U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant cranial nerve neoplasm

MedGen UID:
57567
•Concept ID:
C0153644
•
Neoplastic Process
Synonyms: Cranial Nerve Neoplasms, Malignant; Cranial Nerve Tumors, Malignant; Malignant Cranial Nerve Neoplasms; Malignant Cranial Nerve Tumors; Neoplasms, Cranial Nerve, Malignant; Tumors, Cranial Nerve, Malignant
SNOMED CT: Malignant tumor of cranial nerve (188307009)
 
Monarch Initiative: MONDO:0002433

Definition

A primary or metastatic malignant neoplasm that affects a cranial nerve. [from NCI]

Professional guidelines

PubMed

Updated diagnostic criteria and nomenclature for neurofibromatosis type 2 and schwannomatosis: An international consensus recommendation.
Plotkin SR, Messiaen L, Legius E, Pancza P, Avery RA, Blakeley JO, Babovic-Vuksanovic D, Ferner R, Fisher MJ, Friedman JM, Giovannini M, Gutmann DH, Hanemann CO, Kalamarides M, Kehrer-Sawatzki H, Korf BR, Mautner VF, MacCollin M, Papi L, Rauen KA, Riccardi V, Schorry E, Smith MJ, Stemmer-Rachamimov A, Stevenson DA, Ullrich NJ, Viskochil D, Wimmer K, Yohay K; International Consensus Group on Neurofibromatosis Diagnostic Criteria (I-NF-DC), Huson SM, Wolkenstein P, Evans DG
Genet Med 2022 Sep;24(9):1967-1977. Epub 2022 Jun 9 doi: 10.1016/j.gim.2022.05.007. PMID: 35674741
EANO guideline on the diagnosis and treatment of vestibular schwannoma.
Goldbrunner R, Weller M, Regis J, Lund-Johansen M, Stavrinou P, Reuss D, Evans DG, Lefranc F, Sallabanda K, Falini A, Axon P, Sterkers O, Fariselli L, Wick W, Tonn JC
Neuro Oncol 2020 Jan 11;22(1):31-45. doi: 10.1093/neuonc/noz153. PMID: 31504802Free PMC Article
Current treatment of optic nerve gliomas.
Farazdaghi MK, Katowitz WR, Avery RA
Curr Opin Ophthalmol 2019 Sep;30(5):356-363. doi: 10.1097/ICU.0000000000000587. PMID: 31246635Free PMC Article

Recent clinical studies

Etiology

Extracranial Facial Nerve Schwannoma-Histological Surprise or Therapeutic Planning?
Vrinceanu D, Dumitru M, Popa-Cherecheanu M, Marinescu AN, Patrascu OM, Bobirca F
Medicina (Kaunas) 2023 Jun 17;59(6) doi: 10.3390/medicina59061167. PMID: 37374372Free PMC Article
Parasellar Meningiomas.
Graillon T, Regis J, Barlier A, Brue T, Dufour H, Buchfelder M
Neuroendocrinology 2020;110(9-10):780-796. Epub 2020 Jun 3 doi: 10.1159/000509090. PMID: 32492684
Neurofibromatosis 2.
Hoa M, Slattery WH 3rd
Otolaryngol Clin North Am 2012 Apr;45(2):315-32, viii. doi: 10.1016/j.otc.2011.12.005. PMID: 22483819
Peripheral and cranial nerve sheath tumors.
Mrugala MM, Batchelor TT, Plotkin SR
Curr Opin Neurol 2005 Oct;18(5):604-10. doi: 10.1097/01.wco.0000179507.51647.02. PMID: 16155448
Bilateral acoustic neuromas.
Anand VT, Byrnes DP, Walby AP, Kerr AG
Clin Otolaryngol Allied Sci 1993 Oct;18(5):365-71. doi: 10.1111/j.1365-2273.1993.tb00594.x. PMID: 8877201

