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Small cell lung carcinoma(SCCL)

MedGen UID:
57450
•Concept ID:
C0149925
•
Neoplastic Process
Synonyms: Lung oat cell carcinoma; SMALL CELL CANCER OF THE LUNG, SOMATIC; Small cell lung cancer
SNOMED CT: Small cell carcinoma of lung (254632001); SCLC - Small cell lung cancer (254632001); Small cell lung cancer (254632001); Oat cell carcinoma of lung (254633006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Gene (location): RB1 (13q14.2)
 
HPO: HP:0030357
Monarch Initiative: MONDO:0008433
OMIM®: 182280
Orphanet: ORPHA70573

Definition

Small cell lung cancer (SCLC) is a type of highly malignant lung cancer that is composed of small ovoid cells. In the past, SCLC was called oat cell carcinoma because the microscopic appearance of the cells was felt to resemble oats. SLCLC usually originates near the bronchi and in many cases may grow and metastasize quickly. [from HPO]

Clinical features

From HPO
Neoplasm of lung
MedGen UID:
7400
•Concept ID:
C0024121
•
Neoplastic Process
Tumor of the lung.
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall cell lung carcinoma
Follow this link to review classifications for Small cell lung carcinoma in Orphanet.

Professional guidelines

PubMed

Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Treatment of Brain Metastases of Non-Small Cell Lung Carcinoma.
Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article
Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy.
Osmani L, Askin F, Gabrielson E, Li QK
Semin Cancer Biol 2018 Oct;52(Pt 1):103-109. Epub 2017 Nov 26 doi: 10.1016/j.semcancer.2017.11.019. PMID: 29183778Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Small Cell Lung Cancer, 2023

UK NICE guideline NG122, Lung cancer: diagnosis and management, 2023

Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

Recent clinical studies

Therapy

Advancing immunotherapy in small cell lung cancer.
Carlisle JW, Leal T
Cancer 2023 Nov 15;129(22):3525-3534. Epub 2023 Aug 21 doi: 10.1002/cncr.34977. PMID: 37602492
Effect of First-Line Serplulimab vs Placebo Added to Chemotherapy on Survival in Patients With Extensive-Stage Small Cell Lung Cancer: The ASTRUM-005 Randomized Clinical Trial.
Cheng Y, Han L, Wu L, Chen J, Sun H, Wen G, Ji Y, Dvorkin M, Shi J, Pan Z, Shi J, Wang X, Bai Y, Melkadze T, Pan Y, Min X, Viguro M, Li X, Zhao Y, Yang J, Makharadze T, Arkania E, Kang W, Wang Q, Zhu J; ASTRUM-005 Study Group
JAMA 2022 Sep 27;328(12):1223-1232. doi: 10.1001/jama.2022.16464. PMID: 36166026Free PMC Article
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial.
Paz-Ares L, Dvorkin M, Chen Y, Reinmuth N, Hotta K, Trukhin D, Statsenko G, Hochmair MJ, Özgüroğlu M, Ji JH, Voitko O, Poltoratskiy A, Ponce S, Verderame F, Havel L, Bondarenko I, Kazarnowicz A, Losonczy G, Conev NV, Armstrong J, Byrne N, Shire N, Jiang H, Goldman JW; CASPIAN investigators
Lancet 2019 Nov 23;394(10212):1929-1939. Epub 2019 Oct 4 doi: 10.1016/S0140-6736(19)32222-6. PMID: 31590988
Emerging therapies for small cell lung cancer.
Yang S, Zhang Z, Wang Q
J Hematol Oncol 2019 May 2;12(1):47. doi: 10.1186/s13045-019-0736-3. PMID: 31046803Free PMC Article

Prognosis

Global variations in lung cancer incidence by histological subtype in 2020: a population-based study.
Zhang Y, Vaccarella S, Morgan E, Li M, Etxeberria J, Chokunonga E, Manraj SS, Kamate B, Omonisi A, Bray F
Lancet Oncol 2023 Nov;24(11):1206-1218. Epub 2023 Oct 11 doi: 10.1016/S1470-2045(23)00444-8. PMID: 37837979
Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆).
Dingemans AC, Früh M, Ardizzoni A, Besse B, Faivre-Finn C, Hendriks LE, Lantuejoul S, Peters S, Reguart N, Rudin CM, De Ruysscher D, Van Schil PE, Vansteenkiste J, Reck M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2021 Jul;32(7):839-853. Epub 2021 Apr 20 doi: 10.1016/j.annonc.2021.03.207. PMID: 33864941Free PMC Article
High-dose versus standard-dose twice-daily thoracic radiotherapy for patients with limited stage small-cell lung cancer: an open-label, randomised, phase 2 trial.
Grønberg BH, Killingberg KT, Fløtten Ø, Brustugun OT, Hornslien K, Madebo T, Langer SW, Schytte T, Nyman J, Risum S, Tsakonas G, Engleson J, Halvorsen TO
Lancet Oncol 2021 Mar;22(3):321-331. doi: 10.1016/S1470-2045(20)30742-7. PMID: 33662285
Lung Cancer Incidence and Mortality with Extended Follow-up in the National Lung Screening Trial.
National Lung Screening Trial Research Team
J Thorac Oncol 2019 Oct;14(10):1732-1742. Epub 2019 Jun 28 doi: 10.1016/j.jtho.2019.05.044. PMID: 31260833Free PMC Article
Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial.
Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, Le Pechoux C, McMenemin R, Mohammed N, O'Brien M, Pantarotto J, Surmont V, Van Meerbeeck JP, Woll PJ, Lorigan P, Blackhall F; CONVERT Study Team
Lancet Oncol 2017 Aug;18(8):1116-1125. Epub 2017 Jun 20 doi: 10.1016/S1470-2045(17)30318-2. PMID: 28642008Free PMC Article

