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Sydenham chorea

MedGen UID:
57506
•Concept ID:
C0152113
•
Disease or Syndrome
Synonyms: Chorea minor; St. Vitus dance; Sydenham's chorea
SNOMED CT: Rheumatic chorea (46826000); Sydenham's chorea (46826000)
 
Monarch Initiative: MONDO:0017648

Definition

A neurologic disorder characterized by smooth involuntary, uncoordinated movements affecting especially the hands, feet, and face. (ACC-AHA) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSydenham chorea

Professional guidelines

PubMed

Chorea in children: etiology, diagnostic approach and management.
Baizabal-Carvallo JF, Cardoso F
J Neural Transm (Vienna) 2020 Oct;127(10):1323-1342. Epub 2020 Aug 9 doi: 10.1007/s00702-020-02238-3. PMID: 32776155
Efficacy of levetiracetam in the treatment of Sydenham chorea.
Direk M, Epcacan S, Epcacan Z, Yildirim DD, Okuyaz C
Pediatr Int 2020 Nov;62(11):1264-1268. Epub 2020 Nov 5 doi: 10.1111/ped.14318. PMID: 32445412
Principles and approaches to the treatment of immune-mediated movement disorders.
Mohammad SS, Dale RC
Eur J Paediatr Neurol 2018 Mar;22(2):292-300. Epub 2017 Dec 19 doi: 10.1016/j.ejpn.2017.11.010. PMID: 29289523

Recent clinical studies

Etiology

Treatments and Outcomes Among Patients with Sydenham Chorea: A Meta-Analysis.
Eyre M, Thomas T, Ferrarin E, Khamis S, Zuberi SM, Sie A, Newlove-Delgado T, Morton M, Molteni E, Dale RC, Lim M, Nosadini M; Sydenham’s Chorea Systematic Literature Review Working Group
JAMA Netw Open 2024 Apr 1;7(4):e246792. doi: 10.1001/jamanetworkopen.2024.6792. PMID: 38625703Free PMC Article
Postinfectious Inflammation, Autoimmunity, and Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection, and Pediatric Acute-Onset Neuropsychiatric Disorder.
Vreeland A, Calaprice D, Or-Geva N, Frye RE, Agalliu D, Lachman HM, Pittenger C, Pallanti S, Williams K, Ma M, Thienemann M, Gagliano A, Mellins E, Frankovich J
Dev Neurosci 2023;45(6):361-374. Epub 2023 Sep 22 doi: 10.1159/000534261. PMID: 37742615
Managing and treating Sydenham chorea: A systematic review.
Tariq S, Niaz F, Waseem S, Shaikh TG, Ahmed SH, Irfan M, Nashwan AJ, Ullah I
Brain Behav 2023 Jun;13(6):e3035. Epub 2023 May 7 doi: 10.1002/brb3.3035. PMID: 37150977Free PMC Article
Sydenham Chorea: Putaminal Enlargement.
Karalok ZS, Öztürk Z, Gunes A, Gurkas E
J Child Neurol 2021 Jan;36(1):48-53. Epub 2020 Aug 27 doi: 10.1177/0883073820951364. PMID: 32851928
Streptococcus and rheumatic fever.
Cunningham MW
Curr Opin Rheumatol 2012 Jul;24(4):408-16. doi: 10.1097/BOR.0b013e32835461d3. PMID: 22617826Free PMC Article

