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Neonatal chlamydial conjunctivitis

MedGen UID:
575790
•Concept ID:
C0343723
•
Disease or Syndrome
Synonyms: Chlamydial ophthalmia neonatorum; Neonatal Chlamydia Conjunctivitis; Neonatal conjunctivitis due to chlamydiae; Neonatal inclusion blennorrhea; Neonatal inclusion body conjunctivitis; Ophthalmia neonatorum - chlamydial
SNOMED CT: Neonatal inclusion body conjunctivitis (240591000); Neonatal inclusion blennorrhea (240591000); Chlamydial ophthalmia neonatorum (240591000); Neonatal conjunctivitis due to chlamydiae (240591000); Ophthalmia neonatorum - chlamydial (240591000); Neonatal chlamydial conjunctivitis (240591000)

Definition

Inflammation of the conjunctiva in a newborn due to Chlamydia trachomatis which was acquired during labor and delivery. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal chlamydial conjunctivitis

Professional guidelines

PubMed

Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis.
Zikic A, Schünemann H, Wi T, Lincetto O, Broutet N, Santesso N
J Pediatric Infect Dis Soc 2018 Aug 17;7(3):e107-e115. doi: 10.1093/jpids/piy060. PMID: 30007329Free PMC Article
Comparative diagnosis of neonatal chlamydial conjunctivitis by polymerase chain reaction and McCoy cell culture.
Talley AR, Garcia-Ferrer F, Laycock KA, Essary LR, Holcomb WL Jr, Flowers BE, Loeffelholz M, Lewinski C, Pepose JS
Am J Ophthalmol 1994 Jan 15;117(1):50-7. doi: 10.1016/s0002-9394(14)73014-4. PMID: 8291592
Diagnosis of neonatal chlamydial conjunctivitis.
Phillips G, Forsyth JS, Harper IA
Arch Dis Child 1990 Aug;65(8):894-5. doi: 10.1136/adc.65.8.894. PMID: 2205158Free PMC Article

Recent clinical studies

Etiology

Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis.
Zikic A, Schünemann H, Wi T, Lincetto O, Broutet N, Santesso N
J Pediatric Infect Dis Soc 2018 Aug 17;7(3):e107-e115. doi: 10.1093/jpids/piy060. PMID: 30007329Free PMC Article
Incidence of neonatal chlamydial conjunctivitis and its association with nasopharyngeal colonisation in a Hong Kong hospital, assessed by polymerase chain reaction.
Yip TP, Chan WH, Yip KT, Que TL, Lee MM, Kwong NS, Ho CK
Hong Kong Med J 2007 Feb;13(1):22-6. PMID: 17277388
Neonatal haemorrhagic conjunctivitis: a specific sign of chlamydial infection.
Chang K, Cheng VY, Kwong NS
Hong Kong Med J 2006 Feb;12(1):27-32. PMID: 16495586
Prophylaxis of ophthalmia neonatorum: comparison of silver nitrate, tetracycline, erythromycin and no prophylaxis.
Chen JY
Pediatr Infect Dis J 1992 Dec;11(12):1026-30. PMID: 1461692
Efficacy of neonatal ocular prophylaxis for the prevention of chlamydial and gonococcal conjunctivitis.
Hammerschlag MR, Cummings C, Roblin PM, Williams TH, Delke I
N Engl J Med 1989 Mar 23;320(12):769-72. doi: 10.1056/NEJM198903233201204. PMID: 2922026

Diagnosis

Neonatal prophylaxis with antibiotic containing ointments does not reduce incidence of chlamydial conjunctivitis in newborns.
Smith-Norowitz TA, Ukaegbu C, Kohlhoff S, Hammerschlag MR
BMC Infect Dis 2021 Mar 17;21(1):270. doi: 10.1186/s12879-021-05974-3. PMID: 33731049Free PMC Article
Recent trends in chlamydial and gonococcal conjunctivitis among neonates and adults in an Irish hospital.
Quirke M, Cullinane A
Int J Infect Dis 2008 Jul;12(4):371-3. Epub 2008 Feb 21 doi: 10.1016/j.ijid.2007.09.013. PMID: 18093859
Neonatal haemorrhagic conjunctivitis: a specific sign of chlamydial infection.
Chang K, Cheng VY, Kwong NS
Hong Kong Med J 2006 Feb;12(1):27-32. PMID: 16495586
Efficacy of neonatal ocular prophylaxis for the prevention of chlamydial and gonococcal conjunctivitis.
Hammerschlag MR, Cummings C, Roblin PM, Williams TH, Delke I
N Engl J Med 1989 Mar 23;320(12):769-72. doi: 10.1056/NEJM198903233201204. PMID: 2922026
Neonatal chlamydial conjunctivitis.
Persson K, Rönnerstam R, Svanberg L, Polberger S
Arch Dis Child 1986 Jun;61(6):565-8. doi: 10.1136/adc.61.6.565. PMID: 3729525Free PMC Article

