definition

A mild inflammatory dermal tissue reaction; it can be caused by physical contact with an irritant or can be a local response to a systemic trigger. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin irritation

Professional guidelines

PubMed

McKesey J, Tovar-Garza A, Pandya AG
Am J Clin Dermatol 2020 Apr;21(2):173-225. doi: 10.1007/s40257-019-00488-w. PMID: 31802394
Jacob S, VanDaele MA, Brown JN
Dermatol Ther 2019 Nov;32(6):e13103. Epub 2019 Oct 28 doi: 10.1111/dth.13103. PMID: 31583801
Ascenso A, Ribeiro H, Marques HC, Oliveira H, Santos C, Simões S
Mini Rev Med Chem 2014;14(8):629-41. doi: 10.2174/1389557514666140820102735. PMID: 25141855

Recent clinical studies

Etiology

Mitra S, Rauf A, Tareq AM, Jahan S, Emran TB, Shahriar TG, Dhama K, Alhumaydhi FA, Aljohani ASM, Rebezov M, Uddin MS, Jeandet P, Shah ZA, Shariati MA, Rengasamy KR
Food Chem Toxicol 2021 Aug;154:112328. Epub 2021 Jun 8 doi: 10.1016/j.fct.2021.112328. PMID: 34111488
Teo WL
Int J Dermatol 2021 Jul;60(7):799-809. Epub 2021 Feb 12 doi: 10.1111/ijd.15425. PMID: 33576511Free PMC Article
Rahman MS, Islam R, Rana MM, Spitzhorn LS, Rahman MS, Adjaye J, Asaduzzaman SM
BMC Complement Altern Med 2019 Jun 3;19(1):115. doi: 10.1186/s12906-019-2525-5. PMID: 31159783Free PMC Article
Blaak J, Staib P
Curr Probl Dermatol 2018;54:132-142. Epub 2018 Aug 21 doi: 10.1159/000489527. PMID: 30130782
Draelos ZD
J Cosmet Dermatol 2018 Feb;17(1):8-14. Epub 2017 Dec 12 doi: 10.1111/jocd.12469. PMID: 29231284

Diagnosis

Danby SG, Andrew PV, Kay LJ, Pinnock A, Chittock J, Brown K, Williams SF, Cork MJ
Br J Dermatol 2022 May;186(5):875-886. Epub 2022 Apr 3 doi: 10.1111/bjd.20955. PMID: 34921679Free PMC Article
Slaughter RJ, Watts M, Vale JA, Grieve JR, Schep LJ
Clin Toxicol (Phila) 2019 May;57(5):303-311. Epub 2019 Jan 28 doi: 10.1080/15563650.2018.1543889. PMID: 30689457
Draelos ZD
J Cosmet Dermatol 2018 Feb;17(1):8-14. Epub 2017 Dec 12 doi: 10.1111/jocd.12469. PMID: 29231284
Kim HJ, Moon SH, Cho SH, Lee JD, Kim HS
Acta Derm Venereol 2017 Jul 6;97(7):776-781. doi: 10.2340/00015555-2668. PMID: 28374042
American Academy of Pediatrics Task Force on Circumcision
Pediatrics 2012 Sep;130(3):e756-85. Epub 2012 Aug 27 doi: 10.1542/peds.2012-1990. PMID: 22926175

Therapy

Diogo MLG, Campos TM, Fonseca ESR, Pavani C, Horliana ACRT, Fernandes KPS, Bussadori SK, Fantin FGMM, Leite DPV, Yamamoto ÂTA, Navarro RS, Motta LJ
Sensors (Basel) 2021 Oct 19;21(20) doi: 10.3390/s21206943. PMID: 34696155Free PMC Article
Zakarija-Grkovic I, Stewart F
Cochrane Database Syst Rev 2020 Sep 18;9(9):CD006946. doi: 10.1002/14651858.CD006946.pub4. PMID: 32944940Free PMC Article
McKesey J, Tovar-Garza A, Pandya AG
Am J Clin Dermatol 2020 Apr;21(2):173-225. doi: 10.1007/s40257-019-00488-w. PMID: 31802394
Hartmann-Boyce J, Chepkin SC, Ye W, Bullen C, Lancaster T
Cochrane Database Syst Rev 2018 May 31;5(5):CD000146. doi: 10.1002/14651858.CD000146.pub5. PMID: 29852054Free PMC Article
Proksch E, de Bony R, Trapp S, Boudon S
J Dermatolog Treat 2017 Dec;28(8):766-773. Epub 2017 May 14 doi: 10.1080/09546634.2017.1325310. PMID: 28503966

