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Hypophysitis

MedGen UID:
575012
•Concept ID:
C0342409
•
Disease or Syndrome
Synonym: Hypophysitides
SNOMED CT: Hypophysitis (237705001)
 
Monarch Initiative: MONDO:0021156

Definition

An inflammatory process in the pituitary gland. [from NCI]

Professional guidelines

PubMed

Immune-Related Adverse Events (irAEs): Diagnosis, Management, and Clinical Pearls.
Darnell EP, Mooradian MJ, Baruch EN, Yilmaz M, Reynolds KL
Curr Oncol Rep 2020 Mar 21;22(4):39. doi: 10.1007/s11912-020-0897-9. PMID: 32200442
Management of toxicities of immune checkpoint inhibitors.
Spain L, Diem S, Larkin J
Cancer Treat Rev 2016 Mar;44:51-60. Epub 2016 Feb 6 doi: 10.1016/j.ctrv.2016.02.001. PMID: 26874776
Management of immune-related adverse events and kinetics of response with ipilimumab.
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989

Recent clinical studies

Etiology

Pregnancy-related hypophysitis revisited.
Honegger J, Giese S, Nasi-Kordhishti I, Donegan DM
Eur J Endocrinol 2023 Feb 14;188(2) doi: 10.1093/ejendo/lvad003. PMID: 36655394
Immune-related adverse events for anti-PD-1 and anti-PD-L1 drugs: systematic review and meta-analysis.
Baxi S, Yang A, Gennarelli RL, Khan N, Wang Z, Boyce L, Korenstein D
BMJ 2018 Mar 14;360:k793. doi: 10.1136/bmj.k793. PMID: 29540345Free PMC Article
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.
Barroso-Sousa R, Barry WT, Garrido-Castro AC, Hodi FS, Min L, Krop IE, Tolaney SM
JAMA Oncol 2018 Feb 1;4(2):173-182. doi: 10.1001/jamaoncol.2017.3064. PMID: 28973656Free PMC Article
Management of toxicities of immune checkpoint inhibitors.
Spain L, Diem S, Larkin J
Cancer Treat Rev 2016 Mar;44:51-60. Epub 2016 Feb 6 doi: 10.1016/j.ctrv.2016.02.001. PMID: 26874776
Management of immune-related adverse events and kinetics of response with ipilimumab.
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989

Diagnosis

Hypophysitis.
Donegan D, Honegger J
Endocr Pract 2022 Sep;28(9):901-910. Epub 2022 Jun 30 doi: 10.1016/j.eprac.2022.06.009. PMID: 35779833
Hypophysitis, the Growing Spectrum of a Rare Pituitary Disease.
Langlois F, Varlamov EV, Fleseriu M
J Clin Endocrinol Metab 2022 Jan 1;107(1):10-28. doi: 10.1210/clinem/dgab672. PMID: 34528683Free PMC Article
Autoimmune diabetes insipidus.
Scherbaum WA
Handb Clin Neurol 2021;181:193-204. doi: 10.1016/B978-0-12-820683-6.00015-4. PMID: 34238458
The neurology of IGG4-related disease.
Saitakis G, Chwalisz BK
J Neurol Sci 2021 May 15;424:117420. Epub 2021 Mar 27 doi: 10.1016/j.jns.2021.117420. PMID: 33845982
IgG4-related hypophysitis.
Amirbaigloo A, Esfahanian F, Mouodi M, Rakhshani N, Zeinalizadeh M
Endocrine 2021 Aug;73(2):270-291. Epub 2021 Apr 10 doi: 10.1007/s12020-021-02714-0. PMID: 33837927

Therapy

Endocrine toxicities of immune checkpoint inhibitors.
Wright JJ, Powers AC, Johnson DB
Nat Rev Endocrinol 2021 Jul;17(7):389-399. Epub 2021 Apr 19 doi: 10.1038/s41574-021-00484-3. PMID: 33875857Free PMC Article
Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints.
Chang LS, Barroso-Sousa R, Tolaney SM, Hodi FS, Kaiser UB, Min L
Endocr Rev 2019 Feb 1;40(1):17-65. doi: 10.1210/er.2018-00006. PMID: 30184160Free PMC Article
Immune-related adverse events for anti-PD-1 and anti-PD-L1 drugs: systematic review and meta-analysis.
Baxi S, Yang A, Gennarelli RL, Khan N, Wang Z, Boyce L, Korenstein D
BMJ 2018 Mar 14;360:k793. doi: 10.1136/bmj.k793. PMID: 29540345Free PMC Article
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.
Barroso-Sousa R, Barry WT, Garrido-Castro AC, Hodi FS, Min L, Krop IE, Tolaney SM
JAMA Oncol 2018 Feb 1;4(2):173-182. doi: 10.1001/jamaoncol.2017.3064. PMID: 28973656Free PMC Article
Management of toxicities of immune checkpoint inhibitors.
Spain L, Diem S, Larkin J
Cancer Treat Rev 2016 Mar;44:51-60. Epub 2016 Feb 6 doi: 10.1016/j.ctrv.2016.02.001. PMID: 26874776

