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Trabecular follicular adenocarcinoma

MedGen UID:
569646
•Concept ID:
C0334327
•
Neoplastic Process
Synonyms: Follicular adenocarcinoma - moderately differentiated; Follicular adenocarcinoma - trabecular; Follicular adenocarcinoma, moderately differentiated; Follicular adenocarcinoma, trabecular; follicular adenocarcinoma, trabecular; follicular adenocarcinoma, trabecular (morphologic abnormality); Follicular carcinoma - moderately differentiated; Follicular carcinoma - trabecular; Follicular carcinoma, moderately differentiated; Follicular carcinoma, trabecular; Solid/Trabecular Variant Thyroid Gland Papillary Carcinoma; trabecular follicular adenocarcinoma; trabecular follicular carcinoma
SNOMED CT: Follicular adenocarcinoma, trabecular (72174007); Follicular carcinoma, trabecular (72174007); Follicular adenocarcinoma, moderately differentiated (72174007); Follicular carcinoma, moderately differentiated (72174007); Follicular adenocarcinoma - trabecular (72174007); Follicular carcinoma - moderately differentiated (72174007); Follicular carcinoma - trabecular (72174007); Follicular adenocarcinoma - moderately differentiated (72174007)
 
Monarch Initiative: MONDO:0002821

Definition

A morphologic variant of papillary carcinoma of the thyroid gland that predominantly affects children. It is characterized by the presence of a solid growth pattern. The malignant cells have nuclear features that are characteristic of papillary carcinomas of the thyroid gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrabecular follicular adenocarcinoma

Professional guidelines

PubMed

Prognostic Impact of the Turin Criteria in Poorly Differentiated Thyroid Carcinoma.
Akaishi J, Kondo T, Sugino K, Ogimi Y, Masaki C, Hames KY, Yabuta T, Tomoda C, Suzuki A, Matsuzu K, Uruno T, Ohkuwa K, Kitagawa W, Nagahama M, Katoh R, Ito K
World J Surg 2019 Sep;43(9):2235-2244. doi: 10.1007/s00268-019-05028-5. PMID: 31098668

Recent clinical studies

Etiology

High Grade Differentiated Follicular Cell-Derived Thyroid Carcinoma Versus Poorly Differentiated Thyroid Carcinoma: A Clinicopathologic Analysis of 41 Cases.
Thompson LDR
Endocr Pathol 2023 Jun;34(2):234-246. Epub 2023 May 17 doi: 10.1007/s12022-023-09770-4. PMID: 37195480
High-Grade Non-Anaplastic Thyroid Carcinomas of Follicular Cell Origin: A Review of Poorly Differentiated and High-Grade Differentiated Carcinomas.
Cracolici V, Cipriani NA
Endocr Pathol 2023 Mar;34(1):34-47. Epub 2023 Jan 24 doi: 10.1007/s12022-023-09752-6. PMID: 36692728
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Poorly differentiated thyroid carcinoma.
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274
Ultrasonographic features for differentiating follicular thyroid carcinoma and follicular adenoma.
Kuo TC, Wu MH, Chen KY, Hsieh MS, Chen A, Chen CN
Asian J Surg 2020 Jan;43(1):339-346. Epub 2019 Jun 8 doi: 10.1016/j.asjsur.2019.04.016. PMID: 31182260

Diagnosis

Oncocytic nodular hyperplasia of the thyroid.
Suster D, Ronen N, Giorgadze T
Ann Diagn Pathol 2022 Dec;61:152049. Epub 2022 Sep 22 doi: 10.1016/j.anndiagpath.2022.152049. PMID: 36162158
Aggressive variants of follicular cell-derived thyroid carcinoma: an overview.
Pizzimenti C, Fiorentino V, Ieni A, Martini M, Tuccari G, Lentini M, Fadda G
Endocrine 2022 Oct;78(1):1-12. Epub 2022 Jul 21 doi: 10.1007/s12020-022-03146-0. PMID: 35864338
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Poorly differentiated thyroid carcinoma.
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274
Ultrasonographic features for differentiating follicular thyroid carcinoma and follicular adenoma.
Kuo TC, Wu MH, Chen KY, Hsieh MS, Chen A, Chen CN
Asian J Surg 2020 Jan;43(1):339-346. Epub 2019 Jun 8 doi: 10.1016/j.asjsur.2019.04.016. PMID: 31182260

