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Small cell lung carcinoma(SCCL)

MedGen UID:
57450
•Concept ID:
C0149925
•
Neoplastic Process
Synonyms: Lung oat cell carcinoma; SMALL CELL CANCER OF THE LUNG, SOMATIC; Small cell lung cancer
SNOMED CT: Small cell carcinoma of lung (254632001); SCLC - Small cell lung cancer (254632001); Small cell lung cancer (254632001); Oat cell carcinoma of lung (254633006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Gene (location): RB1 (13q14.2)
 
HPO: HP:0030357
Monarch Initiative: MONDO:0008433
OMIM®: 182280
Orphanet: ORPHA70573

Definition

Small cell lung cancer (SCLC) is a type of highly malignant lung cancer that is composed of small ovoid cells. In the past, SCLC was called oat cell carcinoma because the microscopic appearance of the cells was felt to resemble oats. SLCLC usually originates near the bronchi and in many cases may grow and metastasize quickly. [from HPO]

Clinical features

From HPO
Neoplasm of lung
MedGen UID:
7400
•Concept ID:
C0024121
•
Neoplastic Process
Tumor of the lung.
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall cell lung carcinoma
Follow this link to review classifications for Small cell lung carcinoma in Orphanet.

Professional guidelines

PubMed

Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Treatment of Brain Metastases of Non-Small Cell Lung Carcinoma.
Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article
Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy.
Osmani L, Askin F, Gabrielson E, Li QK
Semin Cancer Biol 2018 Oct;52(Pt 1):103-109. Epub 2017 Nov 26 doi: 10.1016/j.semcancer.2017.11.019. PMID: 29183778Free PMC Article

Curated

UK NICE guideline NG122, Lung cancer: diagnosis and management

Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

Recent clinical studies

Etiology

SCLC: Epidemiology, Risk Factors, Genetic Susceptibility, Molecular Pathology, Screening, and Early Detection.
Wang Q, Gümüş ZH, Colarossi C, Memeo L, Wang X, Kong CY, Boffetta P
J Thorac Oncol 2023 Jan;18(1):31-46. Epub 2022 Oct 12 doi: 10.1016/j.jtho.2022.10.002. PMID: 36243387
Radiotherapy for primary lung cancer.
Khalifa J, Lerouge D, Le Péchoux C, Pourel N, Darréon J, Mornex F, Giraud P
Cancer Radiother 2022 Feb-Apr;26(1-2):231-243. Epub 2021 Dec 22 doi: 10.1016/j.canrad.2021.11.005. PMID: 34953709
Lung Cancer.
Lareau S, Slatore C, Smyth R
Am J Respir Crit Care Med 2021 Dec 15;204(12):P21-P22. doi: 10.1164/rccm.20411P21. PMID: 34908517
Identification of Potential Prognostic and Predictive Biomarkers for Immune-Checkpoint Inhibitor Response in Small Cell Lung Cancer.
Gao C, Gu X, Chen Y, Zhou M, Jiang F, Zheng S
Med Sci Monit 2021 Nov 1;27:e932275. doi: 10.12659/MSM.932275. PMID: 34719665Free PMC Article
Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆).
Dingemans AC, Früh M, Ardizzoni A, Besse B, Faivre-Finn C, Hendriks LE, Lantuejoul S, Peters S, Reguart N, Rudin CM, De Ruysscher D, Van Schil PE, Vansteenkiste J, Reck M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2021 Jul;32(7):839-853. Epub 2021 Apr 20 doi: 10.1016/j.annonc.2021.03.207. PMID: 33864941Free PMC Article

