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Plantar fibromatosis

MedGen UID:
56385
Concept ID:
C0158360
Neoplastic Process
Synonyms: Ledderhose disease; Lederhose disease
SNOMED CT: Plantar fascial fibromatosis (13370002); Plantar fibromatosis (13370002); Ledderhose's disease (13370002); Dupuytren disease of foot (13370002)
 
Monarch Initiative: MONDO:0004684
Orphanet: ORPHA199251

Definition

A rare, benign, superficial fibromatosis disease characterized by single or multiple, uni- or bilateral, fixed, slow-growing, round, firm nodules typically located on the medial portion of the plantar aponeurosis, with no calcification. Patients are often asymptomatic or may present with foot pain, difficulty to walk or stand and, rarely, toe contractures. Histopathology reveals dense fibrocellular tissue with parallel and nodular arrays of fibrocytes and fibrillar collagen with a distinctive cork-screw morphology and no atypia. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlantar fibromatosis
Follow this link to review classifications for Plantar fibromatosis in Orphanet.

Professional guidelines

PubMed

Fuiano M, Mosca M, Caravelli S, Massimi S, Benedetti MG, Di Caprio F, Mosca S, Zaffagnini S
Foot Ankle Surg 2019 Oct;25(5):559-564. Epub 2018 Jun 11 doi: 10.1016/j.fas.2018.06.001. PMID: 30321942
Schuster J, Saraiya S, Tennyson N, Nedelka M, Mukhopadhyay N, Weiss E
Pract Radiat Oncol 2015 Nov-Dec;5(6):e651-8. Epub 2015 Jul 2 doi: 10.1016/j.prro.2015.06.010. PMID: 26421835
Gómez FM, Patel PA, Stuart S, Roebuck DJ
Pediatr Radiol 2014 Oct;44(10):1281-9. Epub 2014 May 13 doi: 10.1007/s00247-014-3001-5. PMID: 24821394

Recent clinical studies

Etiology

Hsu CY, Ke DS, Lin CL, Kao CH
PLoS One 2021;16(11):e0259942. Epub 2021 Nov 24 doi: 10.1371/journal.pone.0259942. PMID: 34818359Free PMC Article
Kelenjian S, Mattjie RA, Franz R, Biedermann T, Brockow K
J Dtsch Dermatol Ges 2019 Apr;17(4):393-397. Epub 2019 Mar 13 doi: 10.1111/ddg.13808. PMID: 30865379
Neagu TP, Ţigliş M, Popescu A, Enache V, Popescu ŞA, Lascăr I
Rom J Morphol Embryol 2018;59(3):691-697. PMID: 30534806
Cohen BE, Murthy NS, McKenzie GA
J Ultrasound Med 2018 Nov;37(11):2725-2731. Epub 2018 Mar 30 doi: 10.1002/jum.14615. PMID: 29603334
Robbin MR, Murphey MD, Temple HT, Kransdorf MJ, Choi JJ
Radiographics 2001 May-Jun;21(3):585-600. doi: 10.1148/radiographics.21.3.g01ma21585. PMID: 11353108

Diagnosis

Hsu CY, Ke DS, Lin CL, Kao CH
PLoS One 2021;16(11):e0259942. Epub 2021 Nov 24 doi: 10.1371/journal.pone.0259942. PMID: 34818359Free PMC Article
Newman C, McQuaid SE
Ir Med J 2019 Apr 11;112(4):919. PMID: 31243948
Carroll P, Henshaw RM, Garwood C, Raspovic K, Kumar D
Foot Ankle Spec 2018 Apr;11(2):168-176. Epub 2018 Jan 9 doi: 10.1177/1938640017751184. PMID: 29310463
Zgonis T, Jolly GP, Polyzois V, Kanuck DM, Stamatis ED
Clin Podiatr Med Surg 2005 Jan;22(1):11-8. doi: 10.1016/j.cpm.2004.08.002. PMID: 15555840
Landers PA, Yu GV, White JM, Farrer AK
J Foot Ankle Surg 1993 Jan-Feb;32(1):85-93. PMID: 8318966