Prognosis

IgG4-related hypophysitis.
Amirbaigloo A, Esfahanian F, Mouodi M, Rakhshani N, Zeinalizadeh M
Endocrine 2021 Aug;73(2):270-291. Epub 2021 Apr 10 doi: 10.1007/s12020-021-02714-0. PMID: 33837927
Neuroimmunological adverse events associated with immune checkpoint inhibitor: a retrospective, pharmacovigilance study using FAERS database.
Mikami T, Liaw B, Asada M, Niimura T, Zamami Y, Green-LaRoche D, Pai L, Levy M, Jeyapalan S
J Neurooncol 2021 Mar;152(1):135-144. Epub 2021 Jan 9 doi: 10.1007/s11060-020-03687-2. PMID: 33423151
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.
Barroso-Sousa R, Barry WT, Garrido-Castro AC, Hodi FS, Min L, Krop IE, Tolaney SM
JAMA Oncol 2018 Feb 1;4(2):173-182. doi: 10.1001/jamaoncol.2017.3064. PMID: 28973656Free PMC Article
Pituitary Autoimmunity.
Guaraldi F, Giordano R, Grottoli S, Ghizzoni L, Arvat E, Ghigo E
Front Horm Res 2017;48:48-68. Epub 2017 Feb 28 doi: 10.1159/000452905. PMID: 28245451
Hypophysitis.
Fukuoka H
Endocrinol Metab Clin North Am 2015 Mar;44(1):143-9. Epub 2014 Nov 4 doi: 10.1016/j.ecl.2014.10.011. PMID: 25732650

Clinical prediction guides

Hypophysitis, the Growing Spectrum of a Rare Pituitary Disease.
Langlois F, Varlamov EV, Fleseriu M
J Clin Endocrinol Metab 2022 Jan 1;107(1):10-28. doi: 10.1210/clinem/dgab672. PMID: 34528683Free PMC Article
Long-term outcomes of patients with active melanoma brain metastases treated with combination nivolumab plus ipilimumab (CheckMate 204): final results of an open-label, multicentre, phase 2 study.
Tawbi HA, Forsyth PA, Hodi FS, Algazi AP, Hamid O, Lao CD, Moschos SJ, Atkins MB, Lewis K, Postow MA, Thomas RP, Glaspy J, Jang S, Khushalani NI, Pavlick AC, Ernstoff MS, Reardon DA, Kudchadkar R, Tarhini A, Chung C, Ritchings C, Durani P, Askelson M, Puzanov I, Margolin KA
Lancet Oncol 2021 Dec;22(12):1692-1704. Epub 2021 Nov 10 doi: 10.1016/S1470-2045(21)00545-3. PMID: 34774225Free PMC Article
Neuroimmunological adverse events associated with immune checkpoint inhibitor: a retrospective, pharmacovigilance study using FAERS database.
Mikami T, Liaw B, Asada M, Niimura T, Zamami Y, Green-LaRoche D, Pai L, Levy M, Jeyapalan S
J Neurooncol 2021 Mar;152(1):135-144. Epub 2021 Jan 9 doi: 10.1007/s11060-020-03687-2. PMID: 33423151
Cancer immunotherapy-associated hypophysitis.
Solinas C, Porcu M, De Silva P, Musi M, Aspeslagh S, Scartozzi M, Willard-Gallo K, Mariotti S, Saba L
Semin Oncol 2018 Jun;45(3):181-186. Epub 2018 Oct 21 doi: 10.1053/j.seminoncol.2018.09.002. PMID: 30352754
Management of immune-related adverse events and kinetics of response with ipilimumab.
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989

Recent systematic reviews

Frequency and clinical characteristics of hypophysitis and hypopituitarism in patients undergoing immunotherapy - A systematic review.
Jacques JP, Valadares LP, Moura AC, Oliveira MRF, Naves LA
Front Endocrinol (Lausanne) 2023;14:1091185. Epub 2023 Feb 15 doi: 10.3389/fendo.2023.1091185. PMID: 36875457Free PMC Article
Hypophysitis: A comprehensive overview.
de Vries F, van Furth WR, Biermasz NR, Pereira AM
Presse Med 2021 Dec;50(4):104076. Epub 2021 Oct 21 doi: 10.1016/j.lpm.2021.104076. PMID: 34687912
Immune-related adverse events for anti-PD-1 and anti-PD-L1 drugs: systematic review and meta-analysis.
Baxi S, Yang A, Gennarelli RL, Khan N, Wang Z, Boyce L, Korenstein D
BMJ 2018 Mar 14;360:k793. doi: 10.1136/bmj.k793. PMID: 29540345Free PMC Article
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.
Barroso-Sousa R, Barry WT, Garrido-Castro AC, Hodi FS, Min L, Krop IE, Tolaney SM
JAMA Oncol 2018 Feb 1;4(2):173-182. doi: 10.1001/jamaoncol.2017.3064. PMID: 28973656Free PMC Article
Tumour- and class-specific patterns of immune-related adverse events of immune checkpoint inhibitors: a systematic review.
Khoja L, Day D, Wei-Wu Chen T, Siu LL, Hansen AR
Ann Oncol 2017 Oct 1;28(10):2377-2385. doi: 10.1093/annonc/mdx286. PMID: 28945858

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