Diagnosis

Facial nerve schwannoma and other benign neoplastic facial nerve lesions.
Kitama T, Hosoya M, Oishi N
Curr Opin Otolaryngol Head Neck Surg 2023 Oct 1;31(5):300-305. Epub 2023 Jul 19 doi: 10.1097/MOO.0000000000000913. PMID: 37523215
Trigeminal neuromas: modern diagnosis and treatment.
Bezborodova TY, Zolotova SV
Zh Vopr Neirokhir Im N N Burdenko 2023;87(1):104-110. doi: 10.17116/neiro202387011104. PMID: 36763561
Oculomotor nerve schwannoma: case series and literature review.
Douglas VP, Flores C, Douglas KA, Strominger MB, Kasper E, Torun N
Surv Ophthalmol 2022 Jul-Aug;67(4):1160-1174. Epub 2021 Nov 21 doi: 10.1016/j.survophthal.2021.11.008. PMID: 34813853
Perineural tumor spread.
Maroldi R, Farina D, Borghesi A, Marconi A, Gatti E
Neuroimaging Clin N Am 2008 May;18(2):413-29, xi. doi: 10.1016/j.nic.2008.01.001. PMID: 18466839
Vagal paragangliomas.
Sniezek JC, Netterville JL, Sabri AN
Otolaryngol Clin North Am 2001 Oct;34(5):925-39, vi. doi: 10.1016/s0030-6665(05)70355-8. PMID: 11557447

Therapy

Upfront Radiosurgery vs a Wait-and-Scan Approach for Small- or Medium-Sized Vestibular Schwannoma: The V-REX Randomized Clinical Trial.
Dhayalan D, Tveiten ØV, Finnkirk M, Storstein A, Hufthammer KO, Goplen FK, Lund-Johansen M; V-REX Trial investigators
JAMA 2023 Aug 1;330(5):421-431. doi: 10.1001/jama.2023.12222. PMID: 37526718Free PMC Article
A Critical Overview of Targeted Therapies for Vestibular Schwannoma.
Tamura R, Toda M
Int J Mol Sci 2022 May 13;23(10) doi: 10.3390/ijms23105462. PMID: 35628268Free PMC Article
Current Understanding of Neurofibromatosis Type 1, 2, and Schwannomatosis.
Tamura R
Int J Mol Sci 2021 May 29;22(11) doi: 10.3390/ijms22115850. PMID: 34072574Free PMC Article
Vestibular Schwannomas.
Carlson ML, Link MJ
N Engl J Med 2021 Apr 8;384(14):1335-1348. doi: 10.1056/NEJMra2020394. PMID: 33826821
Current treatment of optic nerve gliomas.
Farazdaghi MK, Katowitz WR, Avery RA
Curr Opin Ophthalmol 2019 Sep;30(5):356-363. doi: 10.1097/ICU.0000000000000587. PMID: 31246635Free PMC Article

Prognosis

Extracranial Facial Nerve Schwannoma-Histological Surprise or Therapeutic Planning?
Vrinceanu D, Dumitru M, Popa-Cherecheanu M, Marinescu AN, Patrascu OM, Bobirca F
Medicina (Kaunas) 2023 Jun 17;59(6) doi: 10.3390/medicina59061167. PMID: 37374372Free PMC Article
Cranial Nerve Schwannomas: Diagnostic Imaging Approach.
Skolnik AD, Loevner LA, Sampathu DM, Newman JG, Lee JY, Bagley LJ, Learned KO
Radiographics 2016 Sep-Oct;36(5):1463-77. Epub 2016 Aug 19 doi: 10.1148/rg.2016150199. PMID: 27541436
Neurofibromatosis 2.
Hoa M, Slattery WH 3rd
Otolaryngol Clin North Am 2012 Apr;45(2):315-32, viii. doi: 10.1016/j.otc.2011.12.005. PMID: 22483819
Perineural tumor spread.
Maroldi R, Farina D, Borghesi A, Marconi A, Gatti E
Neuroimaging Clin N Am 2008 May;18(2):413-29, xi. doi: 10.1016/j.nic.2008.01.001. PMID: 18466839
Vagal paragangliomas.
Sniezek JC, Netterville JL, Sabri AN
Otolaryngol Clin North Am 2001 Oct;34(5):925-39, vi. doi: 10.1016/s0030-6665(05)70355-8. PMID: 11557447

