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Benign neoplasm of spinal cord

MedGen UID:
56329
•Concept ID:
C0154034
•
Neoplastic Process
Synonym: Spinal Cord Neoplasms, Benign
SNOMED CT: Benign tumor of spinal cord (92405007); Benign neoplasm of spinal cord (92405007)
 
Monarch Initiative: MONDO:0021506

Definition

A neoplasm that arises from the spinal cord and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of spinal cord

Professional guidelines

PubMed

Ependymoma: Evaluation and Management Updates.
Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591Free PMC Article
Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma.
Grommes C, Rubenstein JL, DeAngelis LM, Ferreri AJM, Batchelor TT
Neuro Oncol 2019 Feb 19;21(3):296-305. doi: 10.1093/neuonc/noy192. PMID: 30418592Free PMC Article
International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery.
Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan J, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):e597-605. Epub 2012 May 19 doi: 10.1016/j.ijrobp.2012.03.009. PMID: 22608954

Recent clinical studies

Etiology

Challenges in diagnosis and management of adult spinal cord gliomas.
Campello C, Tabouret E, Chinot O
Rev Neurol (Paris) 2021 May;177(5):515-523. Epub 2021 Apr 23 doi: 10.1016/j.neurol.2021.02.384. PMID: 33896651
Management of intramedullary spinal cord tumors: A single-center experience of 247 patients.
Knafo S, Aghakhani N, David P, Parker F
Rev Neurol (Paris) 2021 May;177(5):508-514. Epub 2020 Oct 13 doi: 10.1016/j.neurol.2020.07.014. PMID: 33066996
Spinal Cord Tumor Microenvironment.
Rauschenbach L
Adv Exp Med Biol 2020;1226:97-109. doi: 10.1007/978-3-030-36214-0_8. PMID: 32030679
Metastatic Spinal Cord Compression: Unraveling the Diagnostic and Therapeutic Challenges.
Boussios S, Cooke D, Hayward C, Kanellos FS, Tsiouris AK, Chatziantoniou AA, Zakynthinakis-Kyriakou N, Karathanasi A
Anticancer Res 2018 Sep;38(9):4987-4997. doi: 10.21873/anticanres.12817. PMID: 30194142
Spinal lipomas.
Blount JP, Elton S
Neurosurg Focus 2001 Jan 15;10(1):e3. doi: 10.3171/foc.2001.10.1.4. PMID: 16749755

Diagnosis

Spinal Cord Neoplasms.
McFaline-Figueroa JR
Continuum (Minneap Minn) 2024 Feb 1;30(1):99-118. doi: 10.1212/CON.0000000000001375. PMID: 38330474
The Role of MRI in the Diagnosis of Spinal Cord Tumors.
de Paiva JLR, Sabino JV, Pereira FV, Okuda PA, Villarinho LL, Queiroz LS, França MC Jr, Reis F
Semin Ultrasound CT MR 2023 Oct;44(5):436-451. Epub 2023 Apr 5 doi: 10.1053/j.sult.2023.03.012. PMID: 37555685
Intradural spinal tumors in adults-update on management and outcome.
Ottenhausen M, Ntoulias G, Bodhinayake I, Ruppert FH, Schreiber S, Förschler A, Boockvar JA, Jödicke A
Neurosurg Rev 2019 Jun;42(2):371-388. Epub 2018 Feb 17 doi: 10.1007/s10143-018-0957-x. PMID: 29455369
Pediatric spinal tumors.
Hsu W, Jallo GI
Handb Clin Neurol 2013;112:959-65. doi: 10.1016/B978-0-444-52910-7.00016-7. PMID: 23622304
Spinal lipomas.
Blount JP, Elton S
Neurosurg Focus 2001 Jan 15;10(1):e3. doi: 10.3171/foc.2001.10.1.4. PMID: 16749755

Therapy

GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas.
Majzner RG, Ramakrishna S, Yeom KW, Patel S, Chinnasamy H, Schultz LM, Richards RM, Jiang L, Barsan V, Mancusi R, Geraghty AC, Good Z, Mochizuki AY, Gillespie SM, Toland AMS, Mahdi J, Reschke A, Nie EH, Chau IJ, Rotiroti MC, Mount CW, Baggott C, Mavroukakis S, Egeler E, Moon J, Erickson C, Green S, Kunicki M, Fujimoto M, Ehlinger Z, Reynolds W, Kurra S, Warren KE, Prabhu S, Vogel H, Rasmussen L, Cornell TT, Partap S, Fisher PG, Campen CJ, Filbin MG, Grant G, Sahaf B, Davis KL, Feldman SA, Mackall CL, Monje M
Nature 2022 Mar;603(7903):934-941. Epub 2022 Feb 7 doi: 10.1038/s41586-022-04489-4. PMID: 35130560Free PMC Article
Surgical and Radiotherapeutic Management of Malignant Extradural Spinal Cord Compression.
Loblaw A, George KJ, Misra V
Clin Oncol (R Coll Radiol) 2020 Nov;32(11):745-752. Epub 2020 Aug 19 doi: 10.1016/j.clon.2020.07.022. PMID: 32828635
Neoplastic myelopathies.
Chamberlain MC
Continuum (Minneap Minn) 2015 Feb;21(1 Spinal Cord Disorders):132-45. doi: 10.1212/01.CON.0000461089.02113.1b. PMID: 25651222
Malignant spinal-cord compression.
Prasad D, Schiff D
Lancet Oncol 2005 Jan;6(1):15-24. doi: 10.1016/S1470-2045(04)01709-7. PMID: 15629272
Ependymomas.
Chamberlain MC
Curr Neurol Neurosci Rep 2003 May;3(3):193-9. doi: 10.1007/s11910-003-0078-x. PMID: 12691623

