U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Irritant dermatitis

MedGen UID:
56513
•Concept ID:
C0162823
•
Disease or Syndrome
Synonyms: Dermatitides, Irritant; Dermatitides, Primary Irritant; Dermatitis, Irritant; Dermatitis, Primary Irritant; Irritant Dermatitides; Irritant Dermatitides, Primary; Irritant Dermatitis; Irritant Dermatitis, Primary; Primary Irritant Dermatitides; Primary Irritant Dermatitis
SNOMED CT: ICD - Irritant contact dermatitis (110979008); Primary irritant dermatitis (110979008); Non-allergic contact dermatitis (110979008); Irritant contact dermatitis (110979008)
 
Monarch Initiative: MONDO:0006564

Definition

An inflammatory skin condition caused by direct contact between the skin and an irritating substance. It is typically manifested by erythema, mild edema, and scaling at the affected site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIrritant dermatitis

Professional guidelines

PubMed

Diagnosis and Management of Dermatitis, Including Atopic, Contact, and Hand Eczemas.
Chan CX, Zug KA
Med Clin North Am 2021 Jul;105(4):611-626. doi: 10.1016/j.mcna.2021.04.003. PMID: 34059241
Allergic and irritant dermatitis: pathogenic and management aspects.
Marrakchi S
Recent Pat Inflamm Allergy Drug Discov 2012 Sep;6(3):167-8. doi: 10.2174/187221312802652875. PMID: 22827836
Diagnosis and management of contact dermatitis.
Usatine RP, Riojas M
Am Fam Physician 2010 Aug 1;82(3):249-55. PMID: 20672788

Recent clinical studies

Etiology

The Use of Tranexamic Acid to Prevent and Treat Post-Inflammatory Hyperpigmentation.
Lindgren AL, Austin AH, Welsh KM
J Drugs Dermatol 2021 Mar 1;20(3):344-345. doi: 10.36849/JDD.5622. PMID: 33683077
Peristomal Punctate Pemphigus.
Henning A, Bartenstein D, Kroshinsky D, Nazarian RM
Am J Dermatopathol 2021 Jul 1;43(7):510-513. doi: 10.1097/DAD.0000000000001845. PMID: 33156025
Irritant Contact Dermatitis.
Bains SN, Nash P, Fonacier L
Clin Rev Allergy Immunol 2019 Feb;56(1):99-109. doi: 10.1007/s12016-018-8713-0. PMID: 30293200
Dermatological and environmental toxicological impact of the sunscreen ingredient oxybenzone/benzophenone-3.
DiNardo JC, Downs CA
J Cosmet Dermatol 2018 Feb;17(1):15-19. Epub 2017 Oct 31 doi: 10.1111/jocd.12449. PMID: 29086472
Irritant Contact Dermatitis on Hands.
McGuckin M, Govednik J
Am J Med Qual 2017 Jan/Feb;32(1):93-99. Epub 2016 Jul 9 doi: 10.1177/1062860615611228. PMID: 26472960

Diagnosis

Novel insights into contact dermatitis.
Johansen JD, Bonefeld CM, Schwensen JFB, Thyssen JP, Uter W
J Allergy Clin Immunol 2022 Apr;149(4):1162-1171. Epub 2022 Feb 18 doi: 10.1016/j.jaci.2022.02.002. PMID: 35183605
Contact dermatitis.
Scheinman PL, Vocanson M, Thyssen JP, Johansen JD, Nixon RL, Dear K, Botto NC, Morot J, Goldminz AM
Nat Rev Dis Primers 2021 May 27;7(1):38. doi: 10.1038/s41572-021-00271-4. PMID: 34045488
Irritant Contact Dermatitis.
Bains SN, Nash P, Fonacier L
Clin Rev Allergy Immunol 2019 Feb;56(1):99-109. doi: 10.1007/s12016-018-8713-0. PMID: 30293200
Acute and Chronic Paronychia.
Leggit JC
Am Fam Physician 2017 Jul 1;96(1):44-51. PMID: 28671378
Allergic Contact Dermatitis.
Kostner L, Anzengruber F, Guillod C, Recher M, Schmid-Grendelmeier P, Navarini AA
Immunol Allergy Clin North Am 2017 Feb;37(1):141-152. doi: 10.1016/j.iac.2016.08.014. PMID: 27886903

Therapy

Photocontact Dermatitis and Its Clinical Mimics: an Overview for the Allergist.
Snyder M, Turrentine JE, Cruz PD Jr
Clin Rev Allergy Immunol 2019 Feb;56(1):32-40. doi: 10.1007/s12016-018-8696-x. PMID: 29951786
Contact dermatitis and patch testing for the allergist.
Fonacier L, Noor I
Ann Allergy Asthma Immunol 2018 Jun;120(6):592-598. Epub 2018 Mar 6 doi: 10.1016/j.anai.2018.03.003. PMID: 29522811
Wound-Related Allergic/Irritant Contact Dermatitis.
Alavi A, Sibbald RG, Ladizinski B, Saraiya A, Lee KC, Skotnicki-Grant S, Maibach H
Adv Skin Wound Care 2016 Jun;29(6):278-86. doi: 10.1097/01.ASW.0000482834.94375.1e. PMID: 27171256
Contact dermatitis: allergic and irritant.
Tan CH, Rasool S, Johnston GA
Clin Dermatol 2014 Jan-Feb;32(1):116-24. doi: 10.1016/j.clindermatol.2013.05.033. PMID: 24314385
Lavender.
Wu PA, James WD
Dermatitis 2011 Nov-Dec;22(6):344-7. doi: 10.2310/6620.2011.11040. PMID: 22653008

