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Lentigo Maligna

MedGen UID:
57443
Concept ID:
C0149722
Neoplastic Process
Synonyms: Freckle, Hutchinson's Melanotic; Freckle, Melanotic; Freckles, Melanotic; Hutchinson Melanotic Freckle; Hutchinson's Melanotic Freckle; Hutchinsons Melanotic Freckle; Lentigo, Malignant; Lentigos, Malignant; Malignant Lentigo; Malignant Lentigos; Melanotic Freckle; Melanotic Freckle, Hutchinson's; Melanotic Freckles
SNOMED CT: Hutchinson's melanotic freckle (61217001); Lentigo maligna (61217001); Hutchinson melanotic freckle (61217001); Lentigo maligna (302836005); LM - Lentigo maligna (302836005)

Definition

An atypical proliferation of atypical melanocytes in the dermal-epidermal junction, without infiltration of the papillary or reticular dermis. The melanocytic proliferation is associated with actinic damage and epidermal atrophy. It usually occurs in the sun-exposed skin of elderly people. It is a form of melanoma in situ. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLentigo Maligna

Professional guidelines

PubMed

De Luca EV, Perino F, Di Stefani A, Coco V, Fossati B, Peris K
G Ital Dermatol Venereol 2020 Apr;155(2):179-189. Epub 2018 Apr 19 doi: 10.23736/S0392-0488.18.06003-0. PMID: 29683288
Quintanilla-Dieck MJ, Bichakjian CK
Facial Plast Surg Clin North Am 2019 Feb;27(1):35-42. doi: 10.1016/j.fsc.2018.08.003. PMID: 30420071
Swetter SM, Tsao H, Bichakjian CK, Curiel-Lewandrowski C, Elder DE, Gershenwald JE, Guild V, Grant-Kels JM, Halpern AC, Johnson TM, Sober AJ, Thompson JA, Wisco OJ, Wyatt S, Hu S, Lamina T
J Am Acad Dermatol 2019 Jan;80(1):208-250. Epub 2018 Nov 1 doi: 10.1016/j.jaad.2018.08.055. PMID: 30392755

Recent clinical studies

Etiology

Teixido C, Castillo P, Martinez-Vila C, Arance A, Alos L
Cells 2021 Sep 5;10(9) doi: 10.3390/cells10092320. PMID: 34571969Free PMC Article
Bobos M
Ital J Dermatol Venerol 2021 Jun;156(3):300-321. Epub 2021 May 13 doi: 10.23736/S2784-8671.21.06958-3. PMID: 33982546
Elder DE, Bastian BC, Cree IA, Massi D, Scolyer RA
Arch Pathol Lab Med 2020 Apr;144(4):500-522. Epub 2020 Feb 14 doi: 10.5858/arpa.2019-0561-RA. PMID: 32057276
Longo C, Pellacani G
Dermatol Clin 2016 Oct;34(4):411-419. doi: 10.1016/j.det.2016.05.004. PMID: 27692447
Samaniego E, Redondo P
Actas Dermosifiliogr 2013 Nov;104(9):757-75. Epub 2012 Jul 31 doi: 10.1016/j.ad.2012.05.006. PMID: 22857817

Diagnosis

Bobos M
Ital J Dermatol Venerol 2021 Jun;156(3):300-321. Epub 2021 May 13 doi: 10.23736/S2784-8671.21.06958-3. PMID: 33982546
Lallas A, Paschou E, Manoli SM, Papageorgiou C, Spyridis I, Liopyris K, Bobos M, Moutsoudis A, Lazaridou E, Apalla Z
Ital J Dermatol Venerol 2021 Jun;156(3):274-288. Epub 2020 Dec 14 doi: 10.23736/S2784-8671.20.06784-X. PMID: 33314891
De Luca EV, Perino F, Di Stefani A, Coco V, Fossati B, Peris K
G Ital Dermatol Venereol 2020 Apr;155(2):179-189. Epub 2018 Apr 19 doi: 10.23736/S0392-0488.18.06003-0. PMID: 29683288
Swetter SM, Tsao H, Bichakjian CK, Curiel-Lewandrowski C, Elder DE, Gershenwald JE, Guild V, Grant-Kels JM, Halpern AC, Johnson TM, Sober AJ, Thompson JA, Wisco OJ, Wyatt S, Hu S, Lamina T
J Am Acad Dermatol 2019 Jan;80(1):208-250. Epub 2018 Nov 1 doi: 10.1016/j.jaad.2018.08.055. PMID: 30392755
Samaniego E, Redondo P
Actas Dermosifiliogr 2013 Nov;104(9):757-75. Epub 2012 Jul 31 doi: 10.1016/j.ad.2012.05.006. PMID: 22857817

