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Streptococcal toxic-shock syndrome

MedGen UID:
575664
•Concept ID:
C0343532
•
Disease or Syndrome
Synonyms: Streptococcal toxic shock syndrome; streptococcal toxic-shock syndrome; Streptococcal TSS; streptococcal TSS; Streptococcus caused toxic shock syndrome; Streptococcus toxic shock syndrome
SNOMED CT: Streptococcal toxic shock syndrome (240451000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0020544
Orphanet: ORPHA99918

Definition

Streptococcal toxic-shock syndrome (streptococcal TSS) is an acute disease mediated by the production of superantigenic toxins characterized by the sudden onset of fever and other febrile symptoms, pain, multisystem organ involvement and potentially leading to coma, shock and death due to a <i>Streptococcus pyogenes</i> infection. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStreptococcal toxic-shock syndrome
Follow this link to review classifications for Streptococcal toxic-shock syndrome in Orphanet.

Professional guidelines

PubMed

Outcomes and management of pregnancy and puerperal group A streptococcal infections: A systematic review.
Harris K, Proctor LK, Shinar S, Philippopoulos E, Yudin MH, Murphy KE
Acta Obstet Gynecol Scand 2023 Feb;102(2):138-157. Epub 2023 Jan 12 doi: 10.1111/aogs.14500. PMID: 36636775Free PMC Article
ICU Management of Invasive β-Hemolytic Streptococcal Infections.
Babiker A, Kadri SS
Infect Dis Clin North Am 2022 Dec;36(4):861-887. doi: 10.1016/j.idc.2022.07.007. PMID: 36328640
Toxic shock syndrome - the seven Rs of management and treatment.
Wilkins AL, Steer AC, Smeesters PR, Curtis N
J Infect 2017 Jun;74 Suppl 1:S147-S152. doi: 10.1016/S0163-4453(17)30206-2. PMID: 28646955

Recent clinical studies

Etiology

Prognostic factors for streptococcal toxic shock syndrome: systematic review and meta-analysis.
Bartoszko JJ, Elias Z, Rudziak P, Lo CKL, Thabane L, Mertz D, Loeb M
BMJ Open 2022 Dec 1;12(12):e063023. doi: 10.1136/bmjopen-2022-063023. PMID: 36456018Free PMC Article
ICU Management of Invasive β-Hemolytic Streptococcal Infections.
Babiker A, Kadri SS
Infect Dis Clin North Am 2022 Dec;36(4):861-887. doi: 10.1016/j.idc.2022.07.007. PMID: 36328640
Infections Caused by Group C and G Streptococcus (Streptococcus dysgalactiae subsp. equisimilis and Others): Epidemiological and Clinical Aspects.
Baracco GJ
Microbiol Spectr 2019 Mar;7(2) doi: 10.1128/microbiolspec.GPP3-0016-2018. PMID: 30977463
Toxic shock syndrome - the seven Rs of management and treatment.
Wilkins AL, Steer AC, Smeesters PR, Curtis N
J Infect 2017 Jun;74 Suppl 1:S147-S152. doi: 10.1016/S0163-4453(17)30206-2. PMID: 28646955
Disease manifestations and pathogenic mechanisms of Group A Streptococcus.
Walker MJ, Barnett TC, McArthur JD, Cole JN, Gillen CM, Henningham A, Sriprakash KS, Sanderson-Smith ML, Nizet V
Clin Microbiol Rev 2014 Apr;27(2):264-301. doi: 10.1128/CMR.00101-13. PMID: 24696436Free PMC Article

