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Malignant tumor of oral cavity

MedGen UID:
56298
•Concept ID:
C0153381
•
Neoplastic Process
Synonyms: Cancer of Mouth; Cancer of the Mouth; Cancer, Mouth; Cancer, Oral; Cancers, Mouth; Cancers, Oral; Mouth Cancer; Mouth Cancers; Oral Cancer; Oral Cancers
SNOMED CT: Malignant tumor of mouth (363505006); Cancer of oral cavity (363505006); CA - Mouth cancer (363505006); Mouth cancer (363505006); Malignant neoplasm of mouth (363505006); Malignant tumor of oral cavity (363505006)

Definition

A primary or metastatic malignant neoplasm that affects the lip and/or oral cavity. The majority of cases are carcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant tumor of oral cavity

Professional guidelines

PubMed

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.
Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026
Management of oral potentially malignant disorders.
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
SEOM clinical guidelines for the treatment of head and neck cancer (2020).
Mesia R, Iglesias L, Lambea J, Martínez-Trufero J, Soria A, Taberna M, Trigo J, Chaves M, García-Castaño A, Cruz J
Clin Transl Oncol 2021 May;23(5):913-921. Epub 2021 Feb 26 doi: 10.1007/s12094-020-02533-1. PMID: 33635468Free PMC Article

Recent clinical studies

Etiology

Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Oral Cancer.
Stoopler ET, Sollecito TP
Dent Clin North Am 2018 Jan;62(1):ix-x. Epub 2017 Sep 28 doi: 10.1016/j.cden.2017.09.002. PMID: 29126498
Dental Treatment Planning for the Patient with Oral Cancer.
Levi LE, Lalla RV
Dent Clin North Am 2018 Jan;62(1):121-130. Epub 2017 Oct 7 doi: 10.1016/j.cden.2017.08.009. PMID: 29126489
Essentials of oral cancer.
Rivera C
Int J Clin Exp Pathol 2015;8(9):11884-94. Epub 2015 Sep 1 PMID: 26617944Free PMC Article
Cancer of the oral cavity.
Montero PH, Patel SG
Surg Oncol Clin N Am 2015 Jul;24(3):491-508. Epub 2015 Apr 15 doi: 10.1016/j.soc.2015.03.006. PMID: 25979396Free PMC Article

Diagnosis

Oral squamous cell carcinoma: metastasis, potentially associated malignant disorders, etiology and recent advancements in diagnosis.
Bugshan A, Farooq I
F1000Res 2020;9:229. Epub 2020 Apr 2 doi: 10.12688/f1000research.22941.1. PMID: 32399208Free PMC Article
Oral Cancer.
Stoopler ET, Sollecito TP
Dent Clin North Am 2018 Jan;62(1):ix-x. Epub 2017 Sep 28 doi: 10.1016/j.cden.2017.09.002. PMID: 29126498
Impact of Oral Cancer on Quality of Life.
Valdez JA, Brennan MT
Dent Clin North Am 2018 Jan;62(1):143-154. doi: 10.1016/j.cden.2017.09.001. PMID: 29126491
Dental Treatment Planning for the Patient with Oral Cancer.
Levi LE, Lalla RV
Dent Clin North Am 2018 Jan;62(1):121-130. Epub 2017 Oct 7 doi: 10.1016/j.cden.2017.08.009. PMID: 29126489
Primary malignant melanoma.
Mısır AF, Durmuşlar MC, Zerener T, Gün BD
Saudi Med J 2016 Apr;37(4):446-9. doi: 10.15537/smj.2016.4.15017. PMID: 27052289Free PMC Article

Therapy

Tobacco and its Relationship with Oral Health.
Bhandari A, Bhatta N
JNMA J Nepal Med Assoc 2021 Nov 15;59(243):1204-1206. doi: 10.31729/jnma.6605. PMID: 35199764Free PMC Article
Oral Cancer Screening: Past, Present, and Future.
Warnakulasuriya S, Kerr AR
J Dent Res 2021 Nov;100(12):1313-1320. Epub 2021 May 26 doi: 10.1177/00220345211014795. PMID: 34036828Free PMC Article
Management of recurrent and metastatic oral cavity cancer: Raising the bar a step higher.
Szturz P, Vermorken JB
Oral Oncol 2020 Feb;101:104492. Epub 2019 Dec 11 doi: 10.1016/j.oraloncology.2019.104492. PMID: 31837576
Interventions for treating oral leukoplakia to prevent oral cancer.
Lodi G, Franchini R, Warnakulasuriya S, Varoni EM, Sardella A, Kerr AR, Carrassi A, MacDonald LC, Worthington HV
Cochrane Database Syst Rev 2016 Jul 29;7(7):CD001829. doi: 10.1002/14651858.CD001829.pub4. PMID: 27471845Free PMC Article
Essentials of oral cancer.
Rivera C
Int J Clin Exp Pathol 2015;8(9):11884-94. Epub 2015 Sep 1 PMID: 26617944Free PMC Article

