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Benign neoplasm of choroid

MedGen UID:
57581
•Concept ID:
C0154028
•
Neoplastic Process
Synonyms: Benign Choroid Neoplasm; benign choroid neoplasm; Benign Choroid Tumor; benign choroid tumor; benign choroid tumour; Benign Neoplasm of Choroid; benign neoplasm of choroid; Benign Neoplasm of the Choroid; benign neoplasm of the choroid; Benign tumor of choroid; Benign Tumor of Choroid; benign tumor of choroid; Benign Tumor of the Choroid; benign tumor of the choroid; benign tumour of choroid; benign tumour of the choroid; optic choroid benign neoplasm
SNOMED CT: Benign neoplasm of choroid (92059004); Benign tumor of choroid (92059004)
 
Monarch Initiative: MONDO:0021487

Definition

A neoplasm that arises from the choroid and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of choroid

Professional guidelines

PubMed

Society for Maternal-Fetal Medicine Consult Series #57: Evaluation and management of isolated soft ultrasound markers for aneuploidy in the second trimester: (Replaces Consults #10, Single umbilical artery, October 2010; #16, Isolated echogenic bowel diagnosed on second-trimester ultrasound, August 2011; #17, Evaluation and management of isolated renal pelviectasis on second-trimester ultrasound, December 2011; #25, Isolated fetal choroid plexus cysts, April 2013; #27, Isolated echogenic intracardiac focus, August 2013).
Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Prabhu M, Kuller JA, Biggio JR
Am J Obstet Gynecol 2021 Oct;225(4):B2-B15. Epub 2021 Jun 23 doi: 10.1016/j.ajog.2021.06.079. PMID: 34171388
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article

Recent clinical studies

Etiology

Tamoxifen related chorioretinal structural changes.
Erbahçeci Timur İE, Açıkgöz V, Uğurlu N, Yalçın B, Şendur MAN, Hızal M, Kara H
Cutan Ocul Toxicol 2023 Sep;42(3):109-117. Epub 2023 Jun 15 doi: 10.1080/15569527.2023.2220388. PMID: 37272809
Spectral-domain optical coherence tomography biomarkers in vitreoretinal lymphoma.
Guan W, Xiao Y, Zhao H, Hu F, Chen C, Peng X
Clin Exp Ophthalmol 2023 Mar;51(2):144-153. Epub 2023 Jan 4 doi: 10.1111/ceo.14197. PMID: 36567492
Multimodal Imaging in Choroidal Metastasis.
Cennamo G, Montorio D, Carosielli M, Romano MR, Cennamo G
Ophthalmic Res 2021;64(3):411-416. Epub 2020 Nov 3 doi: 10.1159/000512766. PMID: 33142285
Updates in imaging in ocular oncology.
Davila JR, Mruthyunjaya P
F1000Res 2019;8 Epub 2019 Oct 1 doi: 10.12688/f1000research.19979.1. PMID: 31602297Free PMC Article
Choroidal melanoma and pregnancy.
Lemaître S, Lévy-Gabriel C, Desjardins L, Plancher C, Asselain B, Vincent-Salomon A, Lumbroso-Le Rouic L, Dendale R, Rouzier R, Delacroix S, Cassoux N
Acta Ophthalmol 2016 Nov;94(7):e652-e660. Epub 2016 Mar 24 doi: 10.1111/aos.12984. PMID: 27009598

Diagnosis

Posterior segment manifestations of ocular metastasis.
Kongwattananon W, Pothikamjorn T, Somkijrungroj T
Curr Opin Ophthalmol 2023 Nov 1;34(6):522-528. Epub 2023 Aug 9 doi: 10.1097/ICU.0000000000000988. PMID: 37556166
Choroidal Neurofibromatosis.
Bhatti MT
Ophthalmology 2023 Aug;130(8):862. Epub 2022 Oct 8 doi: 10.1016/j.ophtha.2022.09.001. PMID: 36216646
Intraocular Tumors: Angiographic Patterns.
Bowen RC, Raval V, Soto H, Singh AD
Asia Pac J Ophthalmol (Phila) 2020 Sep-Oct;9(5):449-460. doi: 10.1097/APO.0000000000000323. PMID: 32960821
Choroidal hemangioma.
Singh AD, Kaiser PK, Sears JE
Ophthalmol Clin North Am 2005 Mar;18(1):151-61, ix. doi: 10.1016/j.ohc.2004.07.004. PMID: 15763200
Choroidal osteoma.
Kadrmas EF, Weiter JJ
Int Ophthalmol Clin 1997 Fall;37(4):171-82. doi: 10.1097/00004397-199703740-00015. PMID: 9429940

Therapy

Tebentafusp as a Promising Drug for the Treatment of Uveal Melanoma.
Al Balushi K, Al Hadhrami A, Balushi HA, Al Lawati A, Das S
Curr Drug Targets 2024;25(3):149-157. doi: 10.2174/0113894501280380231214105255. PMID: 38115619
Tamoxifen related chorioretinal structural changes.
Erbahçeci Timur İE, Açıkgöz V, Uğurlu N, Yalçın B, Şendur MAN, Hızal M, Kara H
Cutan Ocul Toxicol 2023 Sep;42(3):109-117. Epub 2023 Jun 15 doi: 10.1080/15569527.2023.2220388. PMID: 37272809
Treatment of Choroidal Hemangioma with Photodynamic Therapy and Bevacizumab.
Durrani AF, Zhou Y, Musch DC, Demirci H
Ophthalmol Retina 2022 Jun;6(6):533-535. Epub 2022 Feb 1 doi: 10.1016/j.oret.2022.01.015. PMID: 35114415
Photodynamic therapy for choroidal melanoma: What is the response rate?
Yordi S, Soto H, Bowen RC, Singh AD
Surv Ophthalmol 2021 Jul-Aug;66(4):552-559. Epub 2021 Jan 2 doi: 10.1016/j.survophthal.2020.09.006. PMID: 33400941
New concepts in the diagnosis and management of choroidal metastases.
Mathis T, Jardel P, Loria O, Delaunay B, Nguyen AM, Lanza F, Mosci C, Caujolle JP, Kodjikian L, Thariat J
Prog Retin Eye Res 2019 Jan;68:144-176. Epub 2018 Sep 19 doi: 10.1016/j.preteyeres.2018.09.003. PMID: 30240895

