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Degenerative myopia

MedGen UID:
57597
•Concept ID:
C0154778
•
Disease or Syndrome
Synonyms: Degenerative Myopia; Degenerative Myopias; Myopia, Degenerative; Myopia, Pathological; Myopias, Degenerative; Myopias, Pathological; Pathological Myopia; Pathological Myopias
SNOMED CT: Degenerative myopia (32022003); Degenerative progressive high myopia (32022003)
 
Monarch Initiative: MONDO:0001383

Definition

A sub-type of myopia characterized by high myopia with any posterior myopia-specific pathology resulting from axial elongation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDegenerative myopia

Professional guidelines

PubMed

Myopic Choroidal Neovascularization: Review, Guidance, and Consensus Statement on Management.
Cheung CMG, Arnold JJ, Holz FG, Park KH, Lai TYY, Larsen M, Mitchell P, Ohno-Matsui K, Chen SJ, Wolf S, Wong TY
Ophthalmology 2017 Nov;124(11):1690-1711. Epub 2017 Jun 24 doi: 10.1016/j.ophtha.2017.04.028. PMID: 28655539
The frequency of genetic eye diseases in a genetic counseling center.
Elçioğlu N, Elçioğlu M, Fuhrmann W
Genet Couns 1995;6(4):329-42. PMID: 8775420
Congenital cataract: management and results.
Jain IS, Pillai P, Gangwar DN, Gopal L, Dhir SP
J Pediatr Ophthalmol Strabismus 1983 Nov-Dec;20(6):243-6. doi: 10.3928/0191-3913-19831101-07. PMID: 6644486

Recent clinical studies

Etiology

Management of Myopic Maculopathy: A Review.
Anderson WJ, Akduman L
Turk J Ophthalmol 2023 Oct 19;53(5):307-312. doi: 10.4274/tjo.galenos.2023.59844. PMID: 37870043Free PMC Article
Peripheral Defocus and Myopia Management: A Mini-Review.
Erdinest N, London N, Lavy I, Berkow D, Landau D, Morad Y, Levinger N
Korean J Ophthalmol 2023 Feb;37(1):70-81. Epub 2023 Feb 3 doi: 10.3341/kjo.2022.0125. PMID: 36796348Free PMC Article
Dome-shaped maculopathy: a review.
Jain M, Gopal L, Padhi TR
Eye (Lond) 2021 Sep;35(9):2458-2467. Epub 2021 Apr 19 doi: 10.1038/s41433-021-01518-w. PMID: 33875828Free PMC Article
Low-Concentration Atropine Eye Drops for Myopia Progression.
Li FF, Yam JC
Asia Pac J Ophthalmol (Phila) 2019 Sep-Oct;8(5):360-365. doi: 10.1097/APO.0000000000000256. PMID: 31478936Free PMC Article
Pathologic Myopia.
Ohno-Matsui K
Asia Pac J Ophthalmol (Phila) 2016 Nov/Dec;5(6):415-423. doi: 10.1097/APO.0000000000000230. PMID: 27898445

Diagnosis

Annual Incidences and Progressions of Myopia and High Myopia in Chinese Schoolchildren Based on a 5-Year Cohort Study.
Li SM, Wei S, Atchison DA, Kang MT, Liu L, Li H, Li S, Yang Z, Wang Y, Zhang F, Wang N
Invest Ophthalmol Vis Sci 2022 Jan 3;63(1):8. doi: 10.1167/iovs.63.1.8. PMID: 34989760Free PMC Article
Continued Increase of Axial Length and Its Risk Factors in Adults With High Myopia.
Du R, Xie S, Igarashi-Yokoi T, Watanabe T, Uramoto K, Takahashi H, Nakao N, Yoshida T, Fang Y, Ohno-Matsui K
JAMA Ophthalmol 2021 Oct 1;139(10):1096-1103. doi: 10.1001/jamaophthalmol.2021.3303. PMID: 34436537Free PMC Article
Biomechanics of Ophthalmic Crosslinking.
Blackburn BJ, Rollins AM, Dupps WJ Jr
Transl Vis Sci Technol 2021 Apr 29;10(5):8. doi: 10.1167/tvst.10.5.8. PMID: 34328498Free PMC Article
IMI Pathologic Myopia.
Ohno-Matsui K, Wu PC, Yamashiro K, Vutipongsatorn K, Fang Y, Cheung CMG, Lai TYY, Ikuno Y, Cohen SY, Gaudric A, Jonas JB
Invest Ophthalmol Vis Sci 2021 Apr 28;62(5):5. doi: 10.1167/iovs.62.5.5. PMID: 33909033Free PMC Article
Pathologic Myopia.
Ohno-Matsui K
Asia Pac J Ophthalmol (Phila) 2016 Nov/Dec;5(6):415-423. doi: 10.1097/APO.0000000000000230. PMID: 27898445

