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Amaurosis fugax

MedGen UID:
57702
•Concept ID:
C0149793
•
Sign or Symptom
Synonym: Transient monocular blindness
SNOMED CT: Amaurosis fugax (88032003); Momentary blindness (88032003); Amaurosis fugax (one sided temporary vision loss) (88032003); AF - Amaurosis fugax (88032003); AFx - Amaurosis fugax (88032003); Transient monocular blindness (88032003)
 
HPO: HP:0100576
Monarch Initiative: MONDO:0043310

Definition

A transient visual disturbance that is typically caused by a circulatory, ocular or neurological underlying condition. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmaurosis fugax

Professional guidelines

PubMed

Current Guidelines on Management of Amaurosis Fugax and Transient Ischemic Attacks.
Mbonde AA, O'Carroll CB, Dulamea OA, Anghel D, Chong BW, Dumitrascu OM
Asia Pac J Ophthalmol (Phila) 2022 Mar-Apr 01;11(2):168-176. Epub 2022 Feb 23 doi: 10.1097/APO.0000000000000511. PMID: 35213421
Ocular ischaemia: signs, symptoms, and clinical considerations for primary eye care practitioners.
Kalloniatis M, Wang H, Katalinic P, Ly A, Apel W, Nivison-Smith L, Kalloniatis KF
Clin Exp Optom 2022 Mar;105(2):117-134. Epub 2022 Jan 4 doi: 10.1080/08164622.2021.1999771. PMID: 34982952
Current management of amaurosis fugax. The Amaurosis Fugax Study Group.
Stroke 1990 Feb;21(2):201-8. doi: 10.1161/01.str.21.2.201. PMID: 2406992

Recent clinical studies

Etiology

Current Guidelines on Management of Amaurosis Fugax and Transient Ischemic Attacks.
Mbonde AA, O'Carroll CB, Dulamea OA, Anghel D, Chong BW, Dumitrascu OM
Asia Pac J Ophthalmol (Phila) 2022 Mar-Apr 01;11(2):168-176. Epub 2022 Feb 23 doi: 10.1097/APO.0000000000000511. PMID: 35213421
Ocular ischaemia: signs, symptoms, and clinical considerations for primary eye care practitioners.
Kalloniatis M, Wang H, Katalinic P, Ly A, Apel W, Nivison-Smith L, Kalloniatis KF
Clin Exp Optom 2022 Mar;105(2):117-134. Epub 2022 Jan 4 doi: 10.1080/08164622.2021.1999771. PMID: 34982952
Cholesterol embolization syndrome.
Saric M, Kronzon I
Curr Opin Cardiol 2011 Nov;26(6):472-9. doi: 10.1097/HCO.0b013e32834b7fdd. PMID: 21993354
Transient monocular blindness.
Kappelle LJ, Donders RC, Algra A
Clin Exp Hypertens 2006 Apr-May;28(3-4):259-63. doi: 10.1080/10641960600549199. PMID: 16833032
Current management of amaurosis fugax. The Amaurosis Fugax Study Group.
Stroke 1990 Feb;21(2):201-8. doi: 10.1161/01.str.21.2.201. PMID: 2406992

Diagnosis

Hypnic Amaurosis Fugax.
Thoveson A, Baig IF, Mortensen PW, Lee AG
J Neuroophthalmol 2022 Mar 1;42(1):e357-e358. Epub 2022 Jan 17 doi: 10.1097/WNO.0000000000001315. PMID: 35051985
Eyes and stroke: the visual aspects of cerebrovascular disease.
Pula JH, Yuen CA
Stroke Vasc Neurol 2017 Dec;2(4):210-220. Epub 2017 Jul 6 doi: 10.1136/svn-2017-000079. PMID: 29507782Free PMC Article
Acute Vision Loss.
Bagheri N, Mehta S
Prim Care 2015 Sep;42(3):347-61. doi: 10.1016/j.pop.2015.05.010. PMID: 26319342
Cholesterol embolization syndrome.
Saric M, Kronzon I
Curr Opin Cardiol 2011 Nov;26(6):472-9. doi: 10.1097/HCO.0b013e32834b7fdd. PMID: 21993354
Carotid artery disease.
Pohl ML
Optom Clin 1994;3(4):157-74. PMID: 7919691

Therapy

Is Management of Central Retinal Artery Occlusion the Next Frontier in Cerebrovascular Diseases?
Limaye K, Wall M, Uwaydat S, Ali S, Shaban A, Al Kasab S, Adams H Jr
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2781-2791. Epub 2018 Jul 27 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.006. PMID: 30060907
Testosterone therapy, thrombosis, thrombophilia, cardiovascular events.
Glueck CJ, Wang P
Metabolism 2014 Aug;63(8):989-94. Epub 2014 May 15 doi: 10.1016/j.metabol.2014.05.005. PMID: 24930993
Therapeutic approach to giant cell arteritis.
Masson C
Joint Bone Spine 2012 May;79(3):219-27. Epub 2011 Nov 26 doi: 10.1016/j.jbspin.2011.09.015. PMID: 22119350
Giant cell (temporal) arteritis.
Caselli RJ, Hunder GG
Neurol Clin 1997 Nov;15(4):893-902. doi: 10.1016/s0733-8619(05)70354-6. PMID: 9367971
Current management of amaurosis fugax. The Amaurosis Fugax Study Group.
Stroke 1990 Feb;21(2):201-8. doi: 10.1161/01.str.21.2.201. PMID: 2406992

