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Moon facies

MedGen UID:
568451
Concept ID:
C0332601
Sign or Symptom
Synonym: Puffy face
SNOMED CT: Cushingoid facies (67967009); Moon face (67967009); Steroid facies (67967009)
 
HPO: HP:0500011

Definition

A rounded, puffy face with fat deposits in the temporal fossa and cheeks, a double chin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMoon facies

Conditions with this feature

Pigmented nodular adrenocortical disease, primary, 4
MedGen UID:
862862
Concept ID:
C4014425
Disease or Syndrome
Cushing syndrome is a clinical designation for the systemic signs and symptoms arising from excess cortisol production. Affected individuals typically show hypertension, impaired glucose tolerance, central obesity, osteoporosis, and sometimes depression. Corticotropin-independent Cushing syndrome results from autonomous cortisol production by the adrenal glands, often associated with adrenocortical tumors. Adrenocortical tumors are most common in adult females (summary by Cao et al., 2014; Sato et al., 2014).
Tessadori-Van Haaften neurodevelopmental syndrome 3
MedGen UID:
1824083
Concept ID:
C5774310
Disease or Syndrome
Tessadori-Bicknell-van Haaften neurodevelopmental syndrome-3 (TEBIVANED3) is characterized by global developmental delay with poor overall growth, impaired intellectual development, and speech difficulties. More variable features include hypotonia, microcephaly, and dysmorphic facies. The severity and manifestations of the disorder are highly variable (Tessadori et al., 2022). For a discussion of genetic heterogeneity of Tessadori-Bicknell-van Haaften neurodevelopmental disorder, see TEBIVANED1 (619758).

Professional guidelines

PubMed

Morand M, Roth M, Peterson SK, Bednar EM, Ramdaney A, Livingston JA, Yarbrough A, Corredor J
Support Care Cancer 2022 Jun;30(6):5481-5489. Epub 2022 Mar 19 doi: 10.1007/s00520-022-06974-y. PMID: 35306607Free PMC Article
Moon J, Choi SH, Lee MJ, Jo DH, Park UC, Yoon SO, Woo SJ, Oh JY
Ocul Surf 2021 Jan;19:16-30. Epub 2020 Nov 22 doi: 10.1016/j.jtos.2020.11.006. PMID: 33238207
Buliman A, Tataranu LG, Paun DL, Mirica A, Dumitrache C
J Med Life 2016 Jan-Mar;9(1):12-18. PMID: 27974908Free PMC Article

Recent clinical studies

Etiology

Narula N, Dhillon A, Zhang D, Sherlock ME, Tondeur M, Zachos M
Cochrane Database Syst Rev 2018 Apr 1;4(4):CD000542. doi: 10.1002/14651858.CD000542.pub3. PMID: 29607496Free PMC Article
Hughes RA, Mehndiratta MM, Rajabally YA
Cochrane Database Syst Rev 2017 Nov 29;11(11):CD002062. doi: 10.1002/14651858.CD002062.pub4. PMID: 29185258Free PMC Article
Hughes RA, Mehndiratta MM
Cochrane Database Syst Rev 2015 Jan 5;1:CD002062. doi: 10.1002/14651858.CD002062.pub3. PMID: 25561247
Kuenzig ME, Rezaie A, Seow CH, Otley AR, Steinhart AH, Griffiths AM, Kaplan GG, Benchimol EI
Cochrane Database Syst Rev 2014 Aug 21;2014(8):CD002913. doi: 10.1002/14651858.CD002913.pub3. PMID: 25141071Free PMC Article
Hughes RA, Mehndiratta MM
Cochrane Database Syst Rev 2012 Aug 15;(8):CD002062. doi: 10.1002/14651858.CD002062.pub2. PMID: 22895925

Diagnosis

Narula N, Dhillon A, Zhang D, Sherlock ME, Tondeur M, Zachos M
Cochrane Database Syst Rev 2018 Apr 1;4(4):CD000542. doi: 10.1002/14651858.CD000542.pub3. PMID: 29607496Free PMC Article
Hughes RA, Mehndiratta MM, Rajabally YA
Cochrane Database Syst Rev 2017 Nov 29;11(11):CD002062. doi: 10.1002/14651858.CD002062.pub4. PMID: 29185258Free PMC Article
Hughes RA, Mehndiratta MM
Cochrane Database Syst Rev 2015 Jan 5;1:CD002062. doi: 10.1002/14651858.CD002062.pub3. PMID: 25561247
Hughes RA, Mehndiratta MM
Cochrane Database Syst Rev 2012 Aug 15;(8):CD002062. doi: 10.1002/14651858.CD002062.pub2. PMID: 22895925
Bochner F, Burke CJ, Lloyd HM, Nurnberg BI
Am J Med 1979 Sep;67(3):507-10. doi: 10.1016/0002-9343(79)90801-5. PMID: 474597