Clinical prediction guides

Parasellar Meningiomas.
Graillon T, Regis J, Barlier A, Brue T, Dufour H, Buchfelder M
Neuroendocrinology 2020;110(9-10):780-796. Epub 2020 Jun 3 doi: 10.1159/000509090. PMID: 32492684
EANO guideline on the diagnosis and treatment of vestibular schwannoma.
Goldbrunner R, Weller M, Regis J, Lund-Johansen M, Stavrinou P, Reuss D, Evans DG, Lefranc F, Sallabanda K, Falini A, Axon P, Sterkers O, Fariselli L, Wick W, Tonn JC
Neuro Oncol 2020 Jan 11;22(1):31-45. doi: 10.1093/neuonc/noz153. PMID: 31504802Free PMC Article
Intratemporal facial nerve schwannoma: clinical presentation and management.
Lahlou G, Nguyen Y, Russo FY, Ferrary E, Sterkers O, Bernardeschi D
Eur Arch Otorhinolaryngol 2016 Nov;273(11):3497-3504. Epub 2015 Dec 16 doi: 10.1007/s00405-015-3850-z. PMID: 26676873
Hearing preservation: microsurgery.
Kari E, Friedman RA
Curr Opin Otolaryngol Head Neck Surg 2012 Oct;20(5):358-66. doi: 10.1097/MOO.0b013e3283579673. PMID: 22929113
The trigeminal nerve.
Nemzek WR
Top Magn Reson Imaging 1996 Jun;8(3):132-54. PMID: 8840469

Recent systematic reviews

Open surgery vs. stereotactic radiosurgery for tumour-related trigeminal neuralgia: A systematic review.
Nugroho SW, Anindya Y, Hafif M, Wicaksana BA, Desbassari F, Sadewo W, Perkasa SAH
Clin Neurol Neurosurg 2023 May;228:107683. Epub 2023 Mar 21 doi: 10.1016/j.clineuro.2023.107683. PMID: 37001475
Long-Term Hearing Outcome After Radiosurgery for Vestibular Schwannoma: A Systematic Review and Meta-Analysis.
Balossier A, Tuleasca C, Delsanti C, Troude L, Thomassin JM, Roche PH, Régis J
Neurosurgery 2023 Jun 1;92(6):1130-1141. Epub 2023 Feb 3 doi: 10.1227/neu.0000000000002354. PMID: 36735500Free PMC Article
Characteristics and Outcomes in Pediatric Versus Adult Craniopharyngiomas: A Systematic Review and Meta-Analysis.
Pang JC, Chung DD, Wang J, Abiri A, Lien BV, Himstead AS, Ovakimyan A, Kim MG, Hsu FPK, Kuan EC
Neurosurgery 2023 Jun 1;92(6):1112-1129. Epub 2023 Jan 13 doi: 10.1227/neu.0000000000002346. PMID: 36639856
Surgical Treatment of Trochlear Nerve Schwannomas: Case Series and Systematic Review.
Ozoner B, Gungor A, Ture H, Ture U
World Neurosurg 2022 Jun;162:e288-e300. Epub 2022 Mar 9 doi: 10.1016/j.wneu.2022.03.006. PMID: 35276398
Treatment for vestibular schwannoma: Systematic review and single arm meta-analysis.
Thai NLB, Mai NY, Vuong NL, Tin NM, Karam D, Refaey MA, Shahin KM, Soliman AL, Al Khudari R, Thuan TM, Sabbah GM, El-Qushayri AE, Karimzadeh S, Hirayama K, Huy NT
Am J Otolaryngol 2022 Mar-Apr;43(2):103337. Epub 2021 Dec 20 doi: 10.1016/j.amjoto.2021.103337. PMID: 34973662

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...