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Polyclonal hypergammaglobulinemia

MedGen UID:
56337
Concept ID:
C0154254
Disease or Syndrome
Synonyms: Polyclonal Hypergammaglobulinemia; polyclonal hypergammaglobulinemia
SNOMED CT: Polyclonal hypergammaglobulinemia (190808009)
 
Monarch Initiative: MONDO:0002272

Definition

A laboratory test result indicating abnormally high proliferation of gamma globulins in the blood originating from multiple cell lines. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolyclonal hypergammaglobulinemia

Professional guidelines

PubMed

Varghese JL, Fung AWS, Mattman A, Quach TTT, Gauiran DTV, Carruthers MN, Chen LYC
Clin Chim Acta 2020 Jul;506:228-235. Epub 2020 Apr 6 doi: 10.1016/j.cca.2020.04.001. PMID: 32272158
Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS
Blood 2017 Mar 23;129(12):1646-1657. Epub 2017 Jan 13 doi: 10.1182/blood-2016-10-746933. PMID: 28087540Free PMC Article
Alizadeh AA, Advani RH
Clin Adv Hematol Oncol 2008 Dec;6(12):899-909. PMID: 19209140

Recent clinical studies

Etiology

Nishikori A, Nishimura MF, Nishimura Y, Otsuka F, Maehama K, Ohsawa K, Momose S, Nakamura N, Sato Y
Int J Mol Sci 2022 Sep 7;23(18) doi: 10.3390/ijms231810301. PMID: 36142213Free PMC Article
Qi R, Chen LYC, Park S, Irvine R, Seidman MA, Kelsall JT, Collins D, Yin V, Slack GW, Mattman A, Lam E, Carruthers MN
Am J Med Sci 2018 Jan;355(1):61-66. Epub 2017 Aug 24 doi: 10.1016/j.amjms.2017.08.014. PMID: 29289265
Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS
Blood 2017 Mar 23;129(12):1646-1657. Epub 2017 Jan 13 doi: 10.1182/blood-2016-10-746933. PMID: 28087540Free PMC Article
Mylona EE, Baraboutis IG, Lekakis LJ, Georgiou O, Papastamopoulos V, Skoutelis A
AIDS Rev 2008 Jan-Mar;10(1):25-35. PMID: 18385778
Shannon KM, Ammann AJ
J Pediatr 1985 Feb;106(2):332-42. doi: 10.1016/s0022-3476(85)80320-6. PMID: 2982008

Diagnosis

Henrie R, Cherniawsky H, Marcon K, Zhao EJ, Marinkovic A, Pourshahnazari P, Parkin S, Chen LYC
Am J Physiol Cell Physiol 2022 Oct 1;323(4):C1121-C1136. Epub 2022 Aug 8 doi: 10.1152/ajpcell.00356.2021. PMID: 35938681
Varghese JL, Fung AWS, Mattman A, Quach TTT, Gauiran DTV, Carruthers MN, Chen LYC
Clin Chim Acta 2020 Jul;506:228-235. Epub 2020 Apr 6 doi: 10.1016/j.cca.2020.04.001. PMID: 32272158
Chen LYC, Mattman A, Seidman MA, Carruthers MN
Haematologica 2019 Mar;104(3):444-455. Epub 2019 Jan 31 doi: 10.3324/haematol.2018.205526. PMID: 30705099Free PMC Article
Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS
Blood 2017 Mar 23;129(12):1646-1657. Epub 2017 Jan 13 doi: 10.1182/blood-2016-10-746933. PMID: 28087540Free PMC Article
Wagner G, Rose C, Klapper W, Sachse MM
J Dtsch Dermatol Ges 2013 Dec;11(12):1161-7. Epub 2013 Aug 12 doi: 10.1111/ddg.12190. PMID: 23937389

Therapy

Qi R, Chen LYC, Park S, Irvine R, Seidman MA, Kelsall JT, Collins D, Yin V, Slack GW, Mattman A, Lam E, Carruthers MN
Am J Med Sci 2018 Jan;355(1):61-66. Epub 2017 Aug 24 doi: 10.1016/j.amjms.2017.08.014. PMID: 29289265
Wagner G, Rose C, Klapper W, Sachse MM
J Dtsch Dermatol Ges 2013 Dec;11(12):1161-7. Epub 2013 Aug 12 doi: 10.1111/ddg.12190. PMID: 23937389
Iannitto E, Ferreri AJ, Minardi V, Tripodo C, Kreipe HH
Crit Rev Oncol Hematol 2008 Dec;68(3):264-71. Epub 2008 Aug 6 doi: 10.1016/j.critrevonc.2008.06.012. PMID: 18684638
Mylona EE, Baraboutis IG, Lekakis LJ, Georgiou O, Papastamopoulos V, Skoutelis A
AIDS Rev 2008 Jan-Mar;10(1):25-35. PMID: 18385778
Dezube BJ, Aboulafia DM, Pantanowitz L
AIDS Read 2004 Jul;14(7):372-4, 377-9. PMID: 15282866

Prognosis

Nishikori A, Nishimura MF, Nishimura Y, Otsuka F, Maehama K, Ohsawa K, Momose S, Nakamura N, Sato Y
Int J Mol Sci 2022 Sep 7;23(18) doi: 10.3390/ijms231810301. PMID: 36142213Free PMC Article
Chen LYC, Mattman A, Seidman MA, Carruthers MN
Haematologica 2019 Mar;104(3):444-455. Epub 2019 Jan 31 doi: 10.3324/haematol.2018.205526. PMID: 30705099Free PMC Article
Alizadeh AA, Advani RH
Clin Adv Hematol Oncol 2008 Dec;6(12):899-909. PMID: 19209140
Iannitto E, Ferreri AJ, Minardi V, Tripodo C, Kreipe HH
Crit Rev Oncol Hematol 2008 Dec;68(3):264-71. Epub 2008 Aug 6 doi: 10.1016/j.critrevonc.2008.06.012. PMID: 18684638
Mylona EE, Baraboutis IG, Lekakis LJ, Georgiou O, Papastamopoulos V, Skoutelis A
AIDS Rev 2008 Jan-Mar;10(1):25-35. PMID: 18385778

Clinical prediction guides

Van Nieuwenhove E, Humblet-Baron S, Van Eyck L, De Somer L, Dooley J, Tousseyn T, Hershfield M, Liston A, Wouters C
Pediatrics 2018 Sep;142(3) doi: 10.1542/peds.2017-2266. PMID: 30139808
Wagner G, Rose C, Klapper W, Sachse MM
J Dtsch Dermatol Ges 2013 Dec;11(12):1161-7. Epub 2013 Aug 12 doi: 10.1111/ddg.12190. PMID: 23937389
Nardelli B, Moore PA, Li Y, Hilbert DM
Leuk Lymphoma 2002 Jul;43(7):1367-73. doi: 10.1080/10428190290033297. PMID: 12389615
Elkon KB
Mol Biol Rep 1992 Jun;16(3):207-12. doi: 10.1007/BF00464709. PMID: 1508160
Shannon KM, Ammann AJ
J Pediatr 1985 Feb;106(2):332-42. doi: 10.1016/s0022-3476(85)80320-6. PMID: 2982008

Recent systematic reviews

Mylona EE, Baraboutis IG, Lekakis LJ, Georgiou O, Papastamopoulos V, Skoutelis A
AIDS Rev 2008 Jan-Mar;10(1):25-35. PMID: 18385778

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