Diagnosis

Evaluating antibiotic regimens for streptococcal toxic shock syndrome in children.
Zhang H, Dong J, Huang J, Zhang K, Lu X, Zhao X, Xiao C
PLoS One 2023;18(10):e0292311. Epub 2023 Oct 12 doi: 10.1371/journal.pone.0292311. PMID: 37824534Free PMC Article
Prognostic factors for streptococcal toxic shock syndrome: systematic review and meta-analysis.
Bartoszko JJ, Elias Z, Rudziak P, Lo CKL, Thabane L, Mertz D, Loeb M
BMJ Open 2022 Dec 1;12(12):e063023. doi: 10.1136/bmjopen-2022-063023. PMID: 36456018Free PMC Article
Toxic shock syndrome - the seven Rs of management and treatment.
Wilkins AL, Steer AC, Smeesters PR, Curtis N
J Infect 2017 Jun;74 Suppl 1:S147-S152. doi: 10.1016/S0163-4453(17)30206-2. PMID: 28646955
Peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess.
Klug TE
Dan Med J 2017 Mar;64(3) PMID: 28260599
Disease manifestations and pathogenic mechanisms of Group A Streptococcus.
Walker MJ, Barnett TC, McArthur JD, Cole JN, Gillen CM, Henningham A, Sriprakash KS, Sanderson-Smith ML, Nizet V
Clin Microbiol Rev 2014 Apr;27(2):264-301. doi: 10.1128/CMR.00101-13. PMID: 24696436Free PMC Article

Therapy

Prognostic factors for streptococcal toxic shock syndrome: systematic review and meta-analysis.
Bartoszko JJ, Elias Z, Rudziak P, Lo CKL, Thabane L, Mertz D, Loeb M
BMJ Open 2022 Dec 1;12(12):e063023. doi: 10.1136/bmjopen-2022-063023. PMID: 36456018Free PMC Article
Infections Caused by Group C and G Streptococcus (Streptococcus dysgalactiae subsp. equisimilis and Others): Epidemiological and Clinical Aspects.
Baracco GJ
Microbiol Spectr 2019 Mar;7(2) doi: 10.1128/microbiolspec.GPP3-0016-2018. PMID: 30977463
Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis.
Parks T, Wilson C, Curtis N, Norrby-Teglund A, Sriskandan S
Clin Infect Dis 2018 Oct 15;67(9):1434-1436. doi: 10.1093/cid/ciy401. PMID: 29788397Free PMC Article
Effectiveness of clindamycin and intravenous immunoglobulin, and risk of disease in contacts, in invasive group a streptococcal infections.
Carapetis JR, Jacoby P, Carville K, Ang SJ, Curtis N, Andrews R
Clin Infect Dis 2014 Aug 1;59(3):358-65. Epub 2014 Apr 29 doi: 10.1093/cid/ciu304. PMID: 24785239
Disease manifestations and pathogenic mechanisms of Group A Streptococcus.
Walker MJ, Barnett TC, McArthur JD, Cole JN, Gillen CM, Henningham A, Sriprakash KS, Sanderson-Smith ML, Nizet V
Clin Microbiol Rev 2014 Apr;27(2):264-301. doi: 10.1128/CMR.00101-13. PMID: 24696436Free PMC Article

Prognosis

Prognostic factors for streptococcal toxic shock syndrome: systematic review and meta-analysis.
Bartoszko JJ, Elias Z, Rudziak P, Lo CKL, Thabane L, Mertz D, Loeb M
BMJ Open 2022 Dec 1;12(12):e063023. doi: 10.1136/bmjopen-2022-063023. PMID: 36456018Free PMC Article
Invasive group A streptococcal disease in pregnant women and young children: a systematic review and meta-analysis.
Sherwood E, Vergnano S, Kakuchi I, Bruce MG, Chaurasia S, David S, Dramowski A, Georges S, Guy R, Lamagni T, Levy-Bruhl D, Lyytikäinen O, Naus M, Okaro JO, Oppegaard O, Vestrheim DF, Zulz T, Steer AC, Van Beneden CA, Seale AC
Lancet Infect Dis 2022 Jul;22(7):1076-1088. Epub 2022 Apr 4 doi: 10.1016/S1473-3099(21)00672-1. PMID: 35390294Free PMC Article
Peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess.
Klug TE
Dan Med J 2017 Mar;64(3) PMID: 28260599
Effectiveness of clindamycin and intravenous immunoglobulin, and risk of disease in contacts, in invasive group a streptococcal infections.
Carapetis JR, Jacoby P, Carville K, Ang SJ, Curtis N, Andrews R
Clin Infect Dis 2014 Aug 1;59(3):358-65. Epub 2014 Apr 29 doi: 10.1093/cid/ciu304. PMID: 24785239
Severe group A streptococcal infection and streptococcal toxic shock syndrome.
Baxter F, McChesney J
Can J Anaesth 2000 Nov;47(11):1129-40. doi: 10.1007/BF03027968. PMID: 11097546

