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Alcohol intolerance

MedGen UID:
57465
•Concept ID:
C0151474
•
Finding
Synonym: Alcohol Intolerance
SNOMED CT: Alcohol intolerance (102612005)

Definition

Increased sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlcohol intolerance

Professional guidelines

PubMed

ALDH2 genotype modulates the association between alcohol consumption and AST/ALT ratio among middle-aged Japanese men: a genome-wide G × E interaction analysis.
Sutoh Y, Hachiya T, Suzuki Y, Komaki S, Ohmomo H, Kakisaka K, Wang T, Takikawa Y, Shimizu A
Sci Rep 2020 Oct 1;10(1):16227. doi: 10.1038/s41598-020-73263-1. PMID: 33004991Free PMC Article
Cefoperazone in the treatment of severe or complicated infections.
Bailey RR, Peddie B, Blake E, Bishop V, Reddy J
Drugs 1981;22 Suppl 1:76-86. doi: 10.2165/00003495-198100221-00017. PMID: 6456895

Recent clinical studies

Etiology

Relationship Between Alcohol Intolerance and Aspirin-Exacerbated Respiratory Disease (AERD): Systematic Review.
Candelo E, McCalla M, Valderrama OA, Avila-Castano K, Chelf C, Olomu O, Donaldson AM
Otolaryngol Head Neck Surg 2023 Jul;169(1):12-20. Epub 2023 Jan 29 doi: 10.1002/ohn.248. PMID: 36939486
Nutrition and its role in human evolution.
James WPT, Johnson RJ, Speakman JR, Wallace DC, Frühbeck G, Iversen PO, Stover PJ
J Intern Med 2019 May;285(5):533-549. Epub 2019 Feb 17 doi: 10.1111/joim.12878. PMID: 30772945
An experimental analysis of acquired impulse control among adult humans intolerant to alcohol.
Wang J, Rao Y, Houser DE
Proc Natl Acad Sci U S A 2017 Feb 7;114(6):1299-1304. Epub 2017 Jan 24 doi: 10.1073/pnas.1610902114. PMID: 28119501Free PMC Article
Alcohol flushing and positive ethanol patch test in patients with coronary spastic angina: possible role of aldehyde dehydrogenase 2 polymorphisms.
Mizuno Y, Morita S, Harada E, Shono M, Morikawa Y, Murohara T, Yasue H
Intern Med 2013;52(23):2593-8. doi: 10.2169/internalmedicine.52.0894. PMID: 24292747
Dimethylformamide and alcohol intolerance.
Lyle WH, Spence TW, McKinneley WM, Duckers K
Br J Ind Med 1979 Feb;36(1):63-6. doi: 10.1136/oem.36.1.63. PMID: 444443Free PMC Article

Diagnosis

Aldehyde dehydrogenase 2 genotype in tolerability of alcohol contained in paclitaxel in Japanese breast cancer patients.
Yagi T, Fujiishi K, Hasegawa A, Otsuka T, Yoshinami T, Nishio M, Fujisawa F, Sugimoto N, Imamura F
Breast Cancer 2019 Mar;26(2):229-234. Epub 2018 Oct 22 doi: 10.1007/s12282-018-0918-9. PMID: 30350259
Quantification of skin erythema response to topical alcohol in alcohol-intolerant East Asians.
Aoki Y, Wehage SL, Talalay P
Skin Res Technol 2017 Nov;23(4):593-596. Epub 2017 May 17 doi: 10.1111/srt.12376. PMID: 28513003
Alcohol: intolerance syndromes, urticarial and anaphylactoid reactions.
Sticherling M, Brasch J
Clin Dermatol 1999 Jul-Aug;17(4):417-22. doi: 10.1016/s0738-081x(99)00027-9. PMID: 10497726
Marihuana and alcohol intolerance in Hodgkin's disease.
Lockwood AH
N Engl J Med 1973 Mar 8;288(10):526. doi: 10.1056/nejm197303082881023. PMID: 4684194
Alcohol intolerance in neoplastic disease.
Brewin TB
Br Med J 1966 Aug 20;2(5511):437-41. doi: 10.1136/bmj.2.5511.437. PMID: 5912509Free PMC Article

