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MedGen UID:
Concept ID:
Cell or Molecular Dysfunction
Synonym: Karyomegaly
SNOMED CT: Macronucleus (6855001); Karyomegaly (6855001)


An increase in the size of a cellular nucleus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMacronucleus

Professional guidelines


Pivovarčíková K, Martínek P, Trpkov K, Alaghehbandan R, Magi-Galluzzi C, Mundo EC, Berney D, Suster S, Gill A, Rychlý B, Michalová K, Pitra T, Hora M, Michal M, Hes O
Cesk Patol 2019 Fall;55(4):244-249. PMID: 31842557

Recent clinical studies


Zhou Y, Fu L, Mochizuki K, Xiong J, Miao W, Wang G
J Eukaryot Microbiol 2022 Jul;69(4):e12907. Epub 2022 May 4 doi: 10.1111/jeu.12907. PMID: 35313044

Clinical prediction guides

Kimura N, Mikami K, Endoh H
Genesis 2004 Sep;40(1):15-21. doi: 10.1002/gene.20060. PMID: 15354289
Yu R, Lu W, Chen J, McCabe CJ, Melmed S
Endocrinology 2003 Nov;144(11):4991-8. Epub 2003 Jul 24 doi: 10.1210/en.2003-0305. PMID: 12960092
Arikawa M, Momokawa N, Saito A, Omura G, Khan SM, Suetomo Y, Kakuta S, Suzaki T
Cell Calcium 2003 Feb;33(2):113-7. doi: 10.1016/s0143-4160(02)00204-x. PMID: 12531187

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    Practice guidelines

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