Prognosis

Oral Cancer: What the General Surgeon Should Know.
Pan C, Rizvi Z
Surg Clin North Am 2022 Apr;102(2):309-324. Epub 2022 Mar 5 doi: 10.1016/j.suc.2021.12.007. PMID: 35344699
Survival outcomes after treatment of cancer of the oral cavity (1985-2015).
Zanoni DK, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I, Patel SG
Oral Oncol 2019 Mar;90:115-121. Epub 2019 Feb 15 doi: 10.1016/j.oraloncology.2019.02.001. PMID: 30846169Free PMC Article
Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer.
Carnielli CM, Macedo CCS, De Rossi T, Granato DC, Rivera C, Domingues RR, Pauletti BA, Yokoo S, Heberle H, Busso-Lopes AF, Cervigne NK, Sawazaki-Calone I, Meirelles GV, Marchi FA, Telles GP, Minghim R, Ribeiro ACP, Brandão TB, de Castro G Jr, González-Arriagada WA, Gomes A, Penteado F, Santos-Silva AR, Lopes MA, Rodrigues PC, Sundquist E, Salo T, da Silva SD, Alaoui-Jamali MA, Graner E, Fox JW, Coletta RD, Paes Leme AF
Nat Commun 2018 Sep 5;9(1):3598. doi: 10.1038/s41467-018-05696-2. PMID: 30185791Free PMC Article
Perspectives on oral squamous cell carcinoma prevention-proliferation, position, progression and prediction.
Thomson PJ
J Oral Pathol Med 2018 Oct;47(9):803-807. Epub 2018 May 27 doi: 10.1111/jop.12733. PMID: 29752860
Essentials of oral cancer.
Rivera C
Int J Clin Exp Pathol 2015;8(9):11884-94. Epub 2015 Sep 1 PMID: 26617944Free PMC Article

Clinical prediction guides

Platelet CLEC2-Podoplanin Axis as a Promising Target for Oral Cancer Treatment.
Hwang BO, Park SY, Cho ES, Zhang X, Lee SK, Ahn HJ, Chun KS, Chung WY, Song NY
Front Immunol 2021;12:807600. Epub 2021 Dec 15 doi: 10.3389/fimmu.2021.807600. PMID: 34987523Free PMC Article
Contribution of Genomics to the Surgical Management and Study of Oral Cancer.
Saidak Z, Lailler C, Testelin S, Chauffert B, Clatot F, Galmiche A
Ann Surg Oncol 2021 Oct;28(11):5842-5854. Epub 2021 Apr 12 doi: 10.1245/s10434-021-09904-0. PMID: 33846893Free PMC Article
Grading systems of oral cavity pre-malignancy: a systematic review and meta-analysis.
Yan F, Reddy PD, Nguyen SA, Chi AC, Neville BW, Day TA
Eur Arch Otorhinolaryngol 2020 Nov;277(11):2967-2976. Epub 2020 May 23 doi: 10.1007/s00405-020-06036-1. PMID: 32447493
Trismus and oral health conditions during diagnosis of malignant oral neoplasms.
Martins CA, Goldenberg DC, Narikawa R, Kowalski LP
Braz J Otorhinolaryngol 2020 Sep-Oct;86(5):552-557. Epub 2019 Mar 18 doi: 10.1016/j.bjorl.2019.02.004. PMID: 30962143Free PMC Article
Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer.
Carnielli CM, Macedo CCS, De Rossi T, Granato DC, Rivera C, Domingues RR, Pauletti BA, Yokoo S, Heberle H, Busso-Lopes AF, Cervigne NK, Sawazaki-Calone I, Meirelles GV, Marchi FA, Telles GP, Minghim R, Ribeiro ACP, Brandão TB, de Castro G Jr, González-Arriagada WA, Gomes A, Penteado F, Santos-Silva AR, Lopes MA, Rodrigues PC, Sundquist E, Salo T, da Silva SD, Alaoui-Jamali MA, Graner E, Fox JW, Coletta RD, Paes Leme AF
Nat Commun 2018 Sep 5;9(1):3598. doi: 10.1038/s41467-018-05696-2. PMID: 30185791Free PMC Article

Recent systematic reviews

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Malignant transformation of oral leukoplakia: Systematic review and meta-analysis of the last 5 years.
Aguirre-Urizar JM, Lafuente-Ibáñez de Mendoza I, Warnakulasuriya S
Oral Dis 2021 Nov;27(8):1881-1895. Epub 2021 Apr 1 doi: 10.1111/odi.13810. PMID: 33606345
Human papillomavirus infection and oral squamous cell carcinoma - a systematic review.
Melo BAC, Vilar LG, Oliveira NR, Lima PO, Pinheiro MB, Domingueti CP, Pereira MC
Braz J Otorhinolaryngol 2021 May-Jun;87(3):346-352. Epub 2020 Nov 29 doi: 10.1016/j.bjorl.2020.10.017. PMID: 33339760Free PMC Article
Diabetes mellitus and oral cancer/oral potentially malignant disorders: A systematic review and meta-analysis.
Ramos-Garcia P, Roca-Rodriguez MDM, Aguilar-Diosdado M, Gonzalez-Moles MA
Oral Dis 2021 Apr;27(3):404-421. Epub 2020 Feb 18 doi: 10.1111/odi.13289. PMID: 31994293
Alcohol consumption and risk of cancer: a systematic literature review.
de Menezes RF, Bergmann A, Thuler LC
Asian Pac J Cancer Prev 2013;14(9):4965-72. doi: 10.7314/apjcp.2013.14.9.4965. PMID: 24175760

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