Therapy

Schoenfeld JD, Agaram NP, Lefkowitz RA, Kelly CM, Healey JH, Gounder MM
Oncologist 2022 Mar 11;27(3):e294-e296. doi: 10.1093/oncolo/oyab050. PMID: 35274715Free PMC Article
Hwang JT, Yoon KJ, Park CH, Choi JH, Park HJ, Park YS, Lee YT
PLoS One 2020;15(8):e0237447. Epub 2020 Aug 10 doi: 10.1371/journal.pone.0237447. PMID: 32776988Free PMC Article
Lehrman JD, Miceli ALL, Tabchi SG, Kaplan MA
J Foot Ankle Surg 2019 Nov;58(6):1281-1284. doi: 10.1053/j.jfas.2019.04.006. PMID: 31679681
Veith NT, Tschernig T, Histing T, Madry H
Foot Ankle Int 2013 Dec;34(12):1742-6. Epub 2013 Sep 16 doi: 10.1177/1071100713505535. PMID: 24043350
Knobloch K, Vogt PM
BMC Res Notes 2012 Oct 2;5:542. doi: 10.1186/1756-0500-5-542. PMID: 23031080Free PMC Article

Prognosis

Hwang JT, Yoon KJ, Park CH, Choi JH, Park HJ, Park YS, Lee YT
PLoS One 2020;15(8):e0237447. Epub 2020 Aug 10 doi: 10.1371/journal.pone.0237447. PMID: 32776988Free PMC Article
Kelenjian S, Mattjie RA, Franz R, Biedermann T, Brockow K
J Dtsch Dermatol Ges 2019 Apr;17(4):393-397. Epub 2019 Mar 13 doi: 10.1111/ddg.13808. PMID: 30865379
Yasui Y, Takao M, Miyamoto W, Matsushita T
J Orthop Sci 2016 May;21(3):395-8. Epub 2015 Jun 29 doi: 10.1016/j.jos.2015.06.003. PMID: 26740438
Argerakis NG, Positano RG, Positano RC, Boccio AK, Adler RS, Saboeiro GR, Dines JS
J Am Podiatr Med Assoc 2015 Mar;105(2):135-40. doi: 10.7547/0003-0538-105.2.135. PMID: 25815653
Godette GA, O'Sullivan M, Menelaus MB
J Pediatr Orthop 1997 Jan-Feb;17(1):16-7. PMID: 8989694

Clinical prediction guides

Hwang JT, Yoon KJ, Park CH, Choi JH, Park HJ, Park YS, Lee YT
PLoS One 2020;15(8):e0237447. Epub 2020 Aug 10 doi: 10.1371/journal.pone.0237447. PMID: 32776988Free PMC Article
Ahmed M, Weinstein JL, Hussain J, Sarwar A, Anderson M, Dillon B
Cardiovasc Intervent Radiol 2018 Feb;41(2):298-304. Epub 2017 Oct 3 doi: 10.1007/s00270-017-1801-3. PMID: 28975378
de Bree E, Zoetmulder FA, Keus RB, Peterse HL, van Coevorden F
Am J Surg 2004 Jan;187(1):33-8. doi: 10.1016/j.amjsurg.2002.11.002. PMID: 14706583
de Palma L, Santucci A, Gigante A, Di Giulio A, Carloni S
Foot Ankle Int 1999 Apr;20(4):253-7. doi: 10.1177/107110079902000408. PMID: 10229282
Godette GA, O'Sullivan M, Menelaus MB
J Pediatr Orthop 1997 Jan-Feb;17(1):16-7. PMID: 8989694

Recent systematic reviews

Fuiano M, Mosca M, Caravelli S, Massimi S, Benedetti MG, Di Caprio F, Mosca S, Zaffagnini S
Foot Ankle Surg 2019 Oct;25(5):559-564. Epub 2018 Jun 11 doi: 10.1016/j.fas.2018.06.001. PMID: 30321942
Espert M, Anderson MR, Baumhauer JF
Foot Ankle Int 2018 Jun;39(6):751-757. Epub 2018 Apr 5 doi: 10.1177/1071100718768051. PMID: 29619843
Gómez FM, Patel PA, Stuart S, Roebuck DJ
Pediatr Radiol 2014 Oct;44(10):1281-9. Epub 2014 May 13 doi: 10.1007/s00247-014-3001-5. PMID: 24821394
Grenfell S, Borg M
J Med Imaging Radiat Oncol 2014 Oct;58(5):641-7. Epub 2014 Apr 14 doi: 10.1111/1754-9485.12178. PMID: 24730457

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

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