Therapy

Neonatal prophylaxis with antibiotic containing ointments does not reduce incidence of chlamydial conjunctivitis in newborns.
Smith-Norowitz TA, Ukaegbu C, Kohlhoff S, Hammerschlag MR
BMC Infect Dis 2021 Mar 17;21(1):270. doi: 10.1186/s12879-021-05974-3. PMID: 33731049Free PMC Article
Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis.
Zikic A, Schünemann H, Wi T, Lincetto O, Broutet N, Santesso N
J Pediatric Infect Dis Soc 2018 Aug 17;7(3):e107-e115. doi: 10.1093/jpids/piy060. PMID: 30007329Free PMC Article
Incidence of neonatal chlamydial conjunctivitis and its association with nasopharyngeal colonisation in a Hong Kong hospital, assessed by polymerase chain reaction.
Yip TP, Chan WH, Yip KT, Que TL, Lee MM, Kwong NS, Ho CK
Hong Kong Med J 2007 Feb;13(1):22-6. PMID: 17277388
Neonatal haemorrhagic conjunctivitis: a specific sign of chlamydial infection.
Chang K, Cheng VY, Kwong NS
Hong Kong Med J 2006 Feb;12(1):27-32. PMID: 16495586
Efficacy of neonatal ocular prophylaxis for the prevention of chlamydial and gonococcal conjunctivitis.
Hammerschlag MR, Cummings C, Roblin PM, Williams TH, Delke I
N Engl J Med 1989 Mar 23;320(12):769-72. doi: 10.1056/NEJM198903233201204. PMID: 2922026

Prognosis

Neonatal prophylaxis with antibiotic containing ointments does not reduce incidence of chlamydial conjunctivitis in newborns.
Smith-Norowitz TA, Ukaegbu C, Kohlhoff S, Hammerschlag MR
BMC Infect Dis 2021 Mar 17;21(1):270. doi: 10.1186/s12879-021-05974-3. PMID: 33731049Free PMC Article
Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis.
Zikic A, Schünemann H, Wi T, Lincetto O, Broutet N, Santesso N
J Pediatric Infect Dis Soc 2018 Aug 17;7(3):e107-e115. doi: 10.1093/jpids/piy060. PMID: 30007329Free PMC Article
Recent trends in chlamydial and gonococcal conjunctivitis among neonates and adults in an Irish hospital.
Quirke M, Cullinane A
Int J Infect Dis 2008 Jul;12(4):371-3. Epub 2008 Feb 21 doi: 10.1016/j.ijid.2007.09.013. PMID: 18093859
Incidence of neonatal chlamydial conjunctivitis and its association with nasopharyngeal colonisation in a Hong Kong hospital, assessed by polymerase chain reaction.
Yip TP, Chan WH, Yip KT, Que TL, Lee MM, Kwong NS, Ho CK
Hong Kong Med J 2007 Feb;13(1):22-6. PMID: 17277388
Neonatal haemorrhagic conjunctivitis: a specific sign of chlamydial infection.
Chang K, Cheng VY, Kwong NS
Hong Kong Med J 2006 Feb;12(1):27-32. PMID: 16495586

Clinical prediction guides

The use of polymerase chain reaction assay versus conventional methods in detecting neonatal chlamydial conjunctivitis.
Yip PP, Chan WH, Yip KT, Que TL, Kwong NS, Ho CK
J Pediatr Ophthalmol Strabismus 2008 Jul-Aug;45(4):234-9. doi: 10.3928/01913913-20080701-17. PMID: 18705621
Neonatal haemorrhagic conjunctivitis: a specific sign of chlamydial infection.
Chang K, Cheng VY, Kwong NS
Hong Kong Med J 2006 Feb;12(1):27-32. PMID: 16495586
Comparison of a chemiluminometric immunoassay with culture for diagnosis of chlamydial infections in infants.
Dumornay W, Roblin PM, Gelling M, Hammerschlag MR, Worku M
J Clin Microbiol 1992 Jul;30(7):1867-9. doi: 10.1128/jcm.30.7.1867-1869.1992. PMID: 1629345Free PMC Article
Diagnosis of neonatal chlamydial conjunctivitis.
Phillips G, Forsyth JS, Harper IA
Arch Dis Child 1990 Aug;65(8):894-5. doi: 10.1136/adc.65.8.894. PMID: 2205158Free PMC Article
Neonatal chlamydial conjunctivitis. A long term follow-up study.
Sandström I, Kallings I, Melen B
Acta Paediatr Scand 1988 Mar;77(2):207-13. doi: 10.1111/j.1651-2227.1988.tb10631.x. PMID: 3258462

Recent systematic reviews

Neonatal prophylaxis with antibiotic containing ointments does not reduce incidence of chlamydial conjunctivitis in newborns.
Smith-Norowitz TA, Ukaegbu C, Kohlhoff S, Hammerschlag MR
BMC Infect Dis 2021 Mar 17;21(1):270. doi: 10.1186/s12879-021-05974-3. PMID: 33731049Free PMC Article
Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis.
Zikic A, Schünemann H, Wi T, Lincetto O, Broutet N, Santesso N
J Pediatric Infect Dis Soc 2018 Aug 17;7(3):e107-e115. doi: 10.1093/jpids/piy060. PMID: 30007329Free PMC Article

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