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Nephrotic Syndrome with Lesion of Proliferative Glomerulonephritis

MedGen UID:
57620
•Concept ID:
C0156227
•
Disease or Syndrome

Definition

A renal functional disorder characterized by proteinuria, edema, hyperlipidemia and hypoalbuminemia. It results from damage to the renal vascular filtration apparatus. It is further characterized by an inflammatory reaction of the glomerular capillaries due to the proliferation of mesangial cells and expansion of the mesangial matrix. Sequelae may include hypertension, atherosclerosis, infection, hypercoagulablity and renal failure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNephrotic Syndrome with Lesion of Proliferative Glomerulonephritis

Professional guidelines

PubMed

Role of light and immunofluorescence microscopy to differentiate primary and secondary membranous nephropathy.
Basu K, Sengupta M, Mukherjee S, Karmakar S, Roychowdhury A, Bandopadhyay M
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):821-827. doi: 10.4103/ijpm.ijpm_22_21. PMID: 36308187
Urinary cytology: a potential tool for differential diagnosis of acute kidney injury in patients with nephrotic syndrome.
de Melo CVB, Tavares MB, Fernandes PN, Dos Santos Silva CA, Couto RD, Oliveira MB, Dos-Santos WLC
BMC Res Notes 2020 Aug 27;13(1):401. doi: 10.1186/s13104-020-05244-6. PMID: 32854763Free PMC Article
Treatment of lupus nephritis in children.
Niaudet P
Pediatr Nephrol 2000 Feb;14(2):158-66. doi: 10.1007/s004670050034. PMID: 10684369

Recent clinical studies

Etiology

Paraprotein-Mediated Glomerular Diseases.
Miao J, Herrmann SM, Obaidi Z, Caza T, Bonilla M
Adv Kidney Dis Health 2024 Jul;31(4):358-373. doi: 10.1053/j.akdh.2024.02.005. PMID: 39084761
Role of light and immunofluorescence microscopy to differentiate primary and secondary membranous nephropathy.
Basu K, Sengupta M, Mukherjee S, Karmakar S, Roychowdhury A, Bandopadhyay M
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):821-827. doi: 10.4103/ijpm.ijpm_22_21. PMID: 36308187
Clinical and Pathological Features of Renal Presentations in Polycythemia Vera.
Yang J, Yu X, Hu N, Su T
Am J Med Sci 2022 Jan;363(1):33-41. Epub 2021 Oct 21 doi: 10.1016/j.amjms.2021.10.009. PMID: 34687616
Epidemiological and clinical characteristics and outcome of monoclonal gammopathy of renal significance-related lesions in Latin America.
Peña C, Schutz NP, Riva E, Valjalo R, Majlis A, López-Vidal H, Lois V, Zamora D, Ochoa P, Shanley C, Gonzalez JT, Fantl D, Correa G, Ramirez J, Mur P, Silva G, Verri V, Rojas C, Escobar K, Glavic G, Méndez GP; Grupo de estudio latinoamericano de mieloma múltiple (GELAMM)
Nephrology (Carlton) 2020 Jun;25(6):442-449. Epub 2019 Dec 19 doi: 10.1111/nep.13685. PMID: 31825549
Mesangial proliferative lupus nephritis with podocytopathy: a special entity of lupus nephritis.
Wang SF, Chen YH, Chen DQ, Liu ZZ, Xu F, Zeng CH, Hu WX
Lupus 2018 Feb;27(2):303-311. Epub 2017 Jul 18 doi: 10.1177/0961203317720526. PMID: 28720048

Diagnosis

Paraprotein-Mediated Glomerular Diseases.
Miao J, Herrmann SM, Obaidi Z, Caza T, Bonilla M
Adv Kidney Dis Health 2024 Jul;31(4):358-373. doi: 10.1053/j.akdh.2024.02.005. PMID: 39084761
Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a nephrologist perspective.
Bridoux F, Javaugue V, Nasr SH, Leung N
Nephrol Dial Transplant 2021 Jan 25;36(2):208-215. doi: 10.1093/ndt/gfz176. PMID: 33494099
Lupus Podocytopathy: An Overview.
Oliva-Damaso N, Payan J, Oliva-Damaso E, Pereda T, Bomback AS
Adv Chronic Kidney Dis 2019 Sep;26(5):369-375. doi: 10.1053/j.ackd.2019.08.011. PMID: 31733721Free PMC Article
Nonproliferative Forms of Lupus Nephritis: An Overview.
Bomback AS
Rheum Dis Clin North Am 2018 Nov;44(4):561-569. Epub 2018 Sep 7 doi: 10.1016/j.rdc.2018.06.003. PMID: 30274623Free PMC Article
C1q Nephropathy: The Unique Underrecognized Pathological Entity.
Devasahayam J, Erode-Singaravelu G, Bhat Z, Oliver T, Chandran A, Zeng X, Dakshinesh P, Pillai U
Anal Cell Pathol (Amst) 2015;2015:490413. Epub 2015 Nov 10 doi: 10.1155/2015/490413. PMID: 26640759Free PMC Article

