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Erythematous plaque

MedGen UID:
568360
Concept ID:
C0332477
Finding
Synonym: Erythematous plaques
SNOMED CT: Erythematous plaque (72768000)
 
HPO: HP:0025474

Definition

A plaque (a solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter) with a red or reddish color often associated with inflammation or irritation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVErythematous plaque

Conditions with this feature

Pityriasis rubra pilaris
MedGen UID:
45939
Concept ID:
C0032027
Disease or Syndrome
Pityriasis rubra pilaris is an uncommon skin disorder characterized by the appearance of keratotic follicular papules, well-demarcated salmon-colored erythematous plaques covered with fine powdery scales interspersed with distinct islands of uninvolved skin, and palmoplantar keratoderma. Most cases are sporadic, although up to 6.5% of PRP-affected individuals report a positive family history. The rare familial cases show autosomal dominant inheritance with incomplete penetrance and variable expression: the disorder is usually present at birth or appears during the first years of life and is characterized by prominent follicular hyperkeratosis, diffuse palmoplantar keratoderma, and erythema, with only a modest response to treatment (summary by Fuchs-Telem et al., 2012).
Annular epidermolytic ichthyosis
MedGen UID:
334410
Concept ID:
C1843463
Disease or Syndrome
A rare clinical variant of epidermolytic ichthyosis, with manifestations of blistering phenotype at birth and the development from early infancy of annular polycyclic erythematous scales on the trunk and extremities. It has been reported in less than 10 families. The disease is caused by mutations in the KRT1 (12q11-q13) and KRT10 (17q21-q23) genes, encoding keratins 1 and 10 respectively. These mutations impair keratin filament formation and weaken the structural stability of the keratinocyte cytoskeleton. Transmission is autosomal dominant.
Erythrokeratodermia variabilis et progressiva 6
MedGen UID:
1681026
Concept ID:
C5193144
Disease or Syndrome
EKVP6 is characterized by erythematous hyperkeratotic plaques that develop within the first year of life, beginning on distal extremities and progressing to involve the face, wrists, and ankles, with sparing of volar surfaces. Intrafamilial variation in severity has been observed, and most affected individuals experience slowly progressive spontaneous remission after puberty (Wang et al., 2019). For a general phenotypic description and discussion of genetic heterogeneity of EKVP, see EKVP1 (133200).

Professional guidelines

PubMed

Cantarini L, Rigante D, Lucherini OM, Cimaz R, Laghi Pasini F, Baldari CT, Benucci M, Simonini G, Di Sabatino V, Brizi MG, Galeazzi M
Int J Immunopathol Pharmacol 2010 Jul-Sep;23(3):701-7. doi: 10.1177/039463201002300303. PMID: 20943039

Recent clinical studies

Etiology

Osto M, Afify O, Musa A, Ahmed U, Rehman R, Mehregan D
Int J Dermatol 2023 Mar;62(3):312-321. Epub 2022 Apr 29 doi: 10.1111/ijd.16224. PMID: 35485962
Lemsanni M, Najeb Y, Zoukal S, Chafik R, Madhar M, Elhaoury H
Hand Surg Rehabil 2021 Sep;40(4):505-512. Epub 2021 Mar 31 doi: 10.1016/j.hansur.2021.02.004. PMID: 33812083
Ganjei Z, Bahmani K
Int J Clin Pharmacol Ther 2021 Mar;59(3):254-256. doi: 10.5414/CP203789. PMID: 33191905
Apalla Z, Errichetti E, Kyrgidis A, Stolz W, Puig S, Malvehy J, Zalaudek I, Moscarella E, Longo C, Blum A, Lanssens S, Savoia F, Tschandl P, Kittler H, Sinz C, Stinco G, Argenziano G, Lazaridou E, Lallas A
J Eur Acad Dermatol Venereol 2019 Oct;33(10):1892-1898. Epub 2019 Jul 3 doi: 10.1111/jdv.15732. PMID: 31270878
Kagaya M, Kondo S, Kamada A, Yamada Y, Matsusaka H, Jimbow K
Dermatology 2002;204(1):72-4. doi: 10.1159/000051815. PMID: 11834855