Diagnosis

SCLC: Epidemiology, Risk Factors, Genetic Susceptibility, Molecular Pathology, Screening, and Early Detection.
Wang Q, Gümüş ZH, Colarossi C, Memeo L, Wang X, Kong CY, Boffetta P
J Thorac Oncol 2023 Jan;18(1):31-46. Epub 2022 Oct 12 doi: 10.1016/j.jtho.2022.10.002. PMID: 36243387
Lung neuroendocrine neoplasms: recent progress and persistent challenges.
Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914Free PMC Article
What Are the Biomarkers for Immunotherapy in SCLC?
Longo V, Catino A, Montrone M, Pizzutilo P, Annese T, Pesola F, Marech I, Cassiano S, Ribatti D, Galetta D
Int J Mol Sci 2021 Oct 15;22(20) doi: 10.3390/ijms222011123. PMID: 34681779Free PMC Article
Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy.
Osmani L, Askin F, Gabrielson E, Li QK
Semin Cancer Biol 2018 Oct;52(Pt 1):103-109. Epub 2017 Nov 26 doi: 10.1016/j.semcancer.2017.11.019. PMID: 29183778Free PMC Article
Small-cell lung cancer.
van Meerbeeck JP, Fennell DA, De Ruysscher DK
Lancet 2011 Nov 12;378(9804):1741-55. Epub 2011 May 10 doi: 10.1016/S0140-6736(11)60165-7. PMID: 21565397

Therapy

Effect of First-Line Serplulimab vs Placebo Added to Chemotherapy on Survival in Patients With Extensive-Stage Small Cell Lung Cancer: The ASTRUM-005 Randomized Clinical Trial.
Cheng Y, Han L, Wu L, Chen J, Sun H, Wen G, Ji Y, Dvorkin M, Shi J, Pan Z, Shi J, Wang X, Bai Y, Melkadze T, Pan Y, Min X, Viguro M, Li X, Zhao Y, Yang J, Makharadze T, Arkania E, Kang W, Wang Q, Zhu J; ASTRUM-005 Study Group
JAMA 2022 Sep 27;328(12):1223-1232. doi: 10.1001/jama.2022.16464. PMID: 36166026Free PMC Article
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial.
Paz-Ares L, Dvorkin M, Chen Y, Reinmuth N, Hotta K, Trukhin D, Statsenko G, Hochmair MJ, Özgüroğlu M, Ji JH, Voitko O, Poltoratskiy A, Ponce S, Verderame F, Havel L, Bondarenko I, Kazarnowicz A, Losonczy G, Conev NV, Armstrong J, Byrne N, Shire N, Jiang H, Goldman JW; CASPIAN investigators
Lancet 2019 Nov 23;394(10212):1929-1939. Epub 2019 Oct 4 doi: 10.1016/S0140-6736(19)32222-6. PMID: 31590988
Emerging therapies for small cell lung cancer.
Yang S, Zhang Z, Wang Q
J Hematol Oncol 2019 May 2;12(1):47. doi: 10.1186/s13045-019-0736-3. PMID: 31046803Free PMC Article
Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer.
Sen T, Rodriguez BL, Chen L, Corte CMD, Morikawa N, Fujimoto J, Cristea S, Nguyen T, Diao L, Li L, Fan Y, Yang Y, Wang J, Glisson BS, Wistuba II, Sage J, Heymach JV, Gibbons DL, Byers LA
Cancer Discov 2019 May;9(5):646-661. Epub 2019 Feb 18 doi: 10.1158/2159-8290.CD-18-1020. PMID: 30777870Free PMC Article

Prognosis

Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆).
Dingemans AC, Früh M, Ardizzoni A, Besse B, Faivre-Finn C, Hendriks LE, Lantuejoul S, Peters S, Reguart N, Rudin CM, De Ruysscher D, Van Schil PE, Vansteenkiste J, Reck M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2021 Jul;32(7):839-853. Epub 2021 Apr 20 doi: 10.1016/j.annonc.2021.03.207. PMID: 33864941Free PMC Article
Myelopreservation with the CDK4/6 inhibitor trilaciclib in patients with small-cell lung cancer receiving first-line chemotherapy: a phase Ib/randomized phase II trial.
Weiss JM, Csoszi T, Maglakelidze M, Hoyer RJ, Beck JT, Domine Gomez M, Lowczak A, Aljumaily R, Rocha Lima CM, Boccia RV, Hanna W, Nikolinakos P, Chiu VK, Owonikoko TK, Schuster SR, Hussein MA, Richards DA, Sawrycki P, Bulat I, Hamm JT, Hart LL, Adler S, Antal JM, Lai AY, Sorrentino JA, Yang Z, Malik RK, Morris SR, Roberts PJ, Dragnev KH; G1T28-02 Study Group
Ann Oncol 2019 Oct 1;30(10):1613-1621. doi: 10.1093/annonc/mdz278. PMID: 31504118Free PMC Article
Lung Cancer Incidence and Mortality with Extended Follow-up in the National Lung Screening Trial.
National Lung Screening Trial Research Team
J Thorac Oncol 2019 Oct;14(10):1732-1742. Epub 2019 Jun 28 doi: 10.1016/j.jtho.2019.05.044. PMID: 31260833Free PMC Article
Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial.
Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, Le Pechoux C, McMenemin R, Mohammed N, O'Brien M, Pantarotto J, Surmont V, Van Meerbeeck JP, Woll PJ, Lorigan P, Blackhall F; CONVERT Study Team
Lancet Oncol 2017 Aug;18(8):1116-1125. Epub 2017 Jun 20 doi: 10.1016/S1470-2045(17)30318-2. PMID: 28642008Free PMC Article
Small cell lung cancer: where do we go from here?
Byers LA, Rudin CM
Cancer 2015 Mar 1;121(5):664-72. Epub 2014 Oct 21 doi: 10.1002/cncr.29098. PMID: 25336398Free PMC Article