Prognosis

Causes of irritant contact dermatitis after occupational skin exposure: a systematic review.
Jacobsen G, Rasmussen K, Bregnhøj A, Isaksson M, Diepgen TL, Carstensen O
Int Arch Occup Environ Health 2022 Jan;95(1):35-65. Epub 2021 Oct 19 doi: 10.1007/s00420-021-01781-0. PMID: 34665298Free PMC Article
Hand Dermatitis: Pathology, Diagnosis, and Management.
LaCour M, Meaux T
Skinmed 2019;17(1):30-34. Epub 2019 Mar 19 PMID: 30888945
Irritant Contact Dermatitis.
Bains SN, Nash P, Fonacier L
Clin Rev Allergy Immunol 2019 Feb;56(1):99-109. doi: 10.1007/s12016-018-8713-0. PMID: 30293200
Wound-Related Allergic/Irritant Contact Dermatitis.
Alavi A, Sibbald RG, Ladizinski B, Saraiya A, Lee KC, Skotnicki-Grant S, Maibach H
Adv Skin Wound Care 2016 Jun;29(6):278-86. doi: 10.1097/01.ASW.0000482834.94375.1e. PMID: 27171256
Management of occupational dermatitis.
Clark SC, Zirwas MJ
Dermatol Clin 2009 Jul;27(3):365-83, vii-viii. doi: 10.1016/j.det.2009.05.002. PMID: 19580930

Clinical prediction guides

Main Clinical Features of Patients with Irritant and Allergic Contact Dermatitis on the Hands in Correlation with Skin CD44 Expression: A Prospective Study.
Novak-Bilić G, Vučić M, Pondeljak N, Bulat V, Japundžić I, Lugović-Mihić L
Acta Dermatovenerol Croat 2022 Nov;30(3):129-139. PMID: 36812269
Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis.
Fortino V, Wisgrill L, Werner P, Suomela S, Linder N, Jalonen E, Suomalainen A, Marwah V, Kero M, Pesonen M, Lundin J, Lauerma A, Aalto-Korte K, Greco D, Alenius H, Fyhrquist N
Proc Natl Acad Sci U S A 2020 Dec 29;117(52):33474-33485. Epub 2020 Dec 14 doi: 10.1073/pnas.2009192117. PMID: 33318199Free PMC Article
Hand Dermatitis: Pathology, Diagnosis, and Management.
LaCour M, Meaux T
Skinmed 2019;17(1):30-34. Epub 2019 Mar 19 PMID: 30888945
N-Acyl ethanolamide and eicosanoid involvement in irritant dermatitis.
Kendall AC, Pilkington SM, Sassano G, Rhodes LE, Nicolaou A
Br J Dermatol 2016 Jul;175(1):163-71. Epub 2016 Apr 28 doi: 10.1111/bjd.14521. PMID: 26947140
Contact dermatitis to topical acne drugs: a review of the literature.
Foti C, Romita P, Borghi A, Angelini G, Bonamonte D, Corazza M
Dermatol Ther 2015 Sep-Oct;28(5):323-9. Epub 2015 Aug 24 doi: 10.1111/dth.12282. PMID: 26302055

Recent systematic reviews

A systematic review of allergic and irritant contact dermatitis of the vulva: The most important allergens/irritants and the role of patch testing.
Vandeweege S, Debaene B, Lapeere H, Verstraelen H
Contact Dermatitis 2023 Apr;88(4):249-262. Epub 2022 Dec 13 doi: 10.1111/cod.14258. PMID: 36458568
Work-related and personal risk factors for occupational contact dermatitis: A systematic review of the literature with meta-analysis.
Schütte MG, Tamminga SJ, de Groene GJ, Kezic S, van der Molen HF
Contact Dermatitis 2023 Mar;88(3):171-187. Epub 2022 Dec 12 doi: 10.1111/cod.14253. PMID: 36444496Free PMC Article
Causes of irritant contact dermatitis after occupational skin exposure: a systematic review.
Jacobsen G, Rasmussen K, Bregnhøj A, Isaksson M, Diepgen TL, Carstensen O
Int Arch Occup Environ Health 2022 Jan;95(1):35-65. Epub 2021 Oct 19 doi: 10.1007/s00420-021-01781-0. PMID: 34665298Free PMC Article
How irritant are n-propanol and isopropanol? - A systematic review.
Tasar R, Wiegand C, Elsner P
Contact Dermatitis 2021 Jan;84(1):1-14. Epub 2020 Nov 11 doi: 10.1111/cod.13722. PMID: 33063847Free PMC Article
Skin diseases in musicians.
Crépy MN
Eur J Dermatol 2015 Sep-Oct;25(5):375-83. doi: 10.1684/ejd.2015.2559. PMID: 25905552

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...