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LH - luteinizing hormone deficiency

MedGen UID:
574995
•Concept ID:
C0342387
•
Disease or Syndrome
Synonym: Luteinizing hormone (LH) deficiency
SNOMED CT: LH - luteinizing hormone deficiency (190481008); Luteinizing hormone deficiency (190481008)

Definition

Subnormal concentration of luteinizing hormone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLH - luteinizing hormone deficiency

Professional guidelines

PubMed

Optimizing Diagnostic Accuracy and Treatment Decisions in Men With Testosterone Deficiency.
Bhasin S, Ozimek N
Endocr Pract 2021 Dec;27(12):1252-1259. Epub 2021 Aug 11 doi: 10.1016/j.eprac.2021.08.002. PMID: 34390882
EAA clinical practice guidelines-gynecomastia evaluation and management.
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174
Management Strategies in Opioid Abuse and Sexual Dysfunction: A Review of Opioid-Induced Androgen Deficiency.
Hsieh A, DiGiorgio L, Fakunle M, Sadeghi-Nejad H
Sex Med Rev 2018 Oct;6(4):618-623. Epub 2018 Jul 26 doi: 10.1016/j.sxmr.2018.04.003. PMID: 30057139

Recent clinical studies

Etiology

Optimizing Diagnostic Accuracy and Treatment Decisions in Men With Testosterone Deficiency.
Bhasin S, Ozimek N
Endocr Pract 2021 Dec;27(12):1252-1259. Epub 2021 Aug 11 doi: 10.1016/j.eprac.2021.08.002. PMID: 34390882
Hypothalamic-Pituitary Dysfunctions Other Than Growth Hormone Deficiency in Cancer Survivors.
van Iersel L, Chemaitilly W
Front Horm Res 2021;54:36-46. Epub 2021 Feb 8 doi: 10.1159/000513806. PMID: 33556939
GONADOPENIA AND AGING IN MEN.
Dhindsa SS, Irwig MS, Wyne K
Endocr Pract 2018 Apr;24(4):375-385. doi: 10.4158/EP-2017-0131. PMID: 29658833
Energy availability and the female athlete triad in elite endurance athletes.
Melin A, Tornberg ÅB, Skouby S, Møller SS, Sundgot-Borgen J, Faber J, Sidelmann JJ, Aziz M, Sjödin A
Scand J Med Sci Sports 2015 Oct;25(5):610-22. Epub 2014 May 30 doi: 10.1111/sms.12261. PMID: 24888644
Hypopituitarism.
Schneider HJ, Aimaretti G, Kreitschmann-Andermahr I, Stalla GK, Ghigo E
Lancet 2007 Apr 28;369(9571):1461-1470. doi: 10.1016/S0140-6736(07)60673-4. PMID: 17467517

Diagnosis

EAA clinical practice guidelines-gynecomastia evaluation and management.
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174
GONADOPENIA AND AGING IN MEN.
Dhindsa SS, Irwig MS, Wyne K
Endocr Pract 2018 Apr;24(4):375-385. doi: 10.4158/EP-2017-0131. PMID: 29658833
Endocrinology Update: Hirsutism.
Heidelbaugh JJ
FP Essent 2016 Dec;451:17-24. PMID: 27936531
Hypopituitarism.
Schneider HJ, Aimaretti G, Kreitschmann-Andermahr I, Stalla GK, Ghigo E
Lancet 2007 Apr 28;369(9571):1461-1470. doi: 10.1016/S0140-6736(07)60673-4. PMID: 17467517
Hypogonadotropic hypogonadism.
Hayes FJ, Seminara SB, Crowley WF Jr
Endocrinol Metab Clin North Am 1998 Dec;27(4):739-63, vii. doi: 10.1016/s0889-8529(05)70039-6. PMID: 9922906

Therapy

Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis.
Huijben M, Lock MTWT, de Kemp VF, de Kort LMO, van Breda HMK
Andrology 2022 Mar;10(3):451-469. Epub 2022 Jan 8 doi: 10.1111/andr.13146. PMID: 34933414
EAA clinical practice guidelines-gynecomastia evaluation and management.
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174
Endocrinology Update: Hirsutism.
Heidelbaugh JJ
FP Essent 2016 Dec;451:17-24. PMID: 27936531
Lutropin alfa.
Dhillon S, Keating GM
Drugs 2008;68(11):1529-40. doi: 10.2165/00003495-200868110-00005. PMID: 18627209
Hypopituitarism.
Schneider HJ, Aimaretti G, Kreitschmann-Andermahr I, Stalla GK, Ghigo E
Lancet 2007 Apr 28;369(9571):1461-1470. doi: 10.1016/S0140-6736(07)60673-4. PMID: 17467517