Therapy

Teixido C, Castillo P, Martinez-Vila C, Arance A, Alos L
Cells 2021 Sep 5;10(9) doi: 10.3390/cells10092320. PMID: 34571969Free PMC Article
DeWane ME, Kelsey A, Oliviero M, Rabinovitz H, Grant-Kels JM
J Am Acad Dermatol 2019 Sep;81(3):823-833. Epub 2019 Mar 28 doi: 10.1016/j.jaad.2019.03.066. PMID: 30930085
Samaniego E, Redondo P
Actas Dermosifiliogr 2013 Nov;104(9):757-75. Epub 2012 Jul 31 doi: 10.1016/j.ad.2012.05.006. PMID: 22857817
Lang PG Jr
Med Clin North Am 1998 Nov;82(6):1325-58. doi: 10.1016/s0025-7125(05)70418-1. PMID: 9889751
Nazzaro-Porro M
J Am Acad Dermatol 1987 Dec;17(6):1033-41. doi: 10.1016/s0190-9622(87)70294-1. PMID: 2963038

Prognosis

Bunnell AM, Nedrud SM, Fernandes RP
Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234. doi: 10.1016/j.coms.2021.12.001. PMID: 35491079
Teixido C, Castillo P, Martinez-Vila C, Arance A, Alos L
Cells 2021 Sep 5;10(9) doi: 10.3390/cells10092320. PMID: 34571969Free PMC Article
Bobos M
Ital J Dermatol Venerol 2021 Jun;156(3):300-321. Epub 2021 May 13 doi: 10.23736/S2784-8671.21.06958-3. PMID: 33982546
Quintanilla-Dieck MJ, Bichakjian CK
Facial Plast Surg Clin North Am 2019 Feb;27(1):35-42. doi: 10.1016/j.fsc.2018.08.003. PMID: 30420071
Smalberger GJ, Siegel DM, Khachemoune A
Dermatol Ther 2008 Nov-Dec;21(6):439-46. doi: 10.1111/j.1529-8019.2008.00244.x. PMID: 19076621

Clinical prediction guides

Bunnell AM, Nedrud SM, Fernandes RP
Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234. doi: 10.1016/j.coms.2021.12.001. PMID: 35491079
Kwak R, Joyce C, Werchniak AE, Lin JY, Tsibris HC
J Dermatolog Treat 2022 Jun;33(4):1995-1999. Epub 2021 Aug 9 doi: 10.1080/09546634.2021.1962001. PMID: 34315342
Bobos M
Ital J Dermatol Venerol 2021 Jun;156(3):300-321. Epub 2021 May 13 doi: 10.23736/S2784-8671.21.06958-3. PMID: 33982546
Martínez-Leboráns L, Garcías-Ladaria J, Oliver-Martínez V, Alegre de Miquel V
Actas Dermosifiliogr 2016 Oct;107(8):e57-63. Epub 2016 May 11 doi: 10.1016/j.ad.2015.10.018. PMID: 27180003
Nazzaro-Porro M
J Am Acad Dermatol 1987 Dec;17(6):1033-41. doi: 10.1016/s0190-9622(87)70294-1. PMID: 2963038

Recent systematic reviews

Elshot YS, Tio DCKS, van Haersma-de With ASE, Ouwerkerk W, Zupan-Kajcovski B, Crijns MB, Limpens CEJM, Klop WMC, Bekkenk MW, Balm AJM, de Rie MA
J Eur Acad Dermatol Venereol 2023 May;37(5):871-883. Epub 2023 Jan 31 doi: 10.1111/jdv.18880. PMID: 36652277
Hendrickx A, Cozzio A, Plasswilm L, Panje CM
Radiat Oncol 2020 Jul 14;15(1):174. doi: 10.1186/s13014-020-01615-2. PMID: 32664998Free PMC Article
Tio D, van der Woude J, Prinsen CAC, Jansma EP, Hoekzema R, van Montfrans C
J Eur Acad Dermatol Venereol 2017 Apr;31(4):616-624. Epub 2017 Jan 23 doi: 10.1111/jdv.14085. PMID: 27987308
Read T, Noonan C, David M, Wagels M, Foote M, Schaider H, Soyer HP, Smithers BM
J Eur Acad Dermatol Venereol 2016 May;30(5):748-53. Epub 2015 Aug 24 doi: 10.1111/jdv.13252. PMID: 26299846
Mora AN, Karia PS, Nguyen BM
J Am Acad Dermatol 2015 Aug;73(2):205-12. Epub 2015 Jun 16 doi: 10.1016/j.jaad.2015.05.022. PMID: 26088690

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