Therapy

Relationship Between Alcohol Intolerance and Aspirin-Exacerbated Respiratory Disease (AERD): Systematic Review.
Candelo E, McCalla M, Valderrama OA, Avila-Castano K, Chelf C, Olomu O, Donaldson AM
Otolaryngol Head Neck Surg 2023 Jul;169(1):12-20. Epub 2023 Jan 29 doi: 10.1002/ohn.248. PMID: 36939486
Cross-sectional study on N,N-dimethylformamide (DMF); effects on liver and alcohol intolerance.
Kilo S, Göen T, Drexler H
Int Arch Occup Environ Health 2016 Nov;89(8):1309-1320. Epub 2016 Sep 1 doi: 10.1007/s00420-016-1164-0. PMID: 27587219
Alcohol: intolerance syndromes, urticarial and anaphylactoid reactions.
Sticherling M, Brasch J
Clin Dermatol 1999 Jul-Aug;17(4):417-22. doi: 10.1016/s0738-081x(99)00027-9. PMID: 10497726
Pharmacological properties of cephalosporins.
Christ W
Infection 1991;19 Suppl 5:S244-52. doi: 10.1007/BF01645535. PMID: 1783440
Prostaglandins in alcohol intolerance and hangover.
Parantainen J
Drug Alcohol Depend 1983 Jun;11(3-4):239-48. doi: 10.1016/0376-8716(83)90016-9. PMID: 6352219

Prognosis

ALDH2 genotype modulates the association between alcohol consumption and AST/ALT ratio among middle-aged Japanese men: a genome-wide G × E interaction analysis.
Sutoh Y, Hachiya T, Suzuki Y, Komaki S, Ohmomo H, Kakisaka K, Wang T, Takikawa Y, Shimizu A
Sci Rep 2020 Oct 1;10(1):16227. doi: 10.1038/s41598-020-73263-1. PMID: 33004991Free PMC Article
Aldehyde dehydrogenase 2 genotype in tolerability of alcohol contained in paclitaxel in Japanese breast cancer patients.
Yagi T, Fujiishi K, Hasegawa A, Otsuka T, Yoshinami T, Nishio M, Fujisawa F, Sugimoto N, Imamura F
Breast Cancer 2019 Mar;26(2):229-234. Epub 2018 Oct 22 doi: 10.1007/s12282-018-0918-9. PMID: 30350259
Alcohol flushing and positive ethanol patch test in patients with coronary spastic angina: possible role of aldehyde dehydrogenase 2 polymorphisms.
Mizuno Y, Morita S, Harada E, Shono M, Morikawa Y, Murohara T, Yasue H
Intern Med 2013;52(23):2593-8. doi: 10.2169/internalmedicine.52.0894. PMID: 24292747
Clinical progress with a new antiandrogen, Casodex (bicalutamide).
Blackledge GR
Eur Urol 1996;29 Suppl 2:96-104. doi: 10.1159/000473847. PMID: 8717470
Castration plus nilutamide vs castration plus placebo in advanced prostate cancer. A review.
Du Plessis DJ
Urology 1991;37(2 Suppl):20-4. doi: 10.1016/0090-4295(91)80097-q. PMID: 1992599

Clinical prediction guides

Relationship Between Alcohol Intolerance and Aspirin-Exacerbated Respiratory Disease (AERD): Systematic Review.
Candelo E, McCalla M, Valderrama OA, Avila-Castano K, Chelf C, Olomu O, Donaldson AM
Otolaryngol Head Neck Surg 2023 Jul;169(1):12-20. Epub 2023 Jan 29 doi: 10.1002/ohn.248. PMID: 36939486
Quantification of skin erythema response to topical alcohol in alcohol-intolerant East Asians.
Aoki Y, Wehage SL, Talalay P
Skin Res Technol 2017 Nov;23(4):593-596. Epub 2017 May 17 doi: 10.1111/srt.12376. PMID: 28513003
De-alcoholization of paclitaxel injection for clinical application.
Tsukiyama I, Takeuchi M, Abe F, Kisi T, Saito H, Obayashi Y, Watanabe K, Wakatsuki A, Miyamoto K, Hasegawa T
Anticancer Res 2011 Dec;31(12):4339-46. PMID: 22199299
Urticarial reaction caused by ethanol.
Nakagawa Y, Sumikawa Y, Nakamura T, Itami S, Katayama I, Aoki T
Allergol Int 2006 Dec;55(4):411-4. doi: 10.2332/allergolint.55.411. PMID: 17130684
Alcohol use in chronic fatigue syndrome.
Woolley J, Allen R, Wessely S
J Psychosom Res 2004 Feb;56(2):203-6. doi: 10.1016/S0022-3999(03)00077-1. PMID: 15016579

Recent systematic reviews

Relationship Between Alcohol Intolerance and Aspirin-Exacerbated Respiratory Disease (AERD): Systematic Review.
Candelo E, McCalla M, Valderrama OA, Avila-Castano K, Chelf C, Olomu O, Donaldson AM
Otolaryngol Head Neck Surg 2023 Jul;169(1):12-20. Epub 2023 Jan 29 doi: 10.1002/ohn.248. PMID: 36939486

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