Diagnosis

Postinfectious Inflammation, Autoimmunity, and Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection, and Pediatric Acute-Onset Neuropsychiatric Disorder.
Vreeland A, Calaprice D, Or-Geva N, Frye RE, Agalliu D, Lachman HM, Pittenger C, Pallanti S, Williams K, Ma M, Thienemann M, Gagliano A, Mellins E, Frankovich J
Dev Neurosci 2023;45(6):361-374. Epub 2023 Sep 22 doi: 10.1159/000534261. PMID: 37742615
Neuroinflammation in Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections, and Pediatric Acute Onset Neuropsychiatric Syndrome.
Vreeland A, Thienemann M, Cunningham M, Muscal E, Pittenger C, Frankovich J
Psychiatr Clin North Am 2023 Mar;46(1):69-88. doi: 10.1016/j.psc.2022.11.004. PMID: 36740356
Chorea in children: etiology, diagnostic approach and management.
Baizabal-Carvallo JF, Cardoso F
J Neural Transm (Vienna) 2020 Oct;127(10):1323-1342. Epub 2020 Aug 9 doi: 10.1007/s00702-020-02238-3. PMID: 32776155
Chorea.
Termsarasab P
Continuum (Minneap Minn) 2019 Aug;25(4):1001-1035. doi: 10.1212/CON.0000000000000763. PMID: 31356291
Autoantibody-associated movement disorders.
Mohammad SS, Ramanathan S, Brilot F, Dale RC
Neuropediatrics 2013 Dec;44(6):336-45. Epub 2013 Nov 7 doi: 10.1055/s-0033-1358603. PMID: 24203856

Therapy

Postinfectious Inflammation, Autoimmunity, and Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection, and Pediatric Acute-Onset Neuropsychiatric Disorder.
Vreeland A, Calaprice D, Or-Geva N, Frye RE, Agalliu D, Lachman HM, Pittenger C, Pallanti S, Williams K, Ma M, Thienemann M, Gagliano A, Mellins E, Frankovich J
Dev Neurosci 2023;45(6):361-374. Epub 2023 Sep 22 doi: 10.1159/000534261. PMID: 37742615
Managing and treating Sydenham chorea: A systematic review.
Tariq S, Niaz F, Waseem S, Shaikh TG, Ahmed SH, Irfan M, Nashwan AJ, Ullah I
Brain Behav 2023 Jun;13(6):e3035. Epub 2023 May 7 doi: 10.1002/brb3.3035. PMID: 37150977Free PMC Article
Neuroinflammation in Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections, and Pediatric Acute Onset Neuropsychiatric Syndrome.
Vreeland A, Thienemann M, Cunningham M, Muscal E, Pittenger C, Frankovich J
Psychiatr Clin North Am 2023 Mar;46(1):69-88. doi: 10.1016/j.psc.2022.11.004. PMID: 36740356
Chorea in children: etiology, diagnostic approach and management.
Baizabal-Carvallo JF, Cardoso F
J Neural Transm (Vienna) 2020 Oct;127(10):1323-1342. Epub 2020 Aug 9 doi: 10.1007/s00702-020-02238-3. PMID: 32776155
Chorea.
Termsarasab P
Continuum (Minneap Minn) 2019 Aug;25(4):1001-1035. doi: 10.1212/CON.0000000000000763. PMID: 31356291

Prognosis

Treatments and Outcomes Among Patients with Sydenham Chorea: A Meta-Analysis.
Eyre M, Thomas T, Ferrarin E, Khamis S, Zuberi SM, Sie A, Newlove-Delgado T, Morton M, Molteni E, Dale RC, Lim M, Nosadini M; Sydenham’s Chorea Systematic Literature Review Working Group
JAMA Netw Open 2024 Apr 1;7(4):e246792. doi: 10.1001/jamanetworkopen.2024.6792. PMID: 38625703Free PMC Article
Neuroinflammation in Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections, and Pediatric Acute Onset Neuropsychiatric Syndrome.
Vreeland A, Thienemann M, Cunningham M, Muscal E, Pittenger C, Frankovich J
Psychiatr Clin North Am 2023 Mar;46(1):69-88. doi: 10.1016/j.psc.2022.11.004. PMID: 36740356
Chorea gravidarum: Case report and review of the literature.
Rengifo-Quintero LJ, Beltrán-Avendaño MA
Rev Colomb Obstet Ginecol 2019 Sep;70(3):189-194. doi: 10.18597/rcog.3251. PMID: 31738489
Principles and approaches to the treatment of immune-mediated movement disorders.
Mohammad SS, Dale RC
Eur J Paediatr Neurol 2018 Mar;22(2):292-300. Epub 2017 Dec 19 doi: 10.1016/j.ejpn.2017.11.010. PMID: 29289523
Acute and chronic chorea in childhood.
Gilbert DL
Semin Pediatr Neurol 2009 Jun;16(2):71-6. doi: 10.1016/j.spen.2009.03.009. PMID: 19501334