Prognosis

The relationship between menopausal syndrome and gut microbes.
Liu Y, Zhou Y, Mao T, Huang Y, Liang J, Zhu M, Yao P, Zong Y, Lang J, Zhang Y
BMC Womens Health 2022 Nov 8;22(1):437. doi: 10.1186/s12905-022-02029-w. PMID: 36348390Free PMC Article
Luteinizing Hormone Suppression Profiles in Men Treated With Exogenous Testosterone.
Miranda EP, Schofield E, Matsushita K, Katz DJ, Nelson CJ, Benfante N, Mulhall JP
J Sex Med 2022 Sep;19(9):1359-1365. Epub 2022 Jul 14 doi: 10.1016/j.jsxm.2022.06.001. PMID: 35842309
Recovery of male reproductive endocrine function after ceasing prolonged testosterone undecanoate injections.
Handelsman DJ, Desai R, Conway AJ, Shankara-Narayana N, Stuckey BGA, Inder WJ, Grossmann M, Yeap BB, Jesudason D, Ly LP, Bracken K, Wittert GA
Eur J Endocrinol 2022 Jan 28;186(3):307-318. doi: 10.1530/EJE-21-0608. PMID: 35000898
Treatment with growth hormone and luteinizing hormone releasing hormone analog improves final adult height in children with congenital adrenal hyperplasia.
Lin-Su K, Vogiatzi MG, Marshall I, Harbison MD, Macapagal MC, Betensky B, Tansil S, New MI
J Clin Endocrinol Metab 2005 Jun;90(6):3318-25. Epub 2005 Mar 29 doi: 10.1210/jc.2004-2128. PMID: 15797962
Diagnosis and treatment of children with growth hormone deficiency.
Preece MA
Clin Endocrinol Metab 1982 Mar;11(1):1-24. doi: 10.1016/s0300-595x(82)80035-2. PMID: 6807584

Clinical prediction guides

The relationship between menopausal syndrome and gut microbes.
Liu Y, Zhou Y, Mao T, Huang Y, Liang J, Zhu M, Yao P, Zong Y, Lang J, Zhang Y
BMC Womens Health 2022 Nov 8;22(1):437. doi: 10.1186/s12905-022-02029-w. PMID: 36348390Free PMC Article
Luteinizing Hormone Suppression Profiles in Men Treated With Exogenous Testosterone.
Miranda EP, Schofield E, Matsushita K, Katz DJ, Nelson CJ, Benfante N, Mulhall JP
J Sex Med 2022 Sep;19(9):1359-1365. Epub 2022 Jul 14 doi: 10.1016/j.jsxm.2022.06.001. PMID: 35842309
Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis.
Huijben M, Lock MTWT, de Kemp VF, de Kort LMO, van Breda HMK
Andrology 2022 Mar;10(3):451-469. Epub 2022 Jan 8 doi: 10.1111/andr.13146. PMID: 34933414
Treatment with growth hormone and luteinizing hormone releasing hormone analog improves final adult height in children with congenital adrenal hyperplasia.
Lin-Su K, Vogiatzi MG, Marshall I, Harbison MD, Macapagal MC, Betensky B, Tansil S, New MI
J Clin Endocrinol Metab 2005 Jun;90(6):3318-25. Epub 2005 Mar 29 doi: 10.1210/jc.2004-2128. PMID: 15797962
Luteinizing hormone on Leydig cell structure and function.
Mendis-Handagama SM
Histol Histopathol 1997 Jul;12(3):869-82. PMID: 9225169

Recent systematic reviews

Luteinizing hormone β-subunit deficiency: Report of a novel LHB likely pathogenic variant and a systematic review of the published literature.
Barnabas R, Jadhav S, Arya S, Lila AR, Sarathi V, Shah GR, Bhandare VV, Shah NS, Kunwar A, Bandgar T
Clin Endocrinol (Oxf) 2023 Mar;98(3):383-393. Epub 2022 May 4 doi: 10.1111/cen.14749. PMID: 35470463
Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis.
Huijben M, Lock MTWT, de Kemp VF, de Kort LMO, van Breda HMK
Andrology 2022 Mar;10(3):451-469. Epub 2022 Jan 8 doi: 10.1111/andr.13146. PMID: 34933414
Xanthomatous Hypophysitis: A Case Report and Comprehensive Literature Review.
Zhu J, Wang Z, Wang W, Fan J, Zhang Y, Li X, Liu J, Jiang S, Deng K, Duan L, Yao Y, Zhu H
Front Endocrinol (Lausanne) 2021;12:735655. Epub 2021 Oct 1 doi: 10.3389/fendo.2021.735655. PMID: 34659121Free PMC Article
A systematic review and meta-analysis of the association between vitamin D and ovarian reserve.
Karimi E, Arab A, Rafiee M, Amani R
Sci Rep 2021 Aug 6;11(1):16005. doi: 10.1038/s41598-021-95481-x. PMID: 34362981Free PMC Article
Do 5α-Reductase Inhibitors Raise Circulating Serum Testosterone Levels? A Comprehensive Review and Meta-Analysis to Explaining Paradoxical Results.
Traish AM, Krakowsky Y, Doros G, Morgentaler A
Sex Med Rev 2019 Jan;7(1):95-114. Epub 2018 Aug 8 doi: 10.1016/j.sxmr.2018.06.002. PMID: 30098986

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