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Malignant neoplasm of endocervix

MedGen UID:
56309
•Concept ID:
C0153569
•
Neoplastic Process
Synonyms: Cancer of endocervix; cancer of endocervix; endocervix cancer; Malignant Endocervical Neoplasm; malignant endocervical neoplasm; Malignant Endocervical Tumor; malignant endocervical tumor; malignant endocervical tumour; Malignant Endocervix Neoplasm; malignant endocervix neoplasm; Malignant Endocervix Tumor; malignant endocervix tumor; malignant endocervix tumour; Malignant neoplasm of endocervical canal; Malignant Neoplasm of Endocervix; malignant neoplasm of endocervix; Malignant Neoplasm of the Endocervix; malignant neoplasm of the endocervix; Malignant Neoplasm of the Uterine Endocervix; malignant neoplasm of the uterine endocervix; Malignant Neoplasm of Uterine Endocervix; malignant neoplasm of uterine endocervix; Malignant Tumor of Endocervix; malignant tumor of endocervix; Malignant Tumor of the Endocervix; malignant tumor of the endocervix; Malignant Tumor of the Uterine Endocervix; malignant tumor of the uterine endocervix; Malignant Tumor of Uterine Endocervix; malignant tumor of uterine endocervix; malignant tumour of endocervix; malignant tumour of the endocervix; malignant tumour of the uterine endocervix; malignant tumour of uterine endocervix; Malignant Uterine Endocervix Neoplasm; malignant uterine endocervix neoplasm; Malignant Uterine Endocervix Tumor; malignant uterine endocervix tumor; malignant uterine endocervix tumour
SNOMED CT: Malignant neoplasm of endocervix (372097009); Malignant neoplasm of endocervical canal (188176007); Cancer of endocervix (372097009)
 
Monarch Initiative: MONDO:0021309

Definition

A malignant neoplasm that affects the endocervix. [from NCI]

Professional guidelines

PubMed

Global challenges of radiotherapy for the treatment of locally advanced cervical cancer.
Mayadev JS, Ke G, Mahantshetty U, Pereira MD, Tarnawski R, Toita T
Int J Gynecol Cancer 2022 Mar;32(3):436-445. doi: 10.1136/ijgc-2021-003001. PMID: 35256434Free PMC Article
Cervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology.
Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Clark R, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, Han E, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Ueda S, Wyse E, Yashar CM, McMillian NR, Scavone JL
J Natl Compr Canc Netw 2019 Jan;17(1):64-84. doi: 10.6004/jnccn.2019.0001. PMID: 30659131
Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy for the definitive treatment of cervix cancer.
Lim K, Small W Jr, Portelance L, Creutzberg C, Jürgenliemk-Schulz IM, Mundt A, Mell LK, Mayr N, Viswanathan A, Jhingran A, Erickson B, De los Santos J, Gaffney D, Yashar C, Beriwal S, Wolfson A, Taylor A, Bosch W, El Naqa I, Fyles A; Gyn IMRT Consortium
Int J Radiat Oncol Biol Phys 2011 Feb 1;79(2):348-55. Epub 2010 May 14 doi: 10.1016/j.ijrobp.2009.10.075. PMID: 20472347

Recent clinical studies

Etiology

Advanced stage (FIGO IVB) neuroendocrine cervical carcinoma.
Salvo G, Ramalingam P, Bhosale P, Frumovitz M
Int J Gynecol Cancer 2022 Nov 7;32(11):1469-1474. doi: 10.1136/ijgc-2022-003946. PMID: 36343974Free PMC Article
Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification.
Park KJ
Histopathology 2020 Jan;76(1):112-127. doi: 10.1111/his.13995. PMID: 31846527
Management of adolescents who have abnormal cytology and histology.
Moscicki AB
Obstet Gynecol Clin North Am 2008 Dec;35(4):633-43; x. doi: 10.1016/j.ogc.2008.09.004. PMID: 19061822Free PMC Article
Colposcopy in pregnancy.
Campion MJ, Sedlacek TV
Obstet Gynecol Clin North Am 1993 Mar;20(1):153-63. PMID: 8332307
The prevention of cervical cancer: the place of the cytological smear test.
Hudson E
Clin Obstet Gynaecol 1985 Mar;12(1):33-51. PMID: 3888487

