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Benign conjunctival neoplasm

MedGen UID:
56328
•Concept ID:
C0154025
•
Neoplastic Process
Synonyms: Benign Conjunctiva Neoplasm; benign conjunctiva neoplasm; Benign Conjunctiva Tumor; benign conjunctiva tumor; benign conjunctiva tumour; Benign Conjunctival Neoplasm; benign conjunctival neoplasm; Benign Conjunctival Tumor; benign conjunctival tumor; benign conjunctival tumour; Benign neoplasm of conjunctiva; Benign Neoplasm of Conjunctiva; benign neoplasm of conjunctiva; Benign Neoplasm of the Conjunctiva; benign neoplasm of the conjunctiva; Benign tumor of conjunctiva; Benign Tumor of Conjunctiva; benign tumor of conjunctiva; Benign Tumor of the Conjunctiva; benign tumor of the conjunctiva; benign tumour of conjunctiva; benign tumour of the conjunctiva; conjunctiva benign neoplasm
SNOMED CT: Benign tumor of conjunctiva (92068002); Benign neoplasm of conjunctiva (92068002)
 
Monarch Initiative: MONDO:0006105

Definition

A neoplasm that arises from the conjunctiva and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

The impact of the COVID-19 pandemic on the diagnosis and treatment of ocular cancer.
Fontes Junior VC, Fernandes AG, Morales MC, Belfort Neto R
Arq Bras Oftalmol 2023 Mar-Apr;86(2):127-130. doi: 10.5935/0004-2749.20230023. PMID: 35417515
Management of pigmented conjunctival lesions.
Oellers P, Karp CL
Ocul Surf 2012 Oct;10(4):251-63. Epub 2012 Aug 11 doi: 10.1016/j.jtos.2012.08.002. PMID: 23084146
Current appraisal of conjunctival melanocytic tumors: classification and treatment.
Harooni H, Schoenfield LR, Singh AD
Future Oncol 2011 Mar;7(3):435-46. doi: 10.2217/fon.11.12. PMID: 21417906

Recent clinical studies

Etiology

Demographic and clinical features of conjunctival tumours at a tertiary care centre.
Mirzayev I, Gündüz AK, Gündüz ÖÖ, Özalp Ateş FS, Nalcı Baytaroğlu H
Clin Exp Optom 2022 Sep;105(7):708-714. Epub 2021 Oct 7 doi: 10.1080/08164622.2021.1971048. PMID: 34617502
Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Clinical and immunohistopathological study of conjunctival melanocytic lesions in pediatric and adolescent patients. A case series.
Bogdănici CM, Costea CF, Dumitrescu GF, Sava A, Ciobanu Apostol DG, Scripcariu DV, Nicoară SD, Tănase DM, Andriescu EC, Cărăuleanu A, Danciu M, Sălăvăstru SC, Schmitzer S, Cucu AI, Niagu IA
Rom J Morphol Embryol 2021 Oct-Dec;62(4):907-915. doi: 10.47162/RJME.62.4.03. PMID: 35673810Free PMC Article
Indocyanine Green Angiographic Assessment of Conjunctival Melanocytic Disorders.
Palme C, Wanner A, Romano V, Franchi A, Haas G, Kaye SB, Steger B
Cornea 2021 Dec 1;40(12):1519-1524. doi: 10.1097/ICO.0000000000002681. PMID: 33591034
Management of pigmented conjunctival lesions.
Oellers P, Karp CL
Ocul Surf 2012 Oct;10(4):251-63. Epub 2012 Aug 11 doi: 10.1016/j.jtos.2012.08.002. PMID: 23084146

Diagnosis

Anterior segment optical coherence tomography in ocular surface tumours and simulating lesions.
Gündüz AK, Mirzayev I, Okcu Heper A, Kuzu I, Gahramanli Z, Cansiz Ersöz C, Gündüz ÖÖ, Ataoğlu Ö
Eye (Lond) 2023 Apr;37(5):925-937. Epub 2022 Dec 13 doi: 10.1038/s41433-022-02339-1. PMID: 36513855Free PMC Article
Conjunctival myxoma: A systematic review of a rare tumor.
Alvarado-Villacorta R, Torres Zavala NM, Marroquín Loayza L, Rodríguez-Reyes AA
Surv Ophthalmol 2022 May-Jun;67(3):729-740. Epub 2021 Aug 27 doi: 10.1016/j.survophthal.2021.08.007. PMID: 34461119
Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Conjunctival and Corneal Fibrous Histiocytoma: Brief review.
Singh T, Ichhpujani P
Semin Ophthalmol 2021 Oct 3;36(7):569-572. Epub 2021 Mar 25 doi: 10.1080/08820538.2021.1900286. PMID: 33764259
Conjunctival lymphoma.
Li JJ, Chen W, Sadeghi N
BMJ Case Rep 2019 Jul 10;12(7) doi: 10.1136/bcr-2019-229599. PMID: 31296640Free PMC Article