Prognosis

Eyes and stroke: the visual aspects of cerebrovascular disease.
Pula JH, Yuen CA
Stroke Vasc Neurol 2017 Dec;2(4):210-220. Epub 2017 Jul 6 doi: 10.1136/svn-2017-000079. PMID: 29507782Free PMC Article
Visual disturbances in (pre)eclampsia.
Roos NM, Wiegman MJ, Jansonius NM, Zeeman GG
Obstet Gynecol Surv 2012 Apr;67(4):242-50. doi: 10.1097/OGX.0b013e318250a457. PMID: 22495060
Transient monocular blindness.
Kappelle LJ, Donders RC, Algra A
Clin Exp Hypertens 2006 Apr-May;28(3-4):259-63. doi: 10.1080/10641960600549199. PMID: 16833032
Cervicocranial arterial dissection.
Anson J, Crowell RM
Neurosurgery 1991 Jul;29(1):89-96. doi: 10.1097/00006123-199107000-00015. PMID: 1870693
Amaurosis fugax.
Mungas JE, Baker WH
Stroke 1977 Mar-Apr;8(2):232-5. doi: 10.1161/01.str.8.2.232. PMID: 847787

Clinical prediction guides

Patients with Carotid Intraplaque Hemorrhage Have Higher Incidence of Cerebral Microbleeds.
Nardi V, Benson JC, Saba L, Bois MC, Meyer FB, Lanzino G, Lerman LO, Lerman A
Curr Probl Cardiol 2023 Sep;48(9):101779. Epub 2023 May 11 doi: 10.1016/j.cpcardiol.2023.101779. PMID: 37172877
(18)F-NaF PET/MRI for Detection of Carotid Atheroma in Acute Neurovascular Syndrome.
Kaczynski J, Sellers S, Seidman MA, Syed M, Dennis M, Mcnaught G, Jansen M, Semple SI, Alcaide-Corral C, Tavares AAS, MacGillivray T, Debono S, Forsythe R, Tambyraja A, Slomka PJ, Leipsic J, Dweck MR, Whiteley W, Wardlaw J, van Beek EJR, Newby DE, Williams MC
Radiology 2022 Oct;305(1):137-148. Epub 2022 Jun 7 doi: 10.1148/radiol.212283. PMID: 35670715Free PMC Article
Computed tomography angiographic biomarkers help identify vulnerable carotid artery plaque.
Lal BK, Khan AA, Kashyap VS, Chrencik MT, Gupta A, King AH, Patel JB, Martinez-Delcid J, Uceda D, Desikan S, Sikdar S, Sorkin JD, Buckler A
J Vasc Surg 2022 Apr;75(4):1311-1322.e3. Epub 2021 Nov 15 doi: 10.1016/j.jvs.2021.10.056. PMID: 34793923
Vascular origin in acute transient visual disturbance: A prospective study.
Obadia M, Lamirel C, Meseguer E, Seners P, Zuber K, Rosenheim M, Yavchitz A, Bidot S, Hage R, Sabben C, Savatovsky J, Lavallée PC, Gout O, Vignal C, Amarenco P
Eur J Neurol 2021 Dec;28(12):4098-4108. Epub 2021 Sep 5 doi: 10.1111/ene.15074. PMID: 34411384
Amaurosis fugax.
Mungas JE, Baker WH
Stroke 1977 Mar-Apr;8(2):232-5. doi: 10.1161/01.str.8.2.232. PMID: 847787

Recent systematic reviews

Ocular Manifestations in Rheumatoid Arthritis, Connective Tissue Disease, and Vasculitis: A Systematic Review and Metaanalysis.
Turk MA, Hayworth JL, Nevskaya T, Pope JE
J Rheumatol 2021 Jan 1;48(1):25-34. Epub 2020 May 1 doi: 10.3899/jrheum.190768. PMID: 32358156
Carotid plaque vulnerability on magnetic resonance imaging and risk of future ischemic events: a systematic review and meta-analysis.
Rizvi A, Seyedsaadat SM, Alzuabi M, Murad MH, Huston J 3rd, Lehman VT, Lanzino G, Saba L, Brinjikji W
J Neurosurg Sci 2020 Oct;64(5):480-486. doi: 10.23736/S0390-5616.20.04959-0. PMID: 33236863
Carotid Plaque Positron Emission Tomography Imaging and Cerebral Ischemic Disease.
Chaker S, Al-Dasuqi K, Baradaran H, Demetres M, Delgado D, Nehmeh S, Osborne JR, Christos PJ, Kamel H, Gupta A
Stroke 2019 Aug;50(8):2072-2079. Epub 2019 Jul 5 doi: 10.1161/STROKEAHA.118.023987. PMID: 31272325Free PMC Article
Stroke risk in the early period after carotid related symptoms: a systematic review.
Tsantilas P, Kühnl A, Kallmayer M, Knappich C, Schmid S, Kuetchou A, Zimmermann A, Eckstein HH
J Cardiovasc Surg (Torino) 2015 Dec;56(6):845-52. Epub 2015 Sep 24 PMID: 26399273
Antiplatelet therapy for preventing stroke and other vascular events after carotid endarterectomy.
Engelter S, Lyrer P
Cochrane Database Syst Rev 2003;2003(3):CD001458. doi: 10.1002/14651858.CD001458. PMID: 12917908Free PMC Article

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