Diagnosis

Interpretation pitfalls and malignant mimics in cervical cytology.
Torous VF, Pitman MB
J Am Soc Cytopathol 2021 Mar-Apr;10(2):115-127. Epub 2020 Jun 25 doi: 10.1016/j.jasc.2020.06.005. PMID: 32732114
Primary malignant melanoma of uterine cervix.
DI Meo N, Conforti C, Nan K, Romano A, Degrassi F, Cova MA, Ukmar M, Zalaudek I
Ital J Dermatol Venerol 2021 Dec;156(Suppl. 1 to No. 6):110-111. Epub 2020 Mar 4 doi: 10.23736/S2784-8671.19.06512-X. PMID: 32129585
An update on uterine cervix pathologies related to infertility.
Donnez J
Fertil Steril 2020 Apr;113(4):683-684. doi: 10.1016/j.fertnstert.2020.02.107. PMID: 32228872
Atypical glandular cells in cervical cytology: what are we talking about? Terminology and the impact of molecular techniques.
Negri G
Cytopathology 2009 Dec;20(6):347-50. doi: 10.1111/j.1365-2303.2009.00718.x. PMID: 19929982
Colposcopy in pregnancy.
Campion MJ, Sedlacek TV
Obstet Gynecol Clin North Am 1993 Mar;20(1):153-63. PMID: 8332307

Therapy

Cervicovaginal microbiome and natural history of HPV in a longitudinal study.
Usyk M, Zolnik CP, Castle PE, Porras C, Herrero R, Gradissimo A, Gonzalez P, Safaeian M, Schiffman M, Burk RD; Costa Rica HPV Vaccine Trial (CVT) Group
PLoS Pathog 2020 Mar;16(3):e1008376. Epub 2020 Mar 26 doi: 10.1371/journal.ppat.1008376. PMID: 32214382Free PMC Article
Cervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology.
Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Clark R, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, Han E, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Ueda S, Wyse E, Yashar CM, McMillian NR, Scavone JL
J Natl Compr Canc Netw 2019 Jan;17(1):64-84. doi: 10.6004/jnccn.2019.0001. PMID: 30659131
Endocervicosis of the Uterine Cervix.
Mobarki M, Karpathiou G, Forest F, Corsini T, Peoc'h M
Int J Gynecol Pathol 2016 Sep;35(5):475-7. doi: 10.1097/PGP.0000000000000277. PMID: 26825004
Classification of radical hysterectomy.
Querleu D, Morrow CP
Lancet Oncol 2008 Mar;9(3):297-303. doi: 10.1016/S1470-2045(08)70074-3. PMID: 18308255
Role of colposcopy in the examination of diethylstilbestrol-exposed women.
Noller KL
Obstet Gynecol Clin North Am 1993 Mar;20(1):165-76. PMID: 8332308

Prognosis

Utility of imaging modalities for predicting carcinogenesis in lobular endocervical glandular hyperplasia.
Omori M, Kondo T, Tagaya H, Watanabe Y, Fukasawa H, Kawai M, Nakazawa K, Hashi A, Hirata S
PLoS One 2019;14(8):e0221088. Epub 2019 Aug 15 doi: 10.1371/journal.pone.0221088. PMID: 31415639Free PMC Article
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article
Invasive adenocarcinoma and related tumors of the uterine cervix.
Young RH, Scully RE
Semin Diagn Pathol 1990 Aug;7(3):205-27. PMID: 2218147
Rhabdomyosarcoma of the uterus in a postmenopausal patient.
Podczaski E, Sees J, Kaminski P, Sorosky J, Larson JE, DeGeest K, Zaino RJ, Mortel R
Gynecol Oncol 1990 Jun;37(3):439-42. doi: 10.1016/0090-8258(90)90384-w. PMID: 2190875
The prevention of cervical cancer: the place of the cytological smear test.
Hudson E
Clin Obstet Gynaecol 1985 Mar;12(1):33-51. PMID: 3888487

