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Malignant Pharyngeal Neoplasm

MedGen UID:
57554
•Concept ID:
C0153405
•
Neoplastic Process
Synonyms: Cancer of Pharynx; Cancer of the Pharynx; Cancer, Pharnyx; Cancer, Pharyngeal; Cancers, Pharnyx; Cancers, Pharyngeal; Pharnyx Cancer; Pharnyx Cancers; Pharyngeal Cancer; Pharyngeal Cancers; Pharynx Cancer; Pharynx Cancers
SNOMED CT: Cancer of pharynx (363507003); CA - Cancer of pharynx (363507003); Malignant neoplasm of pharynx (363507003); Malignant tumor of pharynx (363507003)

Definition

A primary or metastatic malignant neoplasm that affects the pharynx. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Pharyngeal Neoplasm

Professional guidelines

PubMed

HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.
Lechner M, Liu J, Masterson L, Fenton TR
Nat Rev Clin Oncol 2022 May;19(5):306-327. Epub 2022 Feb 1 doi: 10.1038/s41571-022-00603-7. PMID: 35105976Free PMC Article
The Chinese Society of Clinical Oncology (CSCO) clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma.
Tang LL, Chen YP, Chen CB, Chen MY, Chen NY, Chen XZ, Du XJ, Fang WF, Feng M, Gao J, Han F, He X, Hu CS, Hu DS, Hu GY, Jiang H, Jiang W, Jin F, Lang JY, Li JG, Lin SJ, Liu X, Liu QF, Ma L, Mai HQ, Qin JY, Shen LF, Sun Y, Wang PG, Wang RS, Wang RZ, Wang XS, Wang Y, Wu H, Xia YF, Xiao SW, Yang KY, Yi JL, Zhu XD, Ma J
Cancer Commun (Lond) 2021 Nov;41(11):1195-1227. Epub 2021 Oct 26 doi: 10.1002/cac2.12218. PMID: 34699681Free PMC Article
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314

Recent clinical studies

Etiology

Parapharyngeal space primary tumours.
Grilli G, Suarez V, Muñoz MG, Costales M, Llorente JL
Acta Otorrinolaringol Esp (Engl Ed) 2017 May-Jun;68(3):138-144. doi: 10.1016/j.otorri.2016.06.003. PMID: 27663220
Parapharyngeal Tumor.
Bakshi SS
Am J Med 2016 Dec;129(12):e331-e332. Epub 2016 Jul 15 doi: 10.1016/j.amjmed.2016.06.021. PMID: 27427319
A review of the epidemiology of oral and pharyngeal carcinoma: update.
Saman DM
Head Neck Oncol 2012 Jan 13;4:1. doi: 10.1186/1758-3284-4-1. PMID: 22244087Free PMC Article
Parapharyngeal space neoplasms.
Hughes KV 3rd, Olsen KD, McCaffrey TV
Head Neck 1995 Mar-Apr;17(2):124-30. doi: 10.1002/hed.2880170209. PMID: 7558809
Snuff dipper's cancer.
Schottenfeld D
N Engl J Med 1981 Mar 26;304(13):778-9. doi: 10.1056/NEJM198103263041309. PMID: 7193289

Diagnosis

History of endoscopic diagnosis and treatment for esophageal and pharyngeal squamous cell carcinoma.
Ishihara R, Katada C
Dig Endosc 2022 May;34 Suppl 2:23-26. Epub 2021 Jun 24 doi: 10.1111/den.14062. PMID: 34170053
Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Paediatric parapharyngeal ganglioneuroma.
Bach J, Azher Q, Salih A
BMJ Case Rep 2018 Aug 20;2018 doi: 10.1136/bcr-2018-225763. PMID: 30131403Free PMC Article
Parapharyngeal space primary tumours.
Grilli G, Suarez V, Muñoz MG, Costales M, Llorente JL
Acta Otorrinolaringol Esp (Engl Ed) 2017 May-Jun;68(3):138-144. doi: 10.1016/j.otorri.2016.06.003. PMID: 27663220
A review of the epidemiology of oral and pharyngeal carcinoma: update.
Saman DM
Head Neck Oncol 2012 Jan 13;4:1. doi: 10.1186/1758-3284-4-1. PMID: 22244087Free PMC Article

