U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Honey-droplet corneal dystrophy

MedGen UID:
573075
Concept ID:
C0339300
Injury or Poisoning
Synonyms: Climatic droplet keratopathy; Labrador keratopathy
SNOMED CT: Corneal elastosis (231944006); Keratinoid degeneration (231944006); Bietti nodular dystrophy (231944006); Proteinaceous degeneration (231944006); Labrador keratopathy (231944006); Droplet keratopathy (231944006); Spheroidal corneal degeneration (231944006); Climatic keratopathy (231944006)
 
Monarch Initiative: MONDO:0020363
Orphanet: ORPHA98958

Definition

A rare superficial corneal dystrophy characterized by progressive opacity of the most anterior corneal layers. Slit-lamp examination reveals typical confluent translucent subepithelial deposits, extending in size and growing into clusters of golden droplets covering the cornea with disease progression. Patients present variably compromised visual acuity, depending on the stage of the disease. In advanced stages, decreased corneal sensation may lead to corneal trophic changes, perforation, and permanent visual loss. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHoney-droplet corneal dystrophy

Professional guidelines

PubMed

Vazirani J, Sridhar U, Gokhale N, Doddigarla VR, Sharma S, Basu S
Indian J Ophthalmol 2023 Apr;71(4):1357-1363. doi: 10.4103/IJO.IJO_2756_22. PMID: 37026267Free PMC Article
Sciriha GG, Sultana J, Borg J
Expert Rev Clin Pharmacol 2023 Apr;16(4):275-278. Epub 2023 Mar 21 doi: 10.1080/17512433.2023.2193683. PMID: 36945753
Wilson SE
J Ocul Pharmacol Ther 2023 Apr;39(3):191-206. Epub 2023 Mar 6 doi: 10.1089/jop.2022.0174. PMID: 36877777Free PMC Article

Recent systematic reviews

Oie Y, Yamaguchi T, Nishida N, Okumura N, Maeno S, Kawasaki R, Jhanji V, Shimazaki J, Nishida K
Cornea 2023 Dec 1;42(12):1590-1600. Epub 2023 Aug 21 doi: 10.1097/ICO.0000000000003343. PMID: 37603692
Augustin VA, Son HS, Yildirim TM, Meis J, Łabuz G, Auffarth GU, Khoramnia R
J Cataract Refract Surg 2023 Sep 1;49(9):982-987. doi: 10.1097/j.jcrs.0000000000001212. PMID: 37144644
Rocha-de-Lossada C, Rachwani-Anil R, Colmenero-Reina E, Borroni D, Sánchez-González JM
J Cataract Refract Surg 2021 May 1;47(5):662-670. doi: 10.1097/j.jcrs.0000000000000468. PMID: 33149045
Arbelaez JG, Feng MT, Pena TJ, Price MO, Price FW Jr
Asia Pac J Ophthalmol (Phila) 2015 Jan-Feb;4(1):40-50. doi: 10.1097/APO.0000000000000110. PMID: 26068612
Smith SJ, Smith BD, Mohney BG
Br J Ophthalmol 2014 Mar;98(3):292-7. Epub 2013 Nov 1 doi: 10.1136/bjophthalmol-2013-303885. PMID: 24187047

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...