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Proliferative diabetic retinopathy

MedGen UID:
56347
Concept ID:
C0154830
Disease or Syndrome
Synonyms: PDR - proliferative diabetic retinopathy; Proliferative Diabetic Retinopathy; proliferative diabetic retinopathy; Proliferative retinopathy due to diabetes mellitus; Proliferative retinopathy with diabetes mellitus
SNOMED CT: Proliferative retinopathy with diabetes mellitus (59276001); PDR - proliferative diabetic retinopathy (59276001); Proliferative retinopathy due to diabetes mellitus (59276001); Proliferative diabetic retinopathy (59276001)
 
Monarch Initiative: MONDO:0001660

Definition

Advanced retinopathy due to diabetes mellitus characterized by the formation of new vessels in the retina. The new vessels are abnormal and fragile. If hemorrhage occurs due to the vascular fragility, there is increased risk of vision loss or blindness. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProliferative diabetic retinopathy

Professional guidelines

PubMed

Shaikh N, Srishti R, Khanum A, Thirumalesh MB, Dave V, Arora A, Bansal R, Surve A, Azad S, Kumar V
Indian J Ophthalmol 2023 Jan;71(1):28-38. doi: 10.4103/ijo.IJO_928_22. PMID: 36588205Free PMC Article
Stitt AW, Curtis TM, Chen M, Medina RJ, McKay GJ, Jenkins A, Gardiner TA, Lyons TJ, Hammes HP, Simó R, Lois N
Prog Retin Eye Res 2016 Mar;51:156-86. Epub 2015 Aug 18 doi: 10.1016/j.preteyeres.2015.08.001. PMID: 26297071
Kollias AN, Ulbig MW
Dtsch Arztebl Int 2010 Feb;107(5):75-83; quiz 84. Epub 2010 Feb 5 doi: 10.3238/arztebl.2010.0075. PMID: 20186318Free PMC Article

Recent clinical studies

Etiology

Tarasewicz D, Karter AJ, Pimentel N, Moffet HH, Thai KK, Schlessinger D, Sofrygin O, Melles RB
Diabetes Care 2023 May 1;46(5):1068-1075. doi: 10.2337/dc22-1168. PMID: 36930723Free PMC Article
Shi Q, Wang Q, Wang Z, Lu J, Wang R
Front Immunol 2023;14:1088778. Epub 2023 Feb 10 doi: 10.3389/fimmu.2023.1088778. PMID: 36845092Free PMC Article
Stewart S, Lois N
Asia Pac J Ophthalmol (Phila) 2018 Nov-Dec;7(6):422-426. Epub 2018 Jul 30 doi: 10.22608/APO.2018288. PMID: 30058790
Writing Committee for the Diabetic Retinopathy Clinical Research Network, Gross JG, Glassman AR, Jampol LM, Inusah S, Aiello LP, Antoszyk AN, Baker CW, Berger BB, Bressler NM, Browning D, Elman MJ, Ferris FL 3rd, Friedman SM, Marcus DM, Melia M, Stockdale CR, Sun JK, Beck RW
JAMA 2015 Nov 24;314(20):2137-2146. doi: 10.1001/jama.2015.15217. PMID: 26565927Free PMC Article
Neely KA, Quillen DA, Schachat AP, Gardner TW, Blankenship GW
Med Clin North Am 1998 Jul;82(4):847-76. doi: 10.1016/s0025-7125(05)70027-4. PMID: 9706124

Diagnosis

Tarasewicz D, Karter AJ, Pimentel N, Moffet HH, Thai KK, Schlessinger D, Sofrygin O, Melles RB
Diabetes Care 2023 May 1;46(5):1068-1075. doi: 10.2337/dc22-1168. PMID: 36930723Free PMC Article
Shi Q, Wang Q, Wang Z, Lu J, Wang R
Front Immunol 2023;14:1088778. Epub 2023 Feb 10 doi: 10.3389/fimmu.2023.1088778. PMID: 36845092Free PMC Article
Chaudhary S, Zaveri J, Becker N
Dis Mon 2021 May;67(5):101140. Epub 2021 Feb 3 doi: 10.1016/j.disamonth.2021.101140. PMID: 33546872
Villegas VM, Schwartz SG
Curr Pharm Des 2018;24(41):4903-4910. doi: 10.2174/1381612825666190130140717. PMID: 30706803
Writing Committee for the Diabetic Retinopathy Clinical Research Network, Gross JG, Glassman AR, Jampol LM, Inusah S, Aiello LP, Antoszyk AN, Baker CW, Berger BB, Bressler NM, Browning D, Elman MJ, Ferris FL 3rd, Friedman SM, Marcus DM, Melia M, Stockdale CR, Sun JK, Beck RW
JAMA 2015 Nov 24;314(20):2137-2146. doi: 10.1001/jama.2015.15217. PMID: 26565927Free PMC Article

