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Hemoglobin below reference range

MedGen UID:
56401
•Concept ID:
C0162119
•
Finding
Synonyms: Decreased hemoglobin; Low hemoglobin
SNOMED CT: Hemoglobin low (165397008); Hemoglobin below reference range (165397008)

Definition

A laboratory test result demonstrating decreased levels of hemoglobin in a biological specimen. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemoglobin below reference range

Professional guidelines

PubMed

Association of Achieving Time in Range Clinical Targets With Treatment Modality Among Youths With Type 1 Diabetes.
Dovc K, Lanzinger S, Cardona-Hernandez R, Tauschmann M, Marigliano M, Cherubini V, Preikša R, Schierloh U, Clapin H, AlJaser F, Pelicand J, Shukla R, Biester T
JAMA Netw Open 2023 Feb 1;6(2):e230077. doi: 10.1001/jamanetworkopen.2023.0077. PMID: 36808243Free PMC Article
Clinical utility of reticulocyte haemoglobin in the assessment of iron deficiency and iron deficiency anaemia in the paediatric population.
Perchard M, Barbaro P, Rane M, Norman A
J Paediatr Child Health 2023 Jan;59(1):153-158. Epub 2022 Nov 5 doi: 10.1111/jpc.16265. PMID: 36334002
Iron deficiency anemia: evaluation and management.
Short MW, Domagalski JE
Am Fam Physician 2013 Jan 15;87(2):98-104. PMID: 23317073

Recent clinical studies

Etiology

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Transfusion thresholds for guiding red blood cell transfusion.
Carson JL, Stanworth SJ, Dennis JA, Trivella M, Roubinian N, Fergusson DA, Triulzi D, Dorée C, Hébert PC
Cochrane Database Syst Rev 2021 Dec 21;12(12):CD002042. doi: 10.1002/14651858.CD002042.pub5. PMID: 34932836Free PMC Article
Nutrient Intake and Status of German Children and Adolescents Consuming Vegetarian, Vegan or Omnivore Diets: Results of the VeChi Youth Study.
Alexy U, Fischer M, Weder S, Längler A, Michalsen A, Sputtek A, Keller M
Nutrients 2021 May 18;13(5) doi: 10.3390/nu13051707. PMID: 34069944Free PMC Article
Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion.
Carson JL, Stanworth SJ, Roubinian N, Fergusson DA, Triulzi D, Doree C, Hebert PC
Cochrane Database Syst Rev 2016 Oct 12;10(10):CD002042. doi: 10.1002/14651858.CD002042.pub4. PMID: 27731885Free PMC Article
Low hemoglobin deferral in blood donors.
Mast AE
Transfus Med Rev 2014 Jan;28(1):18-22. Epub 2013 Nov 12 doi: 10.1016/j.tmrv.2013.11.001. PMID: 24332843Free PMC Article

Diagnosis

Diagnosing Anemia in Neonates: An Evidence-Based Approach.
Christensen RD, Bahr TM, Tweddell SM, Ohls RK, Henry E
Neoreviews 2023 Jun 1;24(6):e343-e355. doi: 10.1542/neo.24-6-e343. PMID: 37258503
Reference intervals for erythrocyte parameters and hemoglobin electrophoresis parameters for young children in Guangxi.
Zhou C, He S, Liu D, Zuo Y, Chen Q, Wang L, Chen B, Chen F, Luo J, Xu X, Lin L
Int J Lab Hematol 2023 Feb;45(1):104-111. Epub 2022 Sep 5 doi: 10.1111/ijlh.13965. PMID: 36064301
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Severe Anemia at Birth-Incidence and Implications.
Bahr TM, Lawrence SM, Henry E, Ohls RK, Li S, Christensen RD
J Pediatr 2022 Sep;248:39-45.e2. Epub 2022 Jun 1 doi: 10.1016/j.jpeds.2022.05.045. PMID: 35660494
Iron deficiency anemia: evaluation and management.
Short MW, Domagalski JE
Am Fam Physician 2013 Jan 15;87(2):98-104. PMID: 23317073

Therapy

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Transfusion thresholds for guiding red blood cell transfusion.
Carson JL, Stanworth SJ, Dennis JA, Trivella M, Roubinian N, Fergusson DA, Triulzi D, Dorée C, Hébert PC
Cochrane Database Syst Rev 2021 Dec 21;12(12):CD002042. doi: 10.1002/14651858.CD002042.pub5. PMID: 34932836Free PMC Article
Revisiting the basis for haemoglobin screening in pregnancy.
Daru J, Sobhy S, Pavord S
Curr Opin Obstet Gynecol 2019 Dec;31(6):388-392. doi: 10.1097/GCO.0000000000000580. PMID: 31573997
Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion.
Carson JL, Stanworth SJ, Roubinian N, Fergusson DA, Triulzi D, Doree C, Hebert PC
Cochrane Database Syst Rev 2016 Oct 12;10(10):CD002042. doi: 10.1002/14651858.CD002042.pub4. PMID: 27731885Free PMC Article
Iron deficiency anemia: evaluation and management.
Short MW, Domagalski JE
Am Fam Physician 2013 Jan 15;87(2):98-104. PMID: 23317073