Therapy

The Complications of Myopia: A Review and Meta-Analysis.
Haarman AEG, Enthoven CA, Tideman JWL, Tedja MS, Verhoeven VJM, Klaver CCW
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):49. doi: 10.1167/iovs.61.4.49. PMID: 32347918Free PMC Article
Interventions to slow progression of myopia in children.
Walline JJ, Lindsley KB, Vedula SS, Cotter SA, Mutti DO, Ng SM, Twelker JD
Cochrane Database Syst Rev 2020 Jan 13;1(1):CD004916. doi: 10.1002/14651858.CD004916.pub4. PMID: 31930781Free PMC Article
Defocus Incorporated Multiple Segments (DIMS) spectacle lenses slow myopia progression: a 2-year randomised clinical trial.
Lam CSY, Tang WC, Tse DY, Lee RPK, Chun RKM, Hasegawa K, Qi H, Hatanaka T, To CH
Br J Ophthalmol 2020 Mar;104(3):363-368. Epub 2019 May 29 doi: 10.1136/bjophthalmol-2018-313739. PMID: 31142465Free PMC Article
Low-Concentration Atropine Eye Drops for Myopia Progression.
Li FF, Yam JC
Asia Pac J Ophthalmol (Phila) 2019 Sep-Oct;8(5):360-365. doi: 10.1097/APO.0000000000000256. PMID: 31478936Free PMC Article
The epidemics of myopia: Aetiology and prevention.
Morgan IG, French AN, Ashby RS, Guo X, Ding X, He M, Rose KA
Prog Retin Eye Res 2018 Jan;62:134-149. Epub 2017 Sep 23 doi: 10.1016/j.preteyeres.2017.09.004. PMID: 28951126

Prognosis

Annual Incidences and Progressions of Myopia and High Myopia in Chinese Schoolchildren Based on a 5-Year Cohort Study.
Li SM, Wei S, Atchison DA, Kang MT, Liu L, Li H, Li S, Yang Z, Wang Y, Zhang F, Wang N
Invest Ophthalmol Vis Sci 2022 Jan 3;63(1):8. doi: 10.1167/iovs.63.1.8. PMID: 34989760Free PMC Article
Biomechanics of Ophthalmic Crosslinking.
Blackburn BJ, Rollins AM, Dupps WJ Jr
Transl Vis Sci Technol 2021 Apr 29;10(5):8. doi: 10.1167/tvst.10.5.8. PMID: 34328498Free PMC Article
Safety and Efficacy of Low-Dose Atropine Eyedrops for the Treatment of Myopia Progression in Chinese Children: A Randomized Clinical Trial.
Wei S, Li SM, An W, Du J, Liang X, Sun Y, Zhang D, Tian J, Wang N
JAMA Ophthalmol 2020 Nov 1;138(11):1178-1184. doi: 10.1001/jamaophthalmol.2020.3820. PMID: 33001210Free PMC Article
Defocus Incorporated Multiple Segments (DIMS) spectacle lenses slow myopia progression: a 2-year randomised clinical trial.
Lam CSY, Tang WC, Tse DY, Lee RPK, Chun RKM, Hasegawa K, Qi H, Hatanaka T, To CH
Br J Ophthalmol 2020 Mar;104(3):363-368. Epub 2019 May 29 doi: 10.1136/bjophthalmol-2018-313739. PMID: 31142465Free PMC Article
Myopic traction maculopathy.
Gómez-Resa M, Burés-Jelstrup A, Mateo C
Dev Ophthalmol 2014;54:204-12. Epub 2014 Aug 26 doi: 10.1159/000360468. PMID: 25196771

