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Uterine synechiae

MedGen UID:
57629
•Concept ID:
C0156372
•
Disease or Syndrome
Synonyms: Asherman syndrome; Asherman's syndrome; Intrauterine synechiae
SNOMED CT: Asherman's syndrome (48236007); Asherman syndrome (48236007); Traumatic intrauterine synechiae syndrome (48236007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0030712
Monarch Initiative: MONDO:0015299
Orphanet: ORPHA137686

Definition

Adhesions or scar tissue that form inside the cavity of the uterus. [from HPO]

Professional guidelines

PubMed

Comprehensive treatment for infertile women with severe Asherman syndrome.
Tsui KH, Lin LT, Cheng JT, Teng SW, Wang PH
Taiwan J Obstet Gynecol 2014 Sep;53(3):372-5. doi: 10.1016/j.tjog.2014.04.022. PMID: 25286793
Anatomical causes of female infertility and their management.
Abrao MS, Muzii L, Marana R
Int J Gynaecol Obstet 2013 Dec;123 Suppl 2:S18-24. Epub 2013 Sep 11 doi: 10.1016/j.ijgo.2013.09.008. PMID: 24119894
The endoscopic management of uterine synechiae. A clinical study of 78 cases.
Socolov R, Anton E, Butureanu S, Socolov D
Chirurgia (Bucur) 2010 Jul-Aug;105(4):515-8. PMID: 20941974

Recent clinical studies

Etiology

Are synechiae a complication of laparotomic myomectomy?
Capmas P, Pourcelot AG, Fernandez H
Reprod Biomed Online 2018 Apr;36(4):450-454. Epub 2018 Feb 2 doi: 10.1016/j.rbmo.2018.01.010. PMID: 29454580
An overview of the results of hysterosonography prior to in vitro fertilization.
Lopes VM, Barguil JP, Lacerda TS, Souza ALM, Rocha Filho AMD, Roller MF, Barbosa EA, Tierno NZ, Lopes JRC
JBRA Assist Reprod 2017 Dec 1;21(4):302-305. doi: 10.5935/1518-0557.20170051. PMID: 28960053Free PMC Article
Comprehensive treatment for infertile women with severe Asherman syndrome.
Tsui KH, Lin LT, Cheng JT, Teng SW, Wang PH
Taiwan J Obstet Gynecol 2014 Sep;53(3):372-5. doi: 10.1016/j.tjog.2014.04.022. PMID: 25286793
Risk of postpartum uterine synechiae following uterine compression suturing during postpartum haemorrhage.
Ibrahim MI, Raafat TA, Ellaithy MI, Aly RT
Aust N Z J Obstet Gynaecol 2013 Feb;53(1):37-45. Epub 2012 Nov 20 doi: 10.1111/ajo.12017. PMID: 23163583
Uterine synechiae and pregnancy complications.
Tuuli MG, Shanks A, Bernhard L, Odibo AO, Macones GA, Cahill A
Obstet Gynecol 2012 Apr;119(4):810-4. doi: 10.1097/AOG.0b013e31824be28a. PMID: 22433345

Diagnosis

Intrauterine Linear Echogenicities in the Gravid Uterus: What Radiologists Should Know.
Jensen KK, Oh KY, Kennedy AM, Sohaey R
Radiographics 2018 Mar-Apr;38(2):642-657. doi: 10.1148/rg.2018170062. PMID: 29528829
Are synechiae a complication of laparotomic myomectomy?
Capmas P, Pourcelot AG, Fernandez H
Reprod Biomed Online 2018 Apr;36(4):450-454. Epub 2018 Feb 2 doi: 10.1016/j.rbmo.2018.01.010. PMID: 29454580
An overview of the results of hysterosonography prior to in vitro fertilization.
Lopes VM, Barguil JP, Lacerda TS, Souza ALM, Rocha Filho AMD, Roller MF, Barbosa EA, Tierno NZ, Lopes JRC
JBRA Assist Reprod 2017 Dec 1;21(4):302-305. doi: 10.5935/1518-0557.20170051. PMID: 28960053Free PMC Article
Role of 3D sonohysterography in the investigation of uterine synechiae/asherman's syndrome: pictorial assay.
Ahmadi F, Javam M
J Med Imaging Radiat Oncol 2014 Apr;58(2):199-202. Epub 2013 Dec 3 doi: 10.1111/1754-9485.12137. PMID: 24314038
Uterine synechiae and pregnancy complications.
Tuuli MG, Shanks A, Bernhard L, Odibo AO, Macones GA, Cahill A
Obstet Gynecol 2012 Apr;119(4):810-4. doi: 10.1097/AOG.0b013e31824be28a. PMID: 22433345