Therapy

Role of light and immunofluorescence microscopy to differentiate primary and secondary membranous nephropathy.
Basu K, Sengupta M, Mukherjee S, Karmakar S, Roychowdhury A, Bandopadhyay M
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):821-827. doi: 10.4103/ijpm.ijpm_22_21. PMID: 36308187
Clinical and morphologic spectrum of renal involvement in idiopathic hypereosinophilic syndrome.
Dong JH, Xu ST, Xu F, Zhou YC, Li Z, Li SJ
Clin Exp Nephrol 2021 Mar;25(3):270-278. Epub 2021 Jan 4 doi: 10.1007/s10157-020-02012-5. PMID: 33398597
Treatment of lupus nephritis in children.
Niaudet P
Pediatr Nephrol 2000 Feb;14(2):158-66. doi: 10.1007/s004670050034. PMID: 10684369
Monoclonal IgG cryoglobulinemia with secondary development of glomerulonephritis and nephrotic syndrome.
Bengtsson U, Larsson O, Lindstedt G, Svalander C
Q J Med 1975 Jul;44(175):491-503. PMID: 1178819
Nephrotic syndrome in indian children.
Srivastava RN, Mayekar G, Anand R, Choudhry VP, Ghai OP, Tandon HD
Arch Dis Child 1975 Aug;50(8):626-30. doi: 10.1136/adc.50.8.626. PMID: 973Free PMC Article

Prognosis

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a nephrologist perspective.
Bridoux F, Javaugue V, Nasr SH, Leung N
Nephrol Dial Transplant 2021 Jan 25;36(2):208-215. doi: 10.1093/ndt/gfz176. PMID: 33494099
Clinical and morphologic spectrum of renal involvement in idiopathic hypereosinophilic syndrome.
Dong JH, Xu ST, Xu F, Zhou YC, Li Z, Li SJ
Clin Exp Nephrol 2021 Mar;25(3):270-278. Epub 2021 Jan 4 doi: 10.1007/s10157-020-02012-5. PMID: 33398597
Lupus Podocytopathy: An Overview.
Oliva-Damaso N, Payan J, Oliva-Damaso E, Pereda T, Bomback AS
Adv Chronic Kidney Dis 2019 Sep;26(5):369-375. doi: 10.1053/j.ackd.2019.08.011. PMID: 31733721Free PMC Article
Nonproliferative Forms of Lupus Nephritis: An Overview.
Bomback AS
Rheum Dis Clin North Am 2018 Nov;44(4):561-569. Epub 2018 Sep 7 doi: 10.1016/j.rdc.2018.06.003. PMID: 30274623Free PMC Article
C1q Nephropathy: The Unique Underrecognized Pathological Entity.
Devasahayam J, Erode-Singaravelu G, Bhat Z, Oliver T, Chandran A, Zeng X, Dakshinesh P, Pillai U
Anal Cell Pathol (Amst) 2015;2015:490413. Epub 2015 Nov 10 doi: 10.1155/2015/490413. PMID: 26640759Free PMC Article

Clinical prediction guides

Clinical and Pathological Features of Renal Presentations in Polycythemia Vera.
Yang J, Yu X, Hu N, Su T
Am J Med Sci 2022 Jan;363(1):33-41. Epub 2021 Oct 21 doi: 10.1016/j.amjms.2021.10.009. PMID: 34687616
Clinical and morphologic spectrum of renal involvement in idiopathic hypereosinophilic syndrome.
Dong JH, Xu ST, Xu F, Zhou YC, Li Z, Li SJ
Clin Exp Nephrol 2021 Mar;25(3):270-278. Epub 2021 Jan 4 doi: 10.1007/s10157-020-02012-5. PMID: 33398597
Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits without Conspicuous Mesangial Proliferation, Complicated with Squamous Cell Lung Carcinoma.
Higashihara T, Okada A, Nakamura Y, Saigusa H, Homma S, Matsumura M, Kusano T, Shimizu A, Takano H
Intern Med 2020 Feb 15;59(4):557-562. Epub 2019 Oct 15 doi: 10.2169/internalmedicine.2993-19. PMID: 31611527Free PMC Article
Nephrotic syndrome associated with Kimura's disease: a case report and literature review.
Ren S, Li XY, Wang F, Zhang P, Zhang Y, Li GS, Wang L, Zhong X
BMC Nephrol 2018 Nov 8;19(1):316. doi: 10.1186/s12882-018-1123-y. PMID: 30409112Free PMC Article
C1q Nephropathy: The Unique Underrecognized Pathological Entity.
Devasahayam J, Erode-Singaravelu G, Bhat Z, Oliver T, Chandran A, Zeng X, Dakshinesh P, Pillai U
Anal Cell Pathol (Amst) 2015;2015:490413. Epub 2015 Nov 10 doi: 10.1155/2015/490413. PMID: 26640759Free PMC Article

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