Clinical prediction guides

Treatments and Outcomes Among Patients with Sydenham Chorea: A Meta-Analysis.
Eyre M, Thomas T, Ferrarin E, Khamis S, Zuberi SM, Sie A, Newlove-Delgado T, Morton M, Molteni E, Dale RC, Lim M, Nosadini M; Sydenham’s Chorea Systematic Literature Review Working Group
JAMA Netw Open 2024 Apr 1;7(4):e246792. doi: 10.1001/jamanetworkopen.2024.6792. PMID: 38625703Free PMC Article
Efficacy of levetiracetam in the treatment of Sydenham chorea.
Direk M, Epcacan S, Epcacan Z, Yildirim DD, Okuyaz C
Pediatr Int 2020 Nov;62(11):1264-1268. Epub 2020 Nov 5 doi: 10.1111/ped.14318. PMID: 32445412
Preliminary data on prednisone effectiveness in children with Sydenham chorea.
Favaretto E, Gortani G, Simonini G, Pastore S, Di Mascio A, Cimaz R, Taddio A
Eur J Pediatr 2020 Jun;179(6):993-997. Epub 2020 Jan 21 doi: 10.1007/s00431-020-03574-y. PMID: 31965299
Sydenham chorea: clinical and laboratory findings. Analysis of 187 cases.
Goldenberg J, Ferraz MB, Fonseca AS, Hilário MO, Bastos W, Sachetti S
Rev Paul Med 1992 Jul-Aug;110(4):152-7. PMID: 1341004
Sydenham chorea: an update.
Nausieda PA, Grossman BJ, Koller WC, Weiner WJ, Klawans HL
Neurology 1980 Mar;30(3):331-4. doi: 10.1212/wnl.30.3.331. PMID: 7189038

Recent systematic reviews

Chorea following SARS-CoV-2 infection and vaccination: a systematic review of reported cases.
Rosca EC, Bilavu R, Cornea A, Simu M
Int J Infect Dis 2023 Sep;134:256-260. Epub 2023 Jul 7 doi: 10.1016/j.ijid.2023.07.001. PMID: 37423421
Managing and treating Sydenham chorea: A systematic review.
Tariq S, Niaz F, Waseem S, Shaikh TG, Ahmed SH, Irfan M, Nashwan AJ, Ullah I
Brain Behav 2023 Jun;13(6):e3035. Epub 2023 May 7 doi: 10.1002/brb3.3035. PMID: 37150977Free PMC Article
Systematic review of immunoglobulin use in paediatric neurological and neurodevelopmental disorders.
Gadian J, Kirk E, Holliday K, Lim M, Absoud M
Dev Med Child Neurol 2017 Feb;59(2):136-144. Epub 2016 Nov 30 doi: 10.1111/dmcn.13349. PMID: 27900773
Anti-basal ganglia antibodies in primary obsessive-compulsive disorder: systematic review and meta-analysis.
Pearlman DM, Vora HS, Marquis BG, Najjar S, Dudley LA
Br J Psychiatry 2014 Jul;205(1):8-16. doi: 10.1192/bjp.bp.113.137018. PMID: 24986387
Cognitive and psychiatric phenotypes of movement disorders in children: a systematic review.
Ben-Pazi H, Jaworowski S, Shalev RS
Dev Med Child Neurol 2011 Dec;53(12):1077-84. Epub 2011 Sep 27 doi: 10.1111/j.1469-8749.2011.04134.x. PMID: 21950517

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