Prognosis

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Severe Anemia at Birth-Incidence and Implications.
Bahr TM, Lawrence SM, Henry E, Ohls RK, Li S, Christensen RD
J Pediatr 2022 Sep;248:39-45.e2. Epub 2022 Jun 1 doi: 10.1016/j.jpeds.2022.05.045. PMID: 35660494
Glycated Hemoglobin and Subclinical Atherosclerosis in People Without Diabetes.
Rossello X, Raposeiras-Roubin S, Oliva B, Sánchez-Cabo F, García-Ruíz JM, Caimari F, Mendiguren JM, Lara-Pezzi E, Bueno H, Fernández-Friera L, Fernández-Ortiz A, Sanz J, Ibanez B, Fuster V
J Am Coll Cardiol 2021 Jun 8;77(22):2777-2791. doi: 10.1016/j.jacc.2021.03.335. PMID: 34082907
Hemoglobin Himeji and inconsistent hemoglobin A1c values: a case report.
Guedes V, Bettencourt-Silva R, Queirós J, Esteves MDL, Teles MJ, Carvalho D
J Med Case Rep 2017 Jul 26;11(1):201. doi: 10.1186/s13256-017-1377-1. PMID: 28743307Free PMC Article
Albuminuria in children.
Rademacher ER, Sinaiko AR
Curr Opin Nephrol Hypertens 2009 May;18(3):246-51. doi: 10.1097/MNH.0b013e3283294b98. PMID: 19276802

Clinical prediction guides

Association of Achieving Time in Range Clinical Targets With Treatment Modality Among Youths With Type 1 Diabetes.
Dovc K, Lanzinger S, Cardona-Hernandez R, Tauschmann M, Marigliano M, Cherubini V, Preikša R, Schierloh U, Clapin H, AlJaser F, Pelicand J, Shukla R, Biester T
JAMA Netw Open 2023 Feb 1;6(2):e230077. doi: 10.1001/jamanetworkopen.2023.0077. PMID: 36808243Free PMC Article
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Associations of Postoperative Hemoglobin Level and Clinical Outcomes in Patients Undergoing Mitral Valve Surgery.
Fan K, Gui R, Ji H, Ma X, Huang Y, Wu J, Chen B, Tan L, Yang Q, Wang Y
Clin Lab 2022 Jun 1;68(6) doi: 10.7754/Clin.Lab.2021.210838. PMID: 35704724
Glycated Hemoglobin and Subclinical Atherosclerosis in People Without Diabetes.
Rossello X, Raposeiras-Roubin S, Oliva B, Sánchez-Cabo F, García-Ruíz JM, Caimari F, Mendiguren JM, Lara-Pezzi E, Bueno H, Fernández-Friera L, Fernández-Ortiz A, Sanz J, Ibanez B, Fuster V
J Am Coll Cardiol 2021 Jun 8;77(22):2777-2791. doi: 10.1016/j.jacc.2021.03.335. PMID: 34082907
Albuminuria in children.
Rademacher ER, Sinaiko AR
Curr Opin Nephrol Hypertens 2009 May;18(3):246-51. doi: 10.1097/MNH.0b013e3283294b98. PMID: 19276802

Recent systematic reviews

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Transfusion thresholds for guiding red blood cell transfusion.
Carson JL, Stanworth SJ, Dennis JA, Trivella M, Roubinian N, Fergusson DA, Triulzi D, Dorée C, Hébert PC
Cochrane Database Syst Rev 2021 Dec 21;12(12):CD002042. doi: 10.1002/14651858.CD002042.pub5. PMID: 34932836Free PMC Article
Diagnosing type 2 diabetes using Hemoglobin A1c: a systematic review and meta-analysis of the diagnostic cutpoint based on microvascular complications.
Butler AE, English E, Kilpatrick ES, Östlundh L, Chemaitelly HS, Abu-Raddad LJ, Alberti KGMM, Atkin SL, John WG
Acta Diabetol 2021 Mar;58(3):279-300. Epub 2020 Nov 3 doi: 10.1007/s00592-020-01606-5. PMID: 33141338Free PMC Article
Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion.
Carson JL, Stanworth SJ, Roubinian N, Fergusson DA, Triulzi D, Doree C, Hebert PC
Cochrane Database Syst Rev 2016 Oct 12;10(10):CD002042. doi: 10.1002/14651858.CD002042.pub4. PMID: 27731885Free PMC Article
Markers of dysglycaemia and risk of coronary heart disease in people without diabetes: Reykjavik prospective study and systematic review.
Sarwar N, Aspelund T, Eiriksdottir G, Gobin R, Seshasai SR, Forouhi NG, Sigurdsson G, Danesh J, Gudnason V
PLoS Med 2010 May 25;7(5):e1000278. doi: 10.1371/journal.pmed.1000278. PMID: 20520805Free PMC Article

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