Therapy

Are synechiae a complication of laparotomic myomectomy?
Capmas P, Pourcelot AG, Fernandez H
Reprod Biomed Online 2018 Apr;36(4):450-454. Epub 2018 Feb 2 doi: 10.1016/j.rbmo.2018.01.010. PMID: 29454580
Comprehensive treatment for infertile women with severe Asherman syndrome.
Tsui KH, Lin LT, Cheng JT, Teng SW, Wang PH
Taiwan J Obstet Gynecol 2014 Sep;53(3):372-5. doi: 10.1016/j.tjog.2014.04.022. PMID: 25286793
Risk of synechiae following uterine compression sutures in the management of major postpartum haemorrhage.
Poujade O, Grossetti A, Mougel L, Ceccaldi PF, Ducarme G, Luton D
BJOG 2011 Mar;118(4):433-9. Epub 2010 Dec 24 doi: 10.1111/j.1471-0528.2010.02817.x. PMID: 21199289
Is curettage needed for uncomplicated incomplete spontaneous abortion?
Ballagh SA, Harris HA, Demasio K
Am J Obstet Gynecol 1998 Nov;179(5):1279-82. doi: 10.1016/s0002-9378(98)70147-4. PMID: 9822516
Traumatic uterine synechiae.
Karimi R, Chapman K
Ir J Med Sci 1974 Nov;143(6):319-24. doi: 10.1007/BF03004783. PMID: 4474150

Prognosis

Uterine synechiae after intrauterine device use: a case series.
Abel MK, Wald K, Cedars MI, Noel M
J Assist Reprod Genet 2021 Oct;38(10):2625-2629. Epub 2021 Apr 8 doi: 10.1007/s10815-021-02173-6. PMID: 33830411Free PMC Article
An overview of the results of hysterosonography prior to in vitro fertilization.
Lopes VM, Barguil JP, Lacerda TS, Souza ALM, Rocha Filho AMD, Roller MF, Barbosa EA, Tierno NZ, Lopes JRC
JBRA Assist Reprod 2017 Dec 1;21(4):302-305. doi: 10.5935/1518-0557.20170051. PMID: 28960053Free PMC Article
Accuracy of three dimensional ultrasound and treatment outcomes of intrauterine adhesion in infertile women.
Kim MJ, Lee Y, Lee C, Chun S, Kim A, Kim HY, Lee JY
Taiwan J Obstet Gynecol 2015 Dec;54(6):737-41. doi: 10.1016/j.tjog.2015.10.011. PMID: 26700995
Role of laporoscopy-hysteroscopy in cases of infertility with pregnancy outcome.
Neerja, Jain K
J Indian Med Assoc 2014 Feb;112(2):85-6, 88. PMID: 25935960
Cryocoagulation of the endometrium at the uterine cornua.
Droegemueller W, Greer BE, Davis JR, Makowski EL, Chvapil M, Pollard A
Am J Obstet Gynecol 1978 May 1;131(1):1-9. doi: 10.1016/0002-9378(78)90466-0. PMID: 417630

Clinical prediction guides

Association of intrauterine synechiae with pituitary gonadotrophin pulse patterns: A pilot study.
Gianfaldoni A, Roa C, Dos Santos Simões R, Baracat MCP, Maggio da Fonseca A, Bagnoli VR, Sopreso ICE, Silva Rivas FW, Monteleone P, Baracat EC, Soares Júnior JM
PLoS One 2023;18(12):e0289075. Epub 2023 Dec 15 doi: 10.1371/journal.pone.0289075. PMID: 38100407Free PMC Article
Are synechiae a complication of laparotomic myomectomy?
Capmas P, Pourcelot AG, Fernandez H
Reprod Biomed Online 2018 Apr;36(4):450-454. Epub 2018 Feb 2 doi: 10.1016/j.rbmo.2018.01.010. PMID: 29454580
An overview of the results of hysterosonography prior to in vitro fertilization.
Lopes VM, Barguil JP, Lacerda TS, Souza ALM, Rocha Filho AMD, Roller MF, Barbosa EA, Tierno NZ, Lopes JRC
JBRA Assist Reprod 2017 Dec 1;21(4):302-305. doi: 10.5935/1518-0557.20170051. PMID: 28960053Free PMC Article
Ultrasound is the optimal choice for guidance in difficult hysteroscopy.
Kresowik JD, Syrop CH, Van Voorhis BJ, Ryan GL
Ultrasound Obstet Gynecol 2012 Jun;39(6):715-8. doi: 10.1002/uog.11072. PMID: 22173892
Risk of synechiae following uterine compression sutures in the management of major postpartum haemorrhage.
Poujade O, Grossetti A, Mougel L, Ceccaldi PF, Ducarme G, Luton D
BJOG 2011 Mar;118(4):433-9. Epub 2010 Dec 24 doi: 10.1111/j.1471-0528.2010.02817.x. PMID: 21199289

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