Therapy

Coffee is protective against oral and pharyngeal cancer: A systematic review and meta-analysis.
Miranda J, Monteiro L, Albuquerque R, Pacheco JJ, Khan Z, Lopez-Lopez J, Warnakulasuryia S
Med Oral Patol Oral Cir Bucal 2017 Sep 1;22(5):e554-e561. doi: 10.4317/medoral.21829. PMID: 28809372Free PMC Article
Maté drinking and oral and oro-pharyngeal cancer: a systematic review and meta-analysis.
Dasanayake AP, Silverman AJ, Warnakulasuriya S
Oral Oncol 2010 Feb;46(2):82-6. Epub 2009 Dec 29 doi: 10.1016/j.oraloncology.2009.07.006. PMID: 20036605
The role of foods and nutrients on oral and pharyngeal cancer risk.
Garavello W, Lucenteforte E, Bosetti C, La Vecchia C
Minerva Stomatol 2009 Jan-Feb;58(1-2):25-34. PMID: 19234434
Diet and oral, pharyngeal, and esophageal cancer.
Chainani-Wu N
Nutr Cancer 2002;44(2):104-26. doi: 10.1207/S15327914NC4402_01. PMID: 12734057
Hypopharyngeal stenosis.
McConnel FM, Duck SW, Hester TR
Laryngoscope 1984 Sep;94(9):1162-4. doi: 10.1288/00005537-198409000-00006. PMID: 6472011

Prognosis

Incidence and survival in oral and pharyngeal cancers in Finland and Sweden through half century.
Koskinen AI, Hemminki O, Försti A, Hemminki K
BMC Cancer 2022 Mar 2;22(1):227. doi: 10.1186/s12885-022-09337-2. PMID: 35236321Free PMC Article
Global trends in oral and pharyngeal cancer incidence and mortality.
Bosetti C, Carioli G, Santucci C, Bertuccio P, Gallus S, Garavello W, Negri E, La Vecchia C
Int J Cancer 2020 Aug 15;147(4):1040-1049. Epub 2020 Jan 30 doi: 10.1002/ijc.32871. PMID: 31953840
Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Parapharyngeal Tumor.
Bakshi SS
Am J Med 2016 Dec;129(12):e331-e332. Epub 2016 Jul 15 doi: 10.1016/j.amjmed.2016.06.021. PMID: 27427319
Parapharyngeal space neoplasms.
Hughes KV 3rd, Olsen KD, McCaffrey TV
Head Neck 1995 Mar-Apr;17(2):124-30. doi: 10.1002/hed.2880170209. PMID: 7558809

Clinical prediction guides

Incidence and survival in oral and pharyngeal cancers in Finland and Sweden through half century.
Koskinen AI, Hemminki O, Försti A, Hemminki K
BMC Cancer 2022 Mar 2;22(1):227. doi: 10.1186/s12885-022-09337-2. PMID: 35236321Free PMC Article
Global trends in oral and pharyngeal cancer incidence and mortality.
Bosetti C, Carioli G, Santucci C, Bertuccio P, Gallus S, Garavello W, Negri E, La Vecchia C
Int J Cancer 2020 Aug 15;147(4):1040-1049. Epub 2020 Jan 30 doi: 10.1002/ijc.32871. PMID: 31953840
Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Coffee is protective against oral and pharyngeal cancer: A systematic review and meta-analysis.
Miranda J, Monteiro L, Albuquerque R, Pacheco JJ, Khan Z, Lopez-Lopez J, Warnakulasuryia S
Med Oral Patol Oral Cir Bucal 2017 Sep 1;22(5):e554-e561. doi: 10.4317/medoral.21829. PMID: 28809372Free PMC Article
Effective Biomarkers and Radiation Treatment in Head and Neck Cancer.
Ow TJ, Pitts CE, Kabarriti R, Garg MK
Arch Pathol Lab Med 2015 Nov;139(11):1379-88. Epub 2015 Jun 5 doi: 10.5858/arpa.2014-0574-RA. PMID: 26046489

Recent systematic reviews

Treatment de-escalation for HPV+ oropharyngeal cancer: A systematic review and meta-analysis.
Petrelli F, Luciani A, Ghidini A, Cherri S, Gamba P, Maddalo M, Bossi P, Zaniboni A
Head Neck 2022 May;44(5):1255-1266. Epub 2022 Mar 3 doi: 10.1002/hed.27019. PMID: 35238114
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Chemotherapy in Combination With Radiotherapy for Definitive-Intent Treatment of Stage II-IVA Nasopharyngeal Carcinoma: CSCO and ASCO Guideline.
Chen YP, Ismaila N, Chua MLK, Colevas AD, Haddad R, Huang SH, Wee JTS, Whitley AC, Yi JL, Yom SS, Chan ATC, Hu CS, Lang JY, Le QT, Lee AWM, Lee N, Lin JC, Ma B, Morgan TJ, Shah J, Sun Y, Ma J
J Clin Oncol 2021 Mar 1;39(7):840-859. Epub 2021 Jan 6 doi: 10.1200/JCO.20.03237. PMID: 33405943
Dietary acrylamide and cancer risk: an updated meta-analysis.
Pelucchi C, Bosetti C, Galeone C, La Vecchia C
Int J Cancer 2015 Jun 15;136(12):2912-22. Epub 2014 Nov 26 doi: 10.1002/ijc.29339. PMID: 25403648
Alcohol consumption and risk of cancer: a systematic literature review.
de Menezes RF, Bergmann A, Thuler LC
Asian Pac J Cancer Prev 2013;14(9):4965-72. doi: 10.7314/apjcp.2013.14.9.4965. PMID: 24175760

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