Diagnosis

Masood M, Heath CR, Usatine RP
J Fam Pract 2022 Dec;71(10):E13-E14. doi: 10.12788/jfp.0528. PMID: 36735943
Leite LL, Bakos RM
Cutis 2022 Apr;109(4):E21-E23. doi: 10.12788/cutis.0521. PMID: 35659852
Roque Quintana B, Peñate Y, Montenegro Dámaso T
Dermatol Online J 2020 May 15;26(5) PMID: 32621704
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Miguel TS, Costa DAD, Almeida APM, Pino LCM, Goldemberg DC, Miguel BS, Coelho Filho SCH
Rev Assoc Med Bras (1992) 2018 Jun;64(6):492-497. doi: 10.1590/1806-9282.64.06.492. PMID: 30304305

Therapy

Edminister JR, Patel HA, Pixley JN, Huang WW, Jorizzo JL
JAMA Dermatol 2023 Jun 1;159(6):669-671. doi: 10.1001/jamadermatol.2023.0435. PMID: 37043228
Osto M, Afify O, Musa A, Ahmed U, Rehman R, Mehregan D
Int J Dermatol 2023 Mar;62(3):312-321. Epub 2022 Apr 29 doi: 10.1111/ijd.16224. PMID: 35485962
Garg T, Ramchander, Shrihar R, Gupta TP, Aggarwal S
Skinmed 2011 Mar-Apr;9(2):125-6. PMID: 21548522
Kagaya M, Kondo S, Kamada A, Yamada Y, Matsusaka H, Jimbow K
Dermatology 2002;204(1):72-4. doi: 10.1159/000051815. PMID: 11834855
Wong SS, Goh CL
Clin Exp Dermatol 1999 May;24(3):183-5. doi: 10.1046/j.1365-2230.1999.00449.x. PMID: 10354175

Prognosis

Osto M, Afify O, Musa A, Ahmed U, Rehman R, Mehregan D
Int J Dermatol 2023 Mar;62(3):312-321. Epub 2022 Apr 29 doi: 10.1111/ijd.16224. PMID: 35485962
Lemsanni M, Najeb Y, Zoukal S, Chafik R, Madhar M, Elhaoury H
Hand Surg Rehabil 2021 Sep;40(4):505-512. Epub 2021 Mar 31 doi: 10.1016/j.hansur.2021.02.004. PMID: 33812083
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Drago F, Ciccarese G, Rebora A, Broccolo F, Parodi A
Dermatology 2016;232(4):431-7. Epub 2016 Apr 21 doi: 10.1159/000445375. PMID: 27096928
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article

Clinical prediction guides

Lemsanni M, Najeb Y, Zoukal S, Chafik R, Madhar M, Elhaoury H
Hand Surg Rehabil 2021 Sep;40(4):505-512. Epub 2021 Mar 31 doi: 10.1016/j.hansur.2021.02.004. PMID: 33812083
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Beutler BD, Cohen PR
Dermatol Online J 2014 Dec 12;21(2) PMID: 25756481
Lencastre A, Cabete J, Apetato MM
An Bras Dermatol 2013 Sep-Oct;88(5):828-30. doi: 10.1590/abd1806-4841.20132311. PMID: 24173197Free PMC Article
Wilmer A, Kaatz M, Bocker T, Wollina U
Eur J Dermatol 1999 Jan-Feb;9(1):51-3. PMID: 9920990

Recent systematic reviews

Osto M, Afify O, Musa A, Ahmed U, Rehman R, Mehregan D
Int J Dermatol 2023 Mar;62(3):312-321. Epub 2022 Apr 29 doi: 10.1111/ijd.16224. PMID: 35485962
Wang X, Wang P, Wang M, Huang X, Wang C, Qu X, Xu J, Lu Y, Chai B, Huang C
Int J Dermatol 2021 Oct;60(10):1190-1198. Epub 2021 Feb 17 doi: 10.1111/ijd.15397. PMID: 33598913
Pedrosa MS, de Paiva M, Oliveira L, Pereira S, da Silva C, Pompeu J
Aust Dent J 2017 Dec;62(4):404-411. Epub 2017 Jun 28 doi: 10.1111/adj.12516. PMID: 28379606

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