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Malignant cranial nerve neoplasm

MedGen UID:
57567
•Concept ID:
C0153644
•
Neoplastic Process
Synonyms: Cranial Nerve Neoplasms, Malignant; Cranial Nerve Tumors, Malignant; Malignant Cranial Nerve Neoplasms; Malignant Cranial Nerve Tumors; Neoplasms, Cranial Nerve, Malignant; Tumors, Cranial Nerve, Malignant
SNOMED CT: Malignant tumor of cranial nerve (188307009)
 
Monarch Initiative: MONDO:0002433

Definition

A primary or metastatic malignant neoplasm that affects a cranial nerve. [from NCI]

Professional guidelines

PubMed

Updated diagnostic criteria and nomenclature for neurofibromatosis type 2 and schwannomatosis: An international consensus recommendation.
Plotkin SR, Messiaen L, Legius E, Pancza P, Avery RA, Blakeley JO, Babovic-Vuksanovic D, Ferner R, Fisher MJ, Friedman JM, Giovannini M, Gutmann DH, Hanemann CO, Kalamarides M, Kehrer-Sawatzki H, Korf BR, Mautner VF, MacCollin M, Papi L, Rauen KA, Riccardi V, Schorry E, Smith MJ, Stemmer-Rachamimov A, Stevenson DA, Ullrich NJ, Viskochil D, Wimmer K, Yohay K; International Consensus Group on Neurofibromatosis Diagnostic Criteria (I-NF-DC), Huson SM, Wolkenstein P, Evans DG
Genet Med 2022 Sep;24(9):1967-1977. Epub 2022 Jun 9 doi: 10.1016/j.gim.2022.05.007. PMID: 35674741
EANO guideline on the diagnosis and treatment of vestibular schwannoma.
Goldbrunner R, Weller M, Regis J, Lund-Johansen M, Stavrinou P, Reuss D, Evans DG, Lefranc F, Sallabanda K, Falini A, Axon P, Sterkers O, Fariselli L, Wick W, Tonn JC
Neuro Oncol 2020 Jan 11;22(1):31-45. doi: 10.1093/neuonc/noz153. PMID: 31504802Free PMC Article
Current treatment of optic nerve gliomas.
Farazdaghi MK, Katowitz WR, Avery RA
Curr Opin Ophthalmol 2019 Sep;30(5):356-363. doi: 10.1097/ICU.0000000000000587. PMID: 31246635Free PMC Article

Recent clinical studies

Etiology

Parasellar Meningiomas.
Graillon T, Regis J, Barlier A, Brue T, Dufour H, Buchfelder M
Neuroendocrinology 2020;110(9-10):780-796. Epub 2020 Jun 3 doi: 10.1159/000509090. PMID: 32492684
Neurofibromatosis 2.
Hoa M, Slattery WH 3rd
Otolaryngol Clin North Am 2012 Apr;45(2):315-32, viii. doi: 10.1016/j.otc.2011.12.005. PMID: 22483819
Peripheral and cranial nerve sheath tumors.
Mrugala MM, Batchelor TT, Plotkin SR
Curr Opin Neurol 2005 Oct;18(5):604-10. doi: 10.1097/01.wco.0000179507.51647.02. PMID: 16155448
Bilateral acoustic neuromas.
Anand VT, Byrnes DP, Walby AP, Kerr AG
Clin Otolaryngol Allied Sci 1993 Oct;18(5):365-71. doi: 10.1111/j.1365-2273.1993.tb00594.x. PMID: 8877201
Clinoidal meningiomas.
al-Mefty O, Ayoubi S
Acta Neurochir Suppl (Wien) 1991;53:92-7. doi: 10.1007/978-3-7091-9183-5_16. PMID: 1803892

Diagnosis

Facial nerve schwannoma and other benign neoplastic facial nerve lesions.
Kitama T, Hosoya M, Oishi N
Curr Opin Otolaryngol Head Neck Surg 2023 Oct 1;31(5):300-305. Epub 2023 Jul 19 doi: 10.1097/MOO.0000000000000913. PMID: 37523215
Trigeminal neuromas: modern diagnosis and treatment.
Bezborodova TY, Zolotova SV
Zh Vopr Neirokhir Im N N Burdenko 2023;87(1):104-110. doi: 10.17116/neiro202387011104. PMID: 36763561
Oculomotor nerve schwannoma: case series and literature review.
Douglas VP, Flores C, Douglas KA, Strominger MB, Kasper E, Torun N
Surv Ophthalmol 2022 Jul-Aug;67(4):1160-1174. Epub 2021 Nov 21 doi: 10.1016/j.survophthal.2021.11.008. PMID: 34813853
Perineural tumor spread.
Maroldi R, Farina D, Borghesi A, Marconi A, Gatti E
Neuroimaging Clin N Am 2008 May;18(2):413-29, xi. doi: 10.1016/j.nic.2008.01.001. PMID: 18466839
Vagal paragangliomas.
Sniezek JC, Netterville JL, Sabri AN
Otolaryngol Clin North Am 2001 Oct;34(5):925-39, vi. doi: 10.1016/s0030-6665(05)70355-8. PMID: 11557447