Clinical prediction guides

Prognostic factors for streptococcal toxic shock syndrome: systematic review and meta-analysis.
Bartoszko JJ, Elias Z, Rudziak P, Lo CKL, Thabane L, Mertz D, Loeb M
BMJ Open 2022 Dec 1;12(12):e063023. doi: 10.1136/bmjopen-2022-063023. PMID: 36456018Free PMC Article
Nationwide study of mortality and survival in pregnancy-related streptococcal toxic shock syndrome.
Hayata E, Nakata M, Hasegawa J, Tanaka H, Murakoshi T, Mitsuda N, Sekizawa A, Ikeda T, Ishiwata I
J Obstet Gynaecol Res 2021 Mar;47(3):928-934. Epub 2020 Dec 21 doi: 10.1111/jog.14619. PMID: 33350021
Manifestations of Toxic Shock Syndrome in Children, Columbus, Ohio, USA, 2010-2017(1).
Cook A, Janse S, Watson JR, Erdem G
Emerg Infect Dis 2020 Jun;26(6):1077-1083. doi: 10.3201/eid2606.190783. PMID: 32442091Free PMC Article
Peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess.
Klug TE
Dan Med J 2017 Mar;64(3) PMID: 28260599
Effectiveness of clindamycin and intravenous immunoglobulin, and risk of disease in contacts, in invasive group a streptococcal infections.
Carapetis JR, Jacoby P, Carville K, Ang SJ, Curtis N, Andrews R
Clin Infect Dis 2014 Aug 1;59(3):358-65. Epub 2014 Apr 29 doi: 10.1093/cid/ciu304. PMID: 24785239

Recent systematic reviews

Outcomes and management of pregnancy and puerperal group A streptococcal infections: A systematic review.
Harris K, Proctor LK, Shinar S, Philippopoulos E, Yudin MH, Murphy KE
Acta Obstet Gynecol Scand 2023 Feb;102(2):138-157. Epub 2023 Jan 12 doi: 10.1111/aogs.14500. PMID: 36636775Free PMC Article
Prognostic factors for streptococcal toxic shock syndrome: systematic review and meta-analysis.
Bartoszko JJ, Elias Z, Rudziak P, Lo CKL, Thabane L, Mertz D, Loeb M
BMJ Open 2022 Dec 1;12(12):e063023. doi: 10.1136/bmjopen-2022-063023. PMID: 36456018Free PMC Article
Invasive group A streptococcal disease in pregnant women and young children: a systematic review and meta-analysis.
Sherwood E, Vergnano S, Kakuchi I, Bruce MG, Chaurasia S, David S, Dramowski A, Georges S, Guy R, Lamagni T, Levy-Bruhl D, Lyytikäinen O, Naus M, Okaro JO, Oppegaard O, Vestrheim DF, Zulz T, Steer AC, Van Beneden CA, Seale AC
Lancet Infect Dis 2022 Jul;22(7):1076-1088. Epub 2022 Apr 4 doi: 10.1016/S1473-3099(21)00672-1. PMID: 35390294Free PMC Article
Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis.
Parks T, Wilson C, Curtis N, Norrby-Teglund A, Sriskandan S
Clin Infect Dis 2018 Oct 15;67(9):1434-1436. doi: 10.1093/cid/ciy401. PMID: 29788397Free PMC Article
Group A streptococci infection. A systematic clinical review exemplified by cases from an obstetric department.
Gustafson LW, Blaakær J, Helmig RB
Eur J Obstet Gynecol Reprod Biol 2017 Aug;215:33-40. Epub 2017 Jun 1 doi: 10.1016/j.ejogrb.2017.05.020. PMID: 28600919

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