U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Impaired social interactions

MedGen UID:
57707
•Concept ID:
C0150080
•
Mental or Behavioral Dysfunction
Synonyms: Communication Disorder, Pragmatic; Communication Disorder, Social; Communication Disorders, Pragmatic; Communication Disorders, Social; Disorders, Pragmatic Communication; Pragmatic Communication Disorder; Pragmatic Communication Disorders; Social Communication Disorder; Social Communication Disorders
SNOMED CT: Social interaction disorder (88598008); Social communication disorder (88598008); Impaired social interaction (88598008)

Definition

Persistent difficulties in the social uses of verbal and nonverbal communications. (DSM-V) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Impaired social interactions

Professional guidelines

PubMed

The phenotypic spectrum and genotype-phenotype correlations in 106 patients with variants in major autism gene CHD8.
Dingemans AJM, Truijen KMG, van de Ven S, Bernier R, Bongers EMHF, Bouman A, de Graaff-Herder L, Eichler EE, Gerkes EH, De Geus CM, van Hagen JM, Jansen PR, Kerkhof J, Kievit AJA, Kleefstra T, Maas SM, de Man SA, McConkey H, Patterson WG, Dobson AT, Prijoles EJ, Sadikovic B, Relator R, Stevenson RE, Stumpel CTRM, Heijligers M, Stuurman KE, Löhner K, Zeidler S, Lee JA, Lindy A, Zou F, Tedder ML, Vissers LELM, de Vries BBA
Transl Psychiatry 2022 Oct 1;12(1):421. doi: 10.1038/s41398-022-02189-1. PMID: 36182950Free PMC Article
Apolipoprotein E genotype modifies the risk of behavior problems after infant cardiac surgery.
Gaynor JW, Nord AS, Wernovsky G, Bernbaum J, Solot CB, Burnham N, Zackai E, Heagerty PJ, Clancy RR, Nicolson SC, Jarvik GP, Gerdes M
Pediatrics 2009 Jul;124(1):241-50. doi: 10.1542/peds.2008-2281. PMID: 19564306Free PMC Article
The pathophysiology, medical management, and dental implications of autism.
Friedlander AH, Yagiela JA, Paterno VI, Mahler ME
J Calif Dent Assoc 2003 Sep;31(9):681-2, 684, 686-91. PMID: 14560872

Recent clinical studies

Etiology

Microbiota in Autism Spectrum Disorder: A Systematic Review.
Lewandowska-Pietruszka Z, Figlerowicz M, Mazur-Melewska K
Int J Mol Sci 2023 Nov 23;24(23) doi: 10.3390/ijms242316660. PMID: 38068995Free PMC Article
Loneliness and the Social Brain: How Perceived Social Isolation Impairs Human Interactions.
Lieberz J, Shamay-Tsoory SG, Saporta N, Esser T, Kuskova E, Stoffel-Wagner B, Hurlemann R, Scheele D
Adv Sci (Weinh) 2021 Nov;8(21):e2102076. Epub 2021 Sep 20 doi: 10.1002/advs.202102076. PMID: 34541813Free PMC Article
Abnormal Cerebellar Development in Autism Spectrum Disorders.
van der Heijden ME, Gill JS, Sillitoe RV
Dev Neurosci 2021;43(3-4):181-190. Epub 2021 Apr 6 doi: 10.1159/000515189. PMID: 33823515Free PMC Article
Social isolation and loneliness in old age: Exploring their role in mental and physical health.
Tragantzopoulou P, Giannouli V
Psychiatriki 2021 Mar 8;32(1):59-66. doi: 10.22365/jpsych.2021.009. PMID: 33759810
Behavioral analyses of animal models of intellectual and developmental disabilities.
Crawley JN, Fagiolini M, Harrison FE, Samaco R, Wozniak DF, Robinson MB
Neurobiol Learn Mem 2019 Nov;165:107087. Epub 2019 Sep 6 doi: 10.1016/j.nlm.2019.107087. PMID: 31499164

Diagnosis

Abnormal Cerebellar Development in Autism Spectrum Disorders.
van der Heijden ME, Gill JS, Sillitoe RV
Dev Neurosci 2021;43(3-4):181-190. Epub 2021 Apr 6 doi: 10.1159/000515189. PMID: 33823515Free PMC Article
Genetic influences of autism candidate genes on circuit wiring and olfactory decoding.
Hartig R, Wolf D, Schmeisser MJ, Kelsch W
Cell Tissue Res 2021 Jan;383(1):581-595. Epub 2021 Jan 30 doi: 10.1007/s00441-020-03390-8. PMID: 33515293Free PMC Article
The problem of overcontrol: Perfectionism, emotional inhibition, and personality disorders.
Dimaggio G, MacBeth A, Popolo R, Salvatore G, Perrini F, Raouna A, Osam CS, Buonocore L, Bandiera A, Montano A
Compr Psychiatry 2018 May;83:71-78. Epub 2018 Mar 20 doi: 10.1016/j.comppsych.2018.03.005. PMID: 29621675
Environmental risk factors for autism spectrum disorders.
Liu L, Zhang D, Rodzinka-Pasko JK, Li YM
Nervenarzt 2016 Dec;87(Suppl 2):55-61. doi: 10.1007/s00115-016-0172-3. PMID: 27531204
Care of the patient with an autism spectrum disorder by the general physician.
Venkat A, Jauch E, Russell WS, Crist CR, Farrell R
Postgrad Med J 2012 Aug;88(1042):472-81. Epub 2012 Mar 16 doi: 10.1136/postgradmedj-2011-130727. PMID: 22427366