Clinical prediction guides

Emerging Strategies for the Treatment of Small Cell Lung Cancer: A Review.
Petty WJ, Paz-Ares L
JAMA Oncol 2023 Mar 1;9(3):419-429. doi: 10.1001/jamaoncol.2022.5631. PMID: 36520421
The efficacy of music therapy to relieve pain, anxiety, and promote sleep quality, in patients with small cell lung cancer receiving platinum-based chemotherapy.
Tang H, Chen L, Wang Y, Zhang Y, Yang N, Yang N
Support Care Cancer 2021 Dec;29(12):7299-7306. Epub 2021 May 26 doi: 10.1007/s00520-021-06152-6. PMID: 34041615
Association of Survival and Immune-Related Biomarkers With Immunotherapy in Patients With Non-Small Cell Lung Cancer: A Meta-analysis and Individual Patient-Level Analysis.
Yu Y, Zeng D, Ou Q, Liu S, Li A, Chen Y, Lin D, Gao Q, Zhou H, Liao W, Yao H
JAMA Netw Open 2019 Jul 3;2(7):e196879. doi: 10.1001/jamanetworkopen.2019.6879. PMID: 31290993Free PMC Article
Immunocytochemistry for predictive biomarker testing in lung cancer cytology.
Jain D, Nambirajan A, Borczuk A, Chen G, Minami Y, Moreira AL, Motoi N, Papotti M, Rekhtman N, Russell PA, Savic Prince S, Yatabe Y, Bubendorf L; IASLC Pathology Committee
Cancer Cytopathol 2019 May;127(5):325-339. Epub 2019 May 3 doi: 10.1002/cncy.22137. PMID: 31050216Free PMC Article
Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial.
Takahashi T, Yamanaka T, Seto T, Harada H, Nokihara H, Saka H, Nishio M, Kaneda H, Takayama K, Ishimoto O, Takeda K, Yoshioka H, Tachihara M, Sakai H, Goto K, Yamamoto N
Lancet Oncol 2017 May;18(5):663-671. Epub 2017 Mar 23 doi: 10.1016/S1470-2045(17)30230-9. PMID: 28343976

Recent systematic reviews

Efficacy and safety of first-line immunotherapy plus chemotherapy in treating patients with extensive-stage small cell lung cancer: a Bayesian network meta-analysis.
Zhang T, Li W, Diwu D, Chen L, Chen X, Wang H
Front Immunol 2023;14:1197044. Epub 2023 Jun 26 doi: 10.3389/fimmu.2023.1197044. PMID: 37435087Free PMC Article
Stereotactic radiosurgery versus whole brain radiotherapy in patients with intracranial metastatic disease and small-cell lung cancer: a systematic review and meta-analysis.
Gaebe K, Li AY, Park A, Parmar A, Lok BH, Sahgal A, Chan KKW, Erickson AW, Das S
Lancet Oncol 2022 Jul;23(7):931-939. Epub 2022 May 26 doi: 10.1016/S1470-2045(22)00271-6. PMID: 35644163
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Comparison of atezolizumab, durvalumab, pembrolizumab, and nivolumab as first-line treatment in patients with extensive-stage small cell lung cancer: A systematic review and network meta-analysis.
Chen J, Wang J, Xu H
Medicine (Baltimore) 2021 Apr 16;100(15):e25180. doi: 10.1097/MD.0000000000025180. PMID: 33847617Free PMC Article
Incidence of Pneumonitis With Use of Programmed Death 1 and Programmed Death-Ligand 1 Inhibitors in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis of Trials.
Khunger M, Rakshit S, Pasupuleti V, Hernandez AV, Mazzone P, Stevenson J, Pennell NA, Velcheti V
Chest 2017 Aug;152(2):271-281. Epub 2017 May 10 doi: 10.1016/j.chest.2017.04.177. PMID: 28499515

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Small Cell Lung Cancer, 2023
    • NICE, 2023
      UK NICE guideline NG122, Lung cancer: diagnosis and management, 2023
    • AHRQ, 2013
      Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

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