Therapy

Conjunctival lymphoma.
Li JJ, Chen W, Sadeghi N
BMJ Case Rep 2019 Jul 10;12(7) doi: 10.1136/bcr-2019-229599. PMID: 31296640Free PMC Article
Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition.
El Zaoui I, Bucher M, Rimoldi D, Nicolas M, Kaya G, Pescini Gobert R, Bedoni N, Schalenbourg A, Sakina E, Zografos L, Leyvraz S, Riggi N, Rivolta C, Moulin AP
Invest Ophthalmol Vis Sci 2019 Jun 3;60(7):2764-2772. doi: 10.1167/iovs.18-26508. PMID: 31247083
Pharmacotherapy and Immunotherapy of Conjunctival Tumors.
Midena E, Frizziero L, Parrozzani R
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):121-131. doi: 10.22608/APO.201751. PMID: 28399343
Current appraisal of conjunctival melanocytic tumors: classification and treatment.
Harooni H, Schoenfield LR, Singh AD
Future Oncol 2011 Mar;7(3):435-46. doi: 10.2217/fon.11.12. PMID: 21417906
Targeted monoclonal antibody therapy and radioimmunotherapy for lymphoproliferative disorders of the ocular adnexa.
Shome D, Esmaeli B
Curr Opin Ophthalmol 2008 Sep;19(5):414-21. doi: 10.1097/ICU.0b013e32830b1539. PMID: 18772675

Prognosis

Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Indocyanine Green Angiographic Assessment of Conjunctival Melanocytic Disorders.
Palme C, Wanner A, Romano V, Franchi A, Haas G, Kaye SB, Steger B
Cornea 2021 Dec 1;40(12):1519-1524. doi: 10.1097/ICO.0000000000002681. PMID: 33591034
Primary conjunctival myxoma: case series and review of the literature.
Ríos Y Valles-Valles D, Hernández-Ayuso I, Rodríguez-Martínez HA, Medina-Cruz A, Salcedo-Casillas G, Rodríguez-Reyes AA
Histopathology 2017 Oct;71(4):635-640. Epub 2017 Aug 2 doi: 10.1111/his.13274. PMID: 28570006
Management of pigmented conjunctival lesions.
Oellers P, Karp CL
Ocul Surf 2012 Oct;10(4):251-63. Epub 2012 Aug 11 doi: 10.1016/j.jtos.2012.08.002. PMID: 23084146
Primary corneal myxoma.
Soong T, Soong V, Salvi SM, Raynor M, Mudhar H, Goel S, Edwards M
Cornea 2008 Dec;27(10):1186-8. doi: 10.1097/ICO.0b013e31817a5d0b. PMID: 19034139

Clinical prediction guides

PRAME expression by immunohistochemistry and reverse transcription quantitative PCR in conjunctival melanocytic lesions-a comprehensive clinicopathologic study of 202 cases and correlation of cytogenetics with PRAME expression in challenging conjunctival melanocytic lesions.
Mudhar HS, Milman T, Stevenson S, Watson M, Kim J, Magan T, Salvi SM, Harley U, Lally SE, Shields CL
Hum Pathol 2023 Apr;134:1-18. Epub 2023 Feb 16 doi: 10.1016/j.humpath.2023.02.002. PMID: 36804828
Clinical and immunohistopathological study of conjunctival melanocytic lesions in pediatric and adolescent patients. A case series.
Bogdănici CM, Costea CF, Dumitrescu GF, Sava A, Ciobanu Apostol DG, Scripcariu DV, Nicoară SD, Tănase DM, Andriescu EC, Cărăuleanu A, Danciu M, Sălăvăstru SC, Schmitzer S, Cucu AI, Niagu IA
Rom J Morphol Embryol 2021 Oct-Dec;62(4):907-915. doi: 10.47162/RJME.62.4.03. PMID: 35673810Free PMC Article
Indocyanine Green Angiographic Assessment of Conjunctival Melanocytic Disorders.
Palme C, Wanner A, Romano V, Franchi A, Haas G, Kaye SB, Steger B
Cornea 2021 Dec 1;40(12):1519-1524. doi: 10.1097/ICO.0000000000002681. PMID: 33591034
Giant conjunctival nevus: clinical features and natural course in 32 cases.
Shields CL, Regillo AC, Mellen PL, Kaliki S, Lally SE, Shields JA
JAMA Ophthalmol 2013 Jul;131(7):857-63. doi: 10.1001/jamaophthalmol.2013.160. PMID: 23702735
Current appraisal of conjunctival melanocytic tumors: classification and treatment.
Harooni H, Schoenfield LR, Singh AD
Future Oncol 2011 Mar;7(3):435-46. doi: 10.2217/fon.11.12. PMID: 21417906

Recent systematic reviews

Conjunctival myxoma: A systematic review of a rare tumor.
Alvarado-Villacorta R, Torres Zavala NM, Marroquín Loayza L, Rodríguez-Reyes AA
Surv Ophthalmol 2022 May-Jun;67(3):729-740. Epub 2021 Aug 27 doi: 10.1016/j.survophthal.2021.08.007. PMID: 34461119

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