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Breast Paget Disease with Invasive Ductal Carcinoma

MedGen UID:
569658
•Concept ID:
C0334386
•
Neoplastic Process
Synonyms: Paget disease and infiltrating duct carcinoma of breast; Paget Disease of the Breast with Invasive Ductal Carcinoma; Paget's disease and infiltrating duct carcinoma of breast; Paget's Disease and Infiltrating Ductal Carcinoma of Breast; Paget's Disease and Infiltrating Ductal Carcinoma of the Breast; Paget's Disease and Invasive Ductal Carcinoma of Breast; Paget's Disease and Invasive Ductal Carcinoma of the Breast; Paget's Disease of Breast with Infiltrating Ductal Carcinoma; Paget's Disease of Breast with Invasive Ductal Carcinoma; Paget's Disease of the Breast with Infiltrating Ductal Carcinoma; Paget's Disease of the Breast with Invasive Ductal Carcinoma
SNOMED CT: Paget's disease and infiltrating duct carcinoma of breast (82591005); Paget disease and infiltrating duct carcinoma of breast (82591005)

Definition

Paget disease involving the skin overlying the mammary gland, accompanied by invasive ductal breast carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Paget Disease with Invasive Ductal Carcinoma

Professional guidelines

PubMed

Paget's disease of the breast: diagnosis and management.
Hudson-Phillips S, Cox K, Patel P, Al Sarakbi W
Br J Hosp Med (Lond) 2023 Jan 2;84(1):1-8. Epub 2023 Jan 24 doi: 10.12968/hmed.2022.0439. PMID: 36708338
Multidisciplinary management of mammary Paget's disease: recommendations to optimize oncological and aesthetic outcomes.
Franceschini G, Mason EJ, Di Leone A, Scardina L, Masetti R
Ann Ital Chir 2022;93:481-482. PMID: 36196555
Breast Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology.
Gradishar WJ, Moran MS, Abraham J, Aft R, Agnese D, Allison KH, Anderson B, Burstein HJ, Chew H, Dang C, Elias AD, Giordano SH, Goetz MP, Goldstein LJ, Hurvitz SA, Isakoff SJ, Jankowitz RC, Javid SH, Krishnamurthy J, Leitch M, Lyons J, Mortimer J, Patel SA, Pierce LJ, Rosenberger LH, Rugo HS, Sitapati A, Smith KL, Smith ML, Soliman H, Stringer-Reasor EM, Telli ML, Ward JH, Wisinski KB, Young JS, Burns J, Kumar R
J Natl Compr Canc Netw 2022 Jun;20(6):691-722. doi: 10.6004/jnccn.2022.0030. PMID: 35714673

Recent clinical studies

Etiology

Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Breast-Conserving Surgery in Patients With Mammary Paget's Disease.
Yao Y, Sun L, Meng Y, Zhuang Y, Zhao L, Yu Q, Si C
J Surg Res 2019 Sep;241:178-187. Epub 2019 Apr 24 doi: 10.1016/j.jss.2019.03.025. PMID: 31026796
Paget's disease of the male breast in the 21st century: A systematic review.
Adams SJ, Kanthan R
Breast 2016 Oct;29:14-23. Epub 2016 Jul 6 doi: 10.1016/j.breast.2016.06.015. PMID: 27394005
Breast cancer.
Berg JW, Hutter RV
Cancer 1995 Jan 1;75(1 Suppl):257-69. doi: 10.1002/1097-0142(19950101)75:1+<257::aid-cncr2820751311>3.0.co;2-y. PMID: 8001000
Anaplastic Paget's disease.
Rayne SC, Santa Cruz DJ
Am J Surg Pathol 1992 Nov;16(11):1085-91. doi: 10.1097/00000478-199211000-00007. PMID: 1335210

Diagnosis

Paget's disease of the breast: diagnosis and management.
Hudson-Phillips S, Cox K, Patel P, Al Sarakbi W
Br J Hosp Med (Lond) 2023 Jan 2;84(1):1-8. Epub 2023 Jan 24 doi: 10.12968/hmed.2022.0439. PMID: 36708338
The nipple-areolar complex: comprehensive imaging review.
Lyons D, Wahab RA, Vijapura C, Mahoney MC
Clin Radiol 2021 Mar;76(3):172-184. Epub 2020 Oct 17 doi: 10.1016/j.crad.2020.09.013. PMID: 33077158
Paget Disease of the Breast in Pregnancy and Lactation.
Gilmore R, Prasath V, Habibi M
Adv Exp Med Biol 2020;1252:133-136. doi: 10.1007/978-3-030-41596-9_18. PMID: 32816273
Nipple Ultrasound: A Pictorial Essay.
Chiorean A, Pintican RM, Szep M, Feier D, Rogojan L, Fetica B, Dindelegan G, Vlad B, Duma M
Korean J Radiol 2020 Aug;21(8):955-966. doi: 10.3348/kjr.2019.0831. PMID: 32677380Free PMC Article
Paget's disease of the nipple.
Sandoval-Leon AC, Drews-Elger K, Gomez-Fernandez CR, Yepes MM, Lippman ME
Breast Cancer Res Treat 2013 Aug;141(1):1-12. Epub 2013 Aug 9 doi: 10.1007/s10549-013-2661-4. PMID: 23929251

