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Cutaneous mucinosis

MedGen UID:
56520
•Concept ID:
C0162855
•
Disease or Syndrome
Synonyms: Mucinoses; Mucinosis
SNOMED CT: Mucinosis (11528001)
 
Monarch Initiative: MONDO:0002523

Definition

The mucinoses are a diverse group of disorders which have in common the deposition of basophilic, finely granular and stringy material (mucin) in the connective tissues of the dermis (dermal mucinoses), in the pilosebaceous follicles (follicular mucinoses), or in the epidermis and tumors derived therefrom (epithelial mucinoses). [from MONDO]

Professional guidelines

PubMed

Diffuse dermal mucinosis secondary to colony-stimulating factor 1 receptor monoclonal antibody treatment: A novel and peculiar drug-induced diffuse cutaneous mucinosis.
Olmos-Alpiste F, Segura S, Tomás-Velázquez A, Aguado L, España A, Arriola E, Martín-Algarra S, Barranco C, Lloreta J, Pujol RM
J Dermatol 2021 Mar;48(3):380-384. Epub 2020 Nov 20 doi: 10.1111/1346-8138.15662. PMID: 33216389

Recent clinical studies

Etiology

New and emerging conditions of acquired cutaneous mucinoses in adults.
Rongioletti F
J Eur Acad Dermatol Venereol 2022 Jul;36(7):1016-1024. Epub 2022 Feb 17 doi: 10.1111/jdv.17983. PMID: 35124832
Lichen myxedematosus: a rare group of cutaneous mucinosis.
Cárdenas-Gonzalez RE, Ruelas MEH, Candiani JO
An Bras Dermatol 2019;94(4):462-469. Epub 2019 Oct 17 doi: 10.1590/abd1806-4841.20198478. PMID: 31644623Free PMC Article
Cutaneous mucinosis of infancy: report of a rare case and review of the literature.
Chan C, Mann JA, Mihm MC Jr, Yan S, Momtahen S
Dermatol Online J 2018 Oct 15;24(10) PMID: 30677812
Self-healing juvenile cutaneous mucinosis: Clinical and histopathologic findings of 9 patients: The relevance of long-term follow-up.
Luchsinger I, Coulombe J, Rongioletti F, Haspeslagh M, Dompmartin A, Melki I, Dagher R, Bader-Meunier B, Fraitag S, Bodemer C
J Am Acad Dermatol 2018 Jun;78(6):1164-1170. Epub 2017 Oct 21 doi: 10.1016/j.jaad.2017.10.023. PMID: 29066274
Scleromyxedema without paraproteinemia.
Abarzúa AA, Giesen LF, Sandoval MO, González SB
Int J Dermatol 2014 Aug;53(8):971-4. Epub 2014 Feb 14 doi: 10.1111/ijd.12124. PMID: 24527753

Diagnosis

Self-healing juvenile cutaneous mucinosis.
Reneses Prieto E, López López A, López-Negrete Arenal EMª, Olmedo Díaz I
An Pediatr (Engl Ed) 2023 Nov;99(5):362-363. Epub 2023 Oct 30 doi: 10.1016/j.anpede.2023.10.004. PMID: 37914636
Lichen myxedematosus: a rare group of cutaneous mucinosis.
Cárdenas-Gonzalez RE, Ruelas MEH, Candiani JO
An Bras Dermatol 2019;94(4):462-469. Epub 2019 Oct 17 doi: 10.1590/abd1806-4841.20198478. PMID: 31644623Free PMC Article
Reticular Erythematous Mucinosis: A Rare Cutaneous.
Almohssen AA, Suresh RV, Schwartz RA
Acta Dermatovenerol Croat 2019 Mar;27(1):16-21. PMID: 31032786
Cutaneous mucinosis of infancy: report of a rare case and review of the literature.
Chan C, Mann JA, Mihm MC Jr, Yan S, Momtahen S
Dermatol Online J 2018 Oct 15;24(10) PMID: 30677812
Mucin as a diagnostic clue in dermatopathology.
Fernandez-Flores A, Saeb-Lima M
J Cutan Pathol 2016 Nov;43(11):1005-1016. Epub 2016 Sep 1 doi: 10.1111/cup.12782. PMID: 27500958