Prognosis

Jalalzadeh H, Groenen H, Buis DR, Dreissen YE, Goosen JH, Ijpma FF, van der Laan MJ, Schaad RR, Segers P, van der Zwet WC, Griekspoor M, Harmsen WJ, Wolfhagen N, Boermeester MA
Lancet Microbe 2022 Oct;3(10):e762-e771. Epub 2022 Aug 16 doi: 10.1016/S2666-5247(22)00187-2. PMID: 35985350
Kebe M, Gadhafi R, Mohammad B, Sanduleanu M, Saleh H, Al-Qutayri M
Sensors (Basel) 2020 Mar 6;20(5) doi: 10.3390/s20051454. PMID: 32155838Free PMC Article
Jacob S, VanDaele MA, Brown JN
Dermatol Ther 2019 Nov;32(6):e13103. Epub 2019 Oct 28 doi: 10.1111/dth.13103. PMID: 31583801
Slaughter RJ, Watts M, Vale JA, Grieve JR, Schep LJ
Clin Toxicol (Phila) 2019 May;57(5):303-311. Epub 2019 Jan 28 doi: 10.1080/15563650.2018.1543889. PMID: 30689457
Cosmetic Ingredient Review Expert Panel
Int J Toxicol 2005;24 Suppl 5:1-31. doi: 10.1080/10915810500434183. PMID: 16596767

Clinical prediction guides

Gustin J, Bohman L, Ogle J, Fadayel G, Mitchell MC, Narendran V, Visscher MO, Carr AN
Pediatr Dermatol 2021 Jul;38(4):768-774. Epub 2021 May 31 doi: 10.1111/pde.14602. PMID: 34060142Free PMC Article
Kebe M, Gadhafi R, Mohammad B, Sanduleanu M, Saleh H, Al-Qutayri M
Sensors (Basel) 2020 Mar 6;20(5) doi: 10.3390/s20051454. PMID: 32155838Free PMC Article
Rahman MS, Islam R, Rana MM, Spitzhorn LS, Rahman MS, Adjaye J, Asaduzzaman SM
BMC Complement Altern Med 2019 Jun 3;19(1):115. doi: 10.1186/s12906-019-2525-5. PMID: 31159783Free PMC Article
Cowley K, Vanoosthuyze K
Int J Cosmet Sci 2016 Jun;38 Suppl 1:17-23. doi: 10.1111/ics.12330. PMID: 27212467
Boehm K, Büssing A, Ostermann T
Afr J Tradit Complement Altern Med 2012;9(4):503-18. Epub 2012 Jul 1 doi: 10.4314/ajtcam.v9i4.7. PMID: 23983386Free PMC Article

Recent systematic reviews

Diogo MLG, Campos TM, Fonseca ESR, Pavani C, Horliana ACRT, Fernandes KPS, Bussadori SK, Fantin FGMM, Leite DPV, Yamamoto ÂTA, Navarro RS, Motta LJ
Sensors (Basel) 2021 Oct 19;21(20) doi: 10.3390/s21206943. PMID: 34696155Free PMC Article
Zakarija-Grkovic I, Stewart F
Cochrane Database Syst Rev 2020 Sep 18;9(9):CD006946. doi: 10.1002/14651858.CD006946.pub4. PMID: 32944940Free PMC Article
McKesey J, Tovar-Garza A, Pandya AG
Am J Clin Dermatol 2020 Apr;21(2):173-225. doi: 10.1007/s40257-019-00488-w. PMID: 31802394
Hartmann-Boyce J, Chepkin SC, Ye W, Bullen C, Lancaster T
Cochrane Database Syst Rev 2018 May 31;5(5):CD000146. doi: 10.1002/14651858.CD000146.pub5. PMID: 29852054Free PMC Article
Kim HJ, Moon SH, Cho SH, Lee JD, Kim HS
Acta Derm Venereol 2017 Jul 6;97(7):776-781. doi: 10.2340/00015555-2668. PMID: 28374042

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