Prognosis

Choroidal biopsies; a review and optimised approach.
Hussain RN, Damato B, Heimann H
Eye (Lond) 2023 Apr;37(5):900-906. Epub 2022 Aug 8 doi: 10.1038/s41433-022-02194-0. PMID: 35941182Free PMC Article
Secondary ocular malignancies: A review.
Yeung AM, Wells JR, Grossniklaus HE
Clin Exp Ophthalmol 2021 Mar;49(2):161-168. Epub 2021 Jan 10 doi: 10.1111/ceo.13889. PMID: 33426794
Conditional Survival in Uveal Melanoma.
Zabor EC, Radivoyevitch T, Singh AD, Kilic E, de Klein JEMM, Kalirai H, Coupland SE
Ophthalmol Retina 2021 Jun;5(6):536-542. Epub 2020 Sep 23 doi: 10.1016/j.oret.2020.09.015. PMID: 32979556
Predictors of recurrence in the management of chordoid meningioma.
Choy W, Ampie L, Lamano JB, Kesavabhotla K, Mao Q, Parsa AT, Bloch O
J Neurooncol 2016 Jan;126(1):107-116. Epub 2015 Sep 26 doi: 10.1007/s11060-015-1940-9. PMID: 26409888Free PMC Article
Choroidal hemangioma.
Singh AD, Kaiser PK, Sears JE
Ophthalmol Clin North Am 2005 Mar;18(1):151-61, ix. doi: 10.1016/j.ohc.2004.07.004. PMID: 15763200

Clinical prediction guides

Spectral-domain optical coherence tomography biomarkers in vitreoretinal lymphoma.
Guan W, Xiao Y, Zhao H, Hu F, Chen C, Peng X
Clin Exp Ophthalmol 2023 Mar;51(2):144-153. Epub 2023 Jan 4 doi: 10.1111/ceo.14197. PMID: 36567492
VITREOUS SEEDING OF CHOROIDAL MELANOMA.
Raval V, Bowen RC, Soto H, Biscotti C, Yeaney G, Sears J, Singh A
Retina 2021 Apr 1;41(4):890-894. doi: 10.1097/IAE.0000000000002989. PMID: 33009220
Uveal Melanoma UK National Guidelines.
Nathan P, Cohen V, Coupland S, Curtis K, Damato B, Evans J, Fenwick S, Kirkpatrick L, Li O, Marshall E, McGuirk K, Ottensmeier C, Pearce N, Salvi S, Stedman B, Szlosarek P, Turnbull N; United Kingdom Uveal Melanoma Guideline Development Working Group
Eur J Cancer 2015 Nov;51(16):2404-12. Epub 2015 Aug 13 doi: 10.1016/j.ejca.2015.07.013. PMID: 26278648
Management of choroidal metastases.
Jardel P, Sauerwein W, Olivier T, Bensoussan E, Maschi C, Lanza F, Mosci C, Gastaud L, Angellier G, Marcy PY, Herault J, Caujolle JP, Dendale R, Thariat J
Cancer Treat Rev 2014 Dec;40(10):1119-28. Epub 2014 Oct 5 doi: 10.1016/j.ctrv.2014.09.006. PMID: 25451606
Circumscribed choroidal hemangioma.
Mashayekhi A, Shields CL
Curr Opin Ophthalmol 2003 Jun;14(3):142-9. doi: 10.1097/00055735-200306000-00006. PMID: 12777933

Recent systematic reviews

Symptomatic intraventricular choroid plexus cysts. Illustrative case and systematic review.
Stanishevskiy A, Gavrilov G, Svistov D, Cherebillo V, Kurnukhina M
Neurosurg Rev 2023 Oct 6;46(1):264. doi: 10.1007/s10143-023-02176-0. PMID: 37801091
Clinical features and therapeutic management of choroidal osteoma: A systematic review.
Zhang L, Ran QB, Lei CY, Zhang MX
Surv Ophthalmol 2023 Nov-Dec;68(6):1084-1092. Epub 2023 Jun 14 doi: 10.1016/j.survophthal.2023.06.002. PMID: 37321477
Management of choroidal metastases.
Jardel P, Sauerwein W, Olivier T, Bensoussan E, Maschi C, Lanza F, Mosci C, Gastaud L, Angellier G, Marcy PY, Herault J, Caujolle JP, Dendale R, Thariat J
Cancer Treat Rev 2014 Dec;40(10):1119-28. Epub 2014 Oct 5 doi: 10.1016/j.ctrv.2014.09.006. PMID: 25451606
Breast cancer (metastatic).
Stebbing J, Ngan S
BMJ Clin Evid 2010 Sep 8;2010 PMID: 21418674Free PMC Article
Breast cancer (metastatic).
Stebbing J, Slater S, Slevin M
BMJ Clin Evid 2007 Feb 1;2007 PMID: 19454050Free PMC Article

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