Therapy

Lichen Myxedematosus: Case Report and Review of Literature.
Geisler A, Hosseinipour M, Vyas NS, Phelps R, Gropper C, Hoffman C
J Drugs Dermatol 2020 Mar 1;19(3):320-322. doi: 10.36849/JDD.2020.4864. PMID: 32550685
An unusual presentation of scleromyxedema as inflammatory myopathy.
Vysakha KV, Poyuran R, Nair SS, Nair M
Acta Myol 2019 Mar;38(1):13-16. Epub 2019 Mar 1 PMID: 31309176Free PMC Article
Atypical Cutaneous Mucinosis Treated with Intravenous Immunoglobulin and Corticosteroid.
Gheisari M, Zerehpoush FB, Amani M, Ardalanrad Y, Dadkhahfar S
Skinmed 2018;16(6):428-431. Epub 2018 Dec 21 PMID: 30575516
Periocular Scleromyxedema.
Qureshi F, Dharmasena A, Leatherbarrow B
Ophthalmic Plast Reconstr Surg 2015 Sep-Oct;31(5):e119-20. doi: 10.1097/IOP.0000000000000144. PMID: 24807804
Scleromyxedema without paraproteinemia.
Abarzúa AA, Giesen LF, Sandoval MO, González SB
Int J Dermatol 2014 Aug;53(8):971-4. Epub 2014 Feb 14 doi: 10.1111/ijd.12124. PMID: 24527753

Prognosis

Lichen myxedematosus: a rare group of cutaneous mucinosis.
Cárdenas-Gonzalez RE, Ruelas MEH, Candiani JO
An Bras Dermatol 2019;94(4):462-469. Epub 2019 Oct 17 doi: 10.1590/abd1806-4841.20198478. PMID: 31644623Free PMC Article
Self-healing juvenile cutaneous mucinosis: Clinical and histopathologic findings of 9 patients: The relevance of long-term follow-up.
Luchsinger I, Coulombe J, Rongioletti F, Haspeslagh M, Dompmartin A, Melki I, Dagher R, Bader-Meunier B, Fraitag S, Bodemer C
J Am Acad Dermatol 2018 Jun;78(6):1164-1170. Epub 2017 Oct 21 doi: 10.1016/j.jaad.2017.10.023. PMID: 29066274
Congenital cutaneous mucinosis with spontaneous regression: an atypical cutaneous mucinosis of infancy?
Chen CW, Tsai TF, Chang SP, Chen YF, Hung CM
Clin Exp Dermatol 2009 Oct;34(7):804-7. Epub 2008 Dec 9 doi: 10.1111/j.1365-2230.2008.03000.x. PMID: 19077089
Lichen myxedematosus (papular mucinosis): new concepts and perspectives for an old disease.
Rongioletti F
Semin Cutan Med Surg 2006 Jun;25(2):100-4. doi: 10.1016/j.sder.2006.04.001. PMID: 16908401
Updated classification of papular mucinosis, lichen myxedematosus, and scleromyxedema.
Rongioletti F, Rebora A
J Am Acad Dermatol 2001 Feb;44(2):273-81. doi: 10.1067/mjd.2001.111630. PMID: 11174386

Clinical prediction guides

Cutaneous mucinosis of infancy: a rare case of joint involvement.
Morreale C, Bleidl D, Sementa AR, Malattia C
Pediatr Rheumatol Online J 2021 Jun 29;19(1):99. doi: 10.1186/s12969-021-00590-6. PMID: 34187505Free PMC Article
Case report and review of solitary cutaneous focal mucinosis: a unique primary cutaneous mucinosis unrelated to mucinosis-associated systemic diseases.
Cohen PR, Erickson CP, Calame A
Dermatol Online J 2020 Aug 15;26(8) PMID: 32941712
Lichen Myxedematosus: Case Report and Review of Literature.
Geisler A, Hosseinipour M, Vyas NS, Phelps R, Gropper C, Hoffman C
J Drugs Dermatol 2020 Mar 1;19(3):320-322. doi: 10.36849/JDD.2020.4864. PMID: 32550685
Scleromyxedema without paraproteinemia.
Abarzúa AA, Giesen LF, Sandoval MO, González SB
Int J Dermatol 2014 Aug;53(8):971-4. Epub 2014 Feb 14 doi: 10.1111/ijd.12124. PMID: 24527753
Plaque-like cutaneous mucinosis: case report and literature review.
Wriston CC, Rubin AI, Martin LK, Kossard S, Murrell DF
Am J Dermatopathol 2012 Jun;34(4):e50-4. doi: 10.1097/DAD.0b013e3181f87e91. PMID: 22617136

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