Prognosis

The Epidemiology of Brain and Spinal Cord Tumors.
Shobeiri P, Seyedmirzaei H, Kalantari A, Mohammadi E, Rezaei N, Hanaei S
Adv Exp Med Biol 2023;1394:19-39. doi: 10.1007/978-3-031-14732-6_2. PMID: 36587379
Literature Review of Spinal Cord Glioblastoma.
Timmons JJ, Zhang K, Fong J, Lok E, Swanson KD, Gautam S, Wong ET
Am J Clin Oncol 2018 Dec;41(12):1281-1287. doi: 10.1097/COC.0000000000000434. PMID: 29528867
Spinal lipomas.
Blount JP, Elton S
Neurosurg Focus 2001 Jan 15;10(1):e3. doi: 10.3171/foc.2001.10.1.4. PMID: 16749755
Lipomyelomeningocele.
Sutton LN
Neurosurg Clin N Am 1995 Apr;6(2):325-38. PMID: 7620357
Spinal cord meningiomas.
Souweidane MM, Benjamin V
Neurosurg Clin N Am 1994 Apr;5(2):283-91. PMID: 8032227

Clinical prediction guides

Intramedullary Subependymoma Of Lower Thoracic Cord.
Bashir HH, Aziz HF, Shamim MS
J Pak Med Assoc 2023 Sep;73(9):1919-1920. doi: 10.47391/JPMA.23-66. PMID: 37817716
Clinical Prediction Modeling in Intramedullary Spinal Tumor Surgery.
Massaad E, Ha Y, Shankar GM, Shin JH
Acta Neurochir Suppl 2022;134:333-339. doi: 10.1007/978-3-030-85292-4_37. PMID: 34862557
Literature Review of Spinal Cord Glioblastoma.
Timmons JJ, Zhang K, Fong J, Lok E, Swanson KD, Gautam S, Wong ET
Am J Clin Oncol 2018 Dec;41(12):1281-1287. doi: 10.1097/COC.0000000000000434. PMID: 29528867
Lumbar paraganglioma.
Dillard-Cannon E, Atsina KB, Ghobrial G, Gnass E, Curtis MT, Heller J
J Clin Neurosci 2016 Aug;30:149-151. Epub 2016 Mar 28 doi: 10.1016/j.jocn.2016.01.019. PMID: 27032749
Pediatric spinal tumors.
Hsu W, Jallo GI
Handb Clin Neurol 2013;112:959-65. doi: 10.1016/B978-0-444-52910-7.00016-7. PMID: 23622304

Recent systematic reviews

Spinal Ganglioneuroma: A Systematic Review of the Literature.
Yousefi O, Saghebdoust S, Abdollahifard S, Motlagh MA, Farrokhi MR, Motiei-Langroudi R, Mousavi SR
World Neurosurg 2023 Dec;180:163-168.e7. Epub 2023 Sep 1 doi: 10.1016/j.wneu.2023.08.057. PMID: 37659751
Non-demyelinating disorders mimicking and misdiagnosed as NMOSD: a literature review.
Zara P, Dinoto A, Carta S, Floris V, Turilli D, Budhram A, Ferrari S, Milia S, Solla P, Mariotto S, Flanagan EP, Lopez Chiriboga AS, Sechi E
Eur J Neurol 2023 Oct;30(10):3367-3376. Epub 2023 Jul 19 doi: 10.1111/ene.15983. PMID: 37433584Free PMC Article
Calcified spinal meningiomas: a systematic review of clinical characteristics, treatment strategies, and outcomes.
Shah DS, Reddy RV, Doğruel Y, Asfour MZ, Pour-Rashidi A, Haider AS, Sharma M, Aoun SG, Umana GE, Palmisciano P
J Neurooncol 2023 Apr;162(2):295-305. Epub 2023 Mar 17 doi: 10.1007/s11060-023-04291-w. PMID: 36932228
A systematic review on the outcome of intramedullary spinal cord cavernous malformations.
Asimakidou E, Meszaros LT, Anestis DM, Tsitsopoulos PP
Eur Spine J 2022 Nov;31(11):3119-3129. Epub 2022 Aug 6 doi: 10.1007/s00586-022-07332-6. PMID: 35931791
Low Back Pain in the Emergency Department: Prevalence of Serious Spinal Pathologies and Diagnostic Accuracy of Red Flags.
Galliker G, Scherer DE, Trippolini MA, Rasmussen-Barr E, LoMartire R, Wertli MM
Am J Med 2020 Jan;133(1):60-72.e14. Epub 2019 Jul 3 doi: 10.1016/j.amjmed.2019.06.005. PMID: 31278933

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