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Severe pre-eclampsia

MedGen UID:
574734
Concept ID:
C0341950
Pathologic Function
Synonym: Severe preeclampsia
SNOMED CT: PET - Severe pre-eclamptic toxemia (46764007); Severe proteinuric hypertension of pregnancy (46764007); Severe pre-eclampsia (46764007); Severe pre-eclamptic toxemia (46764007)
 
Monarch Initiative: MONDO:0001641

Definition

Preeclampsia with a systolic blood pressure of 160 mmHg or higher, or a diastolic blood pressure of 110 mmHg or higher on two occasions at least 4 hours apart while on bedrest. It is associated with thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSevere pre-eclampsia

Professional guidelines

PubMed

Yanque-Robles O, Becerra-Chauca N, Nieto-Gutiérrez W, Alegría Guerrero R, Uriarte-Morales M, Valencia-Vargas W, Arroyo-Campuzano J, Torres-Peña LS, Meza-Padilla RA, Meza-Luis C, Salvador-Salvador S, Carrera-Acosta L
Rev Colomb Obstet Ginecol 2022 Mar 30;73(1):48-141. doi: 10.18597/rcog.3810. PMID: 35503297Free PMC Article
Bonnet MP, Garnier M, Keita H, Compère V, Arthuis C, Raia-Barjat T, Berveiller P, Burey J, Bouvet L, Bruyère M, Castel A, Clouqueur E, Gonzalez Estevez M, Faitot V, Fischer C, Fuchs F, Lecarpentier E, Le Gouez A, Rigouzzo A, Rossignol M, Simon E, Vial F, Vivanti AJ, Zieleskiewicz L, Camilleri C, Sénat MV, Schmitz T, Sentilhes L
Anaesth Crit Care Pain Med 2021 Oct;40(5):100901. Epub 2021 Oct 1 doi: 10.1016/j.accpm.2021.100901. PMID: 34602381
Ray A, Ray S
Cochrane Database Syst Rev 2017 Nov 28;11(11):CD009540. doi: 10.1002/14651858.CD009540.pub2. PMID: 29181841Free PMC Article

Recent clinical studies

Etiology

Huang C, Wei K, Lee PMY, Qin G, Yu Y, Li J
BMJ 2022 Oct 19;379:e072157. doi: 10.1136/bmj-2022-072157. PMID: 36261141Free PMC Article
von Dadelszen P, Magee LA
Curr Hypertens Rep 2014 Aug;16(8):454. doi: 10.1007/s11906-014-0454-8. PMID: 24915961
Duley L
BMJ Clin Evid 2011 Feb 14;2011 PMID: 21718554Free PMC Article
Hutcheon JA, Lisonkova S, Joseph KS
Best Pract Res Clin Obstet Gynaecol 2011 Aug;25(4):391-403. Epub 2011 Feb 18 doi: 10.1016/j.bpobgyn.2011.01.006. PMID: 21333604
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807

Diagnosis

von Dadelszen P, Magee LA
Curr Hypertens Rep 2014 Aug;16(8):454. doi: 10.1007/s11906-014-0454-8. PMID: 24915961
Arulkumaran N, Lightstone L
Best Pract Res Clin Obstet Gynaecol 2013 Dec;27(6):877-84. Epub 2013 Aug 17 doi: 10.1016/j.bpobgyn.2013.07.003. PMID: 23962474
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807
Sibai BM
Semin Perinatol 2009 Jun;33(3):196-205. doi: 10.1053/j.semperi.2009.02.004. PMID: 19464511
Walker JJ
Baillieres Best Pract Res Clin Obstet Gynaecol 2000 Feb;14(1):57-71. doi: 10.1053/beog.1999.0063. PMID: 10789260

Therapy

Petri M
Transl Res 2020 Nov;225:70-81. Epub 2020 May 12 doi: 10.1016/j.trsl.2020.04.006. PMID: 32413497Free PMC Article
Abalos E, Duley L, Steyn DW, Gialdini C
Cochrane Database Syst Rev 2018 Oct 1;10(10):CD002252. doi: 10.1002/14651858.CD002252.pub4. PMID: 30277556Free PMC Article
von Dadelszen P, Magee LA
Curr Hypertens Rep 2014 Aug;16(8):454. doi: 10.1007/s11906-014-0454-8. PMID: 24915961
James MF
Best Pract Res Clin Obstet Gynaecol 2010 Jun;24(3):327-37. Epub 2009 Dec 14 doi: 10.1016/j.bpobgyn.2009.11.004. PMID: 20005782
Lu JF, Nightingale CH
Clin Pharmacokinet 2000 Apr;38(4):305-14. doi: 10.2165/00003088-200038040-00002. PMID: 10803454

Prognosis

von Dadelszen P, Magee LA
Curr Hypertens Rep 2014 Aug;16(8):454. doi: 10.1007/s11906-014-0454-8. PMID: 24915961
Payne B, Magee LA, von Dadelszen P
Best Pract Res Clin Obstet Gynaecol 2011 Aug;25(4):449-62. Epub 2011 Apr 1 doi: 10.1016/j.bpobgyn.2011.02.003. PMID: 21459048
Hutcheon JA, Lisonkova S, Joseph KS
Best Pract Res Clin Obstet Gynaecol 2011 Aug;25(4):391-403. Epub 2011 Feb 18 doi: 10.1016/j.bpobgyn.2011.01.006. PMID: 21333604
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807
Walker JJ
Baillieres Best Pract Res Clin Obstet Gynaecol 2000 Feb;14(1):57-71. doi: 10.1053/beog.1999.0063. PMID: 10789260

Clinical prediction guides

Huang C, Wei K, Lee PMY, Qin G, Yu Y, Li J
BMJ 2022 Oct 19;379:e072157. doi: 10.1136/bmj-2022-072157. PMID: 36261141Free PMC Article
von Dadelszen P, Magee LA
Curr Hypertens Rep 2014 Aug;16(8):454. doi: 10.1007/s11906-014-0454-8. PMID: 24915961
Duley L
BMJ Clin Evid 2011 Feb 14;2011 PMID: 21718554Free PMC Article
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807
Duley L
BMJ Clin Evid 2008 Aug 14;2008 PMID: 19445808Free PMC Article

Recent systematic reviews

Abalos E, Duley L, Steyn DW, Gialdini C
Cochrane Database Syst Rev 2018 Oct 1;10(10):CD002252. doi: 10.1002/14651858.CD002252.pub4. PMID: 30277556Free PMC Article
Ray A, Ray S
Cochrane Database Syst Rev 2017 Nov 28;11(11):CD009540. doi: 10.1002/14651858.CD009540.pub2. PMID: 29181841Free PMC Article
Amorim MM, Souza ASR, Katz L
Cochrane Database Syst Rev 2017 Oct 23;10(10):CD009430. doi: 10.1002/14651858.CD009430.pub2. PMID: 29058762Free PMC Article
Duley L
BMJ Clin Evid 2011 Feb 14;2011 PMID: 21718554Free PMC Article
Duley L
BMJ Clin Evid 2008 Aug 14;2008 PMID: 19445808Free PMC Article

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