Therapy

Narula N, Dhillon A, Zhang D, Sherlock ME, Tondeur M, Zachos M
Cochrane Database Syst Rev 2018 Apr 1;4(4):CD000542. doi: 10.1002/14651858.CD000542.pub3. PMID: 29607496Free PMC Article
Hughes RA, Mehndiratta MM, Rajabally YA
Cochrane Database Syst Rev 2017 Nov 29;11(11):CD002062. doi: 10.1002/14651858.CD002062.pub4. PMID: 29185258Free PMC Article
Hughes RA, Mehndiratta MM
Cochrane Database Syst Rev 2015 Jan 5;1:CD002062. doi: 10.1002/14651858.CD002062.pub3. PMID: 25561247
Kuenzig ME, Rezaie A, Seow CH, Otley AR, Steinhart AH, Griffiths AM, Kaplan GG, Benchimol EI
Cochrane Database Syst Rev 2014 Aug 21;2014(8):CD002913. doi: 10.1002/14651858.CD002913.pub3. PMID: 25141071Free PMC Article
Hughes RA, Mehndiratta MM
Cochrane Database Syst Rev 2012 Aug 15;(8):CD002062. doi: 10.1002/14651858.CD002062.pub2. PMID: 22895925

Prognosis

Hurtado MD, Cortes T, Natt N, Young WF Jr, Bancos I
Clin Endocrinol (Oxf) 2018 Dec;89(6):721-733. Epub 2018 Jul 23 doi: 10.1111/cen.13803. PMID: 29968420Free PMC Article
Hughes RA, Mehndiratta MM, Rajabally YA
Cochrane Database Syst Rev 2017 Nov 29;11(11):CD002062. doi: 10.1002/14651858.CD002062.pub4. PMID: 29185258Free PMC Article
Hughes RA, Mehndiratta MM
Cochrane Database Syst Rev 2015 Jan 5;1:CD002062. doi: 10.1002/14651858.CD002062.pub3. PMID: 25561247
Kuenzig ME, Rezaie A, Seow CH, Otley AR, Steinhart AH, Griffiths AM, Kaplan GG, Benchimol EI
Cochrane Database Syst Rev 2014 Aug 21;2014(8):CD002913. doi: 10.1002/14651858.CD002913.pub3. PMID: 25141071Free PMC Article
Hughes RA, Mehndiratta MM
Cochrane Database Syst Rev 2012 Aug 15;(8):CD002062. doi: 10.1002/14651858.CD002062.pub2. PMID: 22895925

Clinical prediction guides

Hurtado MD, Cortes T, Natt N, Young WF Jr, Bancos I
Clin Endocrinol (Oxf) 2018 Dec;89(6):721-733. Epub 2018 Jul 23 doi: 10.1111/cen.13803. PMID: 29968420Free PMC Article
Hughes RA, Mehndiratta MM, Rajabally YA
Cochrane Database Syst Rev 2017 Nov 29;11(11):CD002062. doi: 10.1002/14651858.CD002062.pub4. PMID: 29185258Free PMC Article
Hughes RA, Mehndiratta MM
Cochrane Database Syst Rev 2015 Jan 5;1:CD002062. doi: 10.1002/14651858.CD002062.pub3. PMID: 25561247
Kuenzig ME, Rezaie A, Seow CH, Otley AR, Steinhart AH, Griffiths AM, Kaplan GG, Benchimol EI
Cochrane Database Syst Rev 2014 Aug 21;2014(8):CD002913. doi: 10.1002/14651858.CD002913.pub3. PMID: 25141071Free PMC Article
Hughes RA, Mehndiratta MM
Cochrane Database Syst Rev 2012 Aug 15;(8):CD002062. doi: 10.1002/14651858.CD002062.pub2. PMID: 22895925

Recent systematic reviews

Narula N, Dhillon A, Zhang D, Sherlock ME, Tondeur M, Zachos M
Cochrane Database Syst Rev 2018 Apr 1;4(4):CD000542. doi: 10.1002/14651858.CD000542.pub3. PMID: 29607496Free PMC Article
Hughes RA, Mehndiratta MM, Rajabally YA
Cochrane Database Syst Rev 2017 Nov 29;11(11):CD002062. doi: 10.1002/14651858.CD002062.pub4. PMID: 29185258Free PMC Article
Hughes RA, Mehndiratta MM
Cochrane Database Syst Rev 2015 Jan 5;1:CD002062. doi: 10.1002/14651858.CD002062.pub3. PMID: 25561247
Kuenzig ME, Rezaie A, Seow CH, Otley AR, Steinhart AH, Griffiths AM, Kaplan GG, Benchimol EI
Cochrane Database Syst Rev 2014 Aug 21;2014(8):CD002913. doi: 10.1002/14651858.CD002913.pub3. PMID: 25141071Free PMC Article
Hughes RA, Mehndiratta MM
Cochrane Database Syst Rev 2012 Aug 15;(8):CD002062. doi: 10.1002/14651858.CD002062.pub2. PMID: 22895925

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