Clinical prediction guides

Machine Learning Models for Predicting Long-Term Visual Acuity in Highly Myopic Eyes.
Wang Y, Du R, Xie S, Chen C, Lu H, Xiong J, Ting DSW, Uramoto K, Kamoi K, Ohno-Matsui K
JAMA Ophthalmol 2023 Dec 1;141(12):1117-1124. doi: 10.1001/jamaophthalmol.2023.4786. PMID: 37883115Free PMC Article
Biomechanics of Ophthalmic Crosslinking.
Blackburn BJ, Rollins AM, Dupps WJ Jr
Transl Vis Sci Technol 2021 Apr 29;10(5):8. doi: 10.1167/tvst.10.5.8. PMID: 34328498Free PMC Article
Update and guidance on management of myopia. European Society of Ophthalmology in cooperation with International Myopia Institute.
Németh J, Tapasztó B, Aclimandos WA, Kestelyn P, Jonas JB, De Faber JHN, Januleviciene I, Grzybowski A, Nagy ZZ, Pärssinen O, Guggenheim JA, Allen PM, Baraas RC, Saunders KJ, Flitcroft DI, Gray LS, Polling JR, Haarman AE, Tideman JWL, Wolffsohn JS, Wahl S, Mulder JA, Smirnova IY, Formenti M, Radhakrishnan H, Resnikoff S
Eur J Ophthalmol 2021 May;31(3):853-883. Epub 2021 Mar 5 doi: 10.1177/1120672121998960. PMID: 33673740Free PMC Article
Myopia control with novel central and peripheral plus contact lenses and extended depth of focus contact lenses: 2 year results from a randomised clinical trial.
Sankaridurg P, Bakaraju RC, Naduvilath T, Chen X, Weng R, Tilia D, Xu P, Li W, Conrad F, Smith EL 3rd, Ehrmann K
Ophthalmic Physiol Opt 2019 Jul;39(4):294-307. Epub 2019 Jun 10 doi: 10.1111/opo.12621. PMID: 31180155Free PMC Article
International photographic classification and grading system for myopic maculopathy.
Ohno-Matsui K, Kawasaki R, Jonas JB, Cheung CM, Saw SM, Verhoeven VJ, Klaver CC, Moriyama M, Shinohara K, Kawasaki Y, Yamazaki M, Meuer S, Ishibashi T, Yasuda M, Yamashita H, Sugano A, Wang JJ, Mitchell P, Wong TY; META-analysis for Pathologic Myopia (META-PM) Study Group
Am J Ophthalmol 2015 May;159(5):877-83.e7. Epub 2015 Jan 26 doi: 10.1016/j.ajo.2015.01.022. PMID: 25634530

Recent systematic reviews

Factors associated with pathologic myopia onset and progression: A systematic review and meta-analysis.
Yii F, Nguyen L, Strang N, Bernabeu MO, Tatham AJ, MacGillivray T, Dhillon B
Ophthalmic Physiol Opt 2024 Jul;44(5):963-976. Epub 2024 Apr 2 doi: 10.1111/opo.13312. PMID: 38563652
Pathogenesis of myopic choroidal neovascularization: A systematic review and meta-analysis.
Zhang XJ, Chen XN, Tang FY, Szeto S, Ling XT, Lin ZX, Tham CC, Pang CP, Chen LJ, Yam JC
Surv Ophthalmol 2023 Nov-Dec;68(6):1011-1026. Epub 2023 Jul 28 doi: 10.1016/j.survophthal.2023.07.006. PMID: 37517683
The Complications of Myopia: A Review and Meta-Analysis.
Haarman AEG, Enthoven CA, Tideman JWL, Tedja MS, Verhoeven VJM, Klaver CCW
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):49. doi: 10.1167/iovs.61.4.49. PMID: 32347918Free PMC Article
Interventions to slow progression of myopia in children.
Walline JJ, Lindsley KB, Vedula SS, Cotter SA, Mutti DO, Ng SM, Twelker JD
Cochrane Database Syst Rev 2020 Jan 13;1(1):CD004916. doi: 10.1002/14651858.CD004916.pub4. PMID: 31930781Free PMC Article
Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050.
Holden BA, Fricke TR, Wilson DA, Jong M, Naidoo KS, Sankaridurg P, Wong TY, Naduvilath TJ, Resnikoff S
Ophthalmology 2016 May;123(5):1036-42. Epub 2016 Feb 11 doi: 10.1016/j.ophtha.2016.01.006. PMID: 26875007

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