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Drug-induced hypotension

MedGen UID:
574009
•Concept ID:
C0340858
•
Pathologic Function
Synonyms: Hypotension due to Drug; Hypotension due to drugs
SNOMED CT: Hypotension due to drugs (234171009); Drug-induced hypotension (234171009)

Definition

A condition in which there is hypotension because of the effects of a medication or other substance. (ACC-AHA) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDrug-induced hypotension

Professional guidelines

PubMed

Homoharringtonine as a backbone drug for the treatment of newly diagnosed pediatric acute myeloid leukemia: a report from a single institution in China.
Tang J, Liu Y, Chen J, Xue H, Pan C, Gu L
Int J Hematol 2011 May;93(5):610-617. Epub 2011 Apr 21 doi: 10.1007/s12185-011-0837-4. PMID: 21509439
Vasopressin in the treatment of vasodilatory shock in children.
Masutani S, Senzaki H, Ishido H, Taketazu M, Matsunaga T, Kobayashi T, Sasaki N, Asano H, Kyo S, Yokote Y
Pediatr Int 2005 Apr;47(2):132-6. doi: 10.1111/j.1442-200x.2005.02043.x. PMID: 15771688
Autoregulation of cerebral blood flow in hypertensive patients. The modifying influence of prolonged antihypertensive treatment on the tolerance to acute, drug-induced hypotension.
Strandgaard S
Circulation 1976 Apr;53(4):720-7. doi: 10.1161/01.cir.53.4.720. PMID: 815061

Recent clinical studies

Etiology

Hydroxocobalamin for Vasodilatory Hypotension in Shock: A Systematic Review With Meta-Analysis for Comparison to Methylene Blue.
Brokmeier HM, Seelhammer TG, Nei SD, Gerberi DJ, Mara KC, Wittwer ED, Wieruszewski PM
J Cardiothorac Vasc Anesth 2023 Sep;37(9):1757-1772. Epub 2023 Apr 7 doi: 10.1053/j.jvca.2023.04.006. PMID: 37147207
A multicenter study of the point prevalence of drug-induced hypotension in the ICU.
Kane-Gill SL, LeBlanc JM, Dasta JF, Devabhakthuni S; Critical Care Pharmacotherapy Trials Network
Crit Care Med 2014 Oct;42(10):2197-203. doi: 10.1097/CCM.0000000000000499. PMID: 25014064
Acute circulatory actions of intravenous amiodarone loading in cardiac surgical patients.
Cheung AT, Weiss SJ, Savino JS, Levy WJ, Augoustides JG, Harrington A, Gardner TJ
Ann Thorac Surg 2003 Aug;76(2):535-41. doi: 10.1016/s0003-4975(03)00509-5. PMID: 12902100
Prevalence of orthostatic hypotension among patients presenting with syncope in the ED.
Sarasin FP, Louis-Simonet M, Carballo D, Slama S, Junod AF, Unger PF
Am J Emerg Med 2002 Oct;20(6):497-501. doi: 10.1053/ajem.2002.34964. PMID: 12369019
The influence of nicardipine-, nitroglycerin-, and prostaglandin E(1)-induced hypotension on cerebral pressure autoregulation in adult patients during propofol-fentanyl anesthesia.
Endoh H, Honda T, Ohashi S, Hida S, Shibue C, Komura N
Anesth Analg 2002 Jan;94(1):169-73, table of contents. doi: 10.1097/00000539-200201000-00032. PMID: 11772822

Diagnosis

Hypotension induced by the concomitant use of a calcium-channel blocker and clarithromycin.
Takeuchi S, Kotani Y, Tsujimoto T
BMJ Case Rep 2017 Jan 9;2017 doi: 10.1136/bcr-2016-218388. PMID: 28069789Free PMC Article
Discrepancies in office and ambulatory blood pressure in adolescents: help or hindrance?
Lurbe E, Redon J
Pediatr Nephrol 2008 Mar;23(3):341-5. Epub 2007 Aug 11 doi: 10.1007/s00467-007-0581-4. PMID: 17694335
Syncope in children with Tourette's syndrome treated with guanfacine.
King A, Harris P, Fritzell J, Kurlan R
Mov Disord 2006 Mar;21(3):419-20. doi: 10.1002/mds.20738. PMID: 16229000
Acute circulatory actions of intravenous amiodarone loading in cardiac surgical patients.
Cheung AT, Weiss SJ, Savino JS, Levy WJ, Augoustides JG, Harrington A, Gardner TJ
Ann Thorac Surg 2003 Aug;76(2):535-41. doi: 10.1016/s0003-4975(03)00509-5. PMID: 12902100
Prevalence of orthostatic hypotension among patients presenting with syncope in the ED.
Sarasin FP, Louis-Simonet M, Carballo D, Slama S, Junod AF, Unger PF
Am J Emerg Med 2002 Oct;20(6):497-501. doi: 10.1053/ajem.2002.34964. PMID: 12369019