Therapy

Use of Play Therapy in Nursing Process: A Prospective Randomized Controlled Study.
Sezici E, Ocakci AF, Kadioglu H
J Nurs Scholarsh 2017 Mar;49(2):162-169. Epub 2017 Jan 18 doi: 10.1111/jnu.12277. PMID: 28098954
Understanding taste dysfunction in patients with cancer.
McLaughlin L, Mahon SM
Clin J Oncol Nurs 2012 Apr;16(2):171-8. doi: 10.1188/12.CJON.171-178. PMID: 22459526
Care of the patient with an autism spectrum disorder by the general physician.
Venkat A, Jauch E, Russell WS, Crist CR, Farrell R
Postgrad Med J 2012 Aug;88(1042):472-81. Epub 2012 Mar 16 doi: 10.1136/postgradmedj-2011-130727. PMID: 22427366
A systematic review of the literature on the chiropractic care of patients with autism spectrum disorder.
Alcantara J, Alcantara JD, Alcantara J
Explore (NY) 2011 Nov-Dec;7(6):384-90. doi: 10.1016/j.explore.2011.08.001. PMID: 22051563
Autistic enterocolitis: fact or fiction?
Galiatsatos P, Gologan A, Lamoureux E
Can J Gastroenterol 2009 Feb;23(2):95-8. doi: 10.1155/2009/394317. PMID: 19214283Free PMC Article

Prognosis

Sleepy and Secluded: Sleep Disturbances are Associated With Connectedness in Early Adolescent Social Networks.
Palmer CA, Powell SL, Deutchman DR, Tintzman C, Poppler A, Oosterhoff B
J Res Adolesc 2022 Jun;32(2):756-768. Epub 2021 Aug 2 doi: 10.1111/jora.12670. PMID: 34338382Free PMC Article
Perceptions of Patients with Facial Paralysis: Predicting Social Implications and Setting Goals.
Lyford-Pike S, Nellis JC
Facial Plast Surg Clin North Am 2021 Aug;29(3):369-374. doi: 10.1016/j.fsc.2021.03.008. PMID: 34217438
Genomics of Autism.
Fakhro KA
Adv Neurobiol 2020;24:83-96. doi: 10.1007/978-3-030-30402-7_3. PMID: 32006357
The problem of overcontrol: Perfectionism, emotional inhibition, and personality disorders.
Dimaggio G, MacBeth A, Popolo R, Salvatore G, Perrini F, Raouna A, Osam CS, Buonocore L, Bandiera A, Montano A
Compr Psychiatry 2018 May;83:71-78. Epub 2018 Mar 20 doi: 10.1016/j.comppsych.2018.03.005. PMID: 29621675
Environmental risk factors for autism spectrum disorders.
Liu L, Zhang D, Rodzinka-Pasko JK, Li YM
Nervenarzt 2016 Dec;87(Suppl 2):55-61. doi: 10.1007/s00115-016-0172-3. PMID: 27531204

Clinical prediction guides

The phenotypic spectrum and genotype-phenotype correlations in 106 patients with variants in major autism gene CHD8.
Dingemans AJM, Truijen KMG, van de Ven S, Bernier R, Bongers EMHF, Bouman A, de Graaff-Herder L, Eichler EE, Gerkes EH, De Geus CM, van Hagen JM, Jansen PR, Kerkhof J, Kievit AJA, Kleefstra T, Maas SM, de Man SA, McConkey H, Patterson WG, Dobson AT, Prijoles EJ, Sadikovic B, Relator R, Stevenson RE, Stumpel CTRM, Heijligers M, Stuurman KE, Löhner K, Zeidler S, Lee JA, Lindy A, Zou F, Tedder ML, Vissers LELM, de Vries BBA
Transl Psychiatry 2022 Oct 1;12(1):421. doi: 10.1038/s41398-022-02189-1. PMID: 36182950Free PMC Article
Loneliness and the Social Brain: How Perceived Social Isolation Impairs Human Interactions.
Lieberz J, Shamay-Tsoory SG, Saporta N, Esser T, Kuskova E, Stoffel-Wagner B, Hurlemann R, Scheele D
Adv Sci (Weinh) 2021 Nov;8(21):e2102076. Epub 2021 Sep 20 doi: 10.1002/advs.202102076. PMID: 34541813Free PMC Article
Perceptions of Patients with Facial Paralysis: Predicting Social Implications and Setting Goals.
Lyford-Pike S, Nellis JC
Facial Plast Surg Clin North Am 2021 Aug;29(3):369-374. doi: 10.1016/j.fsc.2021.03.008. PMID: 34217438
Genomics of Autism.
Fakhro KA
Adv Neurobiol 2020;24:83-96. doi: 10.1007/978-3-030-30402-7_3. PMID: 32006357
Behavioral analyses of animal models of intellectual and developmental disabilities.
Crawley JN, Fagiolini M, Harrison FE, Samaco R, Wozniak DF, Robinson MB
Neurobiol Learn Mem 2019 Nov;165:107087. Epub 2019 Sep 6 doi: 10.1016/j.nlm.2019.107087. PMID: 31499164

Recent systematic reviews

Microbiota in Autism Spectrum Disorder: A Systematic Review.
Lewandowska-Pietruszka Z, Figlerowicz M, Mazur-Melewska K
Int J Mol Sci 2023 Nov 23;24(23) doi: 10.3390/ijms242316660. PMID: 38068995Free PMC Article
A systematic review of the literature on the chiropractic care of patients with autism spectrum disorder.
Alcantara J, Alcantara JD, Alcantara J
Explore (NY) 2011 Nov-Dec;7(6):384-90. doi: 10.1016/j.explore.2011.08.001. PMID: 22051563

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...