Clinical prediction guides

Accurate treatment of small cell lung cancer: Current progress, new challenges and expectations.
Zhang C, Wang H
Biochim Biophys Acta Rev Cancer 2022 Sep;1877(5):188798. Epub 2022 Sep 10 doi: 10.1016/j.bbcan.2022.188798. PMID: 36096336
Novel therapeutic combinations with PARP inhibitors for small cell lung cancer: A bench-to-bedside review.
Xiong J, Barayan R, Louie AV, Lok BH
Semin Cancer Biol 2022 Nov;86(Pt 2):521-542. Epub 2022 Jul 30 doi: 10.1016/j.semcancer.2022.07.008. PMID: 35917883
Lung neuroendocrine neoplasms: recent progress and persistent challenges.
Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914Free PMC Article
Heterogeneity of Small Cell Lung Cancer Stem Cells.
Prabavathy D, Ramadoss N
Adv Exp Med Biol 2019;1139:41-57. doi: 10.1007/978-3-030-14366-4_3. PMID: 31134494
Immunocytochemistry for predictive biomarker testing in lung cancer cytology.
Jain D, Nambirajan A, Borczuk A, Chen G, Minami Y, Moreira AL, Motoi N, Papotti M, Rekhtman N, Russell PA, Savic Prince S, Yatabe Y, Bubendorf L; IASLC Pathology Committee
Cancer Cytopathol 2019 May;127(5):325-339. Epub 2019 May 3 doi: 10.1002/cncy.22137. PMID: 31050216Free PMC Article

Recent systematic reviews

Stereotactic radiosurgery versus whole brain radiotherapy in patients with intracranial metastatic disease and small-cell lung cancer: a systematic review and meta-analysis.
Gaebe K, Li AY, Park A, Parmar A, Lok BH, Sahgal A, Chan KKW, Erickson AW, Das S
Lancet Oncol 2022 Jul;23(7):931-939. Epub 2022 May 26 doi: 10.1016/S1470-2045(22)00271-6. PMID: 35644163
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Comparison of First-Line Treatments for Patients With Extensive-Stage Small Cell Lung Cancer: A Systematic Review and Network Meta-analysis.
Zhou T, Zhang Z, Luo F, Zhao Y, Hou X, Liu T, Wang K, Zhao H, Huang Y, Zhang L
JAMA Netw Open 2020 Oct 1;3(10):e2015748. doi: 10.1001/jamanetworkopen.2020.15748. PMID: 33074323Free PMC Article
Incidence of Pneumonitis With Use of Programmed Death 1 and Programmed Death-Ligand 1 Inhibitors in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis of Trials.
Khunger M, Rakshit S, Pasupuleti V, Hernandez AV, Mazzone P, Stevenson J, Pennell NA, Velcheti V
Chest 2017 Aug;152(2):271-281. Epub 2017 May 10 doi: 10.1016/j.chest.2017.04.177. PMID: 28499515
Surgery for limited-stage small-cell lung cancer.
Barnes H, See K, Barnett S, Manser R
Cochrane Database Syst Rev 2017 Apr 21;4(4):CD011917. doi: 10.1002/14651858.CD011917.pub2. PMID: 28429473Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE guideline NG122, Lung cancer: diagnosis and management
    • AHRQ, 2013
      Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

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