Clinical prediction guides

Utility of imaging modalities for predicting carcinogenesis in lobular endocervical glandular hyperplasia.
Omori M, Kondo T, Tagaya H, Watanabe Y, Fukasawa H, Kawai M, Nakazawa K, Hashi A, Hirata S
PLoS One 2019;14(8):e0221088. Epub 2019 Aug 15 doi: 10.1371/journal.pone.0221088. PMID: 31415639Free PMC Article
HPV testing alone is not as safe as cytology and selective HPV testing: AGAINST: There is powerful evidence for primary cervical screening.
Kitchener H
BJOG 2016 Jan;123(1):68. Epub 2015 Nov 3 doi: 10.1111/1471-0528.13638. PMID: 26527427
High expression of TGF-β1 in the vaginal incisional margin predicts poor prognosis in patients with stage Ib-IIa cervical squamous cell carcinoma.
Fan DM, Wang XJ, He T, Wang Y, Zhou D, Kong GQ, Jiang T, Zhang MM
Mol Biol Rep 2012 Apr;39(4):3925-31. Epub 2011 Jul 20 doi: 10.1007/s11033-011-1171-x. PMID: 21773949
Cervical adenocarcinoma in situ: the predictive value of conization margin status.
Young JL, Jazaeri AA, Lachance JA, Stoler MH, Irvin WP, Rice LW, Andersen WA, Modesitt SC
Am J Obstet Gynecol 2007 Aug;197(2):195.e1-7; discussion 195.e7-8. doi: 10.1016/j.ajog.2007.04.035. PMID: 17689647
Dysplastic endocervical curettings: a predictor of cervical squamous cell carcinoma.
Temkin SM, Hellmann M, Lee YC, Abulafia O
Am J Obstet Gynecol 2007 May;196(5):469.e1-4. doi: 10.1016/j.ajog.2006.11.018. PMID: 17466706

Recent systematic reviews

Proportions and incidence of locally advanced cervical cancer: a global systematic literature review.
Monk BJ, Tan DSP, Hernández Chagüi JD, Takyar J, Paskow MJ, Nunes AT, Pujade-Lauraine E
Int J Gynecol Cancer 2022 Dec 5;32(12):1531-1539. doi: 10.1136/ijgc-2022-003801. PMID: 36241221Free PMC Article
Integrating HPV vaccination programs with enhanced cervical cancer screening and treatment, a systematic review.
Wirtz C, Mohamed Y, Engel D, Sidibe A, Holloway M, Bloem P, Kumar S, Brotherton J, Reis V, Morgan C
Vaccine 2022 Mar 31;40 Suppl 1:A116-A123. Epub 2021 Dec 1 doi: 10.1016/j.vaccine.2021.11.013. PMID: 34863615
Patterns of incident genital human papillomavirus infection in women: A literature review and meta-analysis.
Wheeler BS, Rositch AF, Poole C, Taylor SM, Smith JS
Int J STD AIDS 2019 Nov;30(13):1246-1256. Epub 2019 Oct 22 doi: 10.1177/0956462418824441. PMID: 31640474
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article
Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: systematic review and meta-analysis.
Kyrgiou M, Athanasiou A, Paraskevaidi M, Mitra A, Kalliala I, Martin-Hirsch P, Arbyn M, Bennett P, Paraskevaidis E
BMJ 2016 Jul 28;354:i3633. doi: 10.1136/bmj.i3633. PMID: 27469988Free PMC Article

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