Therapy

A Critical Overview of Targeted Therapies for Vestibular Schwannoma.
Tamura R, Toda M
Int J Mol Sci 2022 May 13;23(10) doi: 10.3390/ijms23105462. PMID: 35628268Free PMC Article
Current Understanding of Neurofibromatosis Type 1, 2, and Schwannomatosis.
Tamura R
Int J Mol Sci 2021 May 29;22(11) doi: 10.3390/ijms22115850. PMID: 34072574Free PMC Article
Vestibular Schwannomas.
Carlson ML, Link MJ
N Engl J Med 2021 Apr 8;384(14):1335-1348. doi: 10.1056/NEJMra2020394. PMID: 33826821
Current treatment of optic nerve gliomas.
Farazdaghi MK, Katowitz WR, Avery RA
Curr Opin Ophthalmol 2019 Sep;30(5):356-363. doi: 10.1097/ICU.0000000000000587. PMID: 31246635Free PMC Article
Numb chin syndrome: a rare and often overlooked symptom.
Assaf AT, Jürgens TP, Benecke AW, Riecke B, Blessmann M, Zrnc TA, Much CC, Heiland M, Friedrich RE
J Oral Facial Pain Headache 2014 Winter;28(1):80-90. doi: 10.11607/jop.994. PMID: 24482791

Prognosis

Extracranial Facial Nerve Schwannoma-Histological Surprise or Therapeutic Planning?
Vrinceanu D, Dumitru M, Popa-Cherecheanu M, Marinescu AN, Patrascu OM, Bobirca F
Medicina (Kaunas) 2023 Jun 17;59(6) doi: 10.3390/medicina59061167. PMID: 37374372Free PMC Article
Cranial Nerve Schwannomas: Diagnostic Imaging Approach.
Skolnik AD, Loevner LA, Sampathu DM, Newman JG, Lee JY, Bagley LJ, Learned KO
Radiographics 2016 Sep-Oct;36(5):1463-77. Epub 2016 Aug 19 doi: 10.1148/rg.2016150199. PMID: 27541436
Neurofibromatosis 2.
Hoa M, Slattery WH 3rd
Otolaryngol Clin North Am 2012 Apr;45(2):315-32, viii. doi: 10.1016/j.otc.2011.12.005. PMID: 22483819
Perineural tumor spread.
Maroldi R, Farina D, Borghesi A, Marconi A, Gatti E
Neuroimaging Clin N Am 2008 May;18(2):413-29, xi. doi: 10.1016/j.nic.2008.01.001. PMID: 18466839
Vagal paragangliomas.
Sniezek JC, Netterville JL, Sabri AN
Otolaryngol Clin North Am 2001 Oct;34(5):925-39, vi. doi: 10.1016/s0030-6665(05)70355-8. PMID: 11557447

Clinical prediction guides

Parasellar Meningiomas.
Graillon T, Regis J, Barlier A, Brue T, Dufour H, Buchfelder M
Neuroendocrinology 2020;110(9-10):780-796. Epub 2020 Jun 3 doi: 10.1159/000509090. PMID: 32492684
EANO guideline on the diagnosis and treatment of vestibular schwannoma.
Goldbrunner R, Weller M, Regis J, Lund-Johansen M, Stavrinou P, Reuss D, Evans DG, Lefranc F, Sallabanda K, Falini A, Axon P, Sterkers O, Fariselli L, Wick W, Tonn JC
Neuro Oncol 2020 Jan 11;22(1):31-45. doi: 10.1093/neuonc/noz153. PMID: 31504802Free PMC Article
Intratemporal facial nerve schwannoma: clinical presentation and management.
Lahlou G, Nguyen Y, Russo FY, Ferrary E, Sterkers O, Bernardeschi D
Eur Arch Otorhinolaryngol 2016 Nov;273(11):3497-3504. Epub 2015 Dec 16 doi: 10.1007/s00405-015-3850-z. PMID: 26676873
Hearing preservation: microsurgery.
Kari E, Friedman RA
Curr Opin Otolaryngol Head Neck Surg 2012 Oct;20(5):358-66. doi: 10.1097/MOO.0b013e3283579673. PMID: 22929113
The trigeminal nerve.
Nemzek WR
Top Magn Reson Imaging 1996 Jun;8(3):132-54. PMID: 8840469

Recent systematic reviews

Lower Cranial Nerve Schwannomas: Cohort Study and Systematic Review.
Carlstrom LP, Bauman MMJ, Oushy S, Perry A, Brown PD, Peris-Celda M, Van Gompel JJ, Graffeo CS, Link MJ
Neurosurgery 2024 Apr 1;94(4):745-755. Epub 2023 Oct 24 doi: 10.1227/neu.0000000000002735. PMID: 37874134
Surgical Treatment of Trochlear Nerve Schwannomas: Case Series and Systematic Review.
Ozoner B, Gungor A, Ture H, Ture U
World Neurosurg 2022 Jun;162:e288-e300. Epub 2022 Mar 9 doi: 10.1016/j.wneu.2022.03.006. PMID: 35276398
Treatment for vestibular schwannoma: Systematic review and single arm meta-analysis.
Thai NLB, Mai NY, Vuong NL, Tin NM, Karam D, Refaey MA, Shahin KM, Soliman AL, Al Khudari R, Thuan TM, Sabbah GM, El-Qushayri AE, Karimzadeh S, Hirayama K, Huy NT
Am J Otolaryngol 2022 Mar-Apr;43(2):103337. Epub 2021 Dec 20 doi: 10.1016/j.amjoto.2021.103337. PMID: 34973662
Indications and contraindications of auditory brainstem implants: systematic review and illustrative cases.
Merkus P, Di Lella F, Di Trapani G, Pasanisi E, Beltrame MA, Zanetti D, Negri M, Sanna M
Eur Arch Otorhinolaryngol 2014 Jan;271(1):3-13. Epub 2013 Feb 13 doi: 10.1007/s00405-013-2378-3. PMID: 23404468
Malignant mental nerve neuropathy: systematic review.
Galán Gil S, Peñarrocha Diago M, Peñarrocha Diago M
Med Oral Patol Oral Cir Bucal 2008 Oct 1;13(10):E616-21. PMID: 18830167

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