Therapy

Hydroxocobalamin for Vasodilatory Hypotension in Shock: A Systematic Review With Meta-Analysis for Comparison to Methylene Blue.
Brokmeier HM, Seelhammer TG, Nei SD, Gerberi DJ, Mara KC, Wittwer ED, Wieruszewski PM
J Cardiothorac Vasc Anesth 2023 Sep;37(9):1757-1772. Epub 2023 Apr 7 doi: 10.1053/j.jvca.2023.04.006. PMID: 37147207
Recognition of Sympathetic Crashing Acute Pulmonary Edema (SCAPE) and use of high-dose nitroglycerin infusion.
Paone S, Clarkson L, Sin B, Punnapuzha S
Am J Emerg Med 2018 Aug;36(8):1526.e5-1526.e7. Epub 2018 May 10 doi: 10.1016/j.ajem.2018.05.013. PMID: 29776826
Hypotension induced by the concomitant use of a calcium-channel blocker and clarithromycin.
Takeuchi S, Kotani Y, Tsujimoto T
BMJ Case Rep 2017 Jan 9;2017 doi: 10.1136/bcr-2016-218388. PMID: 28069789Free PMC Article
Syncope in children with Tourette's syndrome treated with guanfacine.
King A, Harris P, Fritzell J, Kurlan R
Mov Disord 2006 Mar;21(3):419-20. doi: 10.1002/mds.20738. PMID: 16229000
Prevalence of orthostatic hypotension among patients presenting with syncope in the ED.
Sarasin FP, Louis-Simonet M, Carballo D, Slama S, Junod AF, Unger PF
Am J Emerg Med 2002 Oct;20(6):497-501. doi: 10.1053/ajem.2002.34964. PMID: 12369019

Prognosis

Acute circulatory actions of intravenous amiodarone loading in cardiac surgical patients.
Cheung AT, Weiss SJ, Savino JS, Levy WJ, Augoustides JG, Harrington A, Gardner TJ
Ann Thorac Surg 2003 Aug;76(2):535-41. doi: 10.1016/s0003-4975(03)00509-5. PMID: 12902100
Prevalence of orthostatic hypotension among patients presenting with syncope in the ED.
Sarasin FP, Louis-Simonet M, Carballo D, Slama S, Junod AF, Unger PF
Am J Emerg Med 2002 Oct;20(6):497-501. doi: 10.1053/ajem.2002.34964. PMID: 12369019
Posterior ischemic optic neuropathy following bilateral radical neck dissection.
Schobel GA, Schmidbauer M, Millesi W, Undt G
Int J Oral Maxillofac Surg 1995 Aug;24(4):283-7. doi: 10.1016/s0901-5027(95)80030-1. PMID: 7490491
Phase I clinical investigation of 9,10-anthracenedicarboxaldehyde bis[(4,5-dihydro-1 H-imidazol-2-yl)hydrazone] dihydrochloride (CL216,942).
Von Hoff DD, Myers JW, Kuhn J, Sandbach JF, Pocelinko R, Clark G, Coltman CA Jr
Cancer Res 1981 Aug;41(8):3118-21. PMID: 6265075
Prediction of late ischemic complications after cerebral aneurysm surgery by the intraoperative measurement of cerebral blood flow.
Pickard JD, Matheson M, Patterson J, Wyper D
J Neurosurg 1980 Sep;53(3):305-8. doi: 10.3171/jns.1980.53.3.0305. PMID: 7420145

Clinical prediction guides

The use of volatile anesthetic agents for long-term critical care sedation (VALTS): study protocol for a pilot randomized controlled trial.
Jerath A, Ferguson ND, Steel A, Wijeysundera D, Macdonald J, Wasowicz M
Trials 2015 Dec 9;16:560. doi: 10.1186/s13063-015-1083-5. PMID: 26646404Free PMC Article
A multicenter study of the point prevalence of drug-induced hypotension in the ICU.
Kane-Gill SL, LeBlanc JM, Dasta JF, Devabhakthuni S; Critical Care Pharmacotherapy Trials Network
Crit Care Med 2014 Oct;42(10):2197-203. doi: 10.1097/CCM.0000000000000499. PMID: 25014064
Effect of intravenous propacetamol on blood pressure in febrile critically ill patients.
Hersch M, Raveh D, Izbicki G
Pharmacotherapy 2008 Oct;28(10):1205-10. doi: 10.1592/phco.28.10.1205. PMID: 18823215
Effects of a high dose intravenous bolus amiodarone in patients with atrial fibrillation and a rapid ventricular rate.
Hofmann R, Steinwender C, Kammler J, Kypta A, Leisch F
Int J Cardiol 2006 Jun 7;110(1):27-32. Epub 2005 Jul 19 doi: 10.1016/j.ijcard.2005.06.048. PMID: 16046015
Vasopressin in the treatment of vasodilatory shock in children.
Masutani S, Senzaki H, Ishido H, Taketazu M, Matsunaga T, Kobayashi T, Sasaki N, Asano H, Kyo S, Yokote Y
Pediatr Int 2005 Apr;47(2):132-6. doi: 10.1111/j.1442-200x.2005.02043.x. PMID: 15771688

Recent systematic reviews

Hydroxocobalamin for Vasodilatory Hypotension in Shock: A Systematic Review With Meta-Analysis for Comparison to Methylene Blue.
Brokmeier HM, Seelhammer TG, Nei SD, Gerberi DJ, Mara KC, Wittwer ED, Wieruszewski PM
J Cardiothorac Vasc Anesth 2023 Sep;37(9):1757-1772. Epub 2023 Apr 7 doi: 10.1053/j.jvca.2023.04.006. PMID: 37147207

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