Therapy

Pulmonary metastasis of cribriform-morular variant of thyroid carcinoma mimicking primary adenocarcinoma of the lung: A potential pitfall.
Laforga JB, Pedro T, Gasent JM
Diagn Cytopathol 2020 Jan;48(1):78-81. Epub 2019 Sep 4 doi: 10.1002/dc.24312. PMID: 31483569
Low trabecular bone score in postmenopausal women with differentiated thyroid carcinoma after long-term TSH suppressive therapy.
De Mingo Dominguez ML, Guadalix Iglesias S, Martin-Arriscado Arroba C, López Alvarez B, Martínez Diaz-Guerra G, Martinez-Pueyo JI, Ferrero Herrero E, Hawkins Carranza F
Endocrine 2018 Oct;62(1):166-173. Epub 2018 Jul 16 doi: 10.1007/s12020-018-1671-8. PMID: 30014437
Fine needle aspiration of poorly differentiated oxyphilic (Hürthle cell) thyroid carcinoma: a case report.
Ghofrani M, Sosa JA, Ocal IT, Angeletti C
Acta Cytol 2006 Sep-Oct;50(5):560-2. doi: 10.1159/000326016. PMID: 17017447
Prevalence and incidence of cytoplasmic yellow bodies in thyroid neoplasms.
Rothenberg HJ, Goellner JR, Carney JA
Arch Pathol Lab Med 2003 Jun;127(6):715-7. doi: 10.5858/2003-127-715-PAIOCY. PMID: 12741896

Prognosis

High-Grade Non-Anaplastic Thyroid Carcinomas of Follicular Cell Origin: A Review of Poorly Differentiated and High-Grade Differentiated Carcinomas.
Cracolici V, Cipriani NA
Endocr Pathol 2023 Mar;34(1):34-47. Epub 2023 Jan 24 doi: 10.1007/s12022-023-09752-6. PMID: 36692728
Aggressive variants of follicular cell-derived thyroid carcinoma: an overview.
Pizzimenti C, Fiorentino V, Ieni A, Martini M, Tuccari G, Lentini M, Fadda G
Endocrine 2022 Oct;78(1):1-12. Epub 2022 Jul 21 doi: 10.1007/s12020-022-03146-0. PMID: 35864338
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Poorly differentiated thyroid carcinoma.
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274
Prognostic Impact of the Turin Criteria in Poorly Differentiated Thyroid Carcinoma.
Akaishi J, Kondo T, Sugino K, Ogimi Y, Masaki C, Hames KY, Yabuta T, Tomoda C, Suzuki A, Matsuzu K, Uruno T, Ohkuwa K, Kitagawa W, Nagahama M, Katoh R, Ito K
World J Surg 2019 Sep;43(9):2235-2244. doi: 10.1007/s00268-019-05028-5. PMID: 31098668

Clinical prediction guides

Revisiting the cytomorphological features of poorly differentiated thyroid carcinoma: a comparative analysis with indeterminate thyroid fine-needle aspiration samples.
Alwelaie Y, Howaidi A, Tashkandi M, Almotairi A, Saied H, Muzzaffar M, Alghamdi D
J Am Soc Cytopathol 2023 Sep-Oct;12(5):331-340. Epub 2023 May 18 doi: 10.1016/j.jasc.2023.05.002. PMID: 37302972
Re-evaluation of histopathological factors affecting prognosis of differentiated thyroid carcinoma in an iodine-sufficient country.
Sugitani I, Toda K, Yamamoto N, Sakamoto A, Fujimoto Y
World J Surg 2010 Jun;34(6):1265-73. doi: 10.1007/s00268-009-0305-y. PMID: 19953247
Hyalinizing trabecular adenoma of the thyroid revisited: a histologic and immunohistochemical study of thyroid lesions with prominent trabecular architecture and sclerosis.
Galgano MT, Mills SE, Stelow EB
Am J Surg Pathol 2006 Oct;30(10):1269-73. doi: 10.1097/01.pas.0000209858.13035.0a. PMID: 17001158
Prognostic factors of clinical interest in poorly differentiated carcinomas of the thyroid.
Volante M, Cavallo GP, Papotti M
Endocr Pathol 2004 Winter;15(4):313-7. doi: 10.1385/ep:15:4:313. PMID: 15681855
Where to set the threshold between well differentiated and poorly differentiated follicular carcinomas of the thyroid.
Albores-Saavedra J, Carrick K
Endocr Pathol 2004 Winter;15(4):297-305. doi: 10.1385/ep:15:4:297. PMID: 15681853

Recent systematic reviews

Differentiated high grade thyroid carcinomas: Diagnostic consideration and clinical features.
Tondi Resta I, Gubbiotti MA, Montone KT, Livolsi VA, Baloch ZW
Hum Pathol 2024 Feb;144:53-60. Epub 2024 Jan 19 doi: 10.1016/j.humpath.2024.01.002. PMID: 38244615
Prevalence of Differentiated High-Grade Thyroid Carcinoma Among Well-Differentiated Tumors: A Systematic Review and Meta-Analysis.
Poma AM, Macerola E, Ghossein RA, Tallini G, Basolo F
Thyroid 2024 Mar;34(3):314-323. doi: 10.1089/thy.2023.0350. PMID: 38115626Free PMC Article

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