Therapy

Phase II Study of Afatinib in Patients With Tumors With Human Epidermal Growth Factor Receptor 2-Activating Mutations: Results From the National Cancer Institute-Molecular Analysis for Therapy Choice ECOG-ACRIN Trial (EAY131) Subprotocol EAY131-B.
Bedard PL, Li S, Wisinski KB, Yang ES, Limaye SA, Mitchell EP, Zwiebel JA, Moscow JA, Gray RJ, Wang V, McShane LM, Rubinstein LV, Patton DR, Williams PM, Hamilton SR, Conley BA, Arteaga CL, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT
JCO Precis Oncol 2022 Jul;6:e2200165. doi: 10.1200/PO.22.00165. PMID: 35939768Free PMC Article
Paget's disease of the male breast: case report and a point of view from actual literature.
Vergine M, Musella A, Gulotta E, Frusone F, De Luca A, Maceli F, Libia A, Benedetti Panici P, Monti M
G Chir 2018 Mar-Apr;39(2):114-117. PMID: 29694313
Nipple-sparing mastectomy as treatment for patients with ductal carcinoma in situ: A 10-year follow-up study.
Lago V, Maisto V, Gimenez-Climent J, Vila J, Vazquez C, Estevan R
Breast J 2018 May;24(3):298-303. Epub 2017 Nov 15 doi: 10.1111/tbj.12947. PMID: 29139613
Paget's disease of the nipple.
Sandoval-Leon AC, Drews-Elger K, Gomez-Fernandez CR, Yepes MM, Lippman ME
Breast Cancer Res Treat 2013 Aug;141(1):1-12. Epub 2013 Aug 9 doi: 10.1007/s10549-013-2661-4. PMID: 23929251
Feasibility of breast-conserving surgery for patients with breast carcinoma associated with nipple discharge.
Cabioglu N, Krishnamurthy S, Kuerer HM, Hunt KK, Singletary SE, Meric-Bernstam F, Ross MI, Feig BW, Ames FC, Babiera GV
Cancer 2004 Aug 1;101(3):508-17. doi: 10.1002/cncr.20394. PMID: 15274063

Prognosis

Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Paget's disease of the male breast in the 21st century: A systematic review.
Adams SJ, Kanthan R
Breast 2016 Oct;29:14-23. Epub 2016 Jul 6 doi: 10.1016/j.breast.2016.06.015. PMID: 27394005
Paget's disease of the nipple.
Sandoval-Leon AC, Drews-Elger K, Gomez-Fernandez CR, Yepes MM, Lippman ME
Breast Cancer Res Treat 2013 Aug;141(1):1-12. Epub 2013 Aug 9 doi: 10.1007/s10549-013-2661-4. PMID: 23929251
Breast cancer.
Berg JW, Hutter RV
Cancer 1995 Jan 1;75(1 Suppl):257-69. doi: 10.1002/1097-0142(19950101)75:1+<257::aid-cncr2820751311>3.0.co;2-y. PMID: 8001000
Anaplastic Paget's disease.
Rayne SC, Santa Cruz DJ
Am J Surg Pathol 1992 Nov;16(11):1085-91. doi: 10.1097/00000478-199211000-00007. PMID: 1335210

Clinical prediction guides

Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Breast-Conserving Surgery in Patients With Mammary Paget's Disease.
Yao Y, Sun L, Meng Y, Zhuang Y, Zhao L, Yu Q, Si C
J Surg Res 2019 Sep;241:178-187. Epub 2019 Apr 24 doi: 10.1016/j.jss.2019.03.025. PMID: 31026796
Clinicopathological characteristics and survival outcomes in Paget disease: a SEER population-based study.
Zhao Y, Sun HF, Chen MT, Gao SP, Li LD, Jiang HL, Jin W
Cancer Med 2018 Jun;7(6):2307-2318. Epub 2018 May 2 doi: 10.1002/cam4.1475. PMID: 29722170Free PMC Article
Surgical treatment in Paget's disease with invasive ductal carcinoma: an observational study based on SEER.
Wu Q, Ding X, Li J, Sun S, Zhu S, Wu J, Liu Q, Yao F, Sun S
Sci Rep 2017 Apr 19;7:45510. doi: 10.1038/srep45510. PMID: 28422090Free PMC Article
Expression of Cox-2 and Bcl-2 in Paget's disease of the breast.
Alikanoglu AS, Yildirim M, Suren D, Tutus B, Kaya V, Topal CS, Keser S, Karadayi AN, Kapucuoglu FN, Ayva S, Gunduz S
Asian Pac J Cancer Prev 2015;16(3):1041-5. doi: 10.7314/apjcp.2015.16.3.1041. PMID: 25735328

Recent systematic reviews

Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Paget's disease of the male breast in the 21st century: A systematic review.
Adams SJ, Kanthan R
Breast 2016 Oct;29:14-23. Epub 2016 Jul 6 doi: 10.1016/j.breast.2016.06.015. PMID: 27394005

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