Therapy

Shi Q, Wang Q, Wang Z, Lu J, Wang R
Front Immunol 2023;14:1088778. Epub 2023 Feb 10 doi: 10.3389/fimmu.2023.1088778. PMID: 36845092Free PMC Article
Antoszyk AN, Glassman AR, Beaulieu WT, Jampol LM, Jhaveri CD, Punjabi OS, Salehi-Had H, Wells JA 3rd, Maguire MG, Stockdale CR, Martin DF, Sun JK; DRCR Retina Network
JAMA 2020 Dec 15;324(23):2383-2395. doi: 10.1001/jama.2020.23027. PMID: 33320223Free PMC Article
Gross JG, Glassman AR, Liu D, Sun JK, Antoszyk AN, Baker CW, Bressler NM, Elman MJ, Ferris FL 3rd, Gardner TW, Jampol LM, Martin DF, Melia M, Stockdale CR, Beck RW; Diabetic Retinopathy Clinical Research Network
JAMA Ophthalmol 2018 Oct 1;136(10):1138-1148. doi: 10.1001/jamaophthalmol.2018.3255. PMID: 30043039Free PMC Article
Writing Committee for the Diabetic Retinopathy Clinical Research Network, Gross JG, Glassman AR, Jampol LM, Inusah S, Aiello LP, Antoszyk AN, Baker CW, Berger BB, Bressler NM, Browning D, Elman MJ, Ferris FL 3rd, Friedman SM, Marcus DM, Melia M, Stockdale CR, Sun JK, Beck RW
JAMA 2015 Nov 24;314(20):2137-2146. doi: 10.1001/jama.2015.15217. PMID: 26565927Free PMC Article
Ophthalmology 1991 May;98(5 Suppl):741-56. doi: 10.1016/s0161-6420(13)38009-9. PMID: 2062510

Prognosis

Schreur V, Brouwers J, Van Huet RAC, Smeets S, Phan M, Hoyng CB, de Jong EK, Klevering BJ
Acta Ophthalmol 2021 Feb;99(1):83-89. Epub 2020 Jul 9 doi: 10.1111/aos.14482. PMID: 32643273Free PMC Article
Sabanayagam C, Banu R, Chee ML, Lee R, Wang YX, Tan G, Jonas JB, Lamoureux EL, Cheng CY, Klein BEK, Mitchell P, Klein R, Cheung CMG, Wong TY
Lancet Diabetes Endocrinol 2019 Feb;7(2):140-149. Epub 2018 Jul 11 doi: 10.1016/S2213-8587(18)30128-1. PMID: 30005958
Gross JG, Glassman AR, Liu D, Sun JK, Antoszyk AN, Baker CW, Bressler NM, Elman MJ, Ferris FL 3rd, Gardner TW, Jampol LM, Martin DF, Melia M, Stockdale CR, Beck RW; Diabetic Retinopathy Clinical Research Network
JAMA Ophthalmol 2018 Oct 1;136(10):1138-1148. doi: 10.1001/jamaophthalmol.2018.3255. PMID: 30043039Free PMC Article
Hendrick AM, Lavine JA, Domalpally A, Kulkarni AD, Ip MS
Ophthalmic Surg Lasers Imaging Retina 2018 Jan 1;49(1):35-40. doi: 10.3928/23258160-20171215-05. PMID: 29304264
Ophthalmology 1991 May;98(5 Suppl):741-56. doi: 10.1016/s0161-6420(13)38009-9. PMID: 2062510

Clinical prediction guides

Fang J, Luo C, Zhang D, He Q, Liu L
Front Endocrinol (Lausanne) 2023;14:1265711. Epub 2023 Nov 1 doi: 10.3389/fendo.2023.1265711. PMID: 38027162Free PMC Article
Xie X, Lian C, Zhang Z, Feng M, Wang W, Yuan X, Shi Y, Liu T
Front Endocrinol (Lausanne) 2023;14:1144422. Epub 2023 May 16 doi: 10.3389/fendo.2023.1144422. PMID: 37260449Free PMC Article
Shi Q, Wang Q, Wang Z, Lu J, Wang R
Front Immunol 2023;14:1088778. Epub 2023 Feb 10 doi: 10.3389/fimmu.2023.1088778. PMID: 36845092Free PMC Article
Antoszyk AN, Glassman AR, Beaulieu WT, Jampol LM, Jhaveri CD, Punjabi OS, Salehi-Had H, Wells JA 3rd, Maguire MG, Stockdale CR, Martin DF, Sun JK; DRCR Retina Network
JAMA 2020 Dec 15;324(23):2383-2395. doi: 10.1001/jama.2020.23027. PMID: 33320223Free PMC Article
Nawaz IM, Rezzola S, Cancarini A, Russo A, Costagliola C, Semeraro F, Presta M
Prog Retin Eye Res 2019 Sep;72:100756. Epub 2019 Apr 2 doi: 10.1016/j.preteyeres.2019.03.002. PMID: 30951889

Recent systematic reviews

Kataoka SY, Lois N, Kawano S, Kataoka Y, Inoue K, Watanabe N
Cochrane Database Syst Rev 2023 Jun 13;6(6):CD013318. doi: 10.1002/14651858.CD013318.pub2. PMID: 37310870Free PMC Article
Martinez-Zapata MJ, Salvador I, Martí-Carvajal AJ, Pijoan JI, Cordero JA, Ponomarev D, Kernohan A, Solà I, Virgili G
Cochrane Database Syst Rev 2023 Mar 20;3(3):CD008721. doi: 10.1002/14651858.CD008721.pub3. PMID: 36939655Free PMC Article
Perais J, Agarwal R, Evans JR, Loveman E, Colquitt JL, Owens D, Hogg RE, Lawrenson JG, Takwoingi Y, Lois N
Cochrane Database Syst Rev 2023 Feb 22;2(2):CD013775. doi: 10.1002/14651858.CD013775.pub2. PMID: 36815723Free PMC Article
Sabanayagam C, Banu R, Chee ML, Lee R, Wang YX, Tan G, Jonas JB, Lamoureux EL, Cheng CY, Klein BEK, Mitchell P, Klein R, Cheung CMG, Wong TY
Lancet Diabetes Endocrinol 2019 Feb;7(2):140-149. Epub 2018 Jul 11 doi: 10.1016/S2213-8587(18)30128-1. PMID: 30005958
Moutray T, Evans JR, Lois N, Armstrong DJ, Peto T, Azuara-Blanco A
Cochrane Database Syst Rev 2018 Mar 15;3(3):CD012314. doi: 10.1002/14651858.